Bifunctional contrast agent comprising a fluorescent dye and an MRI contrast agent

一种双功能、功能信息的技术，应用在医学诊断成像领域，能够解决没有披露或暗示组合磁共振成像剂、没有披露可活化的光学成像成分等问题，达到高分辨率的效果
CN1684710AInactive Publication Date: 2005-10-19GENERAL ELECTRIC CO
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GENERAL ELECTRIC CO
Publication Date
2005-10-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to bifunctional detection agents useful for providing high-resolution, in vivo imaging of biochemical activity in a living organism. Methods of using these bifunctional detection agents may comprise administering them into a living organism, and then estimating the localization of the detection agent using one modality (i.e., MRI), while concurrently estimating the level of biological activity using a second modality (i.e., optical imaging). One of the bifunctional detection agents comprises a magnetic resonance component and an optical imaging component. The magnetic resonance component comprises a contrast agent that is always activated or 'on'. The optical imaging component comprises an activatable contrast agent or dye that is activated or turned 'on' only in the presence of a particular event. For example, the optical imaging component may be activated by a certain wavelength of light and (1) by the presence of a particular biochemical marker, (2) by enzyme cleavage, or (3) by a change in the temperature or pH of the surrounding medium. These bifunctional detection agents allow both anatomical and functional / metabolic information to be obtained simultaneously.
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Description

technical field

[0001] The present invention relates generally to the field of medical diagnostic imaging. More specifically, the present invention relates to the design and synthesis of bifunctional contrast agents that can be manipulated for magnetic Resonance imaging ("MRI") and optical imaging. Background technique

[0002] Magnetic resonance imaging ("MRI") was established 20 years ago as a medical diagnostic technique capable of providing high-resolution anatomical information about the human body and has been used to detect various diseases. MRI uses the principles of magnetic resonance to produce images of the body. MRI is capable of producing thin-section images of any part of the body, from any angle and / or orientation, in a relatively short period of time, without surgical invasion of the body. MRI is also capable of producing a "map" of biochemical compounds in any cross-section of the body.

[0003] MRI is possible in the human body because the body is full ...

Claims

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