78 results about "Biochemical Activity" patented technology

Spinal disc therapy systems in accordance with the present invention generally include an implant element structured to have a therapeutic effect on a human or animal body when implanted into an intervertebral disc annulus or intervertebral disc nucleus. The implant element may include a biochemically active agent that provides pain relief, inflammation relief or other benefit to the human or animal body. The implant element may be mechanically active or mechanically activatable in being effective in providing a therapeutic effect to the human or animal body when implanted in the intervertebral disc. For example, the implant element may include a mechanically active or mechanically activatable component that radiates wave energy, for example, in the form of electrical or magnetic energy, into the body.

The present invention features novel, diverse, hybrid and engineered recombinase enzymes, and the utility of such proteins with associated recombination factors for carrying out DNA amplification assays. The present invention also features different recombinase ‘systems’ having distinct biochemical activities in DNA amplification assays, and differing requirements for loading factors, single-stranded DNA binding proteins (SSBs), and the quantity of crowding agent employed.

Peptides having general and specific binding affinities for the Src homology region 3 (SH3) domains of proteins are disclosed in the present invention. In particular, SH3 binding peptides have been isolated from phage-displayed random peptide libraries which had been screened for isolates that bind to bacterial fusion proteins having an SH3 domain and glutathione S-transferase (GST). Preferred peptides are disclosed which comprise a core 7-mer sequence (preferably, a consensus motif) and two or more, preferably at least six, additional amino acid residues flanking the core sequence, for a total length of 9, preferably at least 13, amino acid residues and no more than about 45 amino acid residues. Such peptides manifest preferential binding affinities for certain SH3 domains. The preferred peptides exhibit specific binding affinities for the Src-family of proteins. In vitro and in vivo results are presented which demonstrate the biochemical activity of such peptides.

The present, invention provides an oral delivery system for a therapeutic compound that is an acid, a salt of an acid or an unionized compound or a proactive form thereof with pharmacological, physiological or biochemical activity. The present invention particularly provides a swallow formulation comprising a therapeutic compound that is an acid, a salt of an acid or an unionized compound or a proactive form thereof which facilitates the rapid delivery of the therapeutic compound to the circulatory system.

The present invention relates generally to therapeutic formulations. More particularly, this present invention provides an oral delivery system for a therapeutic compound that is a base, a salt of a base or an amphoteric compound or a salt of a amphoteric compound with pharmacological, physiological or biochemical activity or a proactive form thereof. The present invention even more particularly provides a swallow formulation comprising a therapeutic compound that is a base, a salt of a base, an amphoteric compound or a salt of an amphoteric compound which facilitates the rapid delivery of the therapeutic compound to the circulatory system.

A method for preventing and / or treating the signs of skin aging comprises administering as an agent into an individual in need thereof an effective amount of acid ceramidase, polypeptides derived from this protein or analogues thereof, a nucleic sequence encoding such a polypeptide, or an agent for modulating the expression or the biological or biochemical activity of such a polypeptide. A methods for characterizing a state of an epithelium comprises determining a content of acid ceramidase, polypeptides derived from this protein or analogues thereof, or a nucleic sequence encoding such a polypeptide in an epidermis sample.

The invention belongs to the technical field of medicines and particularly relates to a drug composition of bortezomib and a preparation method thereof. The drug composition disclosed by the invention contains bortezomib, tert butyl alcohol, sodium chloride and an excipient in the mass ratio of 1:0.5:(1-5):(5-20). The drug composition adopts freeze-dried powder injection or water injection, preferably the freeze-dried powder injection. The drug composition contains tert butyl alcohol and sodium chloride besides the conventional excipient; through adding tert butyl alcohol, bortezomib can be rapidly dissolved and rapidly reacted with polyalcohol excipients such as mannitol to form more stable borate, so that the stability problem of the bortezomib freeze-dried powder injection per se is solved; and through adding the drug active constituent i.e. sodium chloride, the normal physiological and biochemical activities and functions in vivo are fully guaranteed.

The invention relates to a nelarabine injection composition, wherein the active ingredients of the drug are nelarabine and sodium chloride, wherein the nelarabine is nelarabine crystal compound; the crystal compound is measured by a powder X-ray diffractive determination method; and the obtained X-ray powder diffraction pattern is shown in a figure 2. By adopting the nelarabine injection composition provided by the invention, on one hand, the crystallization problem of the nelarabine injection can be well solved; the used nelarabine is a novel crystal nelarabine compound which is different from that in the prior art, so that the solubility of the nelarabine is increased because of change of the nelarabine crystal type; the nelarabine is fully dissolved, so as to reduce precipitation and avoid crystalline polamer; and on the other hand, the injection composition contains a drug active ingredient sodium chloride, so that normal internal physiological and biochemical activities and functions are fully ensured.

