189 results about "D-Glucosamine" patented technology

C-glycoside compounds are suited for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and / or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and / or proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and / or keratinocytes.

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biochemicals from the activated mast cells, the compositions containg one or more of a flavone or flavonoid glycoside a heavily sulfated, non-bovine proteoglycan, an unrefined olive kernel extract that increases absorption of these compositions in various routes of administration, a hexosamine sulfate such as D-glucosamine sulfate, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, a long-chain unsaturated fatty acid, a phospholipid, Krill oil, a polyamine, glutiramer acetate and interferon. Certain of the present compositions are useful in protecting against the neuropathological components of multiple sclerosis and similar inflammatory neurological diseases.

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, an unrefined olive kernel oil / extract that increases absorption of these compositions in various routes of administration, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.

Disclosed herein are acidic aqueous hard surface cleaners and methods for using them. The cleaners include a surfactant and a poly D-glucosamine such as chitosan. They provides residual benefits on the hard surface such as soil resistance and resistance to bacteria, molds and biofilms.

The present invention provides a composition, and a method of use thereof for treating connective tissue damage in man and in animals, which comprises a therapeutically effective amount of chondroitin sulfate, N-acetyl D-glucosamine, and hyaluronan (hyaluronic acid). Particularly, the present invention provides a composition, and a method of use thereof, for treating connective tissue damage including, but not limited to, arthritic disease, osteoarthritis, rheumatoid arthritis, osterochondrosis dessicans, cartilage damage, joint injury, joint inflammation, joint synovitis, degenerative joint disease (DJD), post surgical DJD, traumatic injury, fracture, tendon damage, ligament damage, skeletal damage, musculoskeletal damage, fiber damage, adipose tissue damage, blood cell damage, and plasma damage. Compositions for delivery of the present invention include those for parenteral, oral, and transmucosal delivery and for direct surgical placement onto the affected tissues.

This invention is concerned with packaged food products which contain specific combinations of functional additives aimed at addressing specific health indicators, in particular flatulence, gastro-intestinal health, stress and immune system responsiveness, in pet animals. There is provided a commercially packaged mammal pet food product that includes a manufactured, shelf-life stable food substrate and a combination of functional additives. The functional additives include at least one non-palatable plant-based remedy and / or dietary fiber source that are present to strengthen and / or maintain a specified health indicator of a mammal pet animal. The food product is portioned and packaged with the functional additives being present in predetermined concentrations and amounts sufficient to be effective in achieving said indications on regular feeding of the pet animal with said food product. The food substrate is present in a proportion sufficient to mask the flavor and / or odor of the non-palatable additive and is made-up of a unique combination of materials that are able to be processed at lower temperatures to preserve the natural botanical functional additive's activity. Functional additives intended to address dietary flatulence problems include a combination of Yucca extract, charcoal and salts of zinc, such as zinc acetate. Functional additives to promote or maintain gastro-intestinal health include a combination of L-glutamine, D-glucosamine sulphate, sugar beet pulp, slippery elm. Functional additives to strengthen or maintain a pet animal's natural body defenses include a combination of vitamin E, vitamin B complex, primrose oil vitamin C and Marigold meal. Functional additives to promote or maintain reduction of stress and / or improved behavior of a pet animal include a combination of Valerian root extract, Kava root extract, vitamin B complex and magnesium salt.

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, an unrefined olive kernel oil / extract that increases absorption of these compositions in various routes of administration, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.

The present invention relates to novel C-glycoside compounds of given absolute configuration, to a process for synthesising them and to compositions containing them. The invention also relates to the cosmetic use of these C-glycoside compounds as agents to stimulate the synthesis of glycosaminoglycans containing a D-glucosamine and / or N-acetyl-D-glucosamine residue, advantageously hyaluronic acid, and / or of proteoglycans, advantageously proteoglycans containing hyaluronic acid, by fibroblasts and / or keratinocytes. The invention also relates to a cosmetic process for treating keratin materials using a composition containing at least one C-glycoside compound according to the invention.

The present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have been also engineered to express biofilm-degrading enzymes, particularly dispersin B (DspB), an enzyme that hydrolyzes β-1,6-N-acetyl-D-glucosamine, a crucial adhesion molecule needed for biofilm formation and integrity in Staphylococcus and E. coli, including E. coli K-12, as well as clinical isolates.

