55results about How to "Guaranteed sustained release effect" patented technology

The invention discloses a sustained-release gel-breaking type fracturing propping agent for fracturing an oilfield. The propping agent sequentially comprises a base material, a medicament carrying layer and a sustained release layer from inside to outside, wherein the medicament carrying layer comprises a gel breaking agent and a filling agent, and the sustained release layer comprises a film forming material and a pore forming agent. The invention further provides a preparation method of the sustained-release gel-breaking type fracturing propping agent. In an actual application, the sustained-release gel-breaking type fracturing propping agent disclosed by the invention can enter the stratum along with fracturing fluid, and the gel breaking agent can be released slowly under the stratum conditions; and as the propping dosage is great, the gel breaking agent is distributed uniformly, and gel breaking can be realized to the greatest extent. Simultaneously, a chemical material coating the gel breaking agent can be stilly firmly coated on matrix particles, thus the problems of breaking, reflux and stratum embedding of the propping agent can be reduced.

A preparing method of a selenium rich slow-release particle matrix fertilizer is disclosed. Waste glass and selenium rich ore are adhered into a whole part so that fertilizer effects are rich, a slow release effect is good, and disadvantages of fertilizers at present, namely single fertilizer effects, easy soil agglomeration and complex compositions, are overcome. The selenium rich slow-release particle matrix fertilizer prepared by the method is good in fertilizer effects, low in raw material cost, rich in sources, simple in preparing process, free of pollution to the environment and beneficial to industrial production.

The invention discloses a formula of a slow-releasing fertilizer coating with a biological-optical difunctional degradable property and a preparation method. The coating material is composed of polyolefin, a biodegradable polymer, a photo-degradation accelerant, an inorganic powder additive, a thermal oxidization accelerant and a crosslinking agent, wherein a solvent is an organic solvent; a preparation method for a coating liquid comprises the steps of: heating a certain amount of solvent to 100-120 DEG C; then successively adding polyolefin, the biodegradable polymer, the photo-degradation accelerant, the thermal oxidization accelerant, the inorganic powder additive and the crosslinking agent in sequence, and continuously stirring the mixture to 140-160 DEG C to form a stable and uniform coating liquid; and coating the coating material to the surface of a fertilizer by using a fluidized bed to form a coating fertilizer, wherein the solvent is recovered. The coating material has a biological and optical difunctional degradable property and prevents secondary pollution brought by the fertilizer coating.

The invention discloses an oil injection containing antibacterial agents / solid polyethylene glycol drug-loading particles. The oil injection is prepared by consisting of the drug-loading particles through antibacterial agents and solid polyethylene glycol and suspending the drug-loading particles in an oil medium. The antibacterial agents comprise enrofloxacin, danofloxacin mesylate, Marbofloxacin, mequindox, tilmicosin, tylosin, oxytetracycline hydrochloride, ceftiofur hydrochloride, cefquinome sulfate, lincomycin hydrochloride, florfenicol, erythrocin and doxycycline hydrochloride; preferentially the polyethylene glycol with the molecular weight of more than 6000 is used for preparing the preparation; more preferentially, any one of isopropyl myristate, soybean oil for injection, corn oil and tea-seed oil is used for preparing the preparation. Hydroxypropyl methyl cellulose or high-substituted hydroxy propyl cellulose can be added into the preparation.

The invention discloses a biological preparation capable of preventing and treating human gastric diseases, i.e., an anti-Helicobacter pylori specific yolk immunoglobulin (anti-HP-IgY) preparation, and especially to a novel dosage form thereof, i.e., a floating tablet in stomach, and the invention belongs to the technical field of biomedicines. The anti-HP-IgY gastric floating tablet uses yolk immunoglobulin specifically resisting Helicobacter pylori (i.e., anti-HP-IgY) as an active component and hydrophobic pharmaceutic adjuvants and hydrophilic pharmaceutic adjuvants as auxiliary components. The gastric floating tablet enables retention time of the active component (anti-HP-IgY) in stomach to be prolonged, which is very helpful for anti-HP-IgY in killing of Helicobacter pylori Hp intermittently floating upward from pylorus; the anti-HP-IgY gastric floating tablet has the advantages of strong specificity, no drug resistance, no toxic and side effects and good thermal stability, acid resistance and antiprotease performance. Raw materials for preparing the tablet are easily available, and a manufacturing method for the table is simple and is convenient for popularization and utilization.

