17 results about "Hypromellose phthalate" patented technology

A rapid disintegration type enteric gelatin hollow capsule shell belongs to the technical field of hollow capsule production, and comprises the following components by mass: 70%-90% of gelatin, 0.01%-5.0% of a humectant, 0.01%-10% of a surfactant, 0.01%-10% of a plasticizer, 0-5% of a disintegrating agent, 0.1%-10% of an opacifying agent, and 1.0%-20% of a coating material. The method comprises the following steps: synchronously forming a glue solution and a coating, alternately dipping in glue, and drying at low temperature; the preparation method has the beneficial effects that a disintegration acceleration mechanism is adopted, the disintegrating agent quickly absorbs water and expands in intestinal juice, and the permeability of the capsule shell is enhanced by cooperating with the surfactant; the proportion of a coating material is optimized, and hydroxypropyl methylcellulose phthalate is greater than or equal to 15%, so that the intestinal juice response speed is increased; and the disintegration time in intestinal juice is about 8 minutes, which is increased by about 50% compared with the disintegration time of about 15 minutes of the traditional capsule.

The invention discloses a duloxetine enteric-coated pellet, a compound preparation and a preparation method. The duloxetine enteric-coated pellet contains a drug-containing pellet and an enteric-coated layer, the enteric-coated layer contains hydroxypropyl methylcellulose phthalate (HPMCP), and the mass ratio of the HPMCP to the enteric-coated layer is 55.6%-90.9%; the HPMCP can be dissolved in a medium of which the pH value is more than 5.5; the weight gain of the enteric-coated layer is more than 12%. According to the duloxetine enteric-coated pellet disclosed by the invention, HPMCP is selected as an enteric-coated material for resisting ethanol dumping by optimizing the type of the material for resisting ethanol dumping and the thickness of the enteric-coated layer, so that the duloxetine enteric-coated pellet has an ethanol dumping resisting effect and an ideal dissolution speed.

The invention relates to the field of medical preparations, and particularly discloses an enteric-coated hollow capsule with good friability resistance and a preparation process of the enteric-coated hollow capsule. The preparation process of the enteric hollow capsule with good friability resistance comprises the following steps: S1, preparing gelatin, a first plasticizer, an opacifying agent and a coloring agent into a glue solution; s2, hydroxypropyl methylcellulose, sodium alginate, chitosan and a second plasticizer are prepared into a first coating solution; s3, preparing a second coating solution from hydroxypropyl methylcellulose acetate succinate, hydroxypropyl methylcellulose phthalate and a neutralizer; and S4, dipping the capsule mold in the glue solution, drying, forming a capsule base, carrying out primary coating, drying, carrying out secondary coating, drying, pulling out the capsule, cutting and sleeving to obtain the enteric hollow capsule. According to the present invention, the layers of the product are tightly combined, such that the high dissolution rate, the high acid resistance and the high friability qualification rate are provided, the experimental data show that the friability qualification rate is not less than 96%, and the good friability resistance is provided.

The invention discloses micro-plastic adsorption chewing gum for a digestive system and a preparation method thereof.The chewing gum comprises an oral cavity adsorption layer, a transition protection layer, an intestinal tract stabilizing layer and a bionic gastric mucosa core layer which are sequentially arranged from outside to inside, and the oral cavity adsorption layer is a film prepared from chitosan microspheres, gutta-percha and nano activated carbon; the transition protection layer is a film prepared from a hydroxypropyl methylcellulose phthalate ethanol solution, the intestinal tract stabilizing layer is a film prepared from PLGA and dichloromethane, and the bionic gastric mucosa core layer is an elastic film prepared from silicone rubber and aluminum hydroxide micro powder. Through the triple design of time-controlled dissolution of the transition layer, mechanical locking of the gum-based grid and physical bottom wrapping of the core layer, it can be ensured that microplastics adsorbed by the oral cavity layer are not released again even though the oral cavity layer is dissolved in the stomach, and the whole process from the oral cavity to discharge is safe.

