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1598 results about "Activated oxygen" patented technology

Activated oxygen is a three atom oxygen molecule. This three atom molecule is a colorless gas with powerful oxidizing properties, formed from oxygen by electrical discharges or ultraviolet light. It differs from normal oxygen (O2) but over time or with forced filtration, will break back down to normal oxygen (O2)...

Electrochemical active oxygen supply device for washing machine and preparation method

The invention provides an electrochemical active oxygen supply device for a washing machine and a preparation method. The device comprises a shell, a single closed reaction chamber is formed in the shell, a bifunctional anode electrode and a bifunctional cathode electrode are integrated in the reaction chamber, and a compact and uniform reaction area is formed between the anode electrode and the cathode electrode. When water flows through the reaction area, hydrogen peroxide (H2O2) and / or hydroxyl radicals (OH) are / is electrochemically generated on the surface in situ by accurately adjusting the electrode potential of the difunctional anode, so that instant generation and instant utilization of active oxygen are realized. The active oxygen directly enters a washing system of the washing machine along with water flow, bacteria, viruses and fungi can be efficiently inactivated under the normal-temperature or low-temperature washing condition without additionally adding chemical disinfectants, organic stains and peculiar smell molecules are synchronously degraded, and green, efficient and intelligent healthy washing is achieved.
Owner:ZHEJIANG QINGYUE TECH CO LTD

Titanium implant multifunctional composite coating with anti-active oxygen and anti-inflammatory dual performance and preparation method thereof

The invention relates to the technical field of biomedical materials, in particular to a titanium implant multifunctional composite coating with anti-active oxygen and anti-inflammatory dual performance and a preparation method of the titanium implant multifunctional composite coating. The coating is composed of a lanthanum oxide (La2O3) nano-particle layer growing on the surface of the titanium implant in situ and queen lily glycoside A (RA) loaded on the lanthanum oxide (La2O3) nano-particle layer and can continuously release La < 3 + > and RA. The preparation method comprises the following steps: performing alkali heat treatment on the titanium substrate; a La (OH) 3 coating is synthesized on the surface in situ through a hydrothermal reaction; the La2O3 nano-particles are calcined and converted into a La2O3 nano-particle layer with a porous structure; and finally loading RA through an impregnation method. The coating can effectively remove ROS, regulate immune inflammatory response, promote osteogenic differentiation and inhibit osteoclast activity, thereby remarkably promoting osseointegration. The problem of osseointegration under the osteoporosis pathological microenvironment is effectively solved, the preparation process is simple and controllable, and the composition is suitable for bone defect repair of osteoporosis patients and has important clinical application value.
Owner:ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Dual-mechanism antibacterial photosensitizer as well as preparation method and application thereof

The invention discloses a dual-mechanism antibacterial photosensitizer as well as a preparation method and application thereof, and relates to the technical field of biomedical photoelectric functional materials. The invention relates to a triphenylamine derivative, which can realize fluorescence imaging of bacterial or fungal infection by utilizing fluorescence characteristics, can generate active oxygen under illumination to play a photodynamic therapy role, is suitable for preparing photodynamic therapy preparations and developing antibacterial materials, and can also be applied to the fields of environment and public health and tumor treatment. The problems that an existing photosensitizer is insufficient in broad spectrum, different in fungus drug resistance mechanism, limited in single treatment effect and the like can be effectively solved, and the photosensitizer has wide application prospects.
Owner:EIGHTH AFFILIATED HOSPITAL SUN YAT SEN UNIV (SHENZHEN FUTIAN)

Ultra-small prussian blue nano-particles carrying tirofian, preparation method and application of nano-particles in preparation of medicine for reducing MVO and MIRI