The invention relates to a method for preparing a feed-grade sodium selenite coated diluting agent, and belongs to the field of a feed additive. The method comprises the steps of weighing raw materials, dissolving, mixing, heating and stirring, completing coating, embedding and diluting treatment through one step, drying and the like. The technical scheme provided by the invention aims at the defects in the prior art; compressed air is sprayed out from the both sides of a nozzle to the inner inclined direction in a physical and mechanical manner; a mixed solution of a feed-grade sodium selenite solution and a coating material solution is sprayed out from the center of the nozzle and is mixed outside the nozzle; the mixed solution is atomized and is sprayed to a carrier, and is mixed in a mixing machine, so that the coating material is coated on the sodium selenite surface and is embedded on the carrier simultaneously; and the coating, embedding and diluting treatment can be completed through only one step. Compared with the conventional chemical coating method and the like, the production efficiency is improved, the cost is reduced, the difficulty of the diluting treatment is reduced, and the coating effect is good.

The invention provides memantine hydrochloride sustained release micro-pill tablets and a preparation method thereof. The memantine hydrochloride sustained release micro-pill tablets are prepared by directly pressing self-protected multi-layer micro-pills, and a filling agent, a disintegrating agent and other auxiliary tablet materials do not need to be added. The self-protected multi-layer micro-pill is composed of a pill core, a medicine layer, a sustained release layer, a protective layer and a compressible composite auxiliary material layer, can tolerate extrusion of a certain tabletting pressure, and contributes to keeping the integrity of a micro-pill sustained release coating and good sustained release properties of the medicine. The self-protected multi-layer micro-pill also has high compressibility, disintegration and lubricating property and can be directly pressed into tablets, and the prepared memantine hydrochloride sustained release micro-pill tablets have good drug content uniformity.

The invention belongs to the technical field of medicine preparation, and discloses a preparation method of a ziconotide injection hypodermic implant as well as the ziconotide injection hypodermic implant prepared by the method. The implant prepared by the method is dissolved by sterile water for injection before use and is then injected to human subcutaneous tissues. The implant prepared by the method is a novel sustained-release preparation which can be subcutaneously injected in form of a liquid. Under the effect of body temperature, the liquor becomes a gel which is slowly released in vivo, so that a long-acting effect of treating and relieving pains is realized.

The invention discloses a slow-release organic fertilizer preparation method, which comprises: S1, uniformly mixing sodium alginate, organic bentonite, PEG600, sodium citrate and deionized water to obtain a mixed solution; S2, under the action of supercritical carbon dioxide, mixing uniformly to form an organic fertilizer emulsion; S3, spraying the organic fertilizer emulsion from a spraying nozzle to obtain microcapsule-coated organic fertilizer particles; S4, placing in an ice bath, adding a biological active agent solution, and mixing by using ultrasonic-assisted mechanical stirring to obtain a slow-release organic fertilizer intermediate; and S5, uniformly mixing cellulose, PEG600, ethanol and deionized water to obtain a coating liquid, and spraying the surface of the slow-release organic fertilizer intermediate particles with the coating liquid to obtain the slow-release organic fertilizer. According to the present invention, the particle size distribution of the organic fertilizer particles and the distribution of the biological active agent are uniform, and the organic fertilizer particles and the biological active agent have significant synergistic sustained-release effectso as to improve the soil quality and improve the crop quality.

The invention provides a biomass charcoal-based fertilizer which comprises the following components in parts by weight: 20-25 parts of urea, 25-31 parts of a phosphate fertilizer, 16-28 parts of a potash fertilizer, 9-11 parts of biomass charcoal, 1-2 parts of fulvic acid, 1-7 parts of organic matters and 1-2 parts of a condiment, wherein the condiment is a mixture of an anti-caking agent, bentonite and a coating agent. Due to adoption of the organic matters and the fulvic acid, sufficient organic nutrients can be provided for crops to grow, and growth and development of plants can be promoted; due to adoption of the fulvic acid, on one hand, a synergetic effect on the urea, the phosphate fertilizer and the potash fertilizer in the biomass charcoal-based fertilizer can be achieved, and theutilization rate of the organic nutrients by the crops can be increased; with the combination of biomass charcoal, the fulvic acid and the organic matters, the fulvic acid and the organic matters canbe slowly released from the biomass charcoal, the fertilizer effect can be prolonged, the organic nutrients can be further enriched, and meanwhile the utilization rates of nutrients can be increased.

