Antrodia cinnamomea effervescent tablet and preparation method thereof

[0016] The embodiment of the present invention also provides a preparation method of Antrodia cinnamomea effervescent tablets, which includes the following steps:

[0017] Mix the Antrodia cinnamomea extract, filler, and sweetener evenly to make a mixture;

[0018] Mixing the mixture with an alkali source and a lubricant to prepare alkali particles;

[0019] Mixing the mixture with an acid source and a lubricant to prepare acid particles;

[0020] The acidic granules and the basic granules are compressed into tablets to obtain the Antrodia camphorata effervescent tablets.

[0021] Specifically, the Antrodia cinnamomea extract includes an Antrodia cinnamomea water extract and/or an alcohol extract of Antrodia cinnamomea encapsulated with cyclodextrin. Among them, the preparation method of the Antrodia cinnamomea water extract is: take the Antrodia cinnamomea raw materials and water in a weight ratio of 1: (5-15), extract at 80-95°C for 30-60 minutes, filter, and take the filtrate; repeat the above extraction Step at least twice; combine the obtained filtrates to obtain the Antrodia camphorata water extract; vacuum concentrate the Antrodia camphorata water extract into a paste at 60-80°C, then use microwave vacuum drying and crushing at 100-120°C to pass 80-200 mesh Sieve to obtain the Antrodia cinnamomea water phase extract. Alternatively, the Antrodia cinnamomea water extract is vacuum-concentrated at 60-80°C to a concentrated solution, and spray-dried at 100-120°C to form a powder, and an 80-200 mesh sieve is used to obtain the Antrodia cinnamomea water phase. Extract.

[0022] Among them, the preparation process of the alcohol extract of Antrodia cinnamomea encapsulated by cyclodextrin includes: taking the raw material of Antrodia cinnamomea after water phase leaching, adding ethanol equivalent to 4-10 times the weight of the raw material, and refluxing for 1-1.5h at 80-90℃ , Filter, take the filtrate; repeat the above extraction steps at least once; combine the obtained filtrate to obtain the Antrodia camphorata ethanol extract;

[0023] Mix cyclodextrin with a volume ratio of 1: (20-25) and purified water, heat to 65°C to dissolve, and cool to below 45°C to obtain a saturated aqueous solution of cyclodextrin; add the ethanol extract to the saturated aqueous solution of cyclodextrin In the process, stir evenly; wherein the weight of the cyclodextrin is 0.1-0.5 times that of the ethanol extract; spray-dried, crushed, and passed through an 80-mesh sieve to obtain an alcohol extract of cinnamomea encapsulated by cyclodextrin.

[0024] Specifically, the process of treating the surface of the alkali source coated with an adhesive includes the following steps: drying the alkali source at 30-45° C., crushing it through an 80-mesh sieve; taking the adhesive equivalent to 0.25 times the weight of the alkali source The agent is melted in a constant temperature water bath at 70-80°C, and the treated alkali source is added, stirred evenly and then cooled into agglomerates, and crushed through an 80 mesh sieve.

[0025] The present invention adopts the process of combining alcohol extraction and water extraction to obtain the effective components of Antrodia cinnamomea to the greatest extent; the effective components of Antrodia cinnamomea obtained include a water extract and an alcohol extract, and the alcohol extract of Antrodia cinnamomea is processed by the technique of cyclodextrin inclusion. In addition, under the action of the rapid disintegration of the disintegrant, the solubility of the alcohol extract of Antrodia cinnamomea is increased, thereby greatly improving the utilization of the effective components of Antrodia cinnamomea; the binder is used to pre-treat the alkali source and the acid and alkali are used. The separate granulation method enhances the stability of the preparation; the prepared Antrodia cinnamomea effervescent tablets are safe and convenient to eat, easy to dissolve and absorb, high bioavailability, sweet and sour taste, and are especially suitable for children, the elderly and those who have difficulty swallowing pills .

[0026] The following further describes in combination with specific process parameters, and the parts are all parts by weight unless otherwise specified.

[0027] Example 1

[0028] Take the Antrodia cinnamomea fruiting bodies obtained by the basswood culture method, wash and chop them. Add Antrodia cinnamomea raw materials and water in a volume ratio of 1:10, extract at 80°C for 60 minutes, filter, and take the filtrate; repeat twice; combine the filtrate obtained three times to obtain an Antrodia cinnamomea water extract. Concentrate in a vacuum at 80°C into a paste, then use microwave vacuum drying, pulverize, and pass through an 80-mesh sieve to obtain a powdered Antrodia camphorata water extract.