The invention relates to ultra-small prussian blue nano-particles (T-USPB-C) carrying tirofian, a preparation method of the nano-particles and application of the nano-particles in preparation of drugs for reducing MVO and MIRI. According to the preparation method, the T-USPB-C is prepared by three steps. The T-USPB-C provided by the invention can carry tirofiban, and has catalase and superoxide dismutase simulated nano-enzyme activity. Moreover, the size of the nano-scale drug is required to reach a nano-scale size, and the drug can be efficiently cleared through kidney excretion, so that the potential long-term toxicity problem is minimized. The ultra-small prussian blue nanoparticle carrying the tirofian has an excellent active oxygen scavenging capability. Microvascular perfusion can be rapidly improved through the antithrombotic effect, then the protection effect is continuously achieved through the anti-oxidation and anti-inflammatory mechanism, and microvascular injury and MIRI are effectively prevented.
Owner:ZHUJIANG HOSPITAL OF SOUTHERN MEDICAL UNIVERSITY

Bifidobacterium longum subsp. Infantis Y46 and application thereof in enhancing cell defense and repair and regulating host metabolic homeostasis

The invention belongs to the technical field of microorganisms and fermentation engineering, and particularly relates to application of bifidobacterium longum subsp. Infantis Y46 in the aspects of enhancing cell defense and repair and regulating metabolic homeostasis of a host. The strain is isolated from infant feces. Animal experiments prove that living cell thalli of the bifidobacterium longum subsp. Infantis Y46, which are obtained by culturing an MRS liquid culture medium added with L-cysteine hydrochloride (0.05%, v / v), can significantly enhance the oxidative stress resistance of an organism and reduce the level of active oxygen in the organism compared with a control bacterium bifidobacterium longum subsp. Infantis 15697. Transcriptomics analysis shows that the bifidobacterium longum subsp. Infantis Y46 can enhance self-protection of cells and improve physiological imbalance caused by external pressure by regulating related signal channels of an organism. The action mechanism is closely related to signaling pathways related to cell defense, metabolic homeostasis and barrier functions. The invention provides a new strain resource and an application scheme for developing functional food or medicinal preparations for enhancing the health defense function of a human body.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

Ternary synergistic nano-enzyme hydrogel as well as preparation method and application thereof

The invention discloses ternary synergistic nano-enzyme hydrogel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving zinc nitrate hexahydrate and ferric nitrate nonahydrate in methanol; dissolving 2-methylimidazole in methanol, adding into a metal salt solution, stirring, and sequentially centrifuging, washing and drying to obtain Fe / ZIF-8 nano-enzyme; the preparation method comprises the following steps: adding methacrylated gelatin and hyaluronic acid into deionized water, stirring, cooling to room temperature, and refrigerating to obtain a GelMA-HA precursor solution; and adding the Fe / ZIF-8 nano-enzyme into the GelMA-HA precursor solution, stirring, injecting into a mold, and carrying out ultraviolet light cross-linking curing to obtain the ternary synergistic nano-enzyme hydrogel. According to the hydrogel disclosed by the invention, active oxygen is efficiently removed and oxygen is produced through Fe / ZIF-8 nano-enzyme, and cartilage repair is promoted in combination with lubrication and slow release functions of gelatin hydrogel, so that a new strategy is provided for treatment of osteoarthritis.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV

Application of biological product overexpressing OsARF7 gene in improving disease resistance of rice

The invention belongs to the technical field of plant genetic engineering, and particularly relates to application of a biological product for overexpressing an OsARF7 gene to improvement of rice disease resistance, the nucleotide sequence of the OsARF7 gene is shown as SEQ ID NO.1, and the amino acid sequence of the OsARF7 gene is shown as SEQ ID NO.2. According to the invention, an OsARF7 overexpression rice strain is constructed by means of transgenosis. Tests show that the overexpression of the OsARF7 can significantly enhance the immunocompetence of the rice, for example, the expression level of a disease-resistant related gene is improved, active oxygen outbreak is significantly induced, and the resistance of the rice to false smut and bacterial leaf blight is significantly improved. The invention proves that the OsARF7 has a positive regulation effect on rice immunity, can be used for improving the disease resistance of rice, and has important significance for creating disease-resistant rice germplasm resources.
Owner:JILIN AGRICULTURAL UNIV

