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Veterinary long-acting analgin injection and preparation method thereof

Analgin and injection technology, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of easy oxidation and discoloration of Analgin injection, and the problem of Analgin injection Oxidative discoloration, antipyretic effect is not durable enough, etc., to achieve the effect of prolonging the antipyretic drug effect, reducing the number of medications, and good effect

Active Publication Date: 2017-08-11
浙江大飞龙动物保健品股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current fever symptoms in swine diseases last for a long time and repeated high fever is more prominent. Clinically, the antipyretic effect of Analgin injection is not long enough, and the body temperature tends to rebound after injection. Injecting twice a day is time-consuming and labor-intensive. and increased stress in sick pigs
At the same time, Analgin Injection is prone to oxidative discoloration, and many farms cannot store it in shading and below 30°C. Oxidative discoloration of Analgin Injection in clinical use often occurs

Method used

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  • Veterinary long-acting analgin injection and preparation method thereof
  • Veterinary long-acting analgin injection and preparation method thereof
  • Veterinary long-acting analgin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A veterinary drug long-acting Analgin injection, containing per 1000L: Analgin (injection grade) 200kg, PVP-K30 50kg, sodium bisulfite 1kg, propylene glycol 50kg, and the balance freshly prepared water for injection.

[0023] A preparation process of veterinary drug long-acting Analgin injection, its preparation method:

[0024] (1) Add a total of 40% freshly prepared water for injection into the 100,000-grade district concentration tank, flush with nitrogen for 15 minutes, control the water temperature at 50-55°C, and immediately add 1kg of sodium bisulfite and Analgin (injection grade) 200kg, stir for 5 minutes to dissolve; add 50kg of PVP-K30, stir for 5 minutes to dissolve; add 50kg of propylene glycol, stir for 3 minutes;

[0025] (2) Add a total of 40% freshly prepared water for injection into the dilute distribution tank of the Wanji District, and flush with nitrogen for 15 minutes;

[0026] (3) Filter the medicinal solution in the concentrated preparation tank ...

Embodiment 2

[0030] A veterinary long-acting Analgin injection, containing per 1000ml: Analgin (injection grade) 300kg, PVP-K30 100kg, sodium bisulfite 2kg, propylene glycol 100kg, and the balance freshly prepared water for injection.

[0031] A preparation process of veterinary drug long-acting Analgin injection, its preparation method:

[0032] (1) Add a total of 40% freshly prepared water for injection into the 100,000-grade district concentration tank, flush with nitrogen for 15 minutes, control the water temperature at 50-55°C, and immediately add 2kg of sodium bisulfite and Analgin (injection grade) 300kg, stir for 5 minutes to dissolve; add 100kg of PVP-K30, stir for 5 minutes to dissolve; add 100kg of propylene glycol, stir for 3 minutes;

[0033] (2) Add a total of 40% freshly prepared water for injection into the dilute distribution tank of the Wanji District, and flush with nitrogen for 15 minutes;

[0034] (3) Filter the medicinal solution in the concentrated preparation tank ...

Embodiment 3

[0038] A long-acting Analgin injection for veterinary use, containing per 1000L: Analgin (injection grade) 400kg, PVP-K30 150kg, sodium bisulfite 5kg, propylene glycol 150kg, and the balance freshly prepared water for injection.

[0039] A preparation process of veterinary drug long-acting Analgin injection, its preparation method:

[0040] (1) Add a total of 40% freshly prepared water for injection into the 100,000-grade district concentration tank, flush with nitrogen for 15 minutes, control the water temperature at 50-55°C, and immediately add 5kg of sodium bisulfite and Analgin (injection grade) 400kg, stir for 5 minutes to dissolve; add 150kg of PVP-K30, stir for 5 minutes to dissolve; add 150kg of propylene glycol, stir for 3 minutes;

[0041] (2) Add a total of 40% freshly prepared water for injection into the dilute distribution tank of the Wanji District, and flush with nitrogen for 15 minutes;

[0042] (3) Filter the medicinal solution in the concentrated preparatio...

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Abstract

The invention relates to a veterinary long-acting analgin injection and a preparation method thereof and belongs to the technical field of veterinary drug preparations. Each 1000L of the injection contains the following components by weight: nearly 200kg-400kg of injection level analgin, 50kg-150kg of PVP-K30, 1kg-5kg of sodium hydrogen sulfite, 50kg-150kg of propylene glycol and the balance of fresh prepared injection water. Compared with a national standard analgin injection, the veterinary long-acting analgin injection has the advantages that the effectively drug peak concentration retention time is doubled, the fever-abatement pesticide effect is prolonged and durable, the medication frequency is reduced, the human stress caused to diseased pigs is reduced, the recovery of the diseased pigs is promoted, and the analgin injection is stable in quality and unlikely to oxidize. Meanwhile, specific auxiliary materials, controlled release agents and production processes are selected according to requirements of a vein injection, and the prepared analgin injection can be used for carrying out intravenous injection and has a good effect on treating hyperpyrexia of sows when being used in cooperation with cephalosporin antibiotics.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a veterinary long-acting analgin injection and a preparation method thereof. Background technique [0002] Fever is a common symptom of swine diseases. Once a pig has a fever, it is often accompanied by loss of appetite and depression. Simple oral administration cannot achieve the desired effect in time, and then it is easy to cause secondary infection, making the condition worse. Therefore, clinically, injection is usually used to resolve symptoms first, and antipyretic is the first choice. [0003] Analgin is one of the most commonly used antipyretic and analgesic drugs for animals. It is a compound combining aminopyrine and sodium sulfite, easily soluble in water, and has faster and stronger antipyretic and analgesic effects than aminopyrine. Analgin Injection, low price, quick effect after administration, but the drug effect time is short, t ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/32A61K47/02A61K47/10A61K31/4152A61K31/545A61K31/546A61P29/00
CPCA61K9/0019A61K9/08A61K31/4152A61K31/545A61K31/546A61K47/02A61K47/10A61K47/32A61K2300/00
Inventor 沈建军舒鑫标唐群霞彭俊平宋占学施伟领胡永明
Owner 浙江大飞龙动物保健品股份有限公司
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