4 results about "Oral hypoglycemic agents" patented technology

The application discloses a Smad5 mutant and application thereof in preventing and treating diabetes.The amino acid sequence of the Smad5 mutant is shown as SEQ NO ID:1.The application further discloses a nucleic acid encoding the Smad5 mutant, a recombinant expression vector containing the nucleic acid and a transformant.The application also includes the application of the nucleic acid, the recombinant expression vector containing the nucleic acid and the transformant in preparing a medicine for preventing and / or treating diabetes.The Smad5 mutant can improve the symptoms of type 1 diabetes and type 2 diabetes in vivo, and has no toxic side effects compared with conventional oral hypoglycemic drugs, and has no damage to the liver and kidney of patients.In addition, an agent for regulating acid-base balance is disclosed, which comprises baking soda alkaline drinking water; the agent can reduce blood sugar and relieve the symptoms of diabetes, and is more economical and convenient to operate for patients.

The invention discloses a polyhydroxy onium salt derivative as well as a preparation method and application thereof, and the onium salt derivative with a brand new structure is designed on the basis of the structure of a natural product through principles of skeleton transition, bioisostere and the like. Compared with a natural product and a reported analogue, the onium salt compound has stronger alpha-glucosidase inhibitory activity and activity of reducing postprandial blood sugar in a mouse body, can be used as an onium salt type alpha-glucosidase inhibitor oral hypoglycemic drug, and is mainly prepared from D-arabinose as a raw material, the onium salt derivative molecule with alpha-glucosidase inhibitory activity is obtained through multi-step reaction, and the molecule has remarkable in-vivo blood sugar reducing activity.

The application discloses a dual-unit fluorescent sensor array for detecting oral anti-diabetic drugs and application thereof, and relates to a supramolecular fluorescent sensor array which comprises a PAL@Q[8] sensing unit and a bpep-Am@Q[8] sensing unit, wherein the PAL@Q[8] sensing unit is composed of palmatine and Q[8], and the bpep-Am@Q[8] sensing unit is composed of a derivative of 1,4-bis[2-(4-pyridyl)vinyl]benzene and Q[8]. The dual-unit fluorescent sensor array can be used for qualitative detection and quantitative detection of metformin, phenformin, buformin hydrochloride, rosiglitazone and sitagliptin in serum or urine, and the method provides a simple and reliable analysis tool for rapid screening of oral hypoglycemic drugs, clinical blood drug concentration monitoring and identification of hypoglycemia causes, so as to realize on-site rapid visual analysis of oral hypoglycemic drugs.

The invention belongs to the technical field of beverage compositions, and particularly relates to a beverage composition as well as a preparation method and application thereof. The hippophae rhamnoides raw pulp, the mature vinegar, the lemon juice, the silybum marianum seed oil, the hippophae rhamnoides fruit oil and the resistant dextrin are matched to form a multi-component synergistic effect, so that the anti-alcohol and sugar-controlling beverage has the effects of dispelling the effects of alcohol and controlling sugar, can be drunk after drinking a large amount of wine in a dinner party, can play the roles of dispelling the effects of alcohol and protecting the liver, can also achieve the purpose of controlling blood sugar, and has a good anti-alcohol effect. Liver injury caused by alcohol and obvious fluctuation of blood sugar after dinner party are avoided, and the problem that the blood sugar cannot be controlled by oral administration of hypoglycemic drugs after drinking is effectively solved. Meanwhile, the aged vinegar is used as a drink main body, all the components and dosage matching are coordinated, and the aged vinegar drink has good taste and unique flavor and is suitable for drinking after drinking.