Application of ZmTCP5 gene in regulation and control of heat resistance of corn

PendingCN121344077APlant peptidesFermentationRos scavengingGermplasm
The invention relates to the field of gene engineering and molecular breeding, and discloses application of a ZmTCP5 gene in regulation and control of heat resistance of corn. According to the invention, three types of knockout mutants of the gene are obtained by using a CRISPR / Cas9 technology, and three overexpression materials are created. At normal temperature (25-28 DEG C), the material has no obvious phenotypic difference with a wild type; however, under high temperature stress (45 DEG C), the ZmTCP5 knockout mutant has enhanced heat resistance, reduced reactive oxygen species (ROS) accumulation, and significantly increased ROS scavenging enzyme activity, chlorophyll content and photochemical efficiency; on the contrary, the ZmTCP5 overexpression strain is more sensitive to heat stress, which indicates that the ZmTCP5 negatively regulates the heat resistance of the corn. The research provides a theoretical basis for analyzing a heat-resistant molecular mechanism of the corn, and also provides an important gene resource for creating a new germplasm of the heat-resistant corn.
Owner:UNIV OF SCI & TECH BEIJING +2

Application of sulfur quantum dot nano-particles in improving waterlogging resistance of plants

The invention discloses application of sulfur quantum dot nanoparticles to improvement of plant waterlogging resistance. The invention provides sulfur quantum dot nanoparticles PEI-SQDs prepared from sulfur, sodium hydroxide, polyethylene glycol and polyethyleneimine. The sulfur quantum dot nanoparticles PEI-SQDs are simple in synthesis method, small in particle size, low in toxicity, low in price, simple to prepare, suitable for large-scale production, good in water solubility and good in biocompatibility; the compound has the capacity of removing active oxygen and ethylene in vitro, and can remove excessive active oxygen and ethylene in plants with waterlogging stress, relieve short-term waterlogging stress suffered by crops and recover growth and development of the crops when being applied to the plants with waterlogging stress; further, long-term waterflooding stress on the crops can be relieved, and the yield of the crops is increased; and the sulfur quantum dot nanoparticles are simple and convenient in use method and obvious in action effect.
Owner:HUAZHONG AGRI UNIV

Fluorescent probe for photodynamic oxidation of beta-amyloid protein as well as preparation method and application of fluorescent probe

The invention relates to the technical field of biological medicines, and particularly discloses a BODIPY (boron dipyrromethene)-based compound and an application of the BODIPY-based compound in photodynamic oxidation of beta-amyloid protein (Abeta). The compound takes iodo-BODIPY as a photosensitive core and is connected with 4-t-butyloxycarboryl benzene as an A beta recognition group. The introduction of iodine atoms significantly enhances the intersystem crossing ability of molecules, so that the molecules have excellent reactive oxygen species (ROS) generation ability. The compound has high ROS yield, good optical stability and biocompatibility, can specifically target A beta aggregate, realizes photodynamic oxidative degradation, and provides a novel potential tool for treatment of Alzheimer's disease.
Owner:BEIJING UNIV OF CHEM TECH

Method for detecting glucose based on cerium dioxide / gold nanocluster-Prussian blue nanoenzyme cascade catalysis

The invention discloses a method for detecting glucose on the basis of cascade catalysis of cerium dioxide / gold nano cluster-Prussian blue nano enzyme (AuNCs-CeO-HMPB). The material is prepared by compounding cerium dioxide (CeO) with similar glucose oxidase activity and hollow Prussian blue nanoparticles (AuNCs-HMPB) modified by gold nanoclusters with similar peroxidase activity through a hydrothermal assembly method. In the presence of glucose, CeO catalyzes oxidation of glucose to generate gluconic acid and H2O2, then AuNCs-HMPB synergistically catalyzes decomposition of newly generated H2O2 to generate high active oxygen species, further a colorless 3, 3 ', 5, 5'-tetramethyl benzidine (TMB) color developing agent is oxidized to generate obvious color change, and based on the cascade catalytic reaction, the enzyme-free glucose colorimetric sensor is successfully constructed. The sensor shows excellent detection performance on glucose under optimized conditions (pH = 4.0, 50 DEG C), the linear detection range is 10.00-90.00 [mu] mol / L, and the detection limit is 2.1 [mu] mol / L (S / N = 3).
Owner:GUILIN UNIV OF ELECTRONIC TECH

