This invention belongs to the field of microencapsulation formulation technology, specifically relating to a biochemical agent and method for regulating the
concentration ratio of ultra-high industrial circulating water using self-
feedback regulation. It solves the technical problems of existing biochemical agents' inability to sense changes in the localized
fouling microenvironment, the spatiotemporal disconnect between
efficacy release and
fouling, and the susceptibility to structural inactivation and damage. The self-feedback regulated biochemical agent is a core-shell microcapsule with a three-layer structure. From the inside out, it comprises an ultra-
high concentration biochemical core in a dehydrated, vitrified dormant state; a flexible stress buffer layer composed of a modified polysiloxane
elastomer; and a stimulus-responsive dynamic
polymer shell assembled from a
polysaccharide backbone grafted with
calcium ion shielding groups, a dynamic covalent crosslinking agent, and
fouling signal molecule receptors. The stimulus-responsive dynamic
polymer shell triggers reversible dissociation and recombination of dynamic covalent bonds based on changes in the concentration of
quorum sensing signal molecules, achieving self-feedback release and termination of biochemically active substances, thus completing the autonomous degradation of fouling.