A kind of monosialotetrahexosyl ganglioside sodium sustained-release capsule and preparation method thereof

Abstract

The invention provides a monosialotetrahexosylganglioside sodium slow-release capsule and a preparation method thereof. The slow-release capsule is composed of a capsule filler and a capsule shell. The capsule filler is mainly composed of the following components in parts by weight: 10-30 parts of monosialotetrahexosylganglioside sodium, 10-20 parts of transesterified polyglycerol ricinoleate, 10-15 parts of methyl poly-L-hydroxyethylacrylate, 10-15 parts of hydroxypropyl methylcellulose, 5-8 parts of guar gum and 5-10 parts of chitosan. The capsule provided by the invention is convenient for oral administration, can effectively enhance the stability of monosialotetrahexosylganglioside sodium in the gastrointestinal tract, can ensure the regular slow constant-speed release of monosialotetrahexosylganglioside sodium, effectively prevents drugs from being quickly decomposed in the gastrointestinal tract, and keeps the drugs in the organism at a relatively constant concentration. The slow-release capsule can effectively reduce the medication frequency, reduces the pains of the patient, and enhances the drug effects.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a monosialotetrahexosylganglioside sodium slow-release capsule and a preparation method thereof. Background technique [0002] Gangliosides are a family of heterogeneous sialic acid-containing complex membrane glycolipids, first discovered by Klenk in 1939. Their molecules are composed of a lipophilic ceramide moiety and a hydrophilic sialooligosaccharide core group. Since Ceccarelli first proved in 1976 that exogenous gangliosides (GLs) can improve peripheral nerve regeneration and promote repair, scholars at home and abroad have conducted in-depth research on the effects of gangliosides on the central nervous system. Monosialotetrahexosyl ganglioside (GM1) is an important class of gangliosides that have multiple biological functions such as neurotrophy and central nervous system repair, and its role in the treatment of nervous system injuries is being widely recognized. Pay ...

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Problems solved by technology

[0005] In order to solve the problem that the existing oral preparation of monosialotetrahexosylganglioside sodium is unstable in the gastrointestinal tract, it is easily decomposed in the gastrointestinal tract, and is rapidly lost under the decomposition of microorganisms and hydrolytic enzymes in the gastrointestinal tract after oral administration. Pharmacological effects, unable to exert curative effect and other problems, the invention provides a monosialotetrahexosyl ganglioside sodium sustained-release capsule and its preparation method

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