56results about How to "Promote dissolution and absorption" patented technology

The present invention relates to coronary heart disease treating medicine composition, and is especially one kind of medicine composition prepared with Chinese herbal medicine material and through special extraction process and other technological process. Specifically, the medicine composition is prepared with notoginseng, red sage and borneol, and through alkali extraction, concentration, alcohol precipitation, and adding supplementary material.

The invention discloses an antrodia cinnamomea effervescent tablet which comprises, by weight, antrodia cinnamomea extractive 100-300 parts, cyclodextrin 20-120 parts, bonding agent 5-15 parts, filling agent 100-260 parts, lubricating agent 1-15 parts, sweetening agent 5-20 parts and a disintegrating agent. The disintegrating agent comprises, by weight, acid source 35-100 parts and alkali source 15-50 parts. The antrodia cinnamomea effervescent tablet is high in effective constituent utilization rate, convenient to take and good in taste. The invention further discloses a preparation method of the antrodia cinnamomea effervescent tablet. The antrodia cinnamomea extractive, the filling agent and the sweetening agent are evenly mixed to prepare a mixture, and then the mixture, the acid source and the alkali source are respectively pelletized and then pressed to form the tablet.

The invention relates to a perampanel dispersible tablet and a preparation method thereof, and belongs to the technical field of medicine. The perampanel dispersible tablet consists of the following components in percentage by weight: 1-15% of perampanel, 20-90% of filler, 10-80% of a disintegrating agent, 1-10% of lubricating agent and a flow aid, 1-10% of a binding agent and 0-10% of a flavoring agent, and the perampanel dispersible tablet undergoes a wet granulation process, wherein the crude perampanel medicine is micronized, so that D90 is less than 50 microns, and preferably D90 is less than 10 microns; and by controlling the grain size of the perampanel, the dissolution rate of the perampanel dispersible tablet can be significantly improved. In clinical field, the dispersible tablet is mainly used for treating partial patients of paroxysmal epilepsy in 12-years old and elder. The dispersible tablet is stable in quality, conducive to the dissolution and the absorption of medicines and is rapid to take effects. The dispersible tablet, which is convenient to take, can be orally taken after being dispersed in water and can be sucked and swallowed in a mouth.

The invention relates to a crosslinking hyaluronic acid gel, a micro-needle film and a manufacturing method for the micro-needle film and belongs to the field of a biomedical material. The crosslinking hyaluronic acid gel is prepared according to the following steps: by taking the hyaluronic acid with molecular weight from 100kDa to 5000kDa, the hyalurate of hyaluronic acid or the mixture of hyaluronic acid and hyalurate thereof as raw materials, reacting for 10-36h under the condition of temperature of 20-50 DEG C with the existence of a cross-linking agent. The crosslinking degree of the acquired hyaluronic acid is 2-35%. The micro-needle film comprises the crosslinking hyaluronic acid gel. The manufacturing method for the micro-needle film comprises the step of injecting the crosslinking hyaluronic acid gel into a mould 200, thereby forming a micro-needle. The micro-needle structure formed by the crosslinking hyaluronic acid gel provided by the invention has high mechanical strength, can effectively penetrate through skin without pain, is long in half-life period, is high in active ingredient content and has a good beautifying effect.

The present invention relates to a chemical fertilizer synergist made of imitation marine biological material, and it is characterized by that said synergist contains polyaspartate and chitosan or its derivative, and the weight ratio of both them is 1:0.1-10. Its formula is simple, it can safely make bio-degration, and has no pollution, and can be used for imporving soil structure, raising yield of crops and improving quality of crops.

The invention discloses a flue gas desulphurization synergist. The desulphurization synergist is characterized by comprising the following components, by weight: 30-60% of adipic acid, 25-50% of carboxymethylcellulose sodium, 2-20% of carbamide and 3-20% of a catalysis oxidizing agent. The flue gas desulphurization synergist provided by the invention has simple formula, high desulphurization efficiency and can reduce NOx content of the flue gas.

The invention discloses a liquidambaric acid or ursolic acid nano-granule, a preparation method and an application thereof. The liquidambaric acid or ursolic acid nano-granule is prepared by the following steps: taking the liquidambaric acid or ursolic acid as a core material, taking one or two mixtures of the gelatin, B-cyclodextrin, rubusoside, soluble starch, stevioside and thea saponin as a wall material, wherein the mass ratio of the core material to the wall material is 1:(5-100). The preparation method is an ultrasonic high-speed refiner method or a high energy ball milling method. By adopting the liquidambaric acid or ursolic acid nano-granule, the cell permeability can be improved and the growths of the human colon carcinoma cell HT-29, the human prostate cancer cell DU145 or the human breast cancer cell MDA-MB-231 can be inhibited.

