Preparation process of compound Jinfeng liniment

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a preparation process of a compound Jinfeng liniment, which comprises the following steps: weighing the weight of each component in the formula of the compound Jinfeng liniment; pretreating and extracting the kaempferia galanga, the ligusticum wallichii and the safflower carthamus; the preparation method comprises the following steps: mixing menthol, peppermint oil, azone and butanediol, adding part of ethanol, stirring and dissolving, and adding polysorbate and poloxamer to form a uniform solution; adding glycerol into the mixed extract of the caesalpinia kaempferi extract, the ligusticum wallichii and the safflower to form colloid, adding the uniform solution, dropwise adding the remaining ethanol, further adding pre-dissolved asiaticoside, allantoin and a hydroxypropyl methyl cellulose aqueous solution, adding methylparaben, propyl hydroxybenzoate and an edetate disodium aqueous solution, uniformly stirring, and cooling to room temperature. And fixing the volume by using purified water to obtain the compound Jinfeng liniment, and finally filtering and packaging the compound Jinfeng liniment. According to the invention, the extraction efficiency of effective components can be improved, the transdermal absorption effect is enhanced, the stability and safety of the preparation are optimized, and the clinical treatment effect is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation process of a compound Jinfeng liniment. Background Art

[0002] In the field of external preparations of traditional Chinese medicine, blood-activating and analgesic liniments are widely used in clinical practice and daily life due to their convenience and significant efficacy. However, the preparation process and formulation of traditional compound liniments have many limitations, which restrict their further development and application. Existing processes mostly use a single extraction method, such as traditional water decoction or ethanol reflux extraction, which makes it difficult to take into account the extraction requirements of different types of active ingredients in medicinal materials. Some heat-sensitive components are prone to degradation during high-temperature extraction or concentration, resulting in loss of efficacy; while fat-soluble components may not be fully dissolved due to incompatibility of solvent polarity, resulting in waste of medicinal material resources and reducing the overall efficacy of the preparation. At the same time, the transdermal absorption efficiency of liniments is insufficient. Due to the natural barrier effect of the skin's stratum corneum, the active ingredients are difficult to quickly penetrate into the lesion site, affecting the performance of the active ingredients of the drug and delaying the treatment effect. In terms of formulation stability, the excipient system design in traditional formulations is relatively simple, focusing primarily on ingredient dissolution and preservative functions, while insufficiently considering the interactions between ingredients and the long-term storage stability of the formulation. This can lead to product delamination and precipitation during storage, affecting both appearance and effectiveness. Furthermore, existing formulations pay little attention to skin irritation. Ingredients such as high concentrations of ethanol may cause skin allergies or discomfort, limiting their applicability and making it difficult to meet diverse clinical treatment needs. Summary of the Invention

[0003] The present invention provides a preparation process of a compound Jinfeng liniment, which can improve the extraction efficiency of effective ingredients, enhance the transdermal absorption effect, optimize the stability and safety of the preparation, and improve the clinical treatment effect.

[0004] The present invention provides a preparation process of a compound Jinfeng liniment, comprising: S1. Accurately weigh the weight of each ingredient in the formula of the compound Jinfeng liniment; wherein the ingredients include goldenrod flower, Chuanxiong rhizome, safflower, menthol, peppermint oil, ethanol, glycerin, butylene glycol, polysorbate, poloxamer, azone, asiaticoside, allantoin, hydroxypropyl methylcellulose, methylparaben, propylparaben, disodium edetate, and purified water; S2. Pre-treating and extracting the medicinal materials of Buttercup Flos, Chuanxiong Rhizome, and Carthamus tinctorius to prepare Buttercup Flos extract, Chuanxiong Rhizome extract, and Carthamus tinctorius extract; S3, menthol, peppermint oil, azone, and butanediol are mixed in a set ratio, and a portion of ethanol preheated to 40° C. is added, and after stirring to dissolve, the polysorbate and poloxamer are added, and stirring is continued until they are completely dissolved to form a uniform solution; S4. Place the mixed extract of Buttercup Flower Extract, Chuanxiong Rhizome, and Carthamus tinctorius in a vacuum emulsifier, add glycerin, and stir at 55° C. to form a uniform colloid; S5. While stirring, slowly add the homogeneous solution from step S3 into the vacuum emulsifying pot, while adding the remaining ethanol dropwise, and continue stirring for 40 minutes; S6. Add pre-dissolved asiaticoside, allantoin, and hydroxypropyl methylcellulose aqueous solution to the vacuum emulsifying pot, stir evenly, then add methylparaben, propylparaben, and disodium edetate aqueous solution, stir evenly, dilute to 1000 g with purified water, and adjust the pH to 5.6±0.1 with 0.05 M phosphoric acid to obtain the compound Jinfeng liniment; S7. Performing three-stage filtration on the compound Jinfeng liniment, and sterilizing and packaging the filtered compound Jinfeng liniment.