[0029] Add 8 times the weight of the Antrodia camphorata raw material to the above-mentioned Antrodia camphorata raw material, reflux at 90°C for 1 hour, filter, and take the filtrate; repeat three times and combine the obtained filtrate three times to obtain the Antrodia camphorata ethanol extract. According to the volume ratio of β-cyclodextrin:purified water=1:20, add β-cyclodextrin and pure water to mix, where the weight of β-cyclodextrin is 0.2 times of the ethanol extract of Antrodia camphorata, and heat to 65℃ Dissolve and cool to below 45℃ to obtain a saturated aqueous solution of β-cyclodextrin; add the ethanol extract of Antrodia camphorata to the saturated aqueous solution of β-cyclodextrin, stir evenly, spray dry and pulverize, pass through an 80 mesh sieve to obtain β-cyclodextrin Ethanol extract of Antrodia cinnamomea encapsulated finely.

[0030] The above powdered Antrodia camphorata water extract and β-cyclodextrin-coated ethanol extract of Antrodia camphorata are mixed uniformly to obtain a powdered Antrodia camphorata total extract.

[0031] Select raw materials by weight, mix 200 parts of Antrodia cinnamomea total extract, 200 parts of polydextrose, and 13 parts of aspartame to make a mixture, which is divided into two parts for use; after 10 parts of polyethylene glycol 6000 packs 46 parts of sodium bicarbonate, one part of mixture, 5 parts of absolute ethanol are mixed and granulated, dried to make alkaline granules; 52 parts of citric acid, one part of mixture, 5 parts of absolute ethanol are mixed and granulated, Dry to prepare acidic granules; mix the basic granules and acidic granules evenly, and then press them under a pressure of 5Kg to form tablets to obtain Antrodia camphorata effervescent tablets.

[0032] Example 2

[0033] An Antrodia cinnamomea mycelium obtained by a liquid submerged fermentation method is taken, washed and crushed. Add Antrodia cinnamomea raw materials and water in a volume ratio of 1:10, extract at 80°C for 60 minutes, filter, and take the filtrate; repeat twice; combine the filtrate obtained three times to obtain an Antrodia cinnamomea water extract. Concentrate in a vacuum at 80°C into a paste, then use microwave vacuum drying, pulverize, and pass through an 80-mesh sieve to obtain a powdered Antrodia camphorata water extract.

[0034] Add 8 times the weight of the Antrodia camphorata raw material to the above-mentioned Antrodia camphorata raw material, reflux at 90°C for 1 hour, filter, and take the filtrate; repeat three times and combine the obtained filtrate three times to obtain the Antrodia camphorata ethanol extract. According to the volume ratio of β-cyclodextrin:purified water=1:20, add β-cyclodextrin and pure water to mix, where the weight of β-cyclodextrin is 0.2 times of the ethanol extract of Antrodia camphorata, and heat to 65℃ Dissolve and cool to below 45℃ to obtain a saturated aqueous solution of β-cyclodextrin; add the ethanol extract of Antrodia camphorata to the saturated aqueous solution of β-cyclodextrin, stir evenly, spray dry and pulverize, pass through an 80 mesh sieve to obtain β-cyclodextrin Ethanol extract of Antrodia cinnamomea encapsulated finely.

[0035] The above powdered Antrodia camphorata water extract and β-cyclodextrin-coated ethanol extract of Antrodia camphorata are mixed uniformly to obtain a powdered Antrodia camphorata total extract.

[0036] Select raw materials by weight, mix 200 parts of Antrodia cinnamomea total extract, 150 parts of lactose, and 15 parts of acesulfame K to make a mixture, which is divided into two parts for use; 38 parts of sodium bicarbonate, one part of mixture, 6 parts of 5% polyvinylpyrrolidone in ethanol solution are mixed and granulated, dried to make alkaline particles; 60 parts of malic acid, one part of mixture, 6 parts of 5% polyvinyl The ethanol solution of vinylpyrrolidone is mixed and granulated and dried to prepare acidic granules; the basic granules and acidic granules are mixed uniformly, and then compressed into tablets under a pressure of 5Kg to prepare Antrodia camphorata effervescent tablets.