Medicinal composition for treating coronary heart disease

A composition and technology for coronary heart disease, applied in the direction of drug combination, drug delivery, cardiovascular system diseases, etc., can solve the problems of being unable to meet the emergency needs of patients with angina pectoris, low content of active ingredients, and no quality control standards, etc., to achieve beneficial Dissolution and absorption, high bioavailability, and the effect of avoiding the first-pass effect

Active Publication Date: 2006-01-04
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are ordinary compound Danshen tablets and capsules on the market, but the production process of ordinary tablets and capsules is relatively backward, the content of active ingredients is low, and there is no quality control standard. They need to be taken orally and absorbed through the gastrointestinal tract, and the first-pass effect occurs in the liver. After being absorbed into the blood, the bioavailability is low and the absorption is slow, so it is not suitable for the first aid needs of patients with angina pectoris

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. Formula dosage

[0041] Danshen 41.06g Panax notoginseng 8.03g Borneol 0.46g

[0042] Excipient polyethylene glycol-6000 18g

[0043]Make 1000 drop pills

[0044] 2. Extraction of Danshen and Panax notoginseng

[0045] Take the coarsely crushed Danshen and Panax notoginseng medicinal materials into the extraction tank, add 0.89g sodium bicarbonate, add 4 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 4 times the amount of water, decoct After 1 hour, filter, discard the filter residue, and combine the filtrates. The filtrate was concentrated under reduced pressure to a relative density of 1.20 (75±1° C.), and 95% ethanol was slowly added to make the alcohol concentration of the medicinal solution at 68%, and it was allowed to stand for 10 hours. Take the supernatant of the medicinal solution after alcohol precipitation, filter it, recover ethanol from the filtrate, and concentrate it into an extract w...

Embodiment 2

[0052] 1. Formula dosage

[0053] Danshen 31.12g Panax notoginseng 9.21g Borneol 0.50g

[0054] Excipient polyethylene glycol-6000 20g

[0055] Make 1000 drop pills

[0056] 2. Extraction of Danshen and Panax notoginseng

[0057] Take the coarsely crushed Danshen and Panax notoginseng medicinal materials into the extraction tank, add 0.40g sodium bicarbonate, add 2 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 8 times the amount of water, decoct After 1 hour, filter, discard the filter residue, and combine the filtrates. The filtrate was concentrated under reduced pressure to a relative density of 1.10 (75±1° C.), and 95% ethanol was slowly added to make the alcohol concentration of the medicinal solution at 50%, and left to stand for 8 hours. Take the supernatant of the medicinal solution after alcohol precipitation, filter it, recover ethanol from the filtrate, and concentrate it into an extract with a rela...

Embodiment 3

[0063] 1. Formula dosage

[0064] Danshen 31.12g Panax notoginseng 9.21g Borneol 0.50g

[0065] Excipient polyethylene glycol-6000 20g

[0066] Make 1000 drop pills

[0067] 2. Extraction of Danshen and Panax notoginseng

[0068] Take the coarsely crushed Danshen and Panax notoginseng medicinal materials into the extraction tank, add 0.40g of sodium carbonate, add 2 times the amount of water, decoct for 2 hours, filter, and extract the filter residue for the second time, add 8 times the amount of water, decoct for 1 hours, filtered, the filter residue was discarded, and the filtrates were combined. The filtrate was concentrated under reduced pressure to a relative density of 1.10 (75±1° C.), and 95% ethanol was slowly added to make the alcohol concentration of the medicinal solution at 50%, and left to stand for 8 hours. Take the supernatant of the medicinal solution after alcohol precipitation, filter it, recover ethanol from the filtrate, and concentrate it into an extra...

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PUM

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Abstract

The present invention relates to coronary heart disease treating medicine composition, and is especially one kind of medicine composition prepared with Chinese herbal medicine material and through special extraction process and other technological process. Specifically, the medicine composition is prepared with notoginseng, red sage and borneol, and through alkali extraction, concentration, alcohol precipitation, and adding supplementary material.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating coronary heart disease, in particular to a pharmaceutical composition prepared by using Chinese herbal medicine as a raw material and using a special extraction method through a specific process. Background technique [0002] With the improvement of living standards, the aging of the world's population and the rejuvenation of the disease population, cardiovascular and cerebrovascular patients are increasing year by year, and have become the second largest disease that endangers human health. Angina pectoris is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Coronary heart disease angina pectoris refers to angina pectoris caused by myocardial ischemia and hypoxia due to coronary artery sclerosis or spasm, accounting for about 90% of angina pectoris patients. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/20A61K9/00A61P9/10
Inventor 杨悦武闫希军
Owner TIANJIN TASLY PHARMA CO LTD
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