Biodegradable redox sensitive polymer and preparation method and application thereof
A polymer and biological technology, applied in the field of pharmaceutical preparations and polymer chemistry, can solve the problems of lack of pertinence, worsening side effects, and limited effects, and achieve the effect of good inhibition, reduction of toxic and side effects, and enhancement of targeting.
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[0027] Example 1 Preparation of Hyaluronic Acid-S-S-Vitamin E Succinate Polymer (HA-SS-VES)
[0028] (1) Preparation method
[0029] 1. Dissolve vitamin E succinate (1.06g, 2mmol) in 50mL of dichloromethane, stir in a 250mL round-bottomed flask until fully dissolved, add EDC (13mmol) and HOBT (13mmol) under ice bath, and avoid light at room temperature Stir overnight. Add cystamine dihydrochloride (1.35g, 6mmol) to the resulting reaction solution, and add 10mL methanol to aid solubilization, add triethylamine to adjust the pH to 7-8, stir for 24h, and use 1mol / L NaHCO for the resulting product 3 The organic layer was washed with anhydrous magnesium sulfate and dried, filtered, and the dichloromethane was removed by rotary evaporation under reduced pressure at 40° C., and dried under vacuum to obtain 0.944 g of vitamin E succinate derivative. The yield was 71.1%. MS(ESI)m / z(%): 665.4[M+H] + ; IR (KBr, cm-1): 3435, 2922, 2862, 2369, 1647, 1749, 1145, 920. 1 HNMR (400MHz, CHCl3): δ7....
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[0031] Example 2 HA-SS-VES drug-loaded nanomicelles
[0032] (1) Preparation of drug-loaded nanomicelles
[0033] Take 20 mg of gambogic acid and 50 mg of polymer HA-SS-VES, place them in a 250 mL eggplant-shaped bottle, and add 10 mL of dichloromethane to dissolve. The dichloromethane was removed by rotary evaporation under reduced pressure at 40°C to obtain a yellow drug film. After that, 50 mL of distilled water was added, and the mixture was hydrated in a water bath at 65°C for 4 hours, then shaken and shaken. Ultrasound the probe in an ice bath (ultrasonic cell disrupter) 3 times, 2min each time, ultrasonic power is 225W, and pass through 0.45μm microporous membrane to obtain HA-SS-VES polymer gambogic acid loaded nanometer Micellar solution.
[0034] (2) Investigation of bath time of drug-loaded nanomicelles
[0035] According to the preparation method described in (1), change the water bath time and hydrate in a 65℃ water bath respectively for 2, 4, 6, and 8 hours. The partic...
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