Sodium hyaluronate fermentation filtrate for repairing scalp and strengthening hair as well as preparation method and application of sodium hyaluronate fermentation filtrate

The invention relates to a sodium hyaluronate fermentation filtrate as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. Through a two-stage fermentation mode, the fermentation filtrate containing sodium hyaluronate is prepared by recombining bacillus subtilis, and then residual nutrient substances in a culture medium are consumed by inoculating bacillus velezensis, so that the nutrient substances are metabolized into active substances with repairing and strengthening effects on hair; the prepared sodium hyaluronate fermentation filtrate has the effects of repairing scalp and strengthening hair. The sodium hyaluronate filtrate disclosed by the invention can be used for well reducing the content of NO in macrophages (the NO content of cells is increased due to malassezia lysate), can be used for removing active oxygen ROS of HaCaT cells and increasing the total tensile strength of hair, and has the potential effects of relieving scalp, resisting oxidative stress and enhancing the toughness of the hair.
Owner:GUANGZHOU JU MICROBIAL TECHNOLOGY CO LTD +1

Nano drug delivery system for treating neovascular eye diseases and preparation method thereof

PendingCN121371203ASenses disorderInorganic active ingredientsMacula lutea degenerationCatalytic decomposition
The invention belongs to the technical field of nano-drugs, and discloses a multifunctional nano-drug delivery system for treating neovascular eye diseases and a preparation method of the multifunctional nano-drug delivery system. The nano drug delivery system disclosed by the invention is a composite nano preparation which takes dendritic mesoporous silica nanoparticles as a carrier and co-loads cerium zirconium oxide nano enzyme and an anti-VEGF (vascular endothelial growth factor) drug, various active oxygen can be efficiently removed, oxygen is continuously released through catalytic decomposition of hydrogen peroxide, a retina hypoxia microenvironment is improved, and the retina hypoxia effect is improved. According to the present invention, the anti-VEGF drug delivery system can reduce the oxidative stress induced retinal pigment epithelial cell apoptosis rate, reduce the inflammatory reaction, and simultaneously achieve the slow release and the controlled release of the anti-VEGF drug, and the drug effect maintenance time can achieve more than 60 days, such that the multi-target synergistic treatment can be achieved through the synergistic regulation of the multiple pathological links such as oxygen deficit-oxidative stress-inflammation-angiogenesis, and the anti-VEGF drug delivery effect can be achieved. The choroidal neovascularization can be effectively inhibited by single intravitreal injection, and a new strategy of multi-target collaborative treatment is provided for neovascular macular degeneration and other eye diseases.
Owner:SHANGHAI UNIV

Electrochemical active oxygen supply device for drum of washing machine and washing machine

The invention provides an electrochemical active oxygen supply device for a drum of a washing machine and the washing machine. The device serves as a functional inner component, is tightly attached to the inner wall of an outer barrel of the washing machine or in a barrel gap, does not need to be connected with an external water path, achieves high integration with the roller, and reduces occupation of the effective washing volume of the roller to the maximum extent. A first shell and a second shell are combined to form a reaction space, and a difunctional anode electrode and a difunctional cathode electrode are integrated in the reaction space and are electrically connected with a positive electrode and a negative electrode of an external power supply respectively to form a complete electrochemical loop. When water flow naturally flows through the reaction space in the washing process, a specific working potential is applied to the difunctional anode electrode under constant potential control, so that hydrogen peroxide (H2O2) and / or hydroxyl radicals (OH) are / is generated on the surface of the difunctional anode electrode in an in-situ electrochemical mode.
Owner:ZHEJIANG QINGYUE TECH CO LTD