[0005] Furthermore, in step S1, the volume fraction of the ethanol is 85%, the butanediol is 1,3-butanediol, the model of the polysorbate is polysorbate 80, and the poloxamer is poloxamer 188.

[0006] Furthermore, the step S2 specifically includes: S201, preparing a Buttercup Flower extract: grinding dried Buttercup Flower medicinal materials into a 12-mesh coarse powder, extracting with supercritical CO2 at an extraction pressure of 25 MPa, a temperature of 40° C., a CO2 flow rate of 15 L / h, and an extraction time of 120 minutes to extract volatile oil and flavonoid components; subjecting the residue after extraction to ultrasonic-assisted ethanol extraction, adding 8 times the amount of 65% ethanol, and extracting twice at 55° C. and 400 W ultrasonic conditions for 30 minutes each time, combining the extract and the extract solution, and concentrating under reduced pressure to a relative density of 1.25 to obtain a Buttercup Flower extract; S202. Preparation of a mixed extract of Chuanxiong and Carthamus tinctorius: Grind the Chuanxiong and Carthamus tinctorius medicinal materials into 30-mesh coarse powder, perform ultrasonic-microwave-assisted extraction, add 7 times the amount of 55% ethanol, use ultrasonic power of 350 W, microwave power of 500 W, and extract at 60°C for 30 minutes; combine the extracts, concentrate under reduced pressure to a relative density of 1.25, add 95% ethanol to make the alcohol content reach 70%, let it stand for 72 hours, filter to remove the precipitate, and obtain a mixed extract of Chuanxiong and Carthamus tinctorius.

[0007] Furthermore, in step S3, the mixing ratio of menthol, peppermint oil, azone and butanediol is 5:4:3:40.

[0008] Furthermore, in step S7, the three-stage filtration specifically includes: S701, coarse filtration: using a 180-mesh stainless steel mesh to filter the compound Jinfeng liniment liquid obtained in step S6 while hot, with the filtration temperature maintained at 50° C.; S702, fine filtration: filtering the compound Jinfeng liniment liquid after coarse filtration through a 0.3 μm polyethersulfone membrane under reduced pressure; S703, sterilization filtration: the compound Jinfeng liniment liquid after fine filtration is filtered using a 0.22 μm polyvinylidene fluoride membrane under a sterile environment.

[0009] Furthermore, in step S7, sterilization and packaging specifically include: The compound Jinfeng liniment liquid after the three-stage filtration was passed into the sterilization equipment using low-temperature plasma sterilization and sterilized for 18 minutes at a temperature of 35°C, a pressure of 60Pa, and a power of 180W. The liquid was then immediately filled into a sterilized brown high-density polyethylene spray bottle, filled with nitrogen, and sealed.

[0010] The present invention also provides a compound Jinfeng liniment, based on the preparation process of the compound Jinfeng liniment as described above, the compound Jinfeng liniment comprises the following components: Buttercup Flower Extract 15% Mixed extract of Chuanxiong and Carthamus tinctorius 12% Menthol 1% Peppermint oil 0.8% Ethanol 35% Glycerin 12% Butanediol 8% Polysorbate 2.5% Poloxamer 0.5% Azone 0.6% Centella asiatica 0.2% Allantoin 0.3% Hydroxypropyl methylcellulose 0.3% Methylparaben 0.08% Propylparaben 0.02% Edetate disodium 0.05% Purified water balance The above percentages are by weight, and the total weight percentage of the above components constitutes 100% of the compound Jinfeng liniment.

