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Nuclear magnetic imaging and photodynamic/chemotherapy degradable silicon-based nano diagnosis agent and preparation method thereof

A photodynamic and imaging technology, used in photodynamic therapy, preparations for in vivo experiments, medical preparations with inactive ingredients, etc., can solve the problems of inability to degrade, dose accumulation, protein denaturation, etc., and achieve a simple and green synthesis process. , Guarantee the effect of slow release ability and easy availability of raw materials

Inactive Publication Date: 2018-04-20
FUZHOU UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the compact structure of silica, silica particles have fairly good thermal stability and cannot be degraded in physiological environments. After entering the body, they are cleared for more than 3 months, which easily causes Accumulation of medium doses can cause DNA damage, protein denaturation, etc. and lead to a series of adverse results. Long-term use will cause serious side effects

Method used

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  • Nuclear magnetic imaging and photodynamic/chemotherapy degradable silicon-based nano diagnosis agent and preparation method thereof
  • Nuclear magnetic imaging and photodynamic/chemotherapy degradable silicon-based nano diagnosis agent and preparation method thereof
  • Nuclear magnetic imaging and photodynamic/chemotherapy degradable silicon-based nano diagnosis agent and preparation method thereof

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Embodiment 1

[0047] A method for preparing a degradable nano-diagnostic agent guided by nuclear magnetic resonance imaging, the specific steps are:

[0048] (1) SiO 2 -TA-Mn-Ce6

[0049] Add 380 μL TEOS and 12 mg TA to ethanol-water solution with a volume ratio of 60:1, stir for 10 min to mix well; add 10 mg chlorin (Ce6) in the dark, stir for 10 min to mix evenly , add 0.5 mL of ammonia water dropwise, react at 25°C for 0.5 h; add 0.28 mg of MnCl to the reaction solution 2 4H 2 O (the molar ratio is TA:Mn=5:1), continue to react in a water bath at 25°C for 5.5 h, and the entire reaction should be completed in the dark; after the reaction is completed, centrifuge, wash the precipitate twice with absolute ethanol, and obtain SiO 2 - TA-Mn-Ce6 nanoparticles;

[0050] (2) SiO 2 -TA-Mn-Ce6-PEI

[0051] Take 1 mL of the nanoparticle solution prepared in step (a), add 200 μL (1 mg / mL) of PEI aqueous solution, and stir at room temperature in the dark for 24 h. After the reaction is complet...

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Abstract

The invention belongs to the field of nano material preparation and biological medical application and particularly relates to a nuclear magnetic imaging and photodynamic / chemotherapy degradable silicon-based nano diagnosis agent and a preparation method thereof. The nano diagnosis agent disclosed by the invention is a SiO2-TA-Mn<+>-medicine-PEI compound nano particle; under a low pH and high GSHenvironment stimulation, a TA-Mn<+> structure in the compound nano particle can perform protonation and reduction reaction, a net structure is deconstructed, and medicine and metal ions for nuclear magnetic imaging are released out. Therefore, the nuclear magnetic imaging and photodynamic / chemotherapy degradable silicon-based nano particle nano diagnosis agent disclosed by the invention has the characteristics that the SiO2-TA-Mn<+>-medicine-PEI compound nano particle nano diagnosis agent has tumor position degradation response, magnetic resonance imaging, medicine response control release andthe like, and photodynamic therapy and chemotherapy combined synergistic oncotherapy under nuclear magnetic resonance imaging guidance is achieved.

Description

technical field [0001] The invention belongs to the fields of nanomaterial preparation and biomedical application, and in particular relates to a degradable silicon-based nanometer diagnostic and therapeutic agent for nuclear magnetic imaging and photodynamic / chemotherapy and a preparation method thereof. Background technique [0002] Cancer is one of the major diseases that currently affect and endanger human health. In recent years, the treatment of cancer is still early detection and early treatment, and the possibility of cure is higher. If cancer can be diagnosed and treated in an early stage, the mortality rate of cancer will be greatly reduced. Therefore, it is of great scientific significance to develop and study high performance, good biocompatibility and diagnostic, monitoring, therapeutic and other therapeutic agents. [0003] There are many materials that can be used for diagnostic and therapeutic agents. Nano-silica is widely studied as a functional carrier fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/18A61K49/10A61K47/58A61K47/54A61P35/00A61P29/00
CPCA61K41/0057A61K49/105A61K49/1854
Inventor 朱春玲郑少秋谢增鸿林旭聪
Owner FUZHOU UNIV
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