A novel compound complex that has no side effects on a liver and is used to alleviate the toxicity of an acetaminophen (APAP) drug to the liver. The composition of the compound consists of (a) acetaminophen in a pharmaceutically effective amount and (b) a commonly-used safe and pharmaceutically acceptable excipient that can be combined with one or more of two drugs to reduce the toxicity of a drug metabolized by the hepatic enzyme CYP2E1 in the liver.The compound is selected from the following group: Tween 20, microcrystalline cellulose, dicalcium phosphate, polyoxyethylene 23 lauryl ether, saccharin, mannitol, polyoxyethylene alkyl ether, sucralose, pyrrolidone, sodium starch glycolate, S100 acrylic resin, sodium carboxymethylcellulose, polyoxyethylene polyoxyethylene, menthol, low-substituted propylcellulose hydrocarbon, pregelatinized starch, Dextrates NF hydrate, citric acid, polyoxyethylene castor oil, colloidal silicon, aliphatic polyethylene glycol monostearate ester, sorbic acid, lemon oil, hydroxypropylcellulose, sorbitol, acesulfame potassium, hypromellose phthalate, lactose monohydrate, maltodextrin, Brij 58, Brij 76, Tween 80, Tween 40, PEG 400, Peg 4000, PEG 2000, and the like, so as to reduce the side effects caused by acetaminophen on the liver.

The present invention provides a solid dispersion comprising lurasidone or a pharmaceutically acceptable salt thereof and a carrier. The carrier material includes polyvinyl acetate phthalate (PVAP), polyvinyl alcohol (PVA), cellulose acetate phthalate (CAP), mesoporous silica, hydroxypropyl methylcellulose (HPMC), polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, acrylic resin, hydroxypropyl cellulose (HPC), povidone, copovidone, ethylcellulose, polyoxyethylene glycol, hypromellose acetate succinate (HPMCAS), hypromellose phthalate (HPMCP), or a combination thereof.

The application belongs to the technical field of medicine, and particularly relates to a self-releasing microcapsule for intestinal sampling and application thereof. The self-releasing microcapsule comprises a capsule cavity, a capsule shell, a sealing member and a coating. The capsule shell is provided with a sampling hole, the capsule cavity is internally provided with sampling hydrogel for absorbing sample fluid, the sealing member is arranged in the capsule cavity between the sampling hydrogel and the sampling hole, wherein the expansion of the sampling hydrogel in the capsule cavity presses the sealing member to engage with the sampling hole to seal the capsule cavity, and the coating is arranged on the surface of the capsule shell. The coating comprises the following coating materials in parts by weight: 15-20 parts of hydroxypropyl methyl cellulose phthalate, 25-30 parts of Eudragit L100, 8-12 parts of algal extract, 1-3 parts of polyethylene glycol and 1-2 parts of talc. The self-releasing microcapsule can be used for precise sampling of the colon.

The invention belongs to the technical field of medicines, and particularly relates to a self-release microcapsule for intestinal sampling and application thereof. The self-release microcapsule comprises a capsule cavity, a capsule shell, a sealing element and a coating; a sampling hole is formed in the capsule shell, and sampling hydrogel is filled in a capsule cavity and is used for absorbing sample fluid; the sealing element is arranged in the bag cavity between the sampling hydrogel and the sampling hole, and expansion of the sampling hydrogel in the bag cavity presses the sealing element to be connected with the sampling hole so as to seal the bag cavity; the coating is arranged on the surface of the capsule shell; the coating is prepared from the following coating materials in parts by weight: 15 to 20 parts of hydroxypropyl methylcellulose phthalate, 25 to 30 parts of EudragL100, 8 to 12 parts of algae extract, 1 to 3 parts of polyethylene glycol and 1 to 2 parts of talcum powder. The self-release microcapsule provided by the invention can be used for accurate sampling of colon.

