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A kind of enteric-coated hollow cellulose capsule and preparation method thereof

A cellulose and enteric coating technology, applied in capsule delivery, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve problems such as no real solutions, and achieve good tolerance and good mechanical properties of capsule membranes.

Active Publication Date: 2022-04-22
宁波市江南胶囊有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that CN201910254934.0 discloses a method for preparing hypromellose enteric-coated hollow capsules with calcium salt and sodium salt gel, essentially using an organic solution of hypromellose phthalate as Enteric-coating solution, and enteric-coating molding of capsule embryos through the second dipping molding process through the volatilization of organic solvents, does not really solve the above-mentioned three problems of ①~③ in the preparation of enteric-coated hollow cellulose capsules. some technical issues

Method used

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  • A kind of enteric-coated hollow cellulose capsule and preparation method thereof
  • A kind of enteric-coated hollow cellulose capsule and preparation method thereof
  • A kind of enteric-coated hollow cellulose capsule and preparation method thereof

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Embodiment Construction

[0032] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.

[0033] 1. The dissolution of hypromellose phthalate, the encapsulation material of enteric-coated hollow cellulose capsules, is the key to the preparation of enteric-coated hollow cellulose capsules. Weigh 16g of Hp55S and dissolve them in 100mL water containing different amounts of ammonia water, stir them well and place them aside to observe the effect of the amount of ammonia water on the solubility of Hp55S and the properties of glue. The results are shown in Table 1.

[0034] Table 1 The effect of the amount of ammonia water on the solubility and glue properties of Hp55S

[0035]

[0036] It can be seen from Table 1 that if the amount of ammonia water used is small to dissolve 16 g of Hp55S, the preparation of the glue solution will take a long time and the glue solution will turn white when the temperature rises to 50°C, indicating th...

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Abstract

The enteric-coated hollow cellulose capsules disclosed in the present invention are composed in weight percent: hypromellose phthalate: 45-60%, hypromellose: 25-40%, agar: 5.5-10%, chlorinated Potassium: 0.5-1%, Tween-80: 0.5-3%, the balance is water; among them, hypromellose phthalate is Hp55S or Hp55, and hypromellose is HPMC-E4. The preparation method of the enteric-coated hollow cellulose capsule of the present invention does not use any organic solvent, and the general-purpose hollow capsule production line can be used for one-time molding to prepare the enteric-coated hollow cellulose capsule. The surface of the hollow capsule of the present invention is smooth and elastic, and has the stability of not swelling, disintegrating and leaking drugs in the simulated gastric juice environment for 2 hours, and has the characteristics of completely disintegrating and releasing drugs within 1 hour or even 30 minutes in the simulated intestinal juice environment, and The tightness and friability of the product are all qualified, the mechanical properties of the capsule are good, and it has good tolerance to the environment.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical excipients, and in particular relates to an enteric-coated hollow cellulose capsule and a preparation method thereof. Background technique [0002] Hollow capsules are divided into gastric-soluble type, enteric-coated type and colonic type, which correspond to the disintegration and release of drugs in the stomach, small intestine and colon regions of the human body respectively. Enteric-coated capsules have the characteristics of being stable in the stomach and disintegrating in the small intestine of the human body to release drugs. They are especially suitable for filling drugs that are easily destroyed by enzymes or gastric acid in the stomach and drugs that strongly stimulate the gastric mucosa. [0003] Enteric-coated hollow capsules currently used clinically are prepared from animal-derived gelatin or plant-derived hypromellose as the capsule material to prepare the blastocyst of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/38A61K47/26A61K47/02
CPCA61K9/4816A61K9/4833A61K47/36A61K47/38A61K47/26A61K47/02
Inventor 刘利萍罗怀琴黄金琴汪飒马坤琴
Owner 宁波市江南胶囊有限公司
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