55results about How to "Guaranteed sustained release effect" patented technology

The invention discloses a formula of a slow-releasing fertilizer coating with a biological-optical difunctional degradable property and a preparation method. The coating material is composed of polyolefin, a biodegradable polymer, a photo-degradation accelerant, an inorganic powder additive, a thermal oxidization accelerant and a crosslinking agent, wherein a solvent is an organic solvent; a preparation method for a coating liquid comprises the steps of: heating a certain amount of solvent to 100-120 DEG C; then successively adding polyolefin, the biodegradable polymer, the photo-degradation accelerant, the thermal oxidization accelerant, the inorganic powder additive and the crosslinking agent in sequence, and continuously stirring the mixture to 140-160 DEG C to form a stable and uniform coating liquid; and coating the coating material to the surface of a fertilizer by using a fluidized bed to form a coating fertilizer, wherein the solvent is recovered. The coating material has a biological and optical difunctional degradable property and prevents secondary pollution brought by the fertilizer coating.

The invention discloses an oil injection containing antibacterial agents/solid polyethylene glycol drug-loading particles. The oil injection is prepared by consisting of the drug-loading particles through antibacterial agents and solid polyethylene glycol and suspending the drug-loading particles in an oil medium. The antibacterial agents comprise enrofloxacin, danofloxacin mesylate, Marbofloxacin, mequindox, tilmicosin, tylosin, oxytetracycline hydrochloride, ceftiofur hydrochloride, cefquinome sulfate, lincomycin hydrochloride, florfenicol, erythrocin and doxycycline hydrochloride; preferentially the polyethylene glycol with the molecular weight of more than 6000 is used for preparing the preparation; more preferentially, any one of isopropyl myristate, soybean oil for injection, corn oil and tea-seed oil is used for preparing the preparation. Hydroxypropyl methyl cellulose or high-substituted hydroxy propyl cellulose can be added into the preparation.

The invention discloses a biological preparation capable of preventing and treating human gastric diseases, i.e., an anti-Helicobacter pylori specific yolk immunoglobulin (anti-HP-IgY) preparation, and especially to a novel dosage form thereof, i.e., a floating tablet in stomach, and the invention belongs to the technical field of biomedicines. The anti-HP-IgY gastric floating tablet uses yolk immunoglobulin specifically resisting Helicobacter pylori (i.e., anti-HP-IgY) as an active component and hydrophobic pharmaceutic adjuvants and hydrophilic pharmaceutic adjuvants as auxiliary components. The gastric floating tablet enables retention time of the active component (anti-HP-IgY) in stomach to be prolonged, which is very helpful for anti-HP-IgY in killing of Helicobacter pylori Hp intermittently floating upward from pylorus; the anti-HP-IgY gastric floating tablet has the advantages of strong specificity, no drug resistance, no toxic and side effects and good thermal stability, acid resistance and antiprotease performance. Raw materials for preparing the tablet are easily available, and a manufacturing method for the table is simple and is convenient for popularization and utilization.

The invention relates to a method for preparing a feed-grade sodium selenite coated diluting agent, and belongs to the field of a feed additive. The method comprises the steps of weighing raw materials, dissolving, mixing, heating and stirring, completing coating, embedding and diluting treatment through one step, drying and the like. The technical scheme provided by the invention aims at the defects in the prior art; compressed air is sprayed out from the both sides of a nozzle to the inner inclined direction in a physical and mechanical manner; a mixed solution of a feed-grade sodium selenite solution and a coating material solution is sprayed out from the center of the nozzle and is mixed outside the nozzle; the mixed solution is atomized and is sprayed to a carrier, and is mixed in a mixing machine, so that the coating material is coated on the sodium selenite surface and is embedded on the carrier simultaneously; and the coating, embedding and diluting treatment can be completed through only one step. Compared with the conventional chemical coating method and the like, the production efficiency is improved, the cost is reduced, the difficulty of the diluting treatment is reduced, and the coating effect is good.

The invention provides memantine hydrochloride sustained release micro-pill tablets and a preparation method thereof. The memantine hydrochloride sustained release micro-pill tablets are prepared by directly pressing self-protected multi-layer micro-pills, and a filling agent, a disintegrating agent and other auxiliary tablet materials do not need to be added. The self-protected multi-layer micro-pill is composed of a pill core, a medicine layer, a sustained release layer, a protective layer and a compressible composite auxiliary material layer, can tolerate extrusion of a certain tabletting pressure, and contributes to keeping the integrity of a micro-pill sustained release coating and good sustained release properties of the medicine. The self-protected multi-layer micro-pill also has high compressibility, disintegration and lubricating property and can be directly pressed into tablets, and the prepared memantine hydrochloride sustained release micro-pill tablets have good drug content uniformity.

The invention discloses a slow-release organic fertilizer preparation method, which comprises: S1, uniformly mixing sodium alginate, organic bentonite, PEG600, sodium citrate and deionized water to obtain a mixed solution; S2, under the action of supercritical carbon dioxide, mixing uniformly to form an organic fertilizer emulsion; S3, spraying the organic fertilizer emulsion from a spraying nozzle to obtain microcapsule-coated organic fertilizer particles; S4, placing in an ice bath, adding a biological active agent solution, and mixing by using ultrasonic-assisted mechanical stirring to obtain a slow-release organic fertilizer intermediate; and S5, uniformly mixing cellulose, PEG600, ethanol and deionized water to obtain a coating liquid, and spraying the surface of the slow-release organic fertilizer intermediate particles with the coating liquid to obtain the slow-release organic fertilizer. According to the present invention, the particle size distribution of the organic fertilizer particles and the distribution of the biological active agent are uniform, and the organic fertilizer particles and the biological active agent have significant synergistic sustained-release effectso as to improve the soil quality and improve the crop quality.

The invention provides a biomass charcoal-based fertilizer which comprises the following components in parts by weight: 20-25 parts of urea, 25-31 parts of a phosphate fertilizer, 16-28 parts of a potash fertilizer, 9-11 parts of biomass charcoal, 1-2 parts of fulvic acid, 1-7 parts of organic matters and 1-2 parts of a condiment, wherein the condiment is a mixture of an anti-caking agent, bentonite and a coating agent. Due to adoption of the organic matters and the fulvic acid, sufficient organic nutrients can be provided for crops to grow, and growth and development of plants can be promoted; due to adoption of the fulvic acid, on one hand, a synergetic effect on the urea, the phosphate fertilizer and the potash fertilizer in the biomass charcoal-based fertilizer can be achieved, and theutilization rate of the organic nutrients by the crops can be increased; with the combination of biomass charcoal, the fulvic acid and the organic matters, the fulvic acid and the organic matters canbe slowly released from the biomass charcoal, the fertilizer effect can be prolonged, the organic nutrients can be further enriched, and meanwhile the utilization rates of nutrients can be increased.

The invention discloses sustained-release tea-containing plastic grains and a preparation method thereof. The sustained-release tea-containing plastic grains mainly comprise the following components in part by mass: 10 to 40 parts of tea powder, 50 to 80 parts of adhesive and 5 to 10 parts of foaming agent. Fine and dense pores are formed in the grains formed in the invention, so the tea powder in the grains can function, and the adhesion by the adhesive ensures the sustained-release effect of the active ingredients. As fillers, the sustained-release tea-containing plastic grains can reduce the consumption of tea leaves, have long service life and lower the requirement on the external material of tea health-care products.

The invention belongs to the technical field of a medicine preparation, and discloses an intragastric floating sustained release tablet of a praziquantel composition and a preparation method thereof. The intragastric floating sustained release tablet of the praziquantel composition comprises the following raw materials: 65-85 parts of praziquantel, 50-60 parts of hydroxypropyl-beta-cyclodextrin, 40-60 parts of hydroxypropyl methyl cellulose, and 30-50 parts of xanthan gum. The intragastric floating sustained release tablet of the praziquantel composition provided by the invention is good in sustained release effect, and the blood concentration curve of praziquantel after medicine administration is smoother, the bioavailability of the praziquantel is significantly improved, and popularization and application of the praziquantel are facilitated.

The invention discloses a complete complex fertilizer and a production method thereof. The complete complex fertilizer comprises, in percent by mass, 30-60 parts of potassium dihydrogen phosphate, 30-60 parts of potassium nitrate, 1-5 parts of EDDHA iron,1-5 parts of EDTA zinc-manganese-molybdenum, 1-5 parts of copper amino acid,1-5 parts of liquid complex organic boron, and 1-5 parts of a polyvinyl alcohol solution with the concentration of 1%. The production method for the complete complex fertilizer comprises the following steps: mixing potassium dihydrogen phosphate and potassium nitrate successively with EDDH iron, EDTA zinc-manganese-molybdenum and copper amino acid in a granulator, uniformly mixing, then gradually spraying a mixture of liquid organic boron and polyvinyl alcohol, and performing granulation molding and drying, so as to obtain the complete complex fertilizer. The fertilizer contains macroelements and also contains medium and trace elements subjected to complexing, is high in nutrient utilization rate, diverse in usage manner, wide in usage scope and flexible for trace-element supplement, the ratio of trace elements can be flexibly adjusted according to the soil element lacking status and demands of different crops on trace elements, and the fertilizer is well applicable to soil testing and fertilizer recommendation.

