309 results about "Attenuated total reflection" patented technology

A patient monitor system implemented by a service provider for users via recording a patients analytes measurements by an attenuated total reflection (ATR) infrared total spectroscopy method. The system comprises an input module that provides a non-invasive method in measuring analytes in a patient, such as a measurement of the glucose level and other blood analytes. The measurement is shared among a plurality of output devices such as computers, personal digital assistants (PDAs), cellular phones, and pagers that are stationed or held by various users such as doctors, patients, researchers, pharmacies, labs, and health insurers. In addition behavioral attributes are recorded and correlated with the analytes measurements to generate a profile. The profile is selectively sent to output devices based on the user profile corresponding to the output device. Also, access to the profile is monitored by a security module that encrypts the profile to prevent access by un-authorized users.

An integrated device for non-invasive analyte measurement is described herein. In typical operation, the glucose measurement device is self-normalizing in that it does not employ an independent reference sample in its operation. The device uses attenuated total reflection (ATR) infrared spectroscopy for glucose measurement from the user's skin surface. The device also includes a pressure and / or user identification sensor(s) to ensure that an authorized user is utilizing the device. The identification sensor may utilize capacitive or infrared detection of biometric identification features, such as fingerprints, for comparison to a stored value indicative of an authorized user. The device may be configured such that verification of a user's identity may be a prerequisite to use and / or activation of the device.

The invention relates to non-linear optical frequency conversion and the application of the non-linear optical frequency conversion and provides a method and a device which can widen the preparation requirements for a biological sample, do not need preparation of the sample, are high in measurement sensitivity, and can achieve high resolution, fast and real-time biological sample moisture content and distribution imaging measurement. The technical scheme is that the biological tissue moisture measurement device based on terahertz wave attenuated total reflectance (ATR) is composed of a tunable terahertz (THz) radiation source, a non-spherical face lens assembly, a total reflection prism, a two-dimensional mobile scanning platform, a terahertz wave detector and a computer. The total reflection prism is placed in the middle of the non-spherical face lens assembly, the face to be tested of a biological sample to be tested clings to the top face of the total reflection prism fixed on the two-dimensional mobile scanning platform, terahertz (THz) waves are projected to the terahertz detector through the non-spherical face lens assembly, and a detection result of the terahertz detector is output to the computer. The biological tissue moisture measurement device and the method based on the terahertz wave attenuated total reflectance (ATR) are mainly used for biological sample moisture content and distribution imaging measurement.

The invention discloses an implantable human blood glucose concentration continuous monitoring system based on optical fiber attenuation total reflection, consisting of double optical paths and comprising a light source, an attenuator, a spectroscope, an optical fiber coupling device, an optical fiber ATR sensor, a measurement photodetector, a reference photodetector, a data collection system anda computer, wherein after being attenuated by the attenuator, the light source is divided into two optical paths formed by a measurement light and a reference light; in one optical path, the measurement light enters the optical fiber ATR sensor in a coupling way through a coupling method by the optical fiber coupling device and is received by the measurement photodetector via a transmission lightof the optical fiber ATR sensor; in the other optical path, the reference light is directly received by the reference photodetector; signals recevied by the measurement photodetector and the reference photodetector are synchronously collected by the data collection system, are sent to the computer and are in analysis treatment, and the computer displays a measurement result and is also connected with the light source. The invention adopts a direct measurement in vivo method to directly measure the glucose concentration in a tissue fluid, thereby avoiding an error of measurement in vitro.

A sensor chip assembly for use in a sensor capable of Surface Plasmon Resonance (SPR) and gravimetric sensing. The assembly comprising a transparent piezoelectric substrate (I) having a first surface and a second surface opposite to the first surface. The assembly also comprising first and second thin film metal electrodes (2,3) respectively provided on the first and second surfaces of the substrate (1). The second thin film metal electrode (3) being position on the second surface of the substrate (1) such that a light beam is capable of being transmitted through the second surface of the substrate and reflected from the first thin film metal electrode. The assembly also comprising an attenuated total reflection (ATR) coupler (11) disposed adjacent to the second thin film metal electrode (3).