[0011] The beneficial effects of the present invention are: The Chinese medicinal material extraction process of the present invention adopts ultrasound-microwave assisted combined technology, combined with a precisely adapted solvent system, which significantly improves the extraction efficiency of the effective ingredients in medicinal materials such as Golden Phoenix Flower, Chuanxiong, and Carthamus tinctorius, and avoids the degradation of heat-sensitive components; the formula introduces menthol, peppermint oil, azone, and butylene glycol as multi-component transdermal enhancers for synergistic effect, and uses polysorbate and hydroxypropyl methylcellulose as composite solubilizers and sustained-release materials to enhance the drug's transdermal penetration ability, achieve the advantages of rapid onset and long-term drug release, significantly improve the dissolution stability of the preparation, and effectively prevent stratification and precipitation during storage. In addition, by adding asiaticoside in combination with ethanol and 1,3-butylene glycol, skin irritation is significantly reduced, and the range of applicable populations is broadened; the effectiveness, safety, and stability of the compound Golden Phoenix liniment are comprehensively improved, and the clinical treatment effect is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 The figure is a schematic flow chart of the preparation process of the compound Jinfeng liniment of the present invention.

[0013] The purpose, features and advantages of the present invention will be further described with reference to the accompanying drawings and in conjunction with the embodiments. DETAILED DESCRIPTION

[0014] It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0015] like Figure 1 As shown, the present invention provides a preparation process of compound Jinfeng liniment, comprising: S1. Accurately weigh the weight of each ingredient in the formula of the compound Jinfeng liniment; wherein the ingredients include goldenrod flower, Chuanxiong rhizome, safflower, menthol, peppermint oil, ethanol, glycerin, butylene glycol, polysorbate, poloxamer, azone, asiaticoside, allantoin, hydroxypropyl methylcellulose, methylparaben, propylparaben, disodium edetate, and purified water.

[0016] In parts by weight, the above ingredients include 15% buttercup flower extract, 12% mixed extract of Chuanxiong and safflower, 1% menthol, 0.8% peppermint oil, 35% ethanol, 12% glycerin, 8% butylene glycol, 2.5% polysorbate, 0.5% poloxamer, 0.6% azone, 0.2% asiaticoside, 0.3% allantoin, 0.3% hydroxypropyl methylcellulose, 0.08% methylparaben, 0.02% propylparaben, 0.05% disodium edetate, and the rest is purified water.

[0017] The volume fraction of ethanol is 85%, representing the concentration of ethanol in the solution. That is, for every 100 volumes of solution, 85 volumes are pure ethanol, with the remaining 15 volumes being water (or other solvent). In the compound Jinfeng liniment, 85% ethanol can dissolve fat-soluble components such as menthol and azone, while also forming a co-solvent system with water, aiding in the extraction of polar components (such as flavonoids and glycosides) from traditional Chinese medicine. When preparing the liniment, 85% ethanol needs to be preheated to 40°C (as in step S3) to enhance its solubility for low-melting-point components such as azone and prevent solute precipitation due to low temperatures.

[0018] The polysorbate model is polysorbate-80. 80 is a specific number within the polysorbate series, used to distinguish products with different structures and properties. Polysorbates are nonionic surfactants made by reacting sorbitol and its dehydration products with varying amounts of ethylene oxide. Polysorbate-80 is characterized by its strong hydrophilicity, with an HLB value (hydrophile-lipophile balance) of approximately 15. As a solubilizer in the compound Jinfeng liniment, it can reduce the surface tension at the oil-water interface, allowing previously insoluble ingredients (such as menthol and some fat-soluble components in the extract) to be evenly dispersed in the solution, preventing stratification and precipitation, thereby ensuring the stability and uniformity of the formulation.