The invention relates to a donepezil hydrochloride dispersible tablet and a preparation method thereof, and belongs to the technical field of medicines. The donepezil hydrochloride dispersible tablet comprises the following components in percentage by weight: 1-5 percent of donepezil hydrochloride, 40-90 percent of disintegrating agent, 1-15 percent of lubricant and glidant and 1-15 percent of adhesive. The preparation method comprises the following steps: screening the components; uniformly mixing the donepezil hydrochloride and the disintegrating agent; adding the adhesive to prepare a soft material; granulating, baking and straightening granulating; adding the disintegrating agent, the lubricant and the glidant, and uniformly mixing; determining tablet weight, and tabletting to obtain the oxycodone hydrochloride dispersible tablet. The medicine is mainly used for treating senile dementia, especially mild or moderate alzheimer disease in clinical application, has stable quality, is beneficial to drug dissolution and absorption, is quick in response and convenient to take, can be taken orally after being dispersed with water, and also can be sucked in the mouth or swallowed.

The recipe of orally disintegrating Nifedipine preparation includes Nifedipine, solid dispersing carrier, stuffing, disintegrating agent, corrective, lubricant, etc. The present invention aims at providing one kind of orally disintegrating Nifedipine preparation with simple preparation process, easy administration, quick effect and obvious treating effect. The present invention reaches the said aim via the synergetic effect of solid dispersing carrier and disintegrating agent. After being taken, the preparation of the present invention is disintegrated in oral cavity into fine powder and this is favorable to the resolution and absorption of the medicine. The preparation is easy to take, especially for special patient with dysphagia.

The present invention relates to cefditoren pivoxil preparation, and is especially dispersed cefditoren pivoxil tablet suitable for children, old people and patient dysphagia of sensitive organism infection and its preparation process. The dispersed cefditoren pivoxil tablet consists of cefditoren pivoxil in 50-150 weight portions, microcrystalline cellulose in 10-500 weight portions, cross-linking polyvidone in 5-50 weight portions, proteoglycan in 5-50 weight portions, 3 % concentration hypromellose solution in proper amount and magnesium stearate in 0.5-5 weight portions. The preparation process includes sieving material, mixing, pelletizing, drying, pressing into tablet and other steps. The dispersed cefditoren pivoxil tablet has the advantages of fast disintegration in water, good taste, high stability, high bioavailability, etc.

The invention discloses coconut peptide water beverage which is mainly composed of a coconut extract and an accessory. The accessory comprises a sweetener, citric acid, table salt and a thickener. The weight ratio of the above ingredients is as follows: the coconut extract: 0.1 to 20%; the sweetener: 0.01 to 10%; the citric acid: 0.01 to 0.5%; the thickener: 0.01 to 0.5%; the table salt: 0.01 to 0.5%; and the rest is water. The coconut extract is adopted as the main raw material, and a food additive is added for blending, split charging and sterilizing, so as to obtain the coconut peptide water beverage which mainly contains diversified nutritious and health care ingredients such as amino acid, polypeptide, microelements and the like. The invention further discloses a preparation method and a purpose of the coconut peptide water beverage. The beverage is good for both children and adults, and has the functions as well as effects of refreshing, detoxifying, invigorating the spleen, promoting appetite, resisting fatigue, enhancing immunity, resisting ageing and the like. With the characteristics of golden luster, distinctive taste, high nutritive value and no pollution, the healthy coconut peptide water beverage is a pure green product for people all the year round.

The invention relates to dipyradimole orally disintegrating tablet and a preparation method thereof, which pertains to a pharmaceutic preparation field. Components and mass percentages thereof of the orally disintegrating tablet are: 5-50 percent of dipyradimole, 20-70 percent of stuffing agent, 10-40 percent of disintegrating agent, 1-5 percent of effervescent, 0-3 percent of correctant, 0.5-1.8 percent of lubricant and 8-20 percent of adhesive. The method of the invention comprises the following steps: 1) the stuffing agent, the disintegrating agent, the correctant and the effervescent are respectively ground for 30-60min and then fully blended into a mixture; 2) the dipyradimole is ground and added in the mixture cumulatively; after fully blended, the mixture passes through a 100 mesh sieve for 2-3 times; 3) the mixture is made into soft material by the adhesive; then the soft material is pelletized through a 16 mesh sieve and forced-air dried for 4-6 hours at the temperature ranging from 40-50 DEG C; the pelletized granules are sifted by a 20 mesh sieve; the lubricant is added in the pelletized granules and fully blended to prepare the dipyradimole orally disintegrating tablet after stamping and slice production. The orally disintegrating tablet of the invention has the advantages of short disintegrating time, rapid effect and convenient using, etc.

The present invention relates to medicine composition and its preparation process, and is especially dispersing tablet prepared with honeysuckle extractive and skullcap root extractive, disintegrating agent and pharmaceutically acceptable supplementary material and for treating upper respiratory tract infection, acute and chronic tonsillitis and acute and chronic pharyngitis and its preparation process. The dispersing tablet contains chlorogenic acid 1-5 mg and baicalin 15-50 mg each. The dispersing tablet is taken orally and disintegrated in stomach into homogeneously dispersive fine particles and has fast medicine leaching and absorption, high bioavailability and convenient taking.