Apparatus and method for acquiring an infrared spectrum of a sample having or suspected to have an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a combination thereof. A representative method includes providing a sample; providing an internal reflecting element (IRE) with a functionalized tip; contacting the sample with the IRE to form a sample-IRE interface; directing a beam of infrared (IR) radiation through the IRE under conditions such that the IR radiation interacts with the sample-IRE interface once; recording a reflectance profile over a range of preselected frequencies, whereby an infrared spectrum of the of a sample having or suspected of having an amide I band, an amide II band, an amide III band, an amide A band, an OH stretching region or a combination thereof, disposed in an aqueous solution is acquired. Representative apparatus includes an internal reflecting element (IRE) comprising a reflection face located on the IRE at a region of intended contact between the IRE and a solublized sample; an infrared radiation source for supplying an evanescent wave of infrared radiation and directing the same from the outside of the IRE to the inside thereof so as to cause the infrared radiation to be incident on the reflection face, wherein the infrared radiation is reflected from the reflection face once; a sample cell; a functionalized tip comprising a surface-immobilized probe that partially or completely fills the volume exposed to the evanescent wave; and a detector for detecting the once-reflected infrared radiation.

An image of a light beam, which has been totally reflected from an interface between a dielectric material block and a thin film layer of an analysis chip for supporting a sample, is detected with photodetector and as a two-dimensional image constituted of pixels arrayed in a beam width direction and an incidence angle direction, which are perpendicular to each other. An abnormal pixel row, which contains a pixel represented by abnormal pixel data, is extracted from among pixel rows, each of which extends in the incidence angle direction, in the array of the pixels constituting the two-dimensional image and in accordance with an output of the photodetector. A position of a dark line in the light beam, which has been totally reflected from the interface, is detected from the pixel data corresponding to the pixel rows other than the abnormal pixel row.

A multiple pipette assembly is used for the purpose of sample immobilization for surface plasmon resonance (SPR) assay, and dispenses and introduces sample fluid of a sample to a sensing surface of a sensor unit. The sensor unit includes a flow channel having first and second orifices, and the sensing surface, positioned in the flow channel, for detecting the reaction of the sample. First and second pipette devices access the orifices. First and second pumps are connected with respectively the pipette devices, for pressurization to dispense the sample fluid through the pipette devices, or for decompression to aspirate the sample fluid through the pipette devices. The pumps are driven in a manner independent from one another. While the first and second pipette devices move away from the sensor unit, the pumps are caused to decompress a space in the first and second pipette devices and the flow channel.

An attenuated-total-reflection measurement apparatus 10 of the present invention collects light onto a contact surface between a sample and an ATR prim 14 at an incident angle greater than or equal to a critical angle and measures total-reflection light from the contact surface. The attenuated-total-reflection measurement apparatus 10 comprises: a light-irradiating system 12 for emitting the light which is collected onto the contact surface; a photodetector 18 for detecting the total-reflection light from the contact surface; an aperture 20 for restricting the light which the photodetector 18 detects to only light from a specific measurement site in the contact surface; and a detection-side scanning mirror 22 provided in a light path extending from the ATR prism 14 to the aperture 20. The detection-side scanning mirror 22 is configured to allow the orientation of a reflecting surface thereof to be changed. And the measurement site in the contact surface, which is to be measured with the photodetector 18, is changed by moving the reflecting surface of the detection-side scanning mirror 22 with respect to the total-reflection light from the contact surface, to perform mapping measurement in the contact surface.

A method for the evaluation of the ultrastructure of connective tissue, such as cartilage, including (a) providing a probe operative in the near-infrared or mid-infrared region of the electromagnetic spectrum, (b) positioning the probe either to be in contact with the connective tissue (for detecting attenuated total reflectance) or within a sufficient distance from the surface of the connective tissue (for detecting reflection), (c) detecting infrared radiation which penetrates the surface of the connective tissue for detecting attenuated total reflectance or which reflects off the surface of the connective tissue and (d) analyzing the infrared radiation from step (c) for at least one of peak height, peak area and frequency, and comparing at least one of the peak height, the peak area and the frequency for established values for at least one of peak height, peak area and frequency for normal connective tissue to detect a modification in the molecular structure of the connective tissue.

This invention relates to a method for verifying unseparately extracted multilever macro-finger makrs with infrared spectrum of Chinese medicine characterizing in cutting, crushing, and screening medicine to add potassium bromide powder into the medicine powder smaller than 200 mesh for table sampling to determine the middle infrared spectrum, diffuse reflection near infrared, diffuse reflection middle infrared spectrum, reflection spectrum and attenuation total reflection spectrum to get and draw the second-order derivative spectrum diagram of related spectrum, to determine the samples two-dimensional celated infrared spection to be compared in level.