The invention discloses sustained-release tea-containing plastic grains and a preparation method thereof. The sustained-release tea-containing plastic grains mainly comprise the following components in part by mass: 10 to 40 parts of tea powder, 50 to 80 parts of adhesive and 5 to 10 parts of foaming agent. Fine and dense pores are formed in the grains formed in the invention, so the tea powder in the grains can function, and the adhesion by the adhesive ensures the sustained-release effect of the active ingredients. As fillers, the sustained-release tea-containing plastic grains can reduce the consumption of tea leaves, have long service life and lower the requirement on the external material of tea health-care products.

The invention belongs to the technical field of a medicine preparation, and discloses an intragastric floating sustained release tablet of a praziquantel composition and a preparation method thereof. The intragastric floating sustained release tablet of the praziquantel composition comprises the following raw materials: 65-85 parts of praziquantel, 50-60 parts of hydroxypropyl-beta-cyclodextrin, 40-60 parts of hydroxypropyl methyl cellulose, and 30-50 parts of xanthan gum. The intragastric floating sustained release tablet of the praziquantel composition provided by the invention is good in sustained release effect, and the blood concentration curve of praziquantel after medicine administration is smoother, the bioavailability of the praziquantel is significantly improved, and popularization and application of the praziquantel are facilitated.

The invention discloses a complete complex fertilizer and a production method thereof. The complete complex fertilizer comprises, in percent by mass, 30-60 parts of potassium dihydrogen phosphate, 30-60 parts of potassium nitrate, 1-5 parts of EDDHA iron,1-5 parts of EDTA zinc-manganese-molybdenum, 1-5 parts of copper amino acid,1-5 parts of liquid complex organic boron, and 1-5 parts of a polyvinyl alcohol solution with the concentration of 1%. The production method for the complete complex fertilizer comprises the following steps: mixing potassium dihydrogen phosphate and potassium nitrate successively with EDDH iron, EDTA zinc-manganese-molybdenum and copper amino acid in a granulator, uniformly mixing, then gradually spraying a mixture of liquid organic boron and polyvinyl alcohol, and performing granulation molding and drying, so as to obtain the complete complex fertilizer. The fertilizer contains macroelements and also contains medium and trace elements subjected to complexing, is high in nutrient utilization rate, diverse in usage manner, wide in usage scope and flexible for trace-element supplement, the ratio of trace elements can be flexibly adjusted according to the soil element lacking status and demands of different crops on trace elements, and the fertilizer is well applicable to soil testing and fertilizer recommendation.

The invention relates to a multifunctional fabric containing mosquito-repellent microcapsules and a preparation method thereof. The preparation method comprises the following steps: 1) preparation ofan essential oil emulsion: taking mosquito-repellent aromatic essential oil, adding the mosquito-repellent aromatic essential oil into an aqueous solution of polyethylene glycol, adding a surfactant,and carrying out high-speed stirring and emulsification so as to obtain the mosquito-repellent aromatic essential oil emulsion; 2) preparation of microcapsules: separately weighing gelatin and Arabicgum, adding the weighed gelatin and Arabic gum into distilled water, carrying out stirring until the gelatin and Arabic gum are completely dissolved so as to prepare a gelatin and Arabic gum solution,adding the essential oil emulsion, then carrying out stirring with a homogenizer, and carrying out emulsification, re-coagulation and curing; and 3) finishing of the fabric: taking the prepared microcapsule emulsion, adding an adhesive, water and a penetrant, carrying out uniform stirring and dispersion, padding the emulsion onto the fabric by using a padding method, and carrying out baking and drying so as to obtain the aromatic mosquito-repellent fabric. The fabric has good persistent mosquito-repellent and aromatic functions.