The present invention relates generally to therapeutic formulations. More particularly, this present invention provides an oral delivery system for a therapeutic compound that is a base, a salt of a base or an amphoteric compound or a salt of a amphoteric compound with pharmacological, physiological or biochemical activity or a proactive form thereof. The present invention even more particularly provides a swallow formulation comprising a therapeutic compound that is a base, a salt of a base, an amphoteric compound or a salt of an amphoteric compound which facilitates the rapid delivery of the therapeutic compound to the circulatory system.

The invention discloses ultra-micro Chinese date powder and a preparation method thereof. The method for preparing the ultra-micro Chinese date powder comprises the steps of 1) cleaning and air-drying dried Chinese dates; 2) slicing the air-dried Chinese dates; 3) dehydrating and drying the sliced Chinese dates in vacuum under the condition of temperature of 10 to 100 DEG C; and 4) performing ultra-micro smashing on the dehydrated Chinese dates, and collecting the Chinese data powder with the particle sizes of 1.5 to 500 microns. The dispersion degree, the dissolving degree, the dissolving rate, the adsorbility, the biochemical activity and the like of the ultra-micro Chinese data powder prepared by the method are better than those of the ultra-micro Chinese data powder prepared by the conventional smashing method; and compared with the conventional smashing method, the preparation method has the advantage that the biological utilization rate and the health protection effect are greatly improved.

The invention discloses a method for treating industrial wastewater through a subcritical water oxidation process in combination with a biochemical process. The method provided by the invention comprises the following processes of (1) subcritical water oxidation process-based pretreatment: strictly controlling the pressure range of the subcritical water oxidation reaction in a reactor within the range from 5 to 12MPa, the temperature within the range from 150 to 240 DEG C, and degrading toxic organic matters in the wastewater; and (2) biochemical process-based after-treatment: performing biochemical process-based treatment on the liquid phase water obtained in the step (1) in biochemical treatment equipment, thus obtaining the industrial wastewater which is up to the emission standards. According to the invention, as the reaction temperature and the reaction pressure are reduced to the specific ranges, the degree of acidic corrosion can be greatly reduced, and toxic organic matters in the wastewater can be effectively removed; as a result, the toxicity of the wastewater is eliminated and certain biochemical activity of the wastewater is maintained; in combination with subsequent biochemical treatment, complete up-to-standard emission of the wastewater can be realized.

The invention discloses a method for preparing a Fe / C composite porous structure material by using limonite. The method is characterized in that the Fe / C composite porous structure material is obtained by using the limonite and biomass powder as raw materials, performing mixing and forming and then performing pyrolysis and reduction reaction under a reducing atmosphere, and the main phase of the material is biomass charcoal and zero-valent iron. The Fe / C composite porous structure material has high open porosity, high magnetic susceptibility, high adsorption and high biochemical activity, is a cheap biological carrier material having biological activity and adsorption performance, has a great application prospect in slightly polluted water purification and is especially suitable for simultaneous denitrification treatment of an eutrophic water body.

The invention relates to a plant herbal nursing gel for cleaning, conserving and protecting female and a preparation method thereof. According to skin structures and physiological principles of private parts of the female, the insufficiencies which exist in conventional related products on the market are systematically analyzed in all aspects based on main components such as laws and regulations, uses, applicable people and technology recipes; a stereoscopic balanced nursing new mechanism for cleaning, conserving and protecting the private parts of the female is provided; modern plant herbal extractives such as European horse chestnut extractive, centella extractive, olive leaf extractive, green tea extractive, peppermint extractive, oat beta-glucan, trehalose, cranberry extractive and beetroot extractive and natural source surface active agents such as olive oil carboxylic acid sodium, sodium lauroyl sarcosine, quillaia bark extractive are selected; biochemical active ingredients such as fish scale collagen protein, ascorbic acid phosphate sodium, allantoin and nicotinamide are coordinated. A new product fit in with the modern concept of being natural, safe and healthy is provided for the nursing of the private parts of the female.