Real time determination of the presence of emulsion in a formation fluid is accomplished using an optical probe, preferably an attenuated total reflectance probe. The determination can then be used to appropriately increase, decrease or leave unchanged the use of demulsification additives or other means to control emulsion formation. The method is particularly useful for free water knock-out separations, where a plurality of probes can be used to distinguish the location and / or volume of emulsion, or “rag”, layer and thereby to facilitate decantation of relatively pure oil and water fractions. It can also be effectively used in pipelines, and can optionally determine the degree of emulsification and trends toward emulsification or demulsification.

A sensor unit of a surface plasmon resonance (SPR) assay system includes a transparent dielectric medium. A thin film has a first surface and a sensing surface. The first surface is connected with the dielectric medium to constitute an interface. The sensing surface is back to the first surface, for detecting (bio)chemical reaction. A flow cell block has a flow channel for flowing of the sample to the sensing surface. Attenuated total reflection of illuminating light is checked at the interface, to analyze interaction between ligand and analyte as samples. The flow channel includes a first inner surface, disposed opposite to the sensing surface to extend along, for passing the sample to flow between. The first inner surface has a height, defined with reference to the sensing surface, and in a range of 200-500 microns.

The invention relates to an infrared spectrum recognition method for adulterated milk. The method comprises the following steps that pure milk, urea-doped milk and glucose-doped milk are taken as objects of study respectively, an infrared spectrogram of a sample is collected by utilizing an ATR-FTIR (attenuated total reflection-fourier transform infrared spectroscopy) technique, and adulterants are recognized qualitatively and analyzed quantitatively through establishing SIMCA (Soft Independent Modeling Of Class Analogy) and PLS (Partial Least Squares) models. According to the invention, when the concentration of the adulterants of urea and glucose is 0.10-1.00%, the recognition rate of the adulterants of urea and glucose by the method is 100%. When the concentration of the adulterants is 0.01-0.10%, the recognition rate and the rejection rate of the pure milk and the milk doped with urea and glucose by a best model are both greater than 82%, and the effect is favorable. The relevance of a prediction value and an actual measured value of a model is favorable for the adulterants of urea and glucose; the established models have favorable prediction capability, and can be used for the quantitative analysis of multiple adulterants in milk.

The invention relates to a device and a method for noninvasively detecting the property of the stomach tissue. The device comprises a light source part, a flexible part extended into a human body, a light spectrum collection device, a computer, and the like. Stomach images are acquired by a micro image acquisition device and sent to the computer; after incident infrared light passes through a secondary attenuated total reflection (ART) probe, the absorption information of the stomach tissue is transmitted to the in-vitro light spectrum collection device, converted into an electrical signal and then sent to the computer; and after a mode identification module distinguishes and analyzes the images and the light spectrum information of the stomach tissue, the mode identification module outputs a detected tissue property. The method comprises the following steps: before measuring and after establishing a distinguishing and analyzing model by utilizing the images and light spectrums of the in-vivo stomach tissue, acquiring the images and the light spectrums of a part to be detected and inputting the images and the light spectrums to the established distinguishing and analyzing model to obtain an analyzing result of the stomach tissue of a patient to be detected. The invention can realize in-vivo, noninvasive, quick and multi-point measurement, avoid missed detection, reduce the pain of the patients, establish the distinguishing and analyzing model by combining the images and full light spectrum information and has high accuracy.

The invention discloses a quick detecting method of the edible vegetable oil quality through using an attenuated total reflection Fourier infrared spectroscopy, and the problems that the current detecting method can not verify whether the edible vegetable oil is repeatedly heated at high temperature or whether swill-cooked dirty oil is mixed in fresh edible vegetable oil can be solved. The method comprises the steps of: indicating the change of oil ingredients by fully utilizing the changes of the peak shape and the peak height of an infrared second derivative spectrometry; measuring the content of trans-fatty acids in the edible vegetable oil through absorbance of a characteristic absorption peak at 966.50cm<-1>; judging whether the edible vegetable oil is heated through the change of the characteristic peak at 988cm<-1>, and calculating the heating time; and determining whether the edible vegetable oil is swill-cooked dirty oil through the change of the characteristic absorption peak at 988cm<-1>. The quick detecting method of the edible vegetable oil quality is simple in operation, low in cost, free of pollution, high in detecting precision, and quick and accurate and can be capable of judging an edible vegetable oil sample to be detected which is repeatedly heated at the high temperature, the swill-cooked dirty oil and the swill-cooked dirty oil mixed in the fresh edible vegetable oil.