The application discloses a preparation method of a tea polyphenol-based antibacterial material and application of the antibacterial material in tobacco extract liquid. The antibacterial material comprises a core material and a pH response coating layer coated on the surface of the core material. The core material comprises the following components in parts by mass: tea polyphenol 10-40%, ethyl cellulose 30-50%, microcrystalline cellulose 20-40% and propylene glycol 5-10%. The pH response coating layer comprises hydroxypropyl methyl cellulose phthalate, triethyl citrate and talc powder in a mass ratio of 100:(12-18):(15-25). The mass ratio of the core material to the pH response coating layer is 100:(10-15). The application realizes self-catalytic closed-loop slow release of tea polyphenol by means of nano-pore diffusion and pH response dissolution controlled release mechanism, relies on pH change of the system, can efficiently inhibit microbial proliferation in the tobacco extract liquid, supports tablet recycling and reuse, and provides a safe, green, long-acting and stable antibacterial solution for the tobacco extract liquid.

A duloxetine enteric-coated pellet, a compound formulation and a preparation method therefor. The duloxetine enteric-coated pellet comprises a drug-containing pellet and an enteric layer, wherein the enteric layer contains hydroxypropyl methylcellulose phthalate (HPMCP), the mass ratio of HPMCP to the enteric layer is 55.6-90.9%, the enteric layer can be dissolved in a medium having a pH value of 5.5 or above, and the weight gain of the enteric layer is 12% or more. By means of optimization of the type of materials preventing ethanol-induced dose dumping and the thickness of the enteric layer, HPMCP is selected as an enteric material for preventing ethanol-induced dose dumping, so that the duloxetine enteric-coated pellet has both good preventing effect on ethanol-induced dose dumping and ideal dissolution speed.

The application discloses albendazole and ivermectin premix and a preparation method thereof. The premix comprises albendazole 8-15%, ivermectin 0.2-0.4%, double-layer inclusion carrier 20-30% and various auxiliary materials in percentage by mass. The application adopts the double-layer inclusion carrier formed by inner layer hydroxypropyl-beta-cyclodextrin and outer layer hydroxypropyl methylcellulose phthalate and povidone K30 to form an enteric barrier. The preparation method comprises the steps of inner layer inclusion, outer layer dispersion, mixing and granulation. The relative bioavailability of the premix reaches 203%-221%, the pig ascarid drive rate is 98.7%-99.5%, the scabies mite negative conversion rate is 98%-100%, the diarrhea incidence is only 2%-3%, the premix is safe for pregnant sow groups, and no adverse reactions such as abortion, premature birth and loss of appetite occur in all test pigs during the test period. The problems of uneven mixing, low bioavailability and large side effects of traditional preparations are solved, and the premix is suitable for livestock and poultry parasite prevention and treatment.

The present application belongs to the technical field of feed processing, and discloses a preparation method of a ruminant fungus enzyme fermented feed, comprising the following steps: S1. low-pressure steam and organic acid are used for synergistic pretreatment of straws; S2. microcapsule-encapsulated composite microbial agents are added to the pretreated straws together with a nutrient substrate, and then mixed thoroughly, and then fermented at 18-22 DEG C for 3-4 weeks to obtain the ruminant fungus enzyme fermented feed; the microcapsule-encapsulated composite microbial agents are formed by layer-by-layer self-assembly technology using sodium alginate and chitosan to form an inner film after mixing of composite microbial species, trehalose and pregelatinized starch, and then coated by hydroxypropyl methylcellulose phthalate to form an outer film; the nutrient substrate is a composite of multiple functional components; the preparation method of the ruminant fungus enzyme fermented feed can efficiently degrade anti-nutritional factors in straws, significantly improve the palatability, digestibility and nutritional value of the feed, and simultaneously enhance rumen health and production performance of ruminants.

The invention discloses a duloxetine enteric-coated pellet, a compound preparation and a preparation method. The duloxetine enteric-coated pellet contains a drug-containing pellet core, an enteric-coated inner layer and an enteric-coated outer layer, the enteric outer layer contains hydroxypropyl methylcellulose phthalate (HPMCP), and the mass ratio of the HPMCP to the enteric outer layer is 55.6%-90.9%; the HPMCP can be dissolved in a medium with the pH value of 5.0 or above or 5.5 or above. According to the duloxetine enteric-coated pellet and the compound preparation thereof, the duloxetine enteric-coated pellet and the compound preparation thereof have an ethanol-pouring-resistant effect and an ideal dissolution speed by optimizing the types of ethanol-pouring-resistant materials and the weight increment of the enteric-coated layer, and the content of impurities generated in a weak-acid dissolution medium with the pH value of 5.0 or below within 2 hours is relatively low.

