A kind of ursolic acid solid dispersion and preparation method thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of solid dispersion and ursolic acid, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of low bioavailability, complicated preparation process, and water-soluble ursolic acid. Poor solubility and other problems, to achieve the effect of broad market prospects, high solubility, and good dissolution in vitro
Active Publication Date: 2016-04-20
CHINA GATEWAY PHARMA DEV CO LTD
View PDF6 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0004] The technical problem to be solved by this invention is to overcome the poor water solubility and low bioavailability of ursolic acid in the prior art and its different pharmaceutical preparations, which cannot meet actual needs, and the conventional preparation of solid dispersion preparations needs to involve There are many kinds of excipients, and the defects such as relatively complicated preparation process provide a kind of good solubility, ursolic acid solid dispersion with higher bioavailability and preparation method thereof
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0036] Take 10g of ursolic acid and 150g of polyethylene glycol 6000, put them in a 10L bottle, add 4L of ethanol to ultrasonically dissolve, and use GeneVac vacuum centrifugation to remove the organic solvent. The temperature control range is 30°C, and the concentration time is 2h. Put it in a vacuum drying oven for 12 hours to remove the residual organic solvent, take it out, grind it through a 10-200-mesh sieve, and obtain it.
Embodiment 2
[0038] Take 10g of ursolic acid and 150g of povidone k29 / 33, put them in a 10L bottle, add 4L of ethanol to ultrasonically dissolve, and use GeneVac vacuum centrifugation to remove the organic solvent. The temperature control range is 40°C, and the concentration time is 3h. Put it in a vacuum oven at 30°C for 14 hours to remove the residual organic solvent, take it out, grind it through a 10-200-mesh sieve, and obtain it.
Embodiment 3
[0040] Take 10g of ursolic acid and 150g of hypromellose E5, put them in a 10L bottle, add 4L of ethanol to ultrasonically dissolve, and use GeneVac vacuum centrifugation to remove the organic solvent. The temperature control range is 50°C, and the concentration time is 12h. Put it in a vacuum oven at 50°C for 16 hours to remove the residual organic solvent, take it out, grind it through a 10-200-mesh sieve, and obtain it.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
solubility (mass)
aaaaa
aaaaa
solubility (mass)
aaaaa
aaaaa
Login to view more
Abstract
The invention discloses an ursolic acid solid dispersion and a preparation method thereof. The formula of the ursolic acid solid dispersion comprises ursolic acid and a carrier material; the mass ratio of the ursolic acid to the carrier material is 1:2 to 1:20; and the carrier material is one or more of PEG6000 (polyethylene glycol 6000), povidone k29 / 33, hypromellose E5, polyving alcohol, poloxamer 68, GELUCIRE 50 / 13, polyacrylic resin EPO, polyacrylic resin L 100-55, povidone-vinyl alcohol, hypromellose AS-HG, hypromellose AS-LG, hypromellose AS-MG, low substituted hypromellose, hypromellose phthalate, cellulose acetate phthalate, glucan, polyoxyethylene, polyoxyethylene stearates and polyvinyl acetate phthalate. The preparation method comprises the following steps: dissolving the ursolic acid and the carrier material into an organic solvent according to the formula; removing the organic solvent; and grinding. The ursolic acid solid dispersion has good solubility and has high bioavailability.
Description
technical field [0001] The invention relates to a solid dispersion of ursolic acid and a preparation method thereof. Background technique [0002] Ursolic acid (ursolic acid, UA), also known as ursolic acid, ursolic acid, belongs to pentacyclic triterpene carboxylic acids. It is widely found in various plants such as apple, raspberry, berry, elderberry, pepper, lavender, mint, thyme, hawthorn, plum tree, etc. Ursolic acid has a wide range of pharmacological activities, such as anti-cancer, anti-ulcer, anti-inflammatory, antibacterial, anti-virus, liver protection, anti-hyperlipidemia, anti-oxidation and sedative effects and other biological effects, these physiological effects make it It has a wide range of applications in cancer, especially liver cancer, fatty liver, heart disease treatment, and even in the cosmetics market. [0003] The molecular weight of ursolic acid is 456.7, which is a small molecular compound. It shows rod-shaped crystals under the microscope, and i...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more