The invention discloses green and environment-friendly fertilizer for crops. The green and environment-friendly fertilizer for the crops, disclosed by the invention, is prepared from the following raw materials in parts by weight: 40 to 50 parts of compound fertilizer, 20 to 30 parts of traditional Chinese medicine juice, 15 to 20 parts of tea seed shell powder, 18 to 38 parts of humic acid, 16 to 26 parts of compound bacteria, 10 to 18 parts of organic fertilizer, 15 to 30 parts of amino acid, 10 to 15 parts of a fertilizer fermentation agent, 5 to 10 parts of antibiotics, 3 to 9 parts of an antioxidant and water. According to the green and environment-friendly fertilizer for the crops, the quality of the crops can be enhanced and the plant disease and insect pest resisting capability of the crops is improved; the biochemical activity of soil is improved and residues of the fertilizer in the soil can be eliminated and decomposed and the absorption rate of chemical fertilizer is improved, so that the utilization rate of pesticide can be reduced and pollution to the environment is reduced; planted products contain various nutrient elements needed by human bodies, have good quality and a delicious taste and are green and environmentally friendly.

The invention discloses a bamboo-willow compound fertilizer, including the following raw materials in parts by weight: 32-50 parts of raw fermentation manure, 6-15 parts of ripening humic acid, 10-20 parts of sodium silicate aqueous solution, 10-22 parts of ammonium sulfate, 6-15 parts of monoammonium phosphate, 10-20 parts of calcium superphosphate, 2-10 parts of potassium sulfate, 0.3-1.8 parts of borax, 0.3-1.8 parts of zinc sulfate heptahydrate, 0.3-1.8 parts of magnesium sulfate monohydrate, 5-15 parts of ammonium bicarbonate, 0.5-2 parts of silica powder, 0.3-1.8 parts of mothproof powder and 0.5-1.4 parts of water-retaining agent. The fertilizer disclosed by the invention can be used for improving the permeability of the soil, dissolving toxins in the soil, improving the absorption of bamboo and willow on nutrients and water, prompting cell division and growth, strengthening a series of internal biochemical activities and promoting the transformation and accumulation of organic matters in vivo, so as to promote the quick growth of the bamboo and willow.

The invention belongs to the technical field of pharmaceuticals and particularly relates to a PI3K inhibitor, a preparation method and application thereof in the pharmacy. The PI3K inhibitor is a compound of the structure shown by the general formula I or medically acceptable salt of the inhibitor. After the PI3K inhibitor is tested with a PI3K biochemical activity test method, the compound has excellent inhibitory activity to PI3K alpha and PI3K gamma, wherein the IC50 values of a plurality of compounds to the PI3K alpha and PI3K gamma reach nanomole grades (smaller than 100 nM). The result shows that the compounds can provide the inhibitor with better effectiveness and selectivity for curing PI3K-acted proliferative disease, and further a targeted drug for curing No. I type diabetes mellitus, lung disease, breast cancer, prostatic cancer, solid tumor, lymphoma, cardiovascular disease, rheumatoid arthritis, leukemia and the like can be hopefully developed. (Please see the general formula I in the description.).

This invention relates to multifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these multifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the multifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or “on”. The optical imaging component comprises a plurality of activatable contrast agents or dyes, at least two of which are different from one another, wherein at least one of the activatable contrast agents can be activated or turned “on” only in the presence of a particular event.

The invention provides a rapid and nondestructive identification method of an optical isomer with biochemical activity. The method comprises steps as follows: (1) adopting a selective adsorption material to perform selective adsorption treatment on an optical isomer sample; (2) collecting vibration spectrum data of a product obtained after treatment in Step (1); (3) identifying whether the sample is the optical isomer with the biochemical activity or not according to characteristic differences of the vibration spectrum data obtained in Step (2) under specific frequency. With the adoption of the method, rapid, efficient and environment-friendly identification can be performed on the optical isomer with the biochemical activity, no polarized light accessory is required, and the application range of vibration spectrum is extended, so that an important technological means is provided for separation, purification, efficient production, safe usage and the like of the optical isomer with the biochemical activity.

The invention discloses a plant growth regulator, prepared from the following raw materials in parts by weight: 11-15 parts of vinegar residue, 13-21 parts of distillers' grains, 10-20 parts of a pine needle nutrient solution, 3-6 parts of bamboo vinegar, 1-3 parts of wood vinegar, 16-34 parts of sodium selenite, 35-45 parts of selenium-enriched yeast, 0.001-0.003 part of S-inducer, 30-40 parts of bunchberry freeze-dried powder, 0.003-0.005 part of hormone naphthylacetic acid, 0.001-0.003 part of gibberellin, 0.001-0.003 part of brassinolide, 6-11 parts of ethylene diamine tetraacetic acid (EDTA) ferric sodium salt, 11-21 parts of magnesium sugar alcohol and 13-23 parts of duckweed ferment powder. The plant growth regulator is capable of remarkably promoting plant growth and improving fruit yield and quality, and can improve soil biochemical activity, improve soil, increase effective absorption rate of fertilizers and reduce soil hardening.