[0019] The butanediol in question is 1,3-butanediol. 1 and 3 represent the positional numbers of the functional groups (hydroxyl groups), clearly identifying the attachment position of the hydroxyl groups (-OH) on the carbon chain. 1,3-Butanediol has high molecular symmetry, with a melting point (-7.5°C) and boiling point (207°C) higher than most monohydric alcohols. The two hydroxyl groups can form intermolecular hydrogen bonds, contributing to its high viscosity (approximately 30 mPa·s at 25°C) and strong hygroscopicity. As a polyol solvent in the compound Jinfeng liniment, 1,3-Butanediol forms a co-solvent system with ethanol, dissolving fat-soluble ingredients such as menthol while also enhancing the solubility of polar components in traditional Chinese medicine extracts (such as flavonoid glycosides) through hydrogen bonding, thereby improving the uniformity of the formulation. The hydroxyl groups in its molecular structure interact with the hydration of the skin's stratum corneum, promoting transdermal drug penetration. Its high hygroscopicity (up to 50% of its own weight at 25°C) can mitigate skin dryness and irritation caused by ethanol evaporation. By forming a hydrogen bond network with ethanol, poloxamer, etc., the stability of the micelle structure is maintained to prevent the extract components from precipitating or settling during storage.

[0020] The poloxamer in question is poloxamer 188, where 188 is a coding identifier for its polymer structure, representing the composition and ratio of the polyoxyethylene (PEO) and polyoxypropylene (PPO) segments within the molecule. Its functions in the compound Jinfeng liniment are as follows: 1) Solubilization and stabilization: By forming a micellar structure (a hydrophobic core encapsulating lipid-soluble ingredients such as menthol and azone, while a hydrophilic shell is dispersed in the aqueous phase), the solubility of poorly soluble drugs is increased; and by regulating the polarity of the ethanol-water system, flavonoids and glycosides in the traditional Chinese medicine extract are prevented from precipitating due to solvent evaporation. 2) Transdermal penetration and skin feel regulation: The micellar structure can interact with the lipids in the skin's stratum corneum, reducing drug transdermal resistance. 3) The high PEO content imparts viscoelasticity, allowing it to form a thin, uniform film upon application, reducing the feeling of tightness caused by ethanol evaporation. 4) Anti-sedimentation effect: Through the steric hindrance effect (steric repulsion of PEO chain segments), the aggregation of TCM particles is prevented, and the suspension stability of the liniment is maintained (for example, stirring to dissolve in step S3 can promote micelle encapsulation of particles).

[0021] Among the above components, menthol, peppermint oil, azone, and 1,3-butanediol are all evenly distributed in the ethanol solvent at the molecular level. Menthol (a crystalline solid) and peppermint oil (a volatile liquid) form a transparent solution through the polar solubility of ethanol. Azone (a low-melting-point liquid) completely melts in 40°C preheated ethanol and dissolves with the solvent, avoiding precipitation problems caused by its high freezing point (-7°C) at low temperatures. 1,3-Butanediol (a high-boiling-point liquid) acts as a polyol solvent, forming a co-solvent system with ethanol, enhancing the polar compatibility of the overall solution.

[0022] Poloxamer 188 is dispersed in the solution in the form of micelles. Leveraging the hydrophilicity of the polyoxyethylene segments (80%) and the hydrophobicity of the polyoxypropylene segments, this block copolymer self-assembles into a nanoscale micelle structure in an ethanol-water mixture. This structure encapsulates and stabilizes fat-soluble ingredients like Buttercup Flower extract, preventing their precipitation due to differences in solvent polarity.

[0023] Extracts from Buttercup Flower, Chuanxiong Rhizome, and Carthamus Tinctorius are uniformly dispersed in the form of molecules or colloidal particles. These extracts are obtained through ultrasound-microwave-assisted extraction. Polar components (such as flavonoid glycosides) are directly dissolved in ethanol, while lipid-soluble components (such as volatile oils) are solubilized by poloxamer 188 micelles, forming a thermodynamically stable colloidal solution. High-molecular-weight polymers (such as polysaccharides) in the extracts are precipitated by ethanol to form a nanoscale dispersed phase, which, together with the micelles, forms a stable multiphase system.

[0024] As the continuous phase solvent, ethanol not only dissolves small molecules like menthol but also forms a solvation layer through hydrogen bonding with 1,3-butanediol and poloxamer 188, maintaining the uniformity of the entire formulation. Ethanol's high volatility (boiling point 78.5°C) creates a dynamic equilibrium under sealed conditions, preventing excessive solvent evaporation and concentration of components.

