Coenzyme Q10 pharmaceutical composition
A technology of composition and coenzyme, which is applied in the field of pharmaceutical compositions for injection, can solve the problems of turbid precipitation and rapid content drop, and does not solve the problem of solubility of freeze-dried preparations, so as to facilitate industrial production and reduce storage and transportation costs , good stability effect
Inactive Publication Date: 2009-07-15
郑微
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AI Technical Summary
Problems solved by technology
[0013] Aiming at the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a coenzyme Q10 pharmaceutical composition with good water solubility for injection, so as to overcome the turbid precipitation and content of the existing coenzyme Q10 injection during storage. The problem of rapid decline, while solving the solubility problem of freeze-dried preparations before use that is not solved in the prior art
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0049] Example 1: 5 g of coenzyme Q10, 150 g of polysorbate 80, 10 g of medium-chain triglycerides, and 15 g of thiourea were used to adjust the pH value to 4.0 with hydrochloric acid, and the volume was adjusted to 2 L with water for injection.
Embodiment 2
[0050] Example 2: Coenzyme Q10 5g, polysorbate 80 150g, polyoxyethylene (40) castor oil 100g, medium chain triglycerides 20g, sodium metabisulfite 5g, adjust the pH value to 5.0 with citric acid, and dilute to 2L with water for injection .
Embodiment 3
[0051] Example 3: 5g of coenzyme Q10, 100g of polysorbate 80, 8150g of poloxamer 18, 20g of linolenic acid, 2.5g of sodium bisulfite, adjust the pH value to 3.5 with lactic acid, and dilute to 2L with water for injection.
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The invention discloses a coenzyme Q10 pharmaceutical composition which mainly comprises components: (1) coenzyme Q10 is active ingredient; (2) one or multiple of polyethylene 15-oxhydryl glycol stearate (Solutol HS 15), polysorbate, PEG, poloxamer, and polyoxyethylene castor oil derived products are solubilizer; (3) one or multiple of midchain monoglyceride and derived products thereof, medium saturated or unsaturated fatty acid are oil component; and (4) injection water is solvent. One or multiple of excipient, chemical inhibitor, and osmotic pressure regulator are added for preparing injection and freeze drying agent. Compared with the traditional coenzyme Q10 pharmaceutical composition, the injection administration coenzyme Q10 pharmaceutical composition has better storage and transportation stability and higher clinical application safety and patient compliance. The injection has simple preparation process, convenient quality control, lower production cost and convenient industrial production.
Description
technical field [0001] The invention relates to a novel pharmaceutical composition for injection with coenzyme Q10 as an active ingredient. Background technique [0002] Coenzyme Q10 is a fat-soluble quinone compound that widely exists in plants, microbial cells, and animal hearts, livers, spleens, and kidneys. It has a variety of biological functions, with small doses and low toxicity. The advantages of disease, widely used clinically. Coenzyme Q10 has the functions of natural anti-oxidation and activation of cell metabolism, which can significantly improve human immunity. Clinically, it is mainly used for the treatment of scurvy, aplastic anemia, duodenal ulcer, acute and chronic viral hepatitis, subacute liver necrosis, congestive heart disease, emphysema and other diseases, as well as adjuvant treatment for cancer patients. [0003] Coenzyme Q10 is insoluble in water and easily decomposed when exposed to light, which brings many difficulties to the research of its prep...
Claims
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IPC IPC(8): A61K31/122A61K47/34A61K47/02A61K47/12A61K47/14A61K47/20A61K47/26A61P7/00A61P7/06A61P1/00A61P1/16A61P9/00A61P11/00A61P31/12A61P35/00A61K9/08A61K9/19A61K47/10A61K47/44
Inventor 喻文涛
Owner 郑微
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