Method for preparing antibacterial porous oxidized graphene/chitosan composite bracket

A composite stent and graphene technology, applied in medical science, prosthesis, etc., can solve the problems of reduced stent strength, difficulty in taking into account short-term antibacterial and long-term antibacterial, antibacterial effect needs to be improved, etc., to achieve long-term antibacterial time and strong antibacterial function , good antibacterial effect

Inactive Publication Date: 2013-07-10
SOUTHWEST JIAOTONG UNIV
View PDF3 Cites 26 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bone implant scaffolds mainly made of titanium, magnesium and other alloys are widely used, but it is difficult to effectively load antimicrobial drugs due to their inertness.
[0003] Although the loading of antimicrobial drugs can be achieved by modifying and functionalizing the scaffold with functional materials, there are still the fol

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of antibacterial porous graphene oxide / chitosan composite scaffold, the specific steps are as follows:

[0025] A. Chitosan is loaded with inorganic antibacterial metal:

[0026] Dissolve silver nitrate in a chitosan solution with a mass fraction of 3% to obtain a solution with a mass fraction of silver ions of 0.01%; then add vitamin C to the solution, the addition amount of vitamin C is 0.01M, and stir for 24 hours to make the solution The silver ions are reduced to silver element; then dialysis is performed, and the solution in the dialysis bag is taken to obtain a silver element-loaded chitosan solution without unreacted vitamin C;

[0027] B. Graphene oxide loaded with antibiotics:

[0028] B1. Carry out the carboxylation reaction of graphene oxide in solution to carboxylate the oxygen-containing groups on the surface of graphene oxide; freeze and dry to obtain carboxylated graphene oxide powder, and then dissolve it in water to obtain a mass fraction ...

Embodiment 2

[0033] This example is basically the same as Example 1, except that the antibiotic used in Example 1 is changed from gentamicin to neomycin.

Embodiment 3

[0035] This example is basically the same as the first example, except that the antibiotic used in the first example is changed from gentamicin to cefradine.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for preparing an antibacterial porous oxidized graphene/chitosan composite bracket. The method comprises the steps of taking carboxylated graphene oxide as an antibiotic carrier; carrying out electrostatic interaction by carboxyl on the surface of the oxidized graphene and amino on the antibiotic, so as to absorb the antibiotic on the oxidized graphene; taking the chitosan as the carrier of antibacterial metal ions, chelating the metal ions in chitosan molecules, restoring the metal ions into metallic single substances through a reducing agent; and finally mixing the carboxyl graphene with the antibiotic and the chitosan solution loaded with antibacterial metal, freezing and drying to obtain the composite bracket with two different antibacterial materials. The composite bracket can release antibiotic within a short period of time and release the antibacterial metal ions for a long period of time, and has short-term antibacterial and long-term antibacterial effects, and good antibacterial effect.

Description

Technical field [0001] The invention relates to a preparation method of an antibacterial porous graphene oxide / chitosan composite scaffold. Background technique [0002] Infection of bone implanted stents after surgery is an important problem faced by clinical medicine in recent years. Bone implant stents based on alloys such as titanium and magnesium are widely used, but it is difficult to effectively load antibacterial drugs due to their inertness. [0003] Although the stent can be modified and functionalized by functional materials to realize the loading of antibacterial drugs, there are still the following problems: the reduction of the strength of the stent cannot meet the strength requirements of bone implant materials, and the release time of antibacterial drugs is difficult to control, especially It is difficult to balance short-term and long-term antibacterial effects, and the antibacterial effect needs to be improved. Summary of the invention [0004] The purpose of the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/20A61L27/36A61L27/54A61L27/56
Inventor 鲁雄谢超鸣姜丽丽韩璐郭亚楠刘敏王振铭
Owner SOUTHWEST JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap