Production process of hypromellose phthalate

Abstract

The invention discloses a production process of hypromellose phthalate, comprising the following steps: a. heating and homogenizing raw materials cellulose ether, acetic anhydride, glacial acetic acid, phthalic anhydride, and succinic anhydride ; b. In the process of adding an appropriate amount of catalyst, add the raw material sodium acetate to obtain a mixture; c. After heating the mixture to 60-85°C, perform a constant temperature reaction. In the present invention, the dust generated in the step of crushing can be absorbed to reduce the dust overflow and the influence of the dust on the workers. Under the action of the driving part, the top block continuously beats the filter element and the rubber block continuously beats the sieve plate The bottom of the filter can be prevented from being blocked by particulate matter on the filter element, which will affect the absorption of dust. During the vibration of the sieve plate, it can facilitate the discharge of the crushed material. The crushing equipment involved in this process is more environmentally friendly and more adaptable. In the preparation of hypromellose phthalate.

Description

technical field [0001] The invention relates to the technical field of chemical preparation, in particular to a production process of hypromellose phthalate. Background technique [0002] Hydroxypropyl methylcellulose phthalate, white odorless and tasteless granules, is a kind of enteric coating material with excellent performance, which can make the drugs work in the intestinal tract or absorb in the small intestine. It is released in the intestine to avoid stomach discomfort or nausea caused by irritating drugs, so enteric coating plays an important role in fully exerting the curative effect of the drug and ensuring the stability of the drug. [0003] In the traditional process of preparing hypromellose phthalate, it is necessary to crush hypromellose phthalate, and during the crushing process, a large amount of dust will be generated, polluting the production environment , causing harm to the health of the staff. Contents of the invention [0004] The object of the pr...

AI Technical Summary

Problems solved by technology

[0003] In the traditional process of preparing hypromellose phthalate, it is necessary to crush hypromellose phthalate, and during the crushing process, a large amount of dust will be generated, polluting the production environment , causing harm to the health of the staff

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