The invention discloses a preparation method of soil matrix for paper mulberry transplanting in the field of paper mulberry planting. The method comprises the steps of raw material selection, sorting treatment, sorting preparation and matrix preparation. At the step of raw material selection, planting land soil, transplanting land soil, peat soil, rice chaff ash, coconut soil and paper mulberry leaves are selected as raw materials; at the step of sorting preparation, the planting land soil, the coconut soil and the rice chaff ash are mixed as a breathing layer, the planting land soil and paper mulberry leaf powder are mixed as a nutrition layer, the planting land soil and the peat soil are mixed as a root hardening layer, and the planting land soil and the transplanting land soil are mixed as a transition layer; at the step of matrix preparation, a film is selected as a support layer, and the breathing layer, the nutrition layer, the root hardening layer and the transition layer are laid on the support layer in sequence from the bottom up. According to the technical scheme, through the matrix added with the planting land soil and the transplanting land soil, the root growth environment is guided step by step in a layered mode, so that roots are familiar with the planting land soil environment gradually, therefore, the survival rate of transplanted paper mulberries is improved.

The invention relates to a pharmaceutical preparation for the treatment of osteoarthritis. The active ingredients of the preparation are composed of cextrogire brufen and glucosamine or the medicinal composite salt according to the proportion of 1: 3. The combination is prepared into the pharmaceutical preparation which has stable quality and convenient administration through the preparation forming mode, and the pharmaceutical preparation comprises orally disintegrating tablets.

The invention discloses an ampelopsin oral preparation with high bioavailability, belongs to the technical field of pharmaceutical dosage forms and preparations, and relates to a method for improvingor increasing oral absorption bioavailability of ampelopsin, which is characterized in that ampelopsin and auxiliary materials with a metabolic enzyme inhibition effect are prepared into the preparation together. The concentration of ampelopsin in in-vivo plasma can be effectively improved or increased, so that the oral curative effect of ampelopsin is improved. The ampelopsin oral preparation ischaracterized in that ampelopsin and auxiliary materials with a metabolic enzyme inhibition effect are prepared into the preparation together, so that the purpose of increasing the oral absorption amount of ampelopsin is achieved.

The invention discloses a preparation method of micromolecular pectin. The method comprises steps of dissolving polymer pectin in deionized water to form a pectin solution, adding pectinase to carry out enzymolysis reaction, after the reaction is finished, adding hydrogen peroxide for reaction, filtering and concentrating by adopting a rotary ceramic membrane, and performing vacuum drying on the micromolecular pectin precipitate. The micromolecular pectin obtained by the method is single in molecular weight distribution; the dissolution and absorption are easier; lead ions can be effectively eliminated; meanwhile, the method is simple to operate, short in technological process, environment-friendly and easy to industrialize.

The invention discloses a formula of traditional Chinese medicine for treating toothache due to wind-fire evil and a preparing method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from, by weight, 30-35 parts of gypsum, 9-10 parts of radix achyranthis bidentatae, 6-7 parts of cortex moutan, 10-12 parts of Chinese prickly ash, 10-12 parts of clove, 15-18 parts of rhizoma zingiberis, 50-60 parts of fresh rhizomes of hiraute shiny bugleweed herb, 30-35 parts of fresh stevia rebaudiana leaves, 5-6 parts of rosin, 10-12 parts of radix astragali extract, 13-15 parts of camellia nitidissima chi, 10-12 parts of pomegranate bark and 5-6 parts of tea tree oil. According to the formula of the traditional Chinese medicine for treating toothache due to wind-fire evil, the characteristic that effective ingredients of the traditional Chinese medicine can be easily dissolved in an organic solvent is utilized, reflux extraction with ethanol solutions with different concentrations and concentration are carried out many times, impurities are removed, and the contained effective ingredients are high in concentration and easy to dissolve and absorb, and the traditional Chinese medicine is capable of taking effect fast, mild in taste without irritation, clear and bright in color, fine in texture and free of sediment.

The invention provides a first-aid compound red sage root buccal tablet, which is prepared from a compound red sage root extract, a compound leech extract, a compound borneol component and a micro-effervescent component. With compatibility of red sage root, Ligusticum chuanxiong Hort, safflower, musk and pharmaceutical ingredients for improving heart circulation and preventing myocardial infarction and even with addition of leech and centipede, the product has efficacy of invigorating the circulation of blood and resisting blood coagulation and has good effects of preventing and treating severe heart ischemia and early myocardial infarction; and with cooperation of borneol, mint and corydalis tuber, the product can mitigate pains of patients and alleviate symptoms of heart ischemia more quickly. By the unique preparation technology, the buccal tablet has high content of effective pharmaceutical ingredients but less impurities, is easy to disintegrate and can be rapidly dissolved and absorbed; dissolution and absorption are fast and safe; absorption speed and treatment effect of the buccal tablet are greatly improved; and curative effect is enhanced.