The invention relates to a composite-aperture electrostatic spinning bracket modified with slow-release desferrioxamine microbubbles and a preparation method of the composite-aperture electrostatic spinning bracket. Glycolide and/or lactide are/is adopted as monomers for a polymerization reaction to prepare a polymer, the polymer is taken as a shell material, desferrioxamine is used as a core material, and the slow-release desferrioxamine microbubbles with the core-shell structure are prepared with a rapid emulsification method; a core liquid containing the slow-release desferrioxamine microbubbles and a shell liquid are subjected to coaxial electrostatic spinning, and an electrostatic spinning bracket modified with the slow-release desferrioxamine microbubbles is obtained; the electrostatic spinning bracket is irradiated by laser for reaming, and the composite-aperture electrostatic spinning bracket modified with the slow-release desferrioxamine microbubbles is obtained. The bionic bracket with 10-500 micrometer composite aperture is obtained, good conditions are provided for growth of new bone and blood vessels, furthermore, release of the desferrioxamine is realized, sufficientconcentration can be obtained at an early stage, and a long-term slow-release effect can be kept.

The invention provides a fertilizer synergist and a preparation method thereof. The preparation method comprises the following steps: preparing a porous support through sepiolite powder and cottonseedhull powder; mixing the porous support with tetrasodium iminodisuccinate to obtain a first mixture; then mixing bacillus licheniformis, chaetomium globosum, enterococcus bacillus, hyssutella and humic acid to obtain a second mixture; and finally mixing the first mixture, the second mixture and N-cyclohexylmaleimide, and uniformly pelletizing to obtain the fertilizer synergist. The fertilizer synergist has the effect of synergizing fertilizer.

The invention belongs to the technical field of skin care products, and particularly relates to a slow-release skin-brightening essence composition and a preparation method thereof. The slow-release skin-brightening essence composition is prepared from the following raw materials in percentage by weight: 5-15% of a skin conditioner, 1-10% of an additive and the balance of a solvent. A film-forming agent in the composition can make a penetration enhancer and active ingredients fully play a synergistic role to form a coated penetration structure, continuous penetration can be ensured through combination of various reactants, and the film-forming agent is selected from a trimethylpentanediol/adipic acid copolymer and can ensure the slow release effect of the functional ingredients; and the penetration enhancer used in the composition can enable reactants in the system to form a lipidosome coating structure, and provides a basis for the occurrence of penetration.

The invention relates to the technical field of pesticide fertilizer production, and particularly relates to a slow-release high-tower pesticide fertilizer and a preparation method thereof. Aiming atthe problems existing in the production of the pesticide fertilizer by a high tower method at the present stage, the invention provides the slow-release high-tower pesticide fertilizer, and the slow-release effect is guaranteed through double slow release guarantee of a pesticide and a chemical fertilizer; the activity of the pesticide is ensured by adding carrier powder; and under the action of anitrification inhibitor or a urease inhibitor, the effective utilization rate of the chemical fertilizer is realized, and the growth requirements of crops are met. In addition, the invention also provides a preparation method of the slow-release high-tower pesticide fertilizer. The method is simple and suitable for industrial production.

The present invention relates to a production device and a production method of a double slow release high dispersion medicinal fertilizer; the production device includes a urea solution pipeline, theurea solution pipeline is connected with a granulation system through a third valve, a fourth flow meter, a first inlet and an outlet of a pipeline mixer, the second inlet of the pipeline mixer is connected with a medicinal fertilizer emulsifying device; the medicinal fertilizer emulsifying device includes a pesticide tank which is connected with one side of the top of an emulsifying tank, a solvent tank is connected with the other side of the top of the emulsifying tank, an emulsifying tank motor is arranged at the middle of the top of the emulsifying tank, an emulsifying tank outlet is connected with the inner chamber of a nozzle through a solution pump, the nozzle is arranged on the lower middle part of a fluidized bed reactor, a middle powder inlet of the fluidized bed reactor is connected with a fertilizer carrier tank by a powder pump, a material outlet at the bottom of the fluidized bed reactor is connected with the second inlet of the pipeline mixer, a pesticide can be evenlydistributed inside a fertilizer without direct contact with the fertilizer, the compatibility effect of the pesticide and the fertilizer is overcome, and the purpose of unified double slow release ofthe pesticide and the fertilizer can be achieved.