The invention belongs to the field of nano material preparation and biological medical application and particularly relates to a nuclear magnetic imaging and photodynamic / chemotherapy degradable silicon-based nano diagnosis agent and a preparation method thereof. The nano diagnosis agent disclosed by the invention is a SiO2-TA-Mn<+>-medicine-PEI compound nano particle; under a low pH and high GSHenvironment stimulation, a TA-Mn<+> structure in the compound nano particle can perform protonation and reduction reaction, a net structure is deconstructed, and medicine and metal ions for nuclear magnetic imaging are released out. Therefore, the nuclear magnetic imaging and photodynamic / chemotherapy degradable silicon-based nano particle nano diagnosis agent disclosed by the invention has the characteristics that the SiO2-TA-Mn<+>-medicine-PEI compound nano particle nano diagnosis agent has tumor position degradation response, magnetic resonance imaging, medicine response control release andthe like, and photodynamic therapy and chemotherapy combined synergistic oncotherapy under nuclear magnetic resonance imaging guidance is achieved.

The present invention belongs to the field of fruit fertilizers, and specifically discloses a compound enzyme carbon aerogel kiwifruit efficient fertilizer, which is characterized by comprising by weight: konjac glucomannan, lignin, sodium polyacrylate, sorbitol, stevioside, polysaccharidase, lactobacillin, bacillus subtilis, nanometer silicon, seaweed gel, winery waste, waste coffee residue, waste mushroom culture materials, MSG residue, brown sugar residue, zinc-rich yeast, compound amino acid, potassium dihydrogen phosphate, succinic acid, iron citrate, high-gluten sticky flour, bamboo charcoal powder, and the like. According to the present invention, the winery waste, the waste coffee residue, the waste mushroom culture materials, the MSG residue, the brown sugar residue and the like are used and are fermented with the zinc-rich yeast so as to be adopted as the main material to prepare the kiwifruit fertilizer, such that the obtained fertilizer is rich in organic matters conveniently absorbed and used, and is rich in nutrition; and the stable compound enzyme carbon aerogel is added, such that the reaction is produced along with the utilization of the fertilizer so as to enrich the nutrients, enrich the taste of the kiwifruit, and co-promote the cultivation of the kiwifruit.

The invention relates to a composite-aperture electrostatic spinning bracket modified with slow-release desferrioxamine microbubbles and a preparation method of the composite-aperture electrostatic spinning bracket. Glycolide and / or lactide are / is adopted as monomers for a polymerization reaction to prepare a polymer, the polymer is taken as a shell material, desferrioxamine is used as a core material, and the slow-release desferrioxamine microbubbles with the core-shell structure are prepared with a rapid emulsification method; a core liquid containing the slow-release desferrioxamine microbubbles and a shell liquid are subjected to coaxial electrostatic spinning, and an electrostatic spinning bracket modified with the slow-release desferrioxamine microbubbles is obtained; the electrostatic spinning bracket is irradiated by laser for reaming, and the composite-aperture electrostatic spinning bracket modified with the slow-release desferrioxamine microbubbles is obtained. The bionic bracket with 10-500 micrometer composite aperture is obtained, good conditions are provided for growth of new bone and blood vessels, furthermore, release of the desferrioxamine is realized, sufficientconcentration can be obtained at an early stage, and a long-term slow-release effect can be kept.

The invention provides a fertilizer synergist and a preparation method thereof. The preparation method comprises the following steps: preparing a porous support through sepiolite powder and cottonseedhull powder; mixing the porous support with tetrasodium iminodisuccinate to obtain a first mixture; then mixing bacillus licheniformis, chaetomium globosum, enterococcus bacillus, hyssutella and humic acid to obtain a second mixture; and finally mixing the first mixture, the second mixture and N-cyclohexylmaleimide, and uniformly pelletizing to obtain the fertilizer synergist. The fertilizer synergist has the effect of synergizing fertilizer.

The invention provides potassium humate urea and a preparation method thereof and relates to the technical field of chemical fertilizers. The method for preparing the potassium humate urea comprises the following steps: dividing 1.6-2 parts by weight of a potassium humate raw material into the first potassium humate and the second potassium humate, wherein the potassium humate raw material refers to liquid potassium humate with the humic acid mass content of more than or equal to 8.2%; mixing the first potassium humate with black soil, and performing first granulation so as to obtain intermediate fertilizer granules; mixing the intermediate fertilizer granules, the second potassium humate and 90-100 parts by weight of urea raw materials, evaporating, performing second granulation, thereby obtaining the product. The intermediate fertilizer granules are taken as a urea carrier, so that each of the prepared potassium humate urea granules is coated with the intermediate fertilizer granule prepared from potassium humate. The granulating effect of the potassium humate urea can be improved, and a sustained release effect of the potassium humate on urea can be guaranteed, so that an excellent synergistic effect is achieved between the potassium humate and urea.

