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Preparation method of cannabinol compound

A compound, the technology of cannabinol, which is applied in the field of efficient preparation of cannabinol compounds, can solve the problems of high technical difficulty and high production cost, and achieve the effects of saving solvent, stable product quality and good extraction effect

Active Publication Date: 2017-06-20
上海阿尔福斯医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The present invention provides a method for preparing cannabinol compounds on the basis of addressing the deficiencies of the prior art, such as high cost of industrial preparation and high technical difficulty. The present invention is suitable for large-scale, simple and efficient production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 1 kg of industrial hemp plant raw material hemp seeds, shell them, dry them at 100°C until the water content is less than 5%, ultrafinely pulverize them, add 2L of weak polar organic solvent hexane, then add 100mL of acetic acid, and heat them at 40°C Ultrasonic assisted extraction for 50 minutes, filtering, adding 50g of activated carbon to the filtrate, stirring and adsorbing at 60°C water bath temperature for 30 minutes, filtering, and recovering the solvent under low pressure to obtain the crude extract of industrial hemp extract, and then adding 1000mL of absolute ethanol to dissolve the crude extract , freeze to -20°C, store for 40 hours, filter, and recover the solvent under low pressure to obtain the primary product of industrial hemp extract, slowly add 15% NaOH aqueous solution to the primary product, stir until pH = 12, stand still, and centrifuge , filter, and slowly add 15% acetic acid aqueous solution to the filtrate, stir until pH = 3, separate, and d...

Embodiment 2

[0030] Take 1 kg of hemp seed, the raw material of industrial hemp plant, shell it, dry it at 100°C until the water content is less than 5%, ultrafinely pulverize it, add 20L of weak polar organic solvent hexane, then add 100mL of acetic acid, and heat it at 40°C Ultrasonic assisted extraction for 40 minutes, filtered, 60g of activated carbon was added to the filtrate, stirred and adsorbed in a water bath at 60°C for 30 minutes, filtered, and the solvent was recovered under low pressure to obtain the crude extract of industrial hemp extract, and then 1000mL of absolute ethanol was added to dissolve the crude extract , freeze to -20°C, store for 40 hours, filter, and recover the solvent under low pressure to obtain the primary product of industrial hemp extract, slowly add 15% NaOH aqueous solution to the primary product, stir until pH = 12, stand still, and centrifuge , filter, slowly add 15% acetic acid aqueous solution to the filtrate, stir until pH = 3, separate, and distill...

Embodiment 3

[0032] Take 1 kg of industrial hemp plant raw material hemp seeds, shell them, dry them at 100°C until the water content is less than 5%, ultrafinely pulverize them, add 6L of weak polar organic solvent hexane, then add 100mL of acetic acid, and heat at 40°C Ultrasonic assisted extraction for 30 minutes, filtering, adding 70g of activated carbon to the filtrate, stirring and adsorbing at 60°C water bath temperature for 30 minutes, filtering, and recovering the solvent under low pressure to obtain the crude extract of industrial hemp extract, and then adding 1000mL of absolute ethanol to dissolve the crude extract , freeze to -20°C, store for 40 hours, filter, and recover the solvent under low pressure to obtain the primary product of industrial hemp extract, slowly add 15% NaOH aqueous solution to the primary product, stir until pH = 12, stand still, and centrifuge , filter, slowly add 15% acetic acid aqueous solution to the filtrate, stir until pH = 3, separate, and distill at...

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Abstract

The invention discloses a preparation method of a cannabinol compound. The method comprises the following steps: screening industrial cannabis plant materials; drying and carrying out ultra-micro pulverization; putting the materials into an ultrasonic extraction device with a stirring function; adding a weak-polar or non-polar organic solvent and weak acid, and carrying out ultrasonic assisted extraction; filtering and adding active carbon in filtrate; filtering and evaporating to remove the solvent so as to obtain extractum of industrial cannabis extract; sufficiently dissolving the extractum by adopting a high-polar organic solvent; freeing, sealing, filtering and evaporating to remove the solvent, so as to obtain a primary product of the industrial cannabis extract; stirring the primary product and slowly adding an alkali solution; centrifuging and filtering; slowly adding an acid solution into filtrate; separating to obtain an industrial cannabis extract product containing the rich cannabinol compound. The method disclosed by the invention has the advantages of high extraction efficiency, low cost, few product impurities, small pollution and easiness of being industrially realized.

Description

technical field [0001] The invention relates to the technical field of preparation of biomedical materials, in particular to an efficient preparation method of cannabinol compounds. Background technique [0002] Cannabis is an annual herb commonly known as hemp, hemp and hemp. Cannabis has a history of at least 6,000 years in my country, and is mainly distributed in Yunnan, Guizhou, Guangxi, Sichuan, Anhui, Shandong, Shanxi, Henan, Hebei, Heilongjiang, Jilin, Liaoning, Inner Mongolia, and Xinjiang. Because marijuana contains a hallucinogenic substance tetrahydrocannabinol (THC), which is easily used by criminals to refine drugs and cause social harm, many countries have made corresponding regulations on the use of this plant. [0003] In the 1990s, the European Union divided marijuana into medicinal type (THC>0.5%), intermediate type (0.3%<THC<0.5%) and Fiber type (THC<0.3%). Among them, fiber-type hemp has extremely low THC content and has no drug utilization...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K36/60A61P25/08A61P25/00
CPCA61K36/185A61K36/60A61K2236/15A61K2236/17A61K2236/35A61K2236/53
Inventor 李大伟邓伟周光大林建华
Owner 上海阿尔福斯医药科技有限公司
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