The present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have been also engineered to express biofilm-degrading enzymes, particularly dispersin B (DspB), an enzyme that hydrolyzes β-1,6-N-acetyl-D-glucosamine, a crucial adhesion molecule needed for biofilm formation and integrity in Staphylococcus and E. coli, including E. coli K-12, as well as clinical isolates.

Glycans are identified which have high affinity for C. difficile toxin A. They share one of two saccharide backbones and may have additional side chains. The backbones are galactose-β1-3 N-acetyl-D-glucosamine-β-1-3-galactose-β-1-4-N-acetyl-D-glucosamine and galactose-α-1-3-galactose-β-1-4-N-acetyl-D-glucosamine. The ligands may be used therapeutically, prophylactically, and diagnostically.

A method of regenerating N-Methyl-D-glu-camine-functional resin that has been used for boron-removal uses a closed recirculating loop for treating the conjugate acid salt of the N-Methyl-D-glucamine functionality of the resin. The new method reduces rinse water demand and improves pH control in a water treatment system. The new method can be used to improve the performance of boron-selective resins in stand-alone systems or as a second stage in a reverse osmosis seawater desalination system. The regeneration method is useful in any application where weakly basic anion exchange resin in the conjugate acid salt form is to be regenerated (neutralized) by alkaline treatment. Possible end use applications are in drinking water processing, agricultural water treatment, sweetener production, waste water processing, mining hydrometallurgy, and condensate polishing.

The invention relates to a Chinese medicine preparation, particularly a Chinese medicine preparation capable of increasing bone density and improving osteoporosis and arthralgia. The Chinese medicine preparation contains epimedium extract, radix salviae miltiorrhizae extract, D-glucosamine hydrochloride, biological calcium carbonate (oyster calcium), collagen hydrolysate, chondroitin sulfate and other active ingredients, wherein the D-glucosamine hydrochloride can obviously promote the proliferation and differentiation actions of the epimedium extract and radix salviae miltiorrhizae extract on osteoblasts. By combining the traditional Chinese medicine theory and the modern medicine research, the preparation tonifies the liver and kidney, strengthens the kidney and bone, promotes the bloodcirculation, dredges the collaterals and directly supplements calcium and collagen in a biological way, so that the kidney-qi is sufficient, and the bone is tonified, thereby improving ostealgia and arthralgia, enhancing the quality of life in the turn of life, and further performing the functions of increasing bone density and improving osteoporosis and arthralgia.

The invention discloses a preparation method of D-glucosamine sulfate sodium chloride salt. The preparation method comprises the following steps of: dissolving D-glucosamine hydrochloride in a solvent; adding a sodium-containing alkaline substance into the obtained solution at the temperature of minus 40-100 DEG C, or adding the sodium-containing alkaline substance into the obtained solution under the protection of one or more protective gas(s) of nitrogen, carbon dioxide and inert gases; adding the sodium-containing alkaline substance into the mixed solution at the maintained temperature of minus 40-90 DEG C; adding sulfuric acid into the obtained solution at the temperature of minus 25 to 90 DEG C for salifying; carrying out complexation reaction to obtain a D-glucosamine sulfate sodium chloride salt complex; and filtering and crystallizing to obtain the D-glucosamine sulfate sodium chloride salt solid. The method is novel and unique and simple and reasonable in technology, product quality is good and purity is high, and completely reaches the standard of United States patent (USP) 34 edition pharmacopeia.

The invention relates to a BMD (bone mineral density)-increased health food composite and a preparation method of the BMD-increased health food composite. The BMD-increased health food composite comprises 180-220 parts by weight of red deer bone, 120-160 parts by weight of D-glucosamine hydrochloride, 80-100 parts by weight of chondroitin sulfate, 25-45 parts by weight of achyranthes root extractive, 20-40 parts by weight of drynaria rhizome extractive, 15-35 parts by weight of herba epimedii extractive, 10-20 parts by weight of casein phosphopeptides, and clinically-acceptable auxiliary materials, so that the hard capsule, the troche, the granule, the powder, the tea bag agent and the soft capsule can be prepared. According to the invention, a calcium source can be compensated by the red deer bone, the symptom of the osteoarthropathy can be improved by the D-glucosamine hydrochloride and the chondroitin sulfate, the calcium absorption can be promoted by the casein phosphopeptides, and the functions of nourishing the liver and kidney and strengthening the bones and muscles can be achieved due to the compatibility of traditional Chinese medicines. The BMD can be effectively increased due to the joint compatibility of the raw materials; a finished product is simple in preparation technology; and the health food provided by the invention is exact in effects, safe, and free of toxic and side effects, and can be taken for a long term, so that the general flavone in every 100g in the content of effect ingredients of the health food composite is higher than 0.5g.

