Pharmaceutical composition containing colistin sulfate and preparation method of pharmaceutical composition

A technology of colistin sulfate and composition, which is applied in the field of pharmaceutical composition containing colistin sulfate and its preparation, and can solve the problems of ineffective treatment and growth promotion, difficulty in achieving content uniformity, and colistin bioavailability. In order to improve the effective drug concentration and action time, improve the intestinal morphology, and reduce the frequency of medication

Inactive Publication Date: 2015-06-24
JINHE ANIMAL PHARMA
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. Colistin sulfate is bitter and has a strong pungent smell, so the powder product has poor palatability;
[0007] 2. Colistin sulfate has strong hygroscopicity. The traditional powder product is simply mixed with colistin sulfate raw powder and organic auxiliary materials such as starch and bran powder, so it is easy to agglomerate, has poor fluidity and uniform content Not easy to reach, not easy to mix with feed;
[0009] 4. The current colistin preparation products are used according to the dosage in the departmental standard, and the therapeutic and growth-promoting effects are not obvious. It is often effective to add more than 3 to 4 times the dosage. The reason for this overdose addition is not only the bioavailability of colistin In addition to the low degree, the main reason is that long-term use increases the drug resistance of animals, which makes the effective concentration increase

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition containing colistin sulfate and preparation method of pharmaceutical composition
  • Pharmaceutical composition containing colistin sulfate and preparation method of pharmaceutical composition
  • Pharmaceutical composition containing colistin sulfate and preparation method of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Select 172.5kg of stearic acid as an embedding agent, put it into a 300L heating tank (effective volume: 200kg), heat it to 100°C-130°C while stirring continuously to completely melt the stearic acid, and then cool it to 90°C-100°C , the accurately weighed 27.5kg colistin sulfate crude drug is dropped into the heating tank, and stirred for 30 minutes with a stirring speed of 100 rev / min, so that the two are fully mixed. Start the centrifugal turntable sprayer, set the rotational speed of the centrifugal turntable to 3500 rpm, the inlet air temperature to ≤15°C, and the outlet air temperature to 25°C. The prepared granules were sieved with a 24-60 mesh vibrating sieve to finally obtain 191.4 kg of 10% colistin sulfate microcapsule granules with a yield of 95.7%.

Embodiment 2

[0050] Select 172.5kg of glyceryl monostearate as an embedding agent, put it into a 300L heating tank (with an effective volume of 200kg), heat it to 100°C-130°C, and stir continuously to completely melt the glyceryl monostearate, and then cool it To 90 ℃ ~ 100 ℃, accurately weighed 27.5kg of colistin sulfate crude drug into the heating tank, stirring with a stirring speed of 100 rpm for 30 minutes, so that the two are fully mixed evenly. Start the centrifugal turntable sprayer, set the rotational speed of the centrifugal turntable to 3500 rpm, the inlet air temperature to ≤15°C, and the outlet air temperature to 25°C. The prepared granules were sieved with a 24-60 mesh vibrating sieve to finally obtain 188.4 kg of 10% colistin sulfate microcapsule granules with a yield of 94.2%.

Embodiment 3

[0052] Select 162.5kg of embedding agent stearic acid and 10kg of paraffin, put them into a 300L heating tank (effective volume is 200kg), heat to 100°C-130°C, and keep stirring at the same time to completely melt the stearic acid and paraffin, and then cool to At 90°C to 100°C, put 27.5kg of accurately weighed colistin sulfate bulk drug into a heating tank, and stir for 30 minutes at a stirring speed of 100 rpm to fully mix the two. Start the centrifugal turntable sprayer, set the rotational speed of the centrifugal turntable to 3500 rpm, the inlet air temperature to ≤15°C, and the outlet air temperature to 25°C. The prepared granules were sieved with a 24-60 mesh vibrating sieve to finally obtain 193.8 kg of 10% colistin sulfate microcapsule granules with a yield of 96.9%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to view more

Abstract

The invention relates to a pharmaceutical composition containing colistin sulfate and a preparation method of the pharmaceutical composition. The pharmaceutical composition containing colistin sulfate comprises the following components in parts by weight: 10-50 parts of colistin sulfate and 50-90 parts of an embedding medium. According to a colistin sulfate micro-capsule, the problems that the traditional colistin sulfate powder is poor in palatability, is easy to block, and not easily and evenly mixed with a feed are solved; the colistin sulfate provided by the invention is combined with the embedding medium through a molecular state; the action time of the colistin sulfate is prolonged by the sustained-release framework property of the embedding medium; the blood concentration is stable; the medication frequency is reduced; the medication cost of a farmer is reduced; and the economic benefits are improved.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a pharmaceutical composition containing colistin sulfate and a preparation method thereof. Background technique [0002] Colistin is an alkaline cationic surfactant with bactericidal effect. It can interact with phospholipids in the bacterial cell membrane to penetrate into the membrane, destroy the membrane structure, and then change the membrane permeability, leading to bacterial death. Colistin generally exists in the form of sulfate, also known as colistin sulfate. [0003] Colistin has a strong antibacterial effect on aerobic bacteria and Gram-negative bacteria such as Escherichia coli, Haemophilus, Klebsiella, Pasteurella, Pseudomonas aeruginosa, Salmonella and Shigella . Bacteria that are sensitive to colistin rarely develop resistance. Proteus and most Serratia species are not affected by colistin. Gram-positive bacteria are generally insensiti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61K9/16A61K9/50A61P31/04A61P1/00
Inventor 李荣顺路赟
Owner JINHE ANIMAL PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap