Glime piride soft capsule and its preparing method

A technology for soft capsules and contents, which is applied in the field of glimepiride soft capsules and its preparation, and can solve problems such as poor stability and low bioavailability

Inactive Publication Date: 2005-12-21
宛六一 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to overcome the problems of poor stability and low bioavailability of existing glimepiride oral solid preparat...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] PEG400 290g

[0010] Glimepiride 3g

[0011] Propylene glycol 32g

[0012] Ethanol 20g

[0013] PVPK17 5g

[0014] Granulation 1000 grains

[0015] Capsule shell glue formula:

[0016] Gelatin: Glycerin: Water = 1:0.6:0.7

[0017] Consideration factors

[0018] Conclusion: After the investigation of the influencing factors of high temperature, high humidity and strong light conditions, the appearance of this product has no change, and the disintegration time and content are stable.

Embodiment 2

[0020] soybean oil 300g

[0021] Glimepiride 3g

[0022] Diglycerides 15g

[0023] Oleic acid 32g

[0024] Granulation 1000 grains

[0025] Capsule shell glue formula:

[0026] Gelatin: sorbitol: water: = 1: 0.6: 0.7

[0027] Adopt above formula to adopt the soft capsule that preparation method makes, through pharmaceutical research influence factor test, investigation result is as follows:

[0028] Consideration factors

[0029] Conclusion: After the investigation of the influencing factors of high temperature, high humidity and strong light conditions, the appearance of this product has no change, and the disintegration time and content are stable.

Embodiment 3

[0031] PEG600 295g

[0032] Glimepiride 3g

[0033] Glycerol 30g

[0034] Ethanol 22g

[0035] PVPK17 4g

[0036] Granulation 1000 grains

[0037] Capsule shell glue formula:

[0038] Gelatin: Sorbitol: Water = 1:0.5:0.8

[0039] Consideration factors

[0040] Conclusion: After the investigation of the influencing factors of high temperature, high humidity and strong light conditions, the appearance of this product has no change, and the disintegration time and content are stable.

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Abstract

The present invention relates to a glimepiride soft capsule and its preparation method. The content of the described soft capsule is solution type or suspension type made up by using glimepiride and one and/or several kinds of solubilization agent, cosolvent, suspension adjuvant, solubility promoter and surfactant, mixing and dissolving them.

Description

technical field [0001] The invention relates to a glimepiride soft capsule and a preparation method thereof. By selecting the composition, the soft capsule whose content is a solution type or a suspension type is prepared. Background technique [0002] It is generally believed that glimepiride belongs to the second generation of oral sulfonylurea hypoglycemic drugs, which has dual hypoglycemic effects, not only stimulating the secretion of insulin by pancreatic islet p cells, but also having an insulin-mimetic hypoglycemic effect independent of insulin. In addition, there is insulin sensitization. Because the hypoglycemic effect of glimepiride is quicker, more effective, and longer-lasting than traditional sulfonamides; the insulin concentration is lower, and the risk of hypoglycemia is small; it is convenient to take, and the patient's compliance is good. Contains two -SH groups, so it is especially suitable for patients who are ineffective to other sulphate-like drugs, so...

Claims

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Application Information

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IPC IPC(8): A61K31/40
Inventor 宛六一
Owner 宛六一
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