The invention relates to the technical field of groundwater remediation, particularly to a slow-release oxidizing agent for removing underground water polluted organic matters, and a process thereof.The slow-release oxidizing agent is prepared from 40 to 60 parts of polyacrylamide, 10 to 15 parts of carboxymethyl cellulose sodium, 0.5 to 1.5 parts of polyvinylpyrrolidone, 1.5 to 3.5 parts of cyclodextrin, 1 to 5 parts of polybutylene succinate, 10 to 15 parts of montmorillonite, 5 to 15 parts of stearic acid, 5 to 15 parts of sodium persulfate and 5 to 15 parts of potassium permanganate. According to the invention, by mixing oxidants sodium persulfate and potassium permanganate, an adsorbent, a slow release agent and a polymer skeleton, the stability and slow release property of the oxidant in the underground aquifer are improved, so that the oxidation efficiency is improved, and the underground water remediation effect is improved; and by mixing acrylamide, carboxymethyl cellulose sodium, polyvinylpyrrolidone, cyclodextrin and stearic acid as a slow-release agent, the slow-release effect of the oxidizing agent is guaranteed, and the compatibility of the slow-release agent and theoxidizing agent can be effectively guaranteed so as to reduce the irrelevant consumption of the oxidizing agent.

The invention belongs to the field of organic fertilizers and preparation thereof. The organic slow-release fertilizer for corn cultivation comprises the following components: 15-20% of livestock andpoultry manure, 0.8-1.5% of tea residue, 8-15% of fruit peel residue, 1.8-4.5% of plant ash, 3-5% of waste bacteria stick, 10-12% of corn straw mixture, 8-10% of vinegar residue or cassava residue, 1-2% of enzyme microorganism, 1.5-3% of peanut shell, 0.5-1.5% of shell, 3-4% of rice bran, 11-15% of humus, 8-10% of cottonseed meal and the balance sludge. The slow-release fertilizer prepared throughfermentation can meet nutrient elements needed by plants, meanwhile, the fertilization frequency is reduced, the fertility is improved, waste utilization, recycling and harmless treatment can be achieved, and the yield and quality of corn crops can be remarkably improved.

The invention belongs to the technical field of medicine preparation, and discloses a preparation method of a ziconotide injection hypodermic implant as well as the ziconotide injection hypodermic implant prepared by the method. The implant prepared by the method is dissolved by sterile water for injection before use and is then injected to human subcutaneous tissues. The implant prepared by the method is a novel sustained-release preparation which can be subcutaneously injected in form of a liquid. Under the effect of body temperature, the liquor becomes a gel which is slowly released in vivo, so that a long-acting effect of treating and relieving pains is realized.

The invention belongs to the technical field of skin care products, and particularly relates to a slow-release skin-brightening essence composition and a preparation method thereof. The slow-release skin-brightening essence composition is prepared from the following raw materials in percentage by weight: 5-15% of a skin conditioner, 1-10% of an additive and the balance of a solvent. A film-forming agent in the composition can make a penetration enhancer and active ingredients fully play a synergistic role to form a coated penetration structure, continuous penetration can be ensured through combination of various reactants, and the film-forming agent is selected from a trimethylpentanediol / adipic acid copolymer and can ensure the slow release effect of the functional ingredients; and the penetration enhancer used in the composition can enable reactants in the system to form a lipidosome coating structure, and provides a basis for the occurrence of penetration.

