Method for preparing antibacterial porous oxidized graphene/chitosan composite bracket

Abstract

The invention discloses a method for preparing an antibacterial porous oxidized graphene / chitosan composite bracket. The method comprises the steps of taking carboxylated graphene oxide as an antibiotic carrier; carrying out electrostatic interaction by carboxyl on the surface of the oxidized graphene and amino on the antibiotic, so as to absorb the antibiotic on the oxidized graphene; taking the chitosan as the carrier of antibacterial metal ions, chelating the metal ions in chitosan molecules, restoring the metal ions into metallic single substances through a reducing agent; and finally mixing the carboxyl graphene with the antibiotic and the chitosan solution loaded with antibacterial metal, freezing and drying to obtain the composite bracket with two different antibacterial materials. The composite bracket can release antibiotic within a short period of time and release the antibacterial metal ions for a long period of time, and has short-term antibacterial and long-term antibacterial effects, and good antibacterial effect.

Description

Technical field [0001] The invention relates to a preparation method of an antibacterial porous graphene oxide / chitosan composite scaffold. Background technique [0002] Infection of bone implanted stents after surgery is an important problem faced by clinical medicine in recent years. Bone implant stents based on alloys such as titanium and magnesium are widely used, but it is difficult to effectively load antibacterial drugs due to their inertness. [0003] Although the stent can be modified and functionalized by functional materials to realize the loading of antibacterial drugs, there are still the following problems: the reduction of the strength of the stent cannot meet the strength requirements of bone implant materials, and the release time of antibacterial drugs is difficult to control, especially It is difficult to balance short-term and long-term antibacterial effects, and the antibacterial effect needs to be improved. Summary of the invention [0004] The purpose of the...

AI Technical Summary

Problems solved by technology

Bone implant scaffolds mainly made of titanium, magnesium and other alloys are widely used, but it is difficult to effectively load antimicrobial drugs due to their inertness.

[0003] Although the loading of antimicrobial drugs can be achieved by modifying and functionalizing the scaffold with functional materials, there are still the following problems: the strength of the scaffold is reduced and cannot meet the strength requirements of bone implant materials, and the release time of antibacterial drugs is difficult to control, especially Difficult to balance short-term antibacterial and long-term antibacterial effects, and the antibacterial effect needs to be improved