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Omeprazole hydrotalcite composite tablet and preparation process thereof

A technology of omeprazole aluminum and omeprazole tablets, which is applied in the field of omeprazole aluminum magnesium carbonate composite tablets and its preparation, can solve the problems of poor ingestibility, environmental pollution and production process of omeprazole and aluminum magnesium carbonate Complicated issues

Pending Publication Date: 2021-09-14
SHANGHAI SINE WANXIANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The present invention proposes a kind of omeprazole aluminum magnesium carbonate composite tablet and its preparation process in order to solve the defects of existing omeprazole and aluminum magnesium carbonate such as poor ingestibility, complex production process and environmental pollution

Method used

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  • Omeprazole hydrotalcite composite tablet and preparation process thereof
  • Omeprazole hydrotalcite composite tablet and preparation process thereof
  • Omeprazole hydrotalcite composite tablet and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] An omeprazole aluminum magnesium carbonate composite tablet is a three-layer composite structure of an omeprazole tablet core layer, an enteric-coated layer and an aluminum magnesium carbonate layer pressed sequentially from the inside to the outside, wherein, in parts by weight:

[0075] (1) Omeprazole tablet core layer prescription (10000 tablets)

[0076]

[0077] (2) Enteric-coated layer prescription

[0078]

[0079] (3) Aluminum magnesium carbonate layer prescription

[0080]

[0081] According to the above prescription, the omeprazole aluminum magnesium carbonate composite sheet is prepared by the following process, which specifically includes the following steps:

[0082] (1) Preparation of Omeprazole Granules

[0083] (1) Add the prescribed amount of omeprazole, sodium hydrogen phosphate, lactose, hydroxypropyl methylcellulose, and magnesium stearate into the high-efficiency mixing granulator, turn on the stirring paddle, mix for 1 to 5 minutes, and ...

Embodiment 2

[0097] An omeprazole aluminum magnesium carbonate composite tablet is a three-layer composite structure of an omeprazole tablet core layer, an enteric-coated layer and an aluminum magnesium carbonate layer pressed sequentially from the inside to the outside, wherein, in parts by weight:

[0098] (1) Omeprazole tablet core layer prescription

[0099]

[0100] (2) Enteric-coated layer prescription

[0101]

[0102] (3) Aluminum magnesium carbonate layer prescription

[0103]

[0104] According to the above prescription, the omeprazole aluminum magnesium carbonate composite sheet is prepared by the following process, which specifically includes the following steps:

[0105] (1) Preparation of Omeprazole Granules

[0106] (1) Add the prescribed amount of omeprazole, sodium hydrogen phosphate, lactose, hydroxypropyl methylcellulose, and magnesium stearate into the high-efficiency mixing granulator, turn on the stirring paddle, mix for 1 to 5 minutes, and set aside;

[0...

Embodiment 3

[0120] An omeprazole aluminum magnesium carbonate composite tablet is a three-layer composite structure of an omeprazole tablet core layer, an enteric layer and an aluminum magnesium carbonate layer compressed sequentially from the inside to the outside, wherein, in parts by weight:

[0121] (1) Omeprazole tablet core layer prescription

[0122]

[0123] (2) Enteric-coated layer prescription

[0124]

[0125] (3) Aluminum magnesium carbonate layer prescription

[0126]

[0127]

[0128] According to the above prescription, the omeprazole aluminum magnesium carbonate composite sheet is prepared by the following process, which specifically includes the following steps:

[0129] (1) Preparation of Omeprazole Granules

[0130] (1) Add the prescribed amount of omeprazole, sodium hydrogen phosphate, lactose, hydroxypropyl methylcellulose, and magnesium stearate into the high-efficiency mixing granulator, turn on the stirring paddle, mix for 1 to 5 minutes, and set asid...

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Abstract

The invention discloses an omeprazole hydrotalcite composite tablet and a preparation process thereof. The omeprazole hydrotalcite composite tablet is of a three-layer composite structure of an omeprazole tablet core layer, an enteric layer and a hydrotalcite layer which are sequentially pressed from inside to outside. The preparation process comprises the following steps: firstly, pressing omeprazole and auxiliary materials into a tablet core; then, directly carrying out secondary pressing by using hydroxypropyl methylcellulose phthalate and the tablet core, and pressing the enteric layer; and finally, carrying out third-time pressing on hydrotalcite, the auxiliary materials and the tablet core subjected to secondary pressing to obtain a pressed tablet of an omeprazole, enteric layer and hydrotalcite quick-acting layer. After a patient takes the composite tablet, the hydrotalcite layer in the medicine is rapidly disintegrated, the concentration of gastric acid is rapidly reduced, the pain of the patient is reduced, then the omeprazole wrapping the enteric layer enters the intestinal tract to be released, the gastric acid release capacity of gastric cells is reduced, and the symptoms are treated firstly and then the cost is reduced.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an omeprazole aluminum magnesium carbonate composite tablet and a preparation process thereof. Background technique [0002] Oral tablet delivery is a matter of concern as the average human lifespan increases and swallowing ability declines with age. It is estimated that about 50% of the population has difficulty swallowing tablets and capsules, affecting compliance with drug therapy. Usually, patients with omeprazole and aluminum magnesium carbonate need to take them separately, which will cause the pain of taking the medicine twice. [0003] At present, most prazole drugs are coated to form an enteric layer. The coating cannot cover all the coating liquid, and there will be a large loss. At the same time, the air discharged from the coating machine will cause large pollution. , Even with air cleaning equipment, the air pollution problem cannot be completely eliminat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/24A61K9/36A61K33/06A61P1/04A61K31/4439
CPCA61K31/4439A61K33/06A61K9/209A61K9/2866A61K9/2095A61P1/04
Inventor 王平郭晶晶黄静董佳丽顾煜姜丽莉张雅文叶之红张弛
Owner SHANGHAI SINE WANXIANG PHARMA
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