Liquidambaric acid or ursolic acid nano-granule and preparation method thereof
A Lulutong acid and nanoparticle technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as low bioavailability, and achieve good effects and stable performance. , good stability
Active Publication Date: 2015-06-24
SHANGHAI APPLIED TECHNOLOGIES COLLEGE
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The invention discloses a liquidambaric acid or ursolic acid nano-granule, a preparation method and an application thereof. The liquidambaric acid or ursolic acid nano-granule is prepared by the following steps: taking the liquidambaric acid or ursolic acid as a core material, taking one or two mixtures of the gelatin, B-cyclodextrin, rubusoside, soluble starch, stevioside and thea saponin as a wall material, wherein the mass ratio of the core material to the wall material is 1:(5-100). The preparation method is an ultrasonic high-speed refiner method or a high energy ball milling method. By adopting the liquidambaric acid or ursolic acid nano-granule, the cell permeability can be improved and the growths of the human colon carcinoma cell HT-29, the human prostate cancer cell DU145 or the human breast cancer cell MDA-MB-231 can be inhibited.
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NanocapsulesHuman prostate +15
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Property | Measurement | Unit |
Solubility in water | 740.0 | µg/ml |
Solubility | 690.0 | µg/ml |
Solubility in water | 729.0 | µg/ml |
tensile | MPa | |
Particle size | Pa | |
strength | 10 |
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