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4 results about "Biphosphonate" patented technology
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A drug or substance used to treat hypercalcemia (abnormally high blood calcium) and bone pain caused by some types of cancer. Forms of bisphosphonates are also used to treat osteoporosis and for bone imaging. Bisphosphonates inhibit a type of bone cell that breaks down bone.
Diagnostic pet imaging of cardiac amyloidosis
A compound or pharmaceutically acceptable salt thereof has at least one bis-phosphonate or bisphosphonate ester group, and a positron emitting radionuclide Po. The positron emitting radionuclide Po is attached to the at least one bisphosphonate or bisphosphonate ester group. The compound may be useful in a method of diagnosis of amyloidosis, such as cardiac amyloidosis.
Owner:HIGUCHI TAKAHIRO
Phosphonate conjugates and uses thereof
Phosphonate conjugates, preferably, bisphosphonate conjugates: methods of inhibiting Ron receptor tyrosine kinase and methods of treatment of bone destruction due to cancer or other conditions utilizing the provided phosphonate conjugates.
Owner:TRANSLATIONAL GENOMICS RESEARCH INSTITUTE +1
Phosphonate conjugates and uses thereof
Phosphonate conjugates, preferably, bisphosphonate conjugates; methods of inhibiting Ron receptor tyrosine kinase and methods of treatment of bone destruction due to cancer or other conditions utilizing the provided phosphonate conjugates.
Owner:TRANSLATIONAL GENOMICS RESEARCH INSTITUTE +1
Method for gene transfer into gamma-delta type T cell
ActiveUS12637658B2Polypeptide with localisation/targeting motifImmunoglobulin superfamilyAntigen receptorsChimeric antigen receptor
The present invention provides a method for efficiently producing highly pure γδT cells introduced with foreign genes by culturing in the presence of IL-7 and IL-15 after stimulating the γδT cells with a bisphosphonic acid ester derivative. When a T cell receptor (TCR) or a chimeric antigen receptor (CAR) is introduced as a foreign gene, γδT cells in which TCR and CAR are functionally expressed can be obtained.
Owner:MIE UNIVERSITY