8 results about "Biphosphonate" patented technology

Described herein are nanoparticles comprising NaLnF4, wherein Ln includes all non-radioactive lanthanide elements, or NaYF4, and methods of making and using the same. The nanoparticles may optionally be modified with PEG or zwitterionic polymers containing a bisphosphonate end group, wherein the bisphosphonate end group optionally comprises an aminohexyl group. As described herein. NaLnF4 or NaYF4 nanoparticles may be used as high-sensitivity reagents for mass cytometry.

A compound or pharmaceutically acceptable salt thereof has at least one bis-phosphonate or bisphosphonate ester group, and a positron emitting radionuclide Po. The positron emitting radionuclide Po is attached to the at least one bisphosphonate or bisphosphonate ester group. The compound may be useful in a method of diagnosis of amyloidosis, such as cardiac amyloidosis.

Phosphonate conjugates, preferably, bisphosphonate conjugates: methods of inhibiting Ron receptor tyrosine kinase and methods of treatment of bone destruction due to cancer or other conditions utilizing the provided phosphonate conjugates.

The present disclosure relates to a compound comprising at least one bisphosphonate or bisphosphonate group and a positron emitting radionuclide Po, or a pharmaceutically acceptable salt thereof, and its use in a method of diagnosing amyloidosis, such as cardiac amyloidosis.

Provided is a method for preparing specific bisphosphonate compounds and their ester derivatives. In this method, specific bisphosphonate compounds such as medronic acid are prepared via the reaction of the corresponding isopropyl ester with (i) trimethylsilyl bromide or trimethylsilyl iodide or (ii) trimethylsilyl chloride and an alkali metal iodide or bromide; followed by treatment with a liquid containing water. The above method surprisingly gives the desired compounds despite the relatively bulky ester group such as isopropyl in the starting bisphosphonate ester.

Phosphonate conjugates, preferably, bisphosphonate conjugates; methods of inhibiting Ron receptor tyrosine kinase and methods of treatment of bone destruction due to cancer or other conditions utilizing the provided phosphonate conjugates.

The present invention provides a method for efficiently producing highly pure γδT cells introduced with foreign genes by culturing in the presence of IL-7 and IL-15 after stimulating the γδT cells with a bisphosphonic acid ester derivative. When a T cell receptor (TCR) or a chimeric antigen receptor (CAR) is introduced as a foreign gene, γδT cells in which TCR and CAR are functionally expressed can be obtained.