Ultrasonic activation type piezoelectric gel dressing as well as preparation method and application thereof

The invention discloses an ultrasonic activation type piezoelectric gel dressing and a preparation method and application thereof.The surface of a system is an antibacterial hydrogel layer, the antibacterial hydrogel layer is composed of polyethyleneimine (PEI) and polyvinyl alcohol (PVA) cross-linked hydrogel, and ultrasound and current can be transmitted to a deep area; bT-dNO piezoelectric nanoparticles are packaged inside, and BT-dNO is prepared by coating a nitric oxide (NO) donor on the surface of piezoelectric barium titanate (BT) subjected to hydroxylation and dopamine modification. Under the stimulation of low intensity focused ultrasound (LIFU), the donor can release NO as required, and the BT nanoparticles can generate reactive oxygen species (ROS) and output piezoelectric current. The dressing system has an effective combined repair effect, excellent biocompatibility and good anti-inflammatory ability.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV

Laundry composition and preparation method therefor

A laundry composition and a preparation method therefor are provided, relating to the field of household necessities. The laundry composition includes a wrapping material, a functional material enveloped in the wrapping material, and an adhesive for bonding the wrapping material; the wrapping material is a film-forming material with laundry function; the functional material is selected from one or more of a softening particle, a fragrant particle, an active oxygen particle, and an enzyme preparation. By enveloping the functional material in the wrapping material with a detergent function, the laundry composition has integrated functions of cleaning, decontamination, pliancy, and fragrance-retaining. Furthermore, since the granular softening particle, a granular fragrant particle, a granular active oxygen particle, and a granular enzyme preparation are not directly added in the wrapping material, even if the wrapping material is formed by high-temperature drying, the functional materials will not fail.
Owner:FOSHAN MAGIC CRYSTAL TECHNOLOGY DEVELOPMENT CO LTD

EGFR targeted nano-drug carrier and preparation method thereof

The invention discloses an EGFR (epidermal growth factor receptor) targeted nano-drug carrier and a preparation method thereof, the EGFR targeted nano-drug carrier comprises drug-loading nanoparticles, an erythrocyte membrane coating the drug-loading nanoparticles and GE11 peptide connected to the erythrocyte membrane, and the drug-loading nanoparticles are formed by connecting tannic acid, ellagic acid and 1, 4-phenyldiboronic acid through boric acid ester bonds. The EGFR targeted nano-drug carrier disclosed by the invention can be enriched at an EGFR overexpressed tumor site in a targeted manner, and can be effectively prevented from being cleared by an immune system, and the drug loaded by the drug-loaded nanoparticles is released in a high-active oxygen environment, so that the treatment effect on tumors can be improved, and the toxic and side effects on normal tissues can be reduced; and photothermal therapy and chemotherapy effects can be simultaneously generated under NIR illumination, and the anticancer efficiency can be remarkably improved through the synergistic effect of the photothermal therapy and the chemotherapy.
Owner:CHONGQING UNIV CANCER HOSPITAL

Laundry composition and preparation method therefor

SOLUTION: A laundry composition comprises an encapsulation material, a functional component encapsulated within the encapsulation material, and a binder used for bonding the encapsulation material, wherein the encapsulation material is a film-forming material having a washing function, and the functional component comprises one or more of softening particles, fragrance-retaining particles, active oxygen particles, and an enzyme preparation.EFFECT: By encapsulating the functional component with the encapsulation material having the washing function, the laundry composition can simultaneously achieve a cleaning and stain removal function, a softening function, and a fragrance-retaining function. In addition, since the softening particles, the fragrance-retaining particles, the active oxygen particles, and the enzyme preparation in the functional component are not directly added to the encapsulation material, it is possible to prevent the functional component from losing effectiveness when the encapsulation material is subjected to high-temperature press-forming, thereby solving a problem that effects are poor or costs are high when functional components are directly added to conventional laundry sheets.SELECTED DRAWING: Figure 1
Owner:FOSHAN MAGIC CRYSTAL TECHNOLOGY DEVELOPMENT CO LTD