The present invention relates to a preparation method of a medical adhesive with high antibacterial performance, which is characterized in that it comprises the following steps: step 1, adding sodium alginate, lignin, tannic acid, and a stabilizer Bacterial water, heated to 100°C, stirred and dissolved for 150min, cooled to room temperature to obtain aqueous solution A; step 2, poly(α-isobutyl cyanoacrylate-α-octyl cyanoacrylate), polyurethane, polyisoprene According to the ratio of parts, add alkenes to seabuckthorn seed oil, heat to 80°C and stir for 75min, cool to room temperature to obtain seabuckthorn seed oil solution B; step 3, mix the above aqueous solution A and seabuckthorn seed oil solution B evenly, and Add high-efficiency antibacterial components and formaldehyde inhibitors, and stir for 4 hours; Step 4, filter and sterilize the product obtained in Step 3, subpackage, seal, and package to obtain a medical adhesive with high antibacterial performance.

The invention provides memantine hydrochloride sustained release micro-pill tablets and a preparation method thereof. The memantine hydrochloride sustained release micro-pill tablets are prepared by directly pressing self-protected multi-layer micro-pills, and a filling agent, a disintegrating agent and other auxiliary tablet materials do not need to be added. The self-protected multi-layer micro-pill is composed of a pill core, a medicine layer, a sustained release layer, a protective layer and a compressible composite auxiliary material layer, can tolerate extrusion of a certain tabletting pressure, and contributes to keeping the integrity of a micro-pill sustained release coating and good sustained release properties of the medicine. The self-protected multi-layer micro-pill also has high compressibility, disintegration and lubricating property and can be directly pressed into tablets, and the prepared memantine hydrochloride sustained release micro-pill tablets have good drug content uniformity.

The invention relates to the technical field of pesticide fertilizer production, and particularly relates to a slow-release high-tower pesticide fertilizer and a preparation method thereof. Aiming atthe problems existing in the production of the pesticide fertilizer by a high tower method at the present stage, the invention provides the slow-release high-tower pesticide fertilizer, and the slow-release effect is guaranteed through double slow release guarantee of a pesticide and a chemical fertilizer; the activity of the pesticide is ensured by adding carrier powder; and under the action of anitrification inhibitor or a urease inhibitor, the effective utilization rate of the chemical fertilizer is realized, and the growth requirements of crops are met. In addition, the invention also provides a preparation method of the slow-release high-tower pesticide fertilizer. The method is simple and suitable for industrial production.

The present invention relates to a production device and a production method of a double slow release high dispersion medicinal fertilizer; the production device includes a urea solution pipeline, theurea solution pipeline is connected with a granulation system through a third valve, a fourth flow meter, a first inlet and an outlet of a pipeline mixer, the second inlet of the pipeline mixer is connected with a medicinal fertilizer emulsifying device; the medicinal fertilizer emulsifying device includes a pesticide tank which is connected with one side of the top of an emulsifying tank, a solvent tank is connected with the other side of the top of the emulsifying tank, an emulsifying tank motor is arranged at the middle of the top of the emulsifying tank, an emulsifying tank outlet is connected with the inner chamber of a nozzle through a solution pump, the nozzle is arranged on the lower middle part of a fluidized bed reactor, a middle powder inlet of the fluidized bed reactor is connected with a fertilizer carrier tank by a powder pump, a material outlet at the bottom of the fluidized bed reactor is connected with the second inlet of the pipeline mixer, a pesticide can be evenlydistributed inside a fertilizer without direct contact with the fertilizer, the compatibility effect of the pesticide and the fertilizer is overcome, and the purpose of unified double slow release ofthe pesticide and the fertilizer can be achieved.

The invention relates to a selenium-containing coating agent for a sustained release fertilizer special for selenium-rich agricultural products and a preparation method for the selenium-containing coating agent. The selenium-containing coating agent contains the following components: cellulose, polyvinyl alcohol, acrylic resin, epoxy resin, a crosslinking agent, an emulsifying agent, an initiator, selenite and deionized water. The invention also provides a method for preparing the selenium-containing coating agent. Selenium is dispersed in a coating agent, and the selenium is slowly released;and the prepared sustained release fertilizer can meet the requirements of the selenium-rich agricultural products in all growth periods through one-time application, solves that problems that a selenium-enriching agent is required to be sprayed on leaf surfaces for multiple times to cause high labor consumption and human poisoning is caused by improper spraying, and also overcomes a defect that the utilization rate of a selenium-enriching fertilizer through soil application is low. The sustained release fertilizer prepared from the coating agent has effects of improving fertilizer utilization rate, increasing crop yield and reducing environmental pollution.