37 results about "Biphosphonate" patented technology

The invention discloses a method for preparing a monophosphonate and biphosphonate mixed fire retardant, which comprises the following steps of: (1) heating tris phosphite and dihalide in the presence of a catalyst: (2) refluxing the mixture after the temperature rises to 110 to130 DEG C and continuously heating the refluxed mixture, wherein the optimal refluxing temperature of 120 DEG C; (3) allowing the refluxing speed to reduce obviously when the temperature is 160 and 180 DEG C, wherein the optimal temperature is 170 DEG C; (4) continuing a reaction, keeping the temperature between 170 and 200 DEG C to perform a reaction for 1 hour when the reflux phenomenon basically disappears, wherein the reaction is performed at 180 to190 DEG C optimally; (5) distilling the reacting product under normal pressure and filtering the distilled product to obtain a colorless transparent product. The total product yield of the monophosphonate and biphosphonate mixed fire retardant is over 90 percent; and the reaction time is shortened, the product has good color and luster, the acid value is low, the viscosity is low and no additional de-coloration treatment is required. Serving as the additive-type phosphine fire retardant, the monophosphonate and biphosphonate mixed fire retardant has higher performance. The monophosphonate and biphosphonate mixed fire retardant has the advantages of high economy, high product utilization efficiency, zero emission in a production process and environmental protection.

Synthesis of biphosphonate compounds can be advantageously carried out in a solvent / diluent comprising a compound of formula (3)wherein R is hydrogen or a C1-C6 alkyl group; each of R1 is a C1-C6 alkyl group or both R1 groups are linked to form a C1-C3 alkylene group; and R2 is hydrogen, a C1-C6 alkyl group, a C1-C6 alkoxy group, or is linked together with R to form a C3-C7 carbon ring.

The patent discloses self-emulsifying formulations of bisphosphonates or bisphosphonic acids in the prevention and treatment of conditions involving calcium or phosphate metabolism. The dosage forms are either capsules, or tablets, or other controlled release drug delivery systems, or devices that contain self-emulsifying formulation of such bisphosphonates or bisphosphonic acids.