The invention relates to d-glucosamine-modified iron oxide nanoparticles used as a tracer for magnetic resonance, a preparation method of lyophilized powder thereof and use thereof. The d-glucosamine-modified iron oxide nanoparticles comprise superparamagnetic iron oxide nanoparticles, wherein the surfaces of the superparamagnetic iron oxide nanoparticles are modified by a substance having carboxyls; the carboxyls react with the aminos of the d-glucosamine to form amido bonds; and thus a structure that the surfaces of the superparamagnetic iron oxide nanoparticles are modified by the d-glucosamine is formed. The invention provides a novel tumor-targeted MRI contrast agent which has high selectivity of tumors for the tumor targeted magnetic resonance diagnostic tests and clinic tumor diagnosis. By preserving the d-glucosamine-modified superparamagnetic iron oxide nanoparticles in form of the lyophilized powder, the unstable problem of the d-glucosamine-modified superparamagnetic iron oxide nanoparticles is solved. The d-glucosamine-modified iron oxide nanoparticles are sterile, anhemolytic and free from vascular stimulation and can meet the requirements of tests of cells, animals and the like.

The invention discloses a medicine composition for treating osteoporosis and a preparation method thereof. The medicine composition is prepared from collagen, chondroitin sulfate sodium salt, calcium carbonate, rhizoma drynariae extract, kudzu vine root extract, D-glucosamine hydrochloride and pseudo-ginseng. The medicine composition can be used for treating the pathogenesis, namely destruction of bone microstructure, of osteoporosis, is capable of solving the problem of bone density abnormality and radically preventing and treating osteoporosis; and the medicine composition can be used for relieving symptoms of ostealgia of osteoporosis patients, healing of bone fracture can be promoted, and the living quality of osteoporosis patients can be improved.

This Invention relates to, for production of N-acetyl-D-glucosamine and D-glucosamine by microbial fermentation: A nongenetic recombinant strain, preserved in the General Microbiology Center of the China Committee for Culture Collection of Microorganisms; NJ090259, a strain of Bacillus subtilis, Preservation No. CGMCC10257; and NJ091195, a strain of Bacillus licheniformis, Preservation No. CGMCC10258 and Preservation Date Dec. 29, 2014. The beneficial effects of this Invention are: Provide a new strain for production of N-acetyl-D-glucosamine and D-glucosamine, and its production methods. By this method, it may achieve stable production and supply of N-acetyl-D-glucosamine, and may also achieve non-animal-derived, safety production of N-acetyl-D-glucosamine and D-glucosamine; the method is of short production phase and low cost, and is more environmentally-friendly.

The invention relates to a composition for increasing the bone mineral density and preparation and a preparation method thereof. The composition is mainly prepared from, by weight of parts, calcium carbonate, D-glucosamine hydrochloride, chondroitin sulfate, collagen protein, a casein phosphopepetides, a davallia mariesii extract and a vitamin K2. On the specific matched condition, the effect of remarkable synergistic interaction for treating osteoporosis is achieved, and the effects of blocking calcium loss and reinforcing calcium absorption are achieved; after traditional Chinese medicines of shaddock peels, chicken shells, purple bergenia herb and schisandra chinensis are added, the effect of increasing the bone density is further enhanced, and meanwhile the effects of treating the joint inflammation, tonifying the spleen and the kidney, strengthening tendons and bones, improving immunity and the like are achieved.

The invention discloses a method for separating and extracting N-acetyl-D-glucosamine and D-glucosamine from ammonia sugar fermentation liquor. The method includes the steps of microfiltration, ultrafiltration, nanofiltration and the like, the fermentation liquor is filtered through a microfiltration membrane with the aperture of 0.1-10 micrometers to remove impurity particles and microbial thalli, protein, nucleic acid, colloidal particle large molecules and other impurities are removed through filtering by means of an ultrafiltration membrane with the aperture of 0.001-0.1 micrometer, and pigment, polypeptide, nucleotide and other small-molecular impurities are removed through a reverse osmosis system; N-acetyl-D-glucosamine is crystallized and separated from the fermentation filtrate containing N-acetyl-D-glucosamine and glucosamine. The method includes the steps of fermentation filtrate heating and concentration, seed crystal addition, temperature-control crystallization, N-acetyl-D-glucosamine crystal collection, residual glucosamine recycling and the like. The method is low in cost and does not influence the structure of N-acetyl-D-glucosamine, and the obtained N-acetyl-D-glucosamine is high in purity.