[0025] S2. Pre-treating and extracting the medicinal materials of Buttercup Flos, Ligusticum chuanxiong and Carthamus tinctorius to prepare Buttercup Flos extract, Ligusticum chuanxiong extract and Carthamus tinctorius extract.

[0026] Step S2 specifically includes: S201, preparing a Buttercup Flower extract: grinding dried Buttercup Flower medicinal materials into a 12-mesh coarse powder, extracting with supercritical CO2 at an extraction pressure of 25 MPa, a temperature of 40° C., a CO2 flow rate of 15 L / h, and an extraction time of 120 minutes to extract volatile oil and flavonoid components; subjecting the residue after extraction to ultrasonic-assisted ethanol extraction, adding 8 times the amount of 65% ethanol, and extracting twice at 55° C. and 400 W ultrasonic conditions for 30 minutes each time, combining the extract and the extract solution, and concentrating under reduced pressure to a relative density of 1.25 to obtain a Buttercup Flower extract; S202. Preparation of a mixed extract of Chuanxiong and Carthamus tinctorius: Grind the Chuanxiong and Carthamus tinctorius medicinal materials into 30-mesh coarse powder, perform ultrasonic-microwave-assisted extraction, add 7 times the amount of 55% ethanol, use ultrasonic power of 350 W, microwave power of 500 W, and extract at 60°C for 30 minutes; combine the extracts, concentrate under reduced pressure to a relative density of 1.25, add 95% ethanol to make the alcohol content reach 70%, let it stand for 72 hours, filter to remove the precipitate, and obtain a mixed extract of Chuanxiong and Carthamus tinctorius.

[0027] S3. Mix menthol, peppermint oil, azone, and butanediol in a set ratio (mixing ratio of 5:4:3:40), add some ethanol preheated to 40°C, stir to dissolve, then add the polysorbate and poloxamer, continue stirring until completely dissolved to form a uniform solution.

[0028] S4. Place the mixed extract of Buttercup Flower Extract, Chuanxiong Rhizome and Carthamus tinctorius in a vacuum emulsifier, add glycerin, and stir at 55° C. and 120 rpm to form a uniform colloid.

[0029] S5. Under stirring, slowly add the homogeneous solution of step S3 into the vacuum emulsifying pot, and at the same time dropwise add the remaining ethanol, control the stirring speed to 200 rpm, and continue stirring for 40 minutes.

[0030] S6. Add pre-dissolved Centella asiatica, allantoin, and hydroxypropyl methylcellulose aqueous solution to the vacuum emulsifying pot, stir evenly, then add methylparaben, propylparaben, and disodium edetate aqueous solution, stir evenly, dilute to 1000 g with purified water, and adjust the pH to 5.6±0.1 with 0.05 M phosphoric acid to obtain the compound Jinfeng liniment.

[0031] S7, performing three-stage filtration on the compound Jinfeng liniment, and sterilizing and packaging the filtered compound Jinfeng liniment. Specifically comprising the following steps: S701, coarse filtration: using a 180-mesh stainless steel mesh to filter the compound Jinfeng liniment liquid obtained in step S6 while hot, with the filtration temperature maintained at 50° C.; S702, fine filtration: filtering the compound Jinfeng liniment liquid after coarse filtration through a 0.3 μm polyethersulfone membrane under reduced pressure; S703, sterilization filtration: the compound Jinfeng liniment liquid after fine filtration is filtered using a 0.22 μm polyvinylidene fluoride membrane under a sterile environment.

[0032] S704. Use low-temperature plasma sterilization to pass the compound Jinfeng ointment liquid after the three-stage filtration into the sterilization equipment, sterilize it at a temperature of 35°C, a pressure of 60Pa, and a power of 180W for 18 minutes, and then immediately fill the liquid into a sterilized brown high-density polyethylene spray bottle, fill it with nitrogen and seal it.

[0033] After filling, the compound Jinfeng ointment is subjected to comprehensive quality inspections such as properties, ethanol content, active