Bifunctional contrast agent comprising a fluorescent dye and an MRI contrast agent

一种双功能、功能信息的技术，应用在医学诊断成像领域，能够解决没有披露或暗示组合磁共振成像剂、没有披露可活化的光学成像成分等问题，达到高分辨率的效果

Inactive Publication Date: 2005-10-19
GENERAL ELECTRIC CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, none of the prior art on dual-function contrast agents discloses or suggests the use of an activatable optical imaging component, nor does it disclose or suggest combining a magnetic resonance imaging agent and an activatable optical imaging component

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  • Bifunctional contrast agent comprising a fluorescent dye and an MRI contrast agent
  • Bifunctional contrast agent comprising a fluorescent dye and an MRI contrast agent
  • Bifunctional contrast agent comprising a fluorescent dye and an MRI contrast agent

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Embodiment Construction

[0028] To facilitate understanding of the present invention, reference will be made to eg Figures 1A-3D Some preferred embodiments of the invention are described in neutral and the specific language used to describe the figure. The terminology used herein is for the purpose of description rather than limitation. Details of specific structures and functions disclosed herein are not to be interpreted as limitations of the invention but merely as a basis for the claims as a representative basis for teaching one of ordinary skill in the art to variously use the invention. Any changes and variations in the described detection agents and methods of using the monitoring agents, as well as such further applications of the principles of the invention described herein, which would normally occur to one of ordinary skill in the art, are contemplated within the spirit of the present invention.

[0029] Embodiments of the invention include dual function detection agents that simultaneou...

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Abstract

This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the bifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or 'on'. The optical imaging component comprises an activatable contrast agent or dye that is activated or turned 'on' only in the presence of a particular event. For example, the optical imaging component may be activated by a certain wavelength of light and (1) by the presence of a particular biochemical marker, (2) by enzyme cleavage, or (3) by a change in the temperature or pH of the surrounding medium. These bifunctional detection agents allow both anatomical and functional / metabolic information to be obtained simultaneously.

Description

technical field [0001] The present invention relates generally to the field of medical diagnostic imaging. More specifically, the present invention relates to the design and synthesis of bifunctional contrast agents that can be manipulated for magnetic Resonance imaging ("MRI") and optical imaging. Background technique [0002] Magnetic resonance imaging ("MRI") was established 20 years ago as a medical diagnostic technique capable of providing high-resolution anatomical information about the human body and has been used to detect various diseases. MRI uses the principles of magnetic resonance to produce images of the body. MRI is capable of producing thin-section images of any part of the body, from any angle and / or orientation, in a relatively short period of time, without surgical invasion of the body. MRI is also capable of producing a "map" of biochemical compounds in any cross-section of the body. [0003] MRI is possible in the human body because the body is full ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K49/10
CPCA61K49/0056A61K49/0002A61K49/0032A61K49/085A61K49/10A61K49/14
Inventor 利娜·汉卡莫汉·M·阿马拉滕加德尼塞·K·威克特帕里托什·达瓦尔内迪姆·艾沙克费萨尔·A·斯尤德布鲁斯·F·约翰逊埃米·C·威廉斯
Owner GENERAL ELECTRIC CO
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