A protective layer setting unit includes a protective agent, and an application unit for applying the protective agent on an image carrying member. An attenuated total reflection (ATR) method is used for detecting a surface condition of the image carrying member after applying the protective agent. A peak Pa at a given wavenumber, attributed to the image carrying member, has a peak area Sa in an infrared spectrum observed after applying the protective agent. A peak Pb at a given wavenumber, attributed to the protective agent, has a peak area Sb in the infrared spectrum observed after applying the protective agent. A peak area ratio of Sb / Sa is used for evaluating the protective layer setting unit. The protective layer setting unit is accepted when the Sb / Sa is set to a given range after applying the protective agent to the image carrying member for a given time period.

Disclosed herein is a sensor utilizing attenuated total reflection. The sensor is constructed of a measuring chip, an optical system, and a measuring section. The measuring chip is equipped with a dielectric block, a thin film layer formed on the dielectric block, and a liquid-sample holding portion for holding a liquid sample. The optical system is used to make a light beam enter the dielectric block at various angles of incidence so that a total internal reflection condition is satisfied at an interface between the dielectric block and the thin film layer. The measuring section measures the state of attenuated total reflection, based on the intensity of the light beam totally reflected at the interface. The liquid-sample holding portion has an opening at its top surface. The sensor further has a lid supply mechanism for placing a lid on the opening to prevent evaporation of the liquid sample.

An assay apparatus of a surface plasmon resonance biosensor system includes a flow channel block loadable with a sensor unit of the chip type removably. A metal film has a sensing surface and a metal / dielectric interface being defined on a dielectric glass substrate. An optical assay unit applies illumination through the glass substrate to the metal / dielectric interface as conditioned for total reflection, detects the illumination reflected by the metal / dielectric interface during the interaction of the ligand and the analyte on the sensing surface. The assay apparatus includes a sensor storage for storing the sensor unit in an unused state. A used sensor receptacle receives the sensor unit in a used state after use in the assay. A transfer assembly retrieves the sensor unit for the assay from the sensor storage, sets the sensor unit on the flow channel block, and discharges the sensor unit toward the used sensor receptacle.

The present invention relates to an apparatus for analyzing concentration and the like of components of urine, and more particularly, to an apparatus for analyzing concentration and the like of components of urine by using ATR-IR (Attenuated Total Reflectance Infrared Spectroscopy) and a method thereof. The apparatus for analyzing components of urine comprises a toilet bowl which has a recessed or flat-shaped urine collecting part; a piping part for guiding the urine collected from the urine collecting part; and an analyzing part for analyzing the components of the urine collected at the urine collecting part, wherein the urine collecting part is formed at an inner front side of the toilet bowl, the analyzing part comprises ATR, and the analyzing part is directly attached to the toilet bowl.

The invention discloses an in-situ electrochemical infrared spectroscopic-mass spectrometric detection system and method. The system is composed of a three-electrode electrolytic bath, a surface-enhanced infrared reflectance spectroscopic analysis apparatus, an in-situ mass spectrometer and an in-situ infrared transmission spectroscopic analysis apparatus, wherein the three-electrode electrolytic bath is composed of a counter electrode electrolytic bath, a working electrode electrolytic bath, a reference electrode electrolytic bath and an ion exchange membrane; the surface-enhanced infrared reflectance spectroscopic analysis apparatus is composed of an attenuated total reflection infrared ray emitter, a ZnSe prism and a reflected infrared signal receiver; the in-situ mass spectrometer is composed of a mass spectrometric rod, a vacuum pump, a glass capillary and a PTFE membrane; and the in-situ infrared transmission spectroscopic analysis apparatus is composed of an electrolyte storage tank, a waste electrolyte tank, a peristaltic pump, a CaF2 capillary glass tube, an infrared transmission light emitter and an infrared transmission light receiver. The system and method provided have the advantages of complete and accurate test information, high sensitivity, a wide application scope, capacity of realizing arbitrary combination, easiness in manufacturing, etc.

A spectroscopic method is disclosed for detecting and measuring contaminants in fluids such as water or oil, where the hydrophilicity of the contaminant is substantially different from that of the contaminated fluid. Good calibrations can be obtained at very low concentrations using infrared spectroscopy with ATR crystals that have not been additionally coated or otherwise modified.