The invention relates to lactobacillus plantarum sustained-release granules, a preparation method thereof and application of the lactobacillus plantarum sustained-release granules in acute enteritis treatment, and belongs to the technical field of biological medicines. The preparation method of the lactobacillus plantarum sustained-release granules comprises the following steps: dissolving an enteric sustained-release material in a solvent to obtain an enteric sustained-release material solution, mixing lactobacillus plantarum powder with a filling agent to obtain a bacterial powder mixture, adding the enteric sustained-release material solution into the bacterial powder mixture, and grinding until bulk mixture granules are formed, so as to obtain the lactobacillus plantarum sustained-release granules. And screening the mixture particles, and drying to obtain the product. According to the lactobacillus plantarum sustained-release granules, hydroxypropyl methylcellulose phthalate and acrylic resin L100 are used as sustained-release enteric-coated materials, sucrose is used as a filler, and the lactobacillus plantarum sustained-release granules with small granules as basic form units are formed through a wet granulation process. The granules play a slow-release role through a slow-release skeleton structure formed by an enteric slow-release material and cane sugar.

The invention relates to the technical field of biological pharmacy, in particular to an antibody targeted modified double-bacterium-prebiotic delivery system as well as a preparation method and application thereof. VCAM-1 antibody fragments are modified on AKK bacteria and bifidobacterium lactis Probio-M8, fructo-oligosaccharide and inulin are used as prebiotics, metabolism of probiotics is improved, colonization of the probiotics in intestinal tracts is promoted, and finally, hydroxypropyl methylcellulose phthalate (HPMCP) enteric coating is used for coating, so that the content of the probiotics in the intestinal tracts is increased, and the content of the probiotics in the intestinal tracts is increased. And constructing to obtain the antibody targeted modified double-bacterium-prebiotic delivery system, namely V-PM8-Am-FI-HPMC. The V-PM8-Am-FI-HPMC provided by the invention can synchronously realize intestinal flora regulation and control, lipid metabolism balance, inflammation inhibition, ischemia improvement and blood vessel anti-calcification, finally realizes the purpose of treating and / or improving atherosclerosis, and ensures targeting and safety at the same time.

This invention relates to the field of biopharmaceutical technology, and in particular to an antibody-targeted modified dual-strain prebiotic delivery system, its preparation method, and its applications. This invention modifies VCAM-1 antibody fragments onto *AKK* bacteria and *Bifidobacterium lactis* Probio-M8, then utilizes fructooligosaccharides and inulin as prebiotics to enhance probiotic metabolism and promote intestinal colonization. Finally, it coats the system with hydroxypropyl methylcellulose phthalate (HPMCP) enteric coating to construct the antibody-targeted modified dual-strain prebiotic delivery system—V-PM8-Am-FI-HPMC. The V-PM8-Am-FI-HPMC provided by this invention can simultaneously achieve intestinal flora regulation, lipid metabolism balance, inflammation suppression, ischemia improvement, and vascular anti-calcification, ultimately achieving the purpose of treating and / or improving atherosclerosis, while ensuring targeting and safety.

The invention discloses a composition for regulating intestinal flora and controlling body weight and a preparation method thereof, and belongs to the technical field of food engineering. Comprising the following raw materials: metagen composite powder, oat beta-glucan micro-powder, konjac glucomannan micro-powder, pumpkin powder, erythritol, green tea polyphenol EGCG nanoparticles, a microcapsule wall material, citrus pectin oligosaccharide and capsaicin microcapsules. The microcapsule wall material is divided into an outer layer and an inner layer, and the outer layer comprises hydroxypropyl methylcellulose phthalate; and the inner layer comprises a cocoa butter-glyceryl monostearate solid fat skeleton. According to the present invention, through the precise matching of the multiple components such as the prebiotics composite powder, the oat beta-glucan micro-powder, the konjac glucomannan micro-powder, the pumpkin powder, the erythritol and the like, the components produce the synergistic effect on the intestinal flora regulation and the body weight control, the effect is superior to the effect of the single component use, and the comprehensive solution is provided for consumers.