Composite positive electrode lithium supplementing additive, preparation method and application thereof

The application discloses a composite positive electrode lithium supplement additive and a preparation method and application thereof. The composite positive electrode lithium supplement additive comprises a core and a functional encapsulation layer coated on the core, the core comprises a positive electrode lithium supplement material, and the functional encapsulation layer contains an oxygen absorber. The composite positive electrode lithium supplement additive can effectively remove active oxygen and inhibit gas production reactions caused by the active oxygen, thereby inhibiting the gas production of a battery containing the composite positive electrode lithium supplement additive during charging and discharging, effectively improving the safety of the battery, and having good lithium supplement effect and processing performance. The preparation method of the composite positive electrode lithium supplement additive can ensure that the prepared composite positive electrode lithium supplement additive has stable structure and electrochemical performance, and has high efficiency and low production cost.
Owner:SHENZHEN DYNANONIC INNOVAZONE NEW ENERGY TECH CO LTD

Collagen-based injectable fiber hydrogel as well as preparation method and application thereof

The invention belongs to the technical field of biomedical materials and regenerative medicine, and relates to collagen-based injectable fiber hydrogel as well as a preparation method and application thereof. According to the injectable fiber hydrogel, methacrylated collagen and dithiothreitol are subjected to a thiol-ene click reaction rapidly under the action of a photoinitiator through illumination, a primary cross-linked network is formed, and the injection and in-situ gel forming requirements are met; then under the conditions that the pH is 6.5-8.0 and the temperature is 30-39 DEG C, collagen molecules are self-assembled into a nanofiber structure, and a bionic network similar to a natural extracellular matrix is obtained. The hydrogel disclosed by the invention has the advantages of rapid gelation, structural biomimetic property and biological activity; residual sulfydryl endows the hydrogel with active oxygen scavenging capacity, so that oxidative stress can be relieved, and immune response can be regulated; the fibrotic structure promotes cell adhesion, migration and tissue regeneration.
Owner:EAST CHINA UNIV OF SCI & TECH

Preparation method of butynedioic acid

The invention relates to the technical field of organic synthesis, in particular to a preparation method of butynedioic acid. The preparation method of the butynedioic acid comprises the following steps that butynediol is oxidized into the butynedioic acid through pypocholoride and a catalyst, and the catalyst comprises carbon black and a metal compound loaded on the carbon black. According to the invention, butynediol is used as a raw material, and butynediol is oxidized by using pypocholoride and a catalyst to prepare butynedioic acid. Wherein butynediol is easy to obtain, and the raw material cost is low. In addition, the catalyst uses carbon black to immobilize a metal compound, conversion of pypocholoride into a large number of reactive oxygen free radicals can be accelerated, butynediol can be efficiently oxidized under the action of pypocholoride and the catalyst, and the whole synthesis route is safe and green, simple and feasible in process, low in equipment requirement, low in operation cost, free of secondary pollution and low in production cost.
Owner:WANHUA CHEM (SICHUAN) CO LTD +1

Application of tea extracellular vesicles in preparation of product for preventing and / or treating UVB-induced skin photoaging

The invention discloses application of tea extracellular vesicles in preparation of a product for preventing and / or treating UVB-induced skin photoaging, and belongs to the technical field of application of the tea extracellular vesicles. The tea extracellular vesicles are derived from tea leaves and / or stem leaves and are prepared by a method of combining enzymolysis, multi-stage filtration and ultracentrifugation, and the particle size of the tea extracellular vesicles is mainly distributed in a range of 60-100nm. Experiments show that the tea extracellular vesicles can effectively reduce active oxygen accumulation and lipid peroxidation caused by UVB radiation, repair mitochondrial membrane potential and inhibit expression of matrix metalloproteinase and inflammatory factors, so that photoaging symptoms such as skin wrinkles, erythema and barrier function damage are relieved. The tea extracellular vesicle provided by the invention has the advantages of natural raw materials, good biocompatibility, small side effect and the like, can be used for preparing a plurality of external dosage forms such as gel, cream, spray and the like, and provides a safe and effective new natural product choice for prevention and treatment of skin photoaging.
Owner:XIAMEN BIYAN BIOTECHNOLOGY CO LTD

