The invention relates to a scale remover for condensation equipment and a preparation method thereof. The scale remover is composed of 15% to 30% of a dissolving agent, 2% to 5% of a penetrating agent, 1% to 5% of a corrosion inhibitor, and a cosolvent 10% to 30%, purified water 20% to 30%, and the rest is ethanol, in terms of mass percentage; the dissolving agent is selected from oxalic acid, citrate, ascorbic acid, salicylic acid and glacial acetic acid, and the penetrant is selected from diethyl succinate Among esters, ethylene glycol monobutyl ether and dioctyl sulfosuccinate sodium salt, the corrosion inhibitor can be hexamethamine, aniline, diethylthiourea or rhodin, and the cosolvent can be p-benzoic acid, urea, Cyclohexanone, acetamide and sodium salicylate. The invention combines the above-mentioned raw materials and utilizes the combination effect to make them have strong descaling ability and fast descaling speed, less corrosion to equipment, low price, can save a lot of cleaning costs, and improve equipment operation level and energy utilization The level and production efficiency have greatly reduced the cost of producing products.