Donepezil hydrochloride dispersible tablet and preparation method thereof

A technology of donepezil hydrochloride and dispersible tablets, applied in the directions of heterocyclic compound active ingredients, pill delivery, nervous system diseases, etc., can solve problems such as unfavorable drug dissolution and absorption, achieve stable indicators, be beneficial to dissolution and absorption, and prolong storage period Effect

Inactive Publication Date: 2014-06-25
张绪伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently marketed oral preparations are common tablets of donepezil hydrochloride, which disintegrate completely within 40 minutes, which is not conducive to drug dissolution and absorption.

Method used

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  • Donepezil hydrochloride dispersible tablet and preparation method thereof
  • Donepezil hydrochloride dispersible tablet and preparation method thereof
  • Donepezil hydrochloride dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Donepezil hydrochloride dispersible tablet, the components are as follows:

[0038]

[0039] The preparation method is as follows:

[0040] (1) First pass the donepezil hydrochloride, starch, and microcrystalline cellulose through a 100-mesh sieve for later use.

[0041](2) Weigh the starch and microcrystalline cellulose according to the prescription, and mix them evenly. Add the prescribed amount of donepezil hydrochloride, mix well, add binder 1% hypromellose aqueous solution to make soft material, granulate with 20 mesh sieve, dry at 50-60°C, granulate with 20 mesh sieve, add cross-linked carboxyl Sodium methylcellulose, magnesium stearate, and silicon dioxide are mixed evenly.

[0042] (3) Take a sample to test the particle content, calculate the tablet weight according to the measured particle content, and compress the tablet.

[0043] (4) Sampling and full inspection, and packaging to obtain finished products after passing the test.

[0044] T...

Embodiment 2

[0045] Embodiment 2: Donepezil hydrochloride dispersible tablets, the components are as follows:

[0046]

[0047] The preparation method is as follows:

[0048] (1) First pass the donepezil hydrochloride, starch, and microcrystalline cellulose through a 100-mesh sieve for later use.

[0049] (2) Weigh the starch and microcrystalline cellulose according to the prescription, and mix them evenly. Add the prescribed amount of donepezil hydrochloride, mix well, add the soft material made of polyvinylpyrrolidone as the binder, granulate with a 20-mesh sieve, dry at 50-60°C, granulate with a 20-mesh sieve, add croscarmellose sodium , magnesium stearate, and micropowder silica gel.

[0050] (3) Take a sample to test the particle content, calculate the tablet weight according to the measured particle content, and compress the tablet.

[0051] (4) Sampling and full inspection, and packaging to obtain finished products after passing the test.

[0052] It completely disintegrates ...

Embodiment 3

[0053] Embodiment 3: Donepezil hydrochloride dispersible tablets, the components are as follows:

[0054]

[0055] The preparation method is as follows:

[0056] (1) Pass the donepezil hydrochloride and the starch through a 100-mesh sieve respectively, and set aside.

[0057] (2) Weigh the starch according to the prescription, add the prescribed amount of donepezil hydrochloride, mix evenly, add 5% starch slurry as binder to make soft material, granulate with 20 mesh sieve, dry at 50-60°C, and granulate with 20 mesh sieve , add crospovidone and magnesium stearate and mix well.

[0058] (3) Take a sample to test the particle content, calculate the tablet weight according to the measured particle content, and compress the tablet.

[0059] (4) Sampling and full inspection, and packaging to obtain finished products after passing the test.

[0060] The disintegration time limit is completely disintegrated in 37°C water within 2 minutes and passes through the No. 2 sieve, whic...

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Abstract

The invention relates to a donepezil hydrochloride dispersible tablet and a preparation method thereof, and belongs to the technical field of medicines. The donepezil hydrochloride dispersible tablet comprises the following components in percentage by weight: 1-5 percent of donepezil hydrochloride, 40-90 percent of disintegrating agent, 1-15 percent of lubricant and glidant and 1-15 percent of adhesive. The preparation method comprises the following steps: screening the components; uniformly mixing the donepezil hydrochloride and the disintegrating agent; adding the adhesive to prepare a soft material; granulating, baking and straightening granulating; adding the disintegrating agent, the lubricant and the glidant, and uniformly mixing; determining tablet weight, and tabletting to obtain the oxycodone hydrochloride dispersible tablet. The medicine is mainly used for treating senile dementia, especially mild or moderate alzheimer disease in clinical application, has stable quality, is beneficial to drug dissolution and absorption, is quick in response and convenient to take, can be taken orally after being dispersed with water, and also can be sucked in the mouth or swallowed.

Description

field of invention [0001] The invention relates to the field of chemical pharmacy, in particular to the field of geriatric diseases, that is, to a donepezil hydrochloride dispersible tablet and a preparation method thereof, and the donepezil hydrochloride dispersible tablet can be used for treating mild or moderate Alzheimer's disease. Background of the invention [0002] The aging trend has increased the number of patients with senile dementia, and my country will enter an aging society. At the same time, it is accompanied by a problem that cannot be ignored-the incidence of AD is increasing year by year. The survey found that: the average age of AD in northern my country is 75 or 76 years old, and the rate of AD among people over 65 years old is over 15%. The ability of daily life of AD patients declines, they do not know their spouses and children, they cannot take care of themselves in dressing, eating, defecating, especially taking medicine; some have auditory hallucina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/445A61P25/28
Inventor 张绪伟代先慧
Owner 张绪伟
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