Catalyst material integrated with Au-Ir cascade catalytic sites as well as preparation method and application of catalyst material

The invention belongs to the technical field of catalyst materials, and particularly relates to a catalyst material integrated with Au-Ir cascade catalytic sites as well as a preparation method and application of the catalyst material. The catalyst material comprises micron-sized urchin-like carbonaceous particles loaded with cascaded Au clusters and Ir monatomic materials, and the micron-sized urchin-like carbonaceous particles have glucose oxidase-like activity, oxidases-like activity, peroxidase-like activity and NADH oxidase-like activity, so that metabolic inhibition can be combined with reactive oxygen attack to eliminate stubborn dental caries related biological membranes.
Owner:SICHUAN UNIV

Preparation method and antibacterial application of naphthothiadiazolyl photosensitizer

PendingCN121758395AGood photodynamic lethalitystable structureBiocideOrganic chemistryPhotosensitive polymerEngineering
The invention discloses a preparation method and antibacterial application of a naphthothiadiazolyl photosensitizer, and belongs to the technical field of biomedical antibacterial materials. The naphthothiadiazole-based photosensitizer provided by the invention overcomes the problem that the existing commercial photosensitizer gathers and quenches the active oxygen efficiency, and meanwhile, the antibacterial photosensitive polymer prepared based on the novel naphthothiadiazole-based photosensitizer has the unique advantages that the structure is stable, photosensitizer micromolecules are not easy to leak and the antibacterial effect is long-acting; the construction of the antibacterial polymer coating on the surface of the medical instrument in the future has important clinical application potential. The naphthothiadiazolyl photosensitizer provided by the invention has good photodynamic killing performance on drug-resistant bacteria MRSA (Methicillin Resistant Staphylococcus Aureus).
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Multifunctional hydrogel patch as well as preparation method and application thereof

The invention discloses a multifunctional hydrogel patch and a preparation method and application thereof.The biological patch comprises decellularized freeze-dried tumor tissue (dFCT) and a hydrogel layer loaded with hair melanin nanoparticles (HNPs), the dFCT is obtained by decellularizing and freeze-drying the tumor tissue, and rich natural extracellular matrix components are reserved; hNPs is extracted from hair and has excellent active oxygen scavenging capacity and photothermal conversion performance; it is preferable that the hydrogel layer is a methacrylated gelatin (GelMA). The patch disclosed by the invention shows a remarkable cell viability promoting effect and antibacterial ability in vitro, and can accelerate wound healing by reducing oxidative stress, inhibiting inflammatory response and promoting angiogenesis in vivo. The patch is simple and convenient in preparation process and natural in component source, has multiple functions of resisting bacteria, resisting oxidation, promoting tissue regeneration and the like, and is suitable for wound repair treatment.
Owner:THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV

Multi-component inulin hydrogel as well as preparation method and application thereof

The invention discloses multi-component inulin hydrogel as well as a preparation method and application thereof, and belongs to the technical field of nano materials and medicines.The multi-component inulin hydrogel is characterized in that a medicine L-alanyl-L-glutamine contributing to intestinal mucosa repair is entrapped in the inulin hydrogel; the multi-component inulin hydrogel has the advantages that the multi-component inulin hydrogel is prepared from the inulin and composite nanoparticles (namely mesoporous polydopamine-gallium composite nanoparticles) composed of an active oxygen scavenger polydopamine and an antibacterial agent gallium ions, the repairing capacity on intestinal barriers is further enhanced, and the prepared multi-component inulin hydrogel can be used for effectively treating inflammatory bowel diseases and non-alcoholic steatohepatitis.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI

