Inclusion method of medicament containing volatile component

A technology of volatile components and drugs, which is applied in the field of inclusion of drug stability, and can solve the problems of large amount of excipients, affecting the formation of preparations, poor stability, etc.

Inactive Publication Date: 2009-07-08
PREMIER SPECIALTY CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, the method to avoid volatilization of borneol and menthol is mainly to adopt β-cyclodextrin inclusion, but the main problem is that the amount of auxiliary materials is large, which affects the molding of the preparation, and the stability is poor

Method used

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  • Inclusion method of medicament containing volatile component
  • Inclusion method of medicament containing volatile component
  • Inclusion method of medicament containing volatile component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] Add crospovidone during the inclusion process of drugs containing peppermint ice. The ratio of peppermint ice to crospovidone is 4:1; grinding is carried out during the inclusion process; organic solvent absolute ethanol and peppermint are added The ratio of ice to absolute ethanol is 2:1, and tablets are made according to conventional technology.

Embodiment 2

[0120] Add crospovidone during the inclusion process of borneol-containing drugs, the ratio of borneol to crospovidone is: 3:1; grinding during the inclusion process; adding organic solvent ether, the ratio of borneol to ether It is 1:1 and is made into capsules according to conventional technology.

Embodiment 3

[0122] Add crospovidone during the inclusion process of medicines containing chuanxiong volatile oil, the ratio of chuanxiong volatile oil to crospovidone is 2:1; grinding during the inclusion process; add organic solvent ether, chuanxiong volatile oil and The ratio of ether is 1:1, and granules are made according to conventional technology.

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Abstract

The invention discloses an inclusion method for enhancing the stability of drug containing volatile components. Crospovidone is added during the inclusion process of the drug containing the volatile component. The proportions of the drugs and the crospovidone are 4:1, 3:1, 2:1, 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7 or 1:8. Materials can be ground during the inclusion process, and regular organic solvent such as ethanol, aether and the like can also be added. The proportions of the drug and the organic solvents are 2:1, 1:1 or 5:1, wherein the drugs mainly includes volatile traditional Chinese medicine in common use, such as borneol, menthol and the like. The invention, by experiments, proves that the crospovidone can reduce the volatile quantity of model drugs such as the borneol and the menthol, and the action can be promoted by certain mixing method and adding proper solvent.

Description

Technical field [0001] The invention relates to an inclusion method for enhancing the stability of medicines containing volatile components. Background technique [0002] Borneol and menthol are commonly used Chinese medicines with strong volatility. Due to the volatilization of borneol and menthol, their content decreases and the quality is unqualified. In addition, especially in solid preparations, the surface of the preparation appears white due to the volatilization of borneol and menthol Patterns, white patches, etc. make the appearance of the preparation unqualified. In the prior art, the method to avoid the volatilization of borneol and menthol is mainly to adopt β-cyclodextrin inclusion, but the main problem is that the amount of auxiliary materials is large, which affects the molding of the preparation, and the stability is poor. Summary of the invention [0003] The purpose of the present invention is to disclose an inclusion method for enhancing the stability of drugs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/34A61K47/48A61K47/32
Inventor 阮克萍张贤英黄大唯胡愈璋谈青松
Owner PREMIER SPECIALTY CHEM
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