Melatonin orally disintegrating tablet and preparation method thereof

Abstract

The invention discloses an oral disintegrating tablet of melatonin which is made by selecting the melatonin, a disintegrator, an effervescing agent, a filling agent, an odor corrective and a lubricating agent for smashing, drying, mixing and tablet forming. The drug can be promptly disintegrated inside the mouth without water and is especially applicable to the patients with the deglutition difficulty or under the special environment, such as the elder, the children, the narcose patient etc. The drug also has good effect when used in the environment, which lacks the water, such as the outdoors, the battle field etc. The invention has simple technology and cheap cost and is provided with the advantages of short production period, simple production equipment etc. The oral disintegrating tablet which is prepared by the method of the invention has the enough rigidity to meet the requirements of the production, the packaging, the storage and the transportation, and at the same time the oral disintegrating tablet has good taste and short disintegrating time, and the inside-body disintegrating time is less than thirty seconds; the dissolved quantity inside the 37 DEG C artificial gastric juice and intestinal juice within one minute is 40 percent, and the dissolved quantity within six minutes is as high as 90 percent.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical production, and specifically relates to a melatonin orally disintegrating tablet and a preparation method thereof. Background technique [0002] Insomnia is a common sleep disorder characterized by difficulty falling asleep and maintaining sleep. Long-term insomnia will seriously affect people's normal life, work and study. At present, insomnia is caused by mental stress, busy work and study, long-term irregular rest and sleep, poor environment, family conflicts, disharmony in interpersonal relationships, various setbacks in life, and long-term psychological conflicts and negative emotional experiences caused by trauma. More and more patients. [0003] Melatonin, whose chemical name is N-acetyl-5-methoxytryptamine, is an indole hormone secreted by the pineal gland of mammals. It has the pharmacological effects of anti-stress, anti-lipid peroxidation, anti-aging, inducing sleep, enhancing immunit...

AI Technical Summary

Problems solved by technology

Therefore, making melatonin into orally disintegrating tablets has extensive clinical significance and market prospects, but there are no related reports in the prior art.