High-performance corrugated carton with waterproof and antibacterial functions and preparation process thereof

The application discloses a high-performance corrugated carton with waterproof and antibacterial functions and a preparation process thereof, and the process comprises the following steps: S1, providing a corrugated paperboard substrate; S2, coating a barrier-enhanced coating liquid on the inner and outer surfaces of the corrugated paperboard substrate respectively, and forming a barrier-enhanced coating layer after solidification; S3, coating a composite antibacterial coating liquid, and forming a composite antibacterial coating layer after solidification to obtain a composite corrugated paperboard; and S4, using the composite corrugated paperboard to make a corrugated carton. The composite antibacterial coating layer can improve the waterproof performance of the composite corrugated paperboard and endow the composite corrugated paperboard with excellent antibacterial performance. Through cooperation of the barrier-enhanced coating layer and the composite antibacterial coating layer and with the excellent barrier effect of the barrier-enhanced coating layer, the waterproof performance of the composite corrugated paperboard can be further improved while avoiding the risk that active oxygen brought by the composite antibacterial coating layer may damage the performance of the corrugated paperboard substrate, and the mechanical strength of the composite corrugated paperboard can be improved, so that the service life of the composite corrugated paperboard can be ensured.
Owner:WUXI YUCHENG PACKAGING MATERIALS CO LTD

Integrated nano platform for bimodal detection and synergistic sterilization of pathogenic bacteria as well as preparation method and application of integrated nano platform

The invention discloses an integrated nano platform for bimodal detection and synergistic sterilization of pathogenic bacteria as well as a preparation method and application of the integrated nano platform, and belongs to the technical field of food safety. The platform is composed of a multifunctional nano probe (MPDA / Pd SA-DA-CDs / Apt) and a magnetic separation assembly (MNRs / PGA / AM). The probe integrates enzyme-like catalysis and photo-thermal performance and is used for generating colorimetric and photo-thermal dual-mode signals so as to realize high-sensitivity and high-reliability detection of pathogenic bacteria. The magnetic separation assembly is used for specifically capturing and enriching target bacteria and eliminating matrix interference. After detection is positive, the platform can immediately start secondary propulsion synergistic sterilization: firstly, the action distance is shortened through magnetic aggregation, and then pathogenic bacteria are efficiently inactivated and biological membranes are disintegrated by utilizing the synergistic effect of near-infrared laser excitation photothermal effect and active oxygen. According to the invention, the integration of detection and disinfection is realized, the operation is convenient, and the method has important application value in the fields of food safety and biomedicine.
Owner:GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1

Boron-nitrogen co-doped porous carbon self-breathing electrode and application thereof in construction of self-breathing heterogeneous electro-Fenton system

The invention relates to the technical field of heterogeneous electro-Fenton catalysis, in particular to a boron-nitrogen co-doped porous carbon self-breathing electrode and application of the boron-nitrogen co-doped porous carbon self-breathing electrode in construction of a self-breathing heterogeneous electro-Fenton system. According to the boron-nitrogen co-doped porous carbon self-breathing electrode, ZIF-8 is used as a precursor, a boron-nitrogen co-doped porous carbon material is prepared through boric acid doping, hydrothermal reaction and high-temperature calcination, then the boron-nitrogen co-doped porous carbon material, a binder, a dispersing agent and the like are prepared into slurry, and the slurry is coated on a hydrophobic breathable conductive carrier to prepare the boron-nitrogen co-doped porous carbon self-breathing electrode. The self-breathing electrode is used as a cathode and is used for constructing a self-breathing heterogeneous electro-Fenton system, oxygen can be efficiently taken in from air by utilizing a self-breathing effect under the condition of no external aeration, active oxygen species are generated in situ, and the self-breathing electrode is used for efficiently treating organic wastewater. The method has the advantages of efficient degradation, experimental condition simplification, energy conservation and consumption reduction.
Owner:DALIAN NATIONALITIES UNIVERSITY