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, an unrefined kernel olive oil that increases absorption of these compositions in various routes of administration, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.

The invention belongs to the field of health care food, and especially relates to a composition used for improving skeletal system health, and applications thereof. The composition comprises skimmed milk powder, fructo-oligosaccharide, yak bone, orange fruit powder, D-glucosamine hydrochloride, bone collagen, chondroitin sulfate, herba epimedii extract, rhizoma drynariae extract, mushroom powder, magnesium carbonate, casein phosphopeptide, and vitamin K2. The composition possesses excellent prevention effects on patients with osteoporosis and skeletal system disorders such as ankylosis, arthritis, osteoproliferation, arthralgia, and myospasm, and is capable of increasing bone mineral density, and improving skeletal system health. The composition can be used for preparing health care food capable of improving skeletal system health; application range is wide; and economic benefit and social benefit are both high.

The invention provides a novel method for externally applied glucosamine for the treatment of arthritis and externally applied formulation of glucosamine, wherein D-glucosamine hydrochlorate and / or D-glucosamine sulfate is combined with transdermal agents, and arthritis is treated through partial external application. The externally used preparation is mixed from glucosamine, transdermal agent and base material, preferably 2-20 parts of D-glucosamine hydrochlorate and / or D-glucosamine sulfate, 2-5 parts of transdermal agent and 65-85 parts of base material. The externally used preparation can be made into the forms of electuary, spray, film preparation or other types of daubing agent.

The embodiment of the invention relates to a preparation method of microbial fermentation-based N-acetyle-D-glucosamine. The preparation method comprises the steps of firstly carrying out two-stage cultivation on engineering strains (metabolism brevibacterium producing N-acetyle-D-glucosamine) subjected to special preservation, then transferring a fermentation medium into a fermentation tank of 30000L, at the same time adding sterilized glucose, then inoculating seeds cultivated in two stages into the fermentation tank of 30000L, strictly controlling fermentation parameters until the fermentation is sufficient, then sterilizing fermentation liquor, removing the strains by filtration through a ceramic membrane or a sheet frame after sterilization, adding chitosan into filtrate for flocculation to remove proteins, adding activated carbon for decoloration, filtering, performing ion exchange and bed mixing, adding a certain amount of ethyl alcohol into feed liquor for low-temperature concentration and crystallization, adding ethyl alcohol of the concentration over 95 percent into a crystalized material for rinsing, and performing centrifugal drying to obtain the high-purity N-acetyle-D-glucosamine.

The invention discloses a method for preparing D-glucoseamine hydrochloride, which comprises the steps as follows: (1) adding chitosan, inorganic acid and low-carbon alcohol to a reaction distillation device, and heating to a temperature of 85-110 DEG C to carry out a reaction to obtain a distillate at the tower top and a residual solution at the tower bottom; (2) filtering the residual solution to remove residue and obtain a filtrate, cooling the filtrate to separate out the solid, and carrying out solid-liquid separation to obtain coarse D-glucoseamine hydrochloride and a first mother liquid; dissolving the coarse D-glucoseamine hydrochloride into the hot water, adding activated carbon, refluxing, filtering, evaporating the filtrate to separate out the solid, dissolve the solid into ethanol, stirring, cooling, and standing to separate out crystals, filtering and drying to obtain D-glucoseamine hydrochloride. The method can remove the acetic acid generated from the reaction from the reaction system in time, thereby improving the utilization ratio of the raw material and the yield of D-glucoseamine hydrochloride and reducing the waste solution discharge and the environmental pollution.

The invention relates to a method for preparing a plant-source D-glucosamine hydrochloride. The plant-source D-glucosamine hydrochloride is mainly prepared by taking waste residues generated in the process of using the plant fermentation method to produce citric acid as raw material, and adopting the steps of acidolysis, cooling, filter pressing, decoloring, distillation and condensation, crystallization, washing, drying, and the like. Compared with prior art, the invention has the advantages of rich raw material resource, no heavy metal or antibiotic pollution, cheapness and easy obtaining. While effectively reducing the production cost, the invention finds a proper approach for treating the environment pollution so as to change waste into a treasure and also save the cost for treating the environment pollution. The invention also has simple and easy production process, good product quality, good economical and social benefit and wide market prospect.