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Medicine composition for treating coronary heart disease and its prepn process and use

A composition and coronary heart disease technology, applied in the direction of drug combination, pharmaceutical formula, cardiovascular system diseases, etc., can solve the problems of increasing the difficulty of quality control and increasing costs, so as to avoid the first-pass effect of the liver, increase stability, Facilitate the effect of dissolution and absorption

Inactive Publication Date: 2005-07-13
成都三明药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the addition of Panax notoginseng, the cost has increased and the difficulty of quality control has also increased

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 The preparation of medicine of the present invention

[0036] Prescription: Salvia miltiorrhiza 100g, Dalbergia 100g, polyethylene glycol 6000, the dosage of polyethylene glycol 6000 is: 1-7 times of medicinal material extract extract powder;

[0037] Make 1000 capsules

[0038] Process:

[0039] 1. Extraction: take 100g of jiangba, wash it and put it in a container, add 10 times of water to carry out distillation according to the steam distillation method. Collect 2000ml of distillate, and redistill the distillate. Get the obtained volatile oil and keep it sealed for future use. Take 100g of Salvia miltiorrhiza, add water to extract three times, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times and 5 times the amount of water for the second and third times, decoct for 1.5 hours each time, combine the decoctions, and filter.

[0040] 2. Concentration and drying: Concentrate the filtrate to 500ml, add 95% ethanol to make...

Embodiment 2

[0051] Embodiment 2 The preparation of medicine of the present invention

[0052] Prescription: Danshen 100g, Dalbergia 100g, glycerin gelatin

[0053] Wherein the dosage of glycerin gelatin is 2 times of medicinal material extract extract powder

[0054] Make 1000 capsules

[0055] Process:

[0056] 1. Extraction: take 100g of jiangba, wash it and put it in a container, add 10 times of water to carry out distillation according to the steam distillation method. Collect 2000ml of distillate, and redistill the distillate. Get the obtained volatile oil and keep it sealed for future use. Take 100g of Salvia miltiorrhiza, add water to extract three times, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times and 5 times the amount of water for the second and third times, decoct for 1.5 hours each time, combine the decoctions, and filter.

[0057] 2. Concentration and drying: Concentrate the filtrate to 500ml, add 95% ethanol to make the ethanol co...

Embodiment 3

[0062] Embodiment 3 selection experiment of matrix

[0063] Choose different substrates and the same amount of main ingredients to mix, drop into the same condensate, observe the physical state of the mixture, the difficulty of dripping and the shape of the mixture.

[0064] Base Condensate Base Consistency Ease of Dropping Formation

[0065] PEG6000 methyl silicone oil Moderate Moderate Spherical, oblate

[0066] PEG4000 Methicone Small Medium Spherical with tail

[0067] Polyether Methicone Larger Moderate Oblate, spherical

[0068] The consistency of the mixture of matrix PEG4000 and drug mixture is small, and dropping pills is relatively easy, but the dropping pills have a spherical tail; while the consistency of the mixture of polyether and drug mixture is relatively large, and it is relatively difficult to drop pills. Mostly oblate in shape. Therefore, PEG6000 is preferred.

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Abstract

The medicine composition for treating coronary heart disease is dripping pill prepared with Chinese medicinal materials red sage and dalbergia wood as effective material and pharmaceutically acceptable matrix. The present invention also provides the preparation process and use of the medicine composition. The dripping pill of the present invention has simple preparation process, low cost, high safety, fast acting, high bioavailability, less side effect and other advantages.

Description

technical field [0001] The invention provides a pharmaceutical composition as well as its preparation method and application, specifically, a dropping pill made from traditional Chinese medicine salvia miltiorrhiza and jiangxiang as raw materials, its preparation method and application, and belongs to the field of traditional Chinese medicine. Background technique [0002] At present, the preparations containing Danshen and Jiangxiang as raw materials mainly include Xiangdan injection and Guanxin Danshen preparation. According to the theory of traditional Chinese medicine, the reason why Salvia miltiorrhiza and Jiangxiang are compatible is that qi is the commander of blood, and blood is the mother of qi, and the two complement each other. Qi stagnation leads to blood stasis, and blood stasis can easily cause Qi stagnation. Salvia miltiorrhiza is bitter and slightly cold, with functions of dispelling blood stasis and relieving pain, activating blood and cooling blood; Jiangx...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P9/10A61P43/00
Inventor 阳向波谢永平张媛
Owner 成都三明药物研究所
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