Rapid and nondestructive identification method of optical isomer with biochemical activity

An optical isomer and activity technology, which is applied in the field of rapid and nondestructive identification of biochemically active optical isomers, can solve the problems of rapid and nondestructive identification of biochemically active optical isomers and the identification principle that has not yet been clearly reported, and achieves improved performance. Industrial and agricultural production efficiency, high work efficiency, and the effect of promoting life sciences

Inactive Publication Date: 2015-07-22
BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The research on terahertz spectroscopy is still in its infancy, and there is no clear report on the rapid and non-destructive identification of biochemically active optical isomers and its identification principle

Method used

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  • Rapid and nondestructive identification method of optical isomer with biochemical activity
  • Rapid and nondestructive identification method of optical isomer with biochemical activity
  • Rapid and nondestructive identification method of optical isomer with biochemical activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Use the following procedure to identify tartaric acid sample A of unknown optical activity:

[0044] (1) Take tartaric acid sample A and β-cyclodextrin, the molar ratio of said tartaric acid sample A and β-cyclodextrin is 1:2.5; fully infiltrate with pure water and mix evenly, air-dried naturally to obtain the adsorption mixture, spare;

[0045] (2) collecting the terahertz-time domain spectral data of the adsorption mixture; the conditions required for collection include:

[0046] Terahertz spectral resolution: 0.0076THz;

[0047] Terahertz spectral frequency: 0.7THz;

[0048] Terahertz spectrum sampling method: attenuated total reflection;

[0049] Terahertz spectral reference: empty optical path;

[0050] Terahertz spectrum accumulation times: 2048 times;

[0051] (3) Through Fourier transform, the terahertz-time domain spectral data is converted into terahertz-refractive index spectrum data; according to the refractive index in the terahertz-refractive index sp...

Embodiment 2

[0054] Compared with Example 1, the only difference is that the molar ratio of tartaric acid sample A to β-cyclodextrin is 1:2, the frequency of the terahertz spectrum is 0.8 THz, and the number of accumulation times of the terahertz spectrum is 2000.

[0055] After testing, the refractive index of the sample was 0.6, and it was determined that the sample was L-tartaric acid with biochemical activity.

Embodiment 3

[0057] Compared with Example 1, the only difference is that the molar ratio of tartaric acid sample A to β-cyclodextrin is 1:3, the terahertz spectral resolution is 0.008THz, the terahertz spectral frequency is 0.6THz, and the number of terahertz spectral accumulations is for 2100 times.

[0058] After testing, the refractive index of the sample was 0.7, and it was determined that the sample was L-tartaric acid with biochemical activity.

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Abstract

The invention provides a rapid and nondestructive identification method of an optical isomer with biochemical activity. The method comprises steps as follows: (1) adopting a selective adsorption material to perform selective adsorption treatment on an optical isomer sample; (2) collecting vibration spectrum data of a product obtained after treatment in Step (1); (3) identifying whether the sample is the optical isomer with the biochemical activity or not according to characteristic differences of the vibration spectrum data obtained in Step (2) under specific frequency. With the adoption of the method, rapid, efficient and environment-friendly identification can be performed on the optical isomer with the biochemical activity, no polarized light accessory is required, and the application range of vibration spectrum is extended, so that an important technological means is provided for separation, purification, efficient production, safe usage and the like of the optical isomer with the biochemical activity.

Description

technical field [0001] The invention relates to the field of food and drug safety, in particular to a rapid and non-destructive identification method for biochemically active optical isomers. Background technique [0002] Organic optical isomerism is a kind of organic geometric isomerism. Optical isomers mainly exist in organic matter, especially those containing sp 3 Hybridized carbon atoms in organic matter. When the carbon atom sp 3 When hybridized, its four outer electron orbitals are distributed in a tetrahedral three-dimensional manner. When the 4 outer electron orbitals of the above-mentioned carbon atoms are combined with different functional groups (A, B, C, D), it is called a chiral carbon atom (ie C * ), resulting in optical isomers (as attached figure 1 shown), where the thin line represents sp 3 Tetrahedral structure of hybridized carbon atoms, thick lines represent chiral carbon atoms (C * ) parallel to the two sp on the paper 3 Hybrid orbitals, solid w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/3581
Inventor 王冬潘立刚马智宏李安靳欣欣贾文珅王纪华
Owner BEIJING ACADEMY OF AGRICULTURE & FORESTRY SCIENCES
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