The invention discloses a method for preparing a Fe / C composite material of a porous structure by using sedimentary siderite .The method is characterized in that the Fe / C composite material is obtained by using the low-grade sedimentary siderite and biomass powder as raw materials, performing mixing and forming and then performing pyrolysis and reduction reaction at the temperature of 650-900 DEG C under a reducing atmosphere, and the main phase of the material is biomass charcoal and zero-valent iron .The Fe / C composite material of the porous structure has high open porosity, high magnetic susceptibility, high adsorption and high biochemical activity, is a cheap biological carrier material having biological activity and adsorption performance, has a great application prospect in slightly polluted water purification and is especially suitable for simultaneous denitrification treatment of an eutrophic water body.

The invention discloses organic fertilizer capable of promoting potato growth. The organic fertilizer is prepared from raw materials in parts by weight as follows: 17-20 parts of sweet potato straw, 18-20 parts of carrot slices, 18-20 parts of boiled soybeans, 17-20 parts of rape seed cakes, 16-20 parts of cottonseed cakes, 10-12 parts of plant ash, 4-6 parts of chicken manure, 3-5 parts of sheep manure, 2-3 parts of rabbit manure, 4-6 parts of cow dung, 5-7 parts of earthworm soil, 1-2 parts of an EM agent and 2-5 parts of a deodorant. The organic fertilizer can improve the biochemical activity of soil effectively, increase the effective fertilizer absorptivity, reduce the soil hardening degree and reduce environmental pollution of the fertilizer. The organic fertilizer can enable potatoes to have developed root systems, strong petioles, large leaves with deep color and thick and large tuberous stems, so that the single yield of the potatoes is increased greatly, and various nutrient elements needed by a human body are increased in the potatoes.

The invention relates to electronically neutral metal complexes as luminescent labels. The positive charge of the metal ion in the complex is neutralized by the negatively charged groups that are covalently linked to the nitrogen-containing diimine ligands, such as 2,2-bipyridine, 1,10-phenanthroline and their derivatives. The electronic neutrality reduces the impact of the metal complexes on the biological and / or biochemical activities of the labeled biomolecules, while the intensity of luminescent emission under electrochemical excitation is enhanced. These luminescent metal complex labels are useful in bioanalytic methodology development, with luminescence as the signal modality, such as electrochemiluminescence.

The invention discloses a biological-activity monitoring device for monitoring abnormal operation of a sewage disposal system and a monitoring method thereof; the biological-activity monitoring device is applied to monitoring the abnormal operation by combining a detecting method of microorganism physiology and biochemistry activity through a constructed biological-activity monitoring device for providing reference basis for corresponding restoration activities; the device and the method have the remarkable advantages that: (1) the detection of the microorganism physiology and biochemistry activity is simple, convenient and rapid; (2) the detection of the microorganism physiology and biochemistry activity is applied to the operating management of the sewage disposal system, mainly aiming at early warning of the abnormal operation, therefore, the method has the advantages of high sensitivity, good pragmaticality, and being capable of timely reflecting the abnormal operation and the like; (3) the method provides reference basis for corresponding restoration activities, the process controlling time is shortened, thus having positive significance for safe and stable operation of a sewage disposal plant.

The invention relates to the field of skincare type cosmetics and in particular relates to a freeze-dried powder active facial mask of a formula of plant proteins and polypeptides and a preparation method of the freeze-dried powder active facial mask. The facial mask comprises freeze-dried powder, facial mask cloth and an essence solvent. More specifically, a "biochemical active substance" formulaof the plant proteins and the polypeptides is optioned, in addition, by using "biochemical active substance" activity protection technologies, that is, a "vacuum freeze-drying technology" and specific freeze-drying processes, the plant proteins and the polypeptides "biochemical active substance" in the formula are directly freeze-dried on the facial mask cloth to make a freeze-dried powder facialmask, and a technology that a facial mask is directly soaked into an essence is replaced; with respect to packaging, the facial mask and the essence are separated, so that the "biochemical activity"of the plant proteins and the polypeptides in the formula can be effectively protected, no preservative is added, and the technical properties, effects and security of the facial mask can be greatly improved; and meanwhile, the active facial mask provided by the invention is fast in volatilization effect, rapid in effect taking after use, and particularly applicable to skin moisturizing, barrier repairing, wrinkle prevention and aging prevention