Imatinib mesylate tablet and preparation method thereof

A technology of imatinib mesylate and imatinib mesylate, which is applied in the field of imatinib mesylate tablets and its preparation, can solve the problems of discoloration of raw materials, and achieve the effect of convenient operation and simple preparation process

Inactive Publication Date: 2013-07-31
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dissolution in 5 minutes is only 40%, and 70% organic solvent is

Method used

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  • Imatinib mesylate tablet and preparation method thereof
  • Imatinib mesylate tablet and preparation method thereof
  • Imatinib mesylate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]

[0030] Imatinib mesylate is granulated with acetone, dried, mixed evenly with crospovidone, lactose, silicon dioxide, and magnesium stearate, and directly compressed into tablets.

Embodiment 2

[0032]

[0033]

[0034] Imatinib mesylate is granulated with absolute ethanol, and after drying, it is evenly mixed with crospovidone, microcrystalline cellulose, silicon dioxide, and magnesium stearate, and directly compressed into tablets.

Embodiment 3

[0036]

[0037] Imatinib mesylate is granulated with absolute ethanol, and after drying, it is evenly mixed with crospovidone, microcrystalline cellulose, silicon dioxide, and magnesium stearate, and directly compressed into tablets.

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Abstract

The invention discloses an imatinib mesylate tablet and a preparation method thereof. The imatinib mesylate tablet comprises 8-30% of crospovidone and 8 to 40% of silica. The preparation method comprises the following steps of carrying out granulation of imatinib mesylate and a waterless organic solvent, drying the granules, uniformly mixing the granules, crospovidone, silica, a filler and a lubricant, and carrying out tabletting. The preparation method solves the problem of a slow dissolution rate of a preparation obtained by the prior art.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to imatinib mesylate tablets and a preparation method thereof. Background technique [0002] Imatinib mesylate is a selective tyrosine kinase inhibitor developed by Swiss Novartis, which belongs to the anilinoquinazoline compounds. It was approved by FDA in May 2001 for the treatment of chronic myelogenous leukemia. In February 2002, FDA further approved imatinib mesylate for the treatment of gastrointestinal stromal tumors. Imatinib mesylate can inhibit Bcr-Abl tyrosine kinase at the cellular level in vivo and in vitro, and can selectively inhibit Bcr-Abl positive cell line cells, Ph chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia Proliferation and induction of apoptosis in fresh cells from patients. In addition, imatinib mesylate can also inhibit platelet-derived growth factor (PDGF) receptor, stem cell factor (SCF), ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/506A61K47/32A61P35/02A61P35/00
Inventor 孙勇马宝华徐丽洒徐平袁海成
Owner QINGDAO UNIV
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