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Glimepiride tablet

A technology for glimepiride tablets and glimepiride, applied in the field of medicine, can solve problems such as tablet pressing, sticking and punching, etc., and achieve the effects of smooth production process, simple preparation process and rapid drug dissolution

Active Publication Date: 2017-06-20
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the organic solvent diethylene glycol monoethyl ether in the preparation, there is a sticking problem in the tablet

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0031]

[0032]

[0033] Preparation Process:

[0034] Dissolve glimepiride, hydroxypropyl beta cyclodextrin and deoxycholic acid in absolute ethanol, then granulate the solution on lactose and cross-linked povidone, dry at 40°C, and granulate with a 20-mesh sieve , magnesium stearate is added to the dry granules, mixed evenly, and compressed into tablets.

Embodiment 2

[0036]

[0037] Preparation Process:

[0038] Dissolve glimepiride, hydroxypropyl beta cyclodextrin and deoxycholic acid in absolute ethanol, then granulate the solution on lactose and croscarmellose sodium, dry at 40°C, 20 mesh Sieve the granules, add magnesium stearate to the dry granules, mix well, and press into tablets.

Embodiment 3

[0040]

[0041]

[0042] Preparation Process:

[0043] Dissolve glimepiride, hydroxypropyl beta cyclodextrin and deoxycholic acid in absolute ethanol, then use this solution to granulate on mannitol and sodium carboxymethyl starch, dry at 40°C, and sieve with 20 mesh Granules, magnesium stearate is added to the dry granules, mixed evenly, and compressed into tablets.

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Abstract

The invention relates to a glimepiride tablet. The glimepiride tablet consists of glimepiride, hydroxypropyl-[beta]-cyclodextrin, deoxycholic acid and a pharmaceutically acceptable carrier. The glimepiride tablet is prepared by virtue of a method comprising the following steps: dissolving the glimepiride, the hydroxypropyl-[beta]-cyclodextrin and the deoxycholic acid to absolute ethyl alcohol; then, granulating an obtained solution with the addition of the pharmaceutically acceptable carrier; drying obtained granules; and adding a lubricating agent, and conducting mixing and tableting. In comparison with the prior art, the glimepiride tablet provided by the invention is simple in preparation process, uniform in drug dispersion, smooth in production process and rapid in drug dissolution.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a glimepiride tablet. Background technique [0002] Glimepiride is a new sulfonylurea hypoglycemic drug developed by Hoechst Marion Roussel (HMR) in Germany. It was first launched in Sweden under the trade name Amaryl in September 1995, and entered the United States with FDA approval in 1996. It is the first FDA-approved sulfonylurea drug that can be used concurrently with insulin. Because the drug has a short action time with the receptor, it shortens the time for insulin secretion, so it has a strong insulin-sparing effect and can overcome the secondary failure of islet cells to a certain extent. Glimepiride has the advantages of high efficiency, long-term effect, less dosage, and less side effects, and is currently the best sulfonylurea hypoglycemic drug in clinical evaluation. [0003] The chemical name of glimepiride is 1-[4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrrol...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/64A61K47/40A61K47/28A61P3/10
CPCA61K9/2013A61K31/64
Inventor 张贵民陈小伟朱会敏刘庆晓
Owner SHANDONG NEWTIME PHARMA
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