A method of evaluating the surface of a material that has a distinguishable infrared spectrum comprising (a) positioning an infrared fiber optic probe to be in contact with a surface of the sample or material at a region of interest for detecting attenuated total reflectance or within a sufficient distance from the surface of the region for detecting reflection, (b) detecting mid- or near-infrared radiation attenuated total reflectance or reflection off of the surface of the sample or the material, (c) analyzing the infrared radiation from step (b) for at least one of peak height, peak area, frequency and chemometric parameters, and (d) actuating the removal device when a signal from the infrared fiber optic probe is between pre-selected values for at least one of peak height, peak area, frequency and chemometric parameters for the sample of the material.

An attenuated total reflection (“ATR”) sensor (3) determines a substance dissolved in a measurement medium (2). A method is taught to verify a calibration and / or to perform an in-line calibration of the sensor. The ATR sensor includes a housing (7) and an ATR body (4). A light source (12) and a detector (13) are arranged in the housing. The ATR body has at least one measurement surface (5) and, arranged parallel to the latter, a calibration surface (10). The measurement surface (5) can be brought into contact with the measurement medium. A calibration chamber (9), arranged in the housing, is delimited on at least one side by the calibration surface.

The invention discloses a method of detecting aging degree of an anti-pollution flashover coating of room temperature vulcanized silicone rubber. The method comprises the following steps of sampling to obtain a sample wafer; testing one surface, exposed to the air, of the sample wafer by adopting an attenuated total reflection fourier infrared spectrometry to obtain an infrared spectrogram; and judging the aging degree of the coating according to the ratio of a peak value of a 1008cm-1 absorption peak and a peak value of a 786cm-1 absorption peak and a peak value of a 1008cm-1 absorption peak through the infrared spectrogram. The detection method provided by the invention can carry out ration judgment on the anti-pollution flashover coating of the room temperature vulcanized silicone rubber through a few of sample wafers, the specific sampling is not needed, the method is simple and practical, the analytical precision and accuracy are high, and the reproducibility is good.

Provided is a liquid crystal cured layer wherein a transferring is easily performed, resulting in reducing the occurrence of defects and exhibiting excellent transparency. A liquid crystal cured layer formed from a polymerizable liquid crystal compound having an ethylenically unsaturated bond and an aromatic ring and satisfying a formula (Y). 0.95>P1 / P2>0.60 (Y) [P1: P value for one of surfaces vertical to a thickness direction of the liquid crystal cured layer, P2: P value for the other of surfaces vertical to a thickness direction of the liquid crystal cured layer, P=I(1) / I(2), I(1): Peak intensity from in-plane deformation vibration of the ethylenically unsaturated bond measured by attenuated total reflection IR spectroscopy, and I(2): Peak intensity from stretching vibration of an unsaturated bond of the aromatic ring measured by attenuated total reflection IR spectroscopy]

A convenient and economical method and instrumentation to efficiently reduce offensive spectral noises due to water vapor and carbon dioxide gas often encountered in FTIR spectrophotometry is provided by spectrally monitoring and controlling the amount of water vapor and carbon dioxide gas inside the spectrophotometer such that both amounts in the sample and background measurements become congruent through remote open-close operation of water-vapor (or carbon dioxide gas) supplier and dehumidifier (or carbon dioxide gas adsorber). This new technique can be used: (1) Under the ambient humidity condition, saving time and money effectively. (2) Both in the closed spectrophotometer and in the open system. (3) And applicable to any FTIR accessory and measurement method, including transmission, external reflection, reflection-absorption, attenuated total reflection (ATR), and microscopy measurements.

The invention provides an ATR spectrum measurement type Fourier transform spectrometer based on integrated optical waveguide. The spectrometer comprises an integrated optical waveguide electro-optical modulator, a voltage function generator, a broadband light source, a photoelectric detector, a signal processing chip and a fiber having an ATR sensitive window. According to the invention, light from the light source is coupled into the fiber, passes through an ATR sensitive window zone along the fiber and coupled into the integrated optical waveguide electro-optical modulator; voltage varying with time is applied on the integrated optical waveguide electro-optical modulator by using the voltage function generator, the intensity of output light of the integrated optical waveguide electro-optical modulator is measured by using the photoelectric detector simultaneously, and the signal processing chip connected with the photoelectric detector and the voltage function generator carries out Fourier transform processing on measured optical signals so as to obtain the spectrum of incident light. The spectrometer provided in the invention can determine visible-infrared absorption spectrum of solid, liquid and monomolecular layers adsorbed on the surface of the ATR sensitive window, has strong anti-interference capability and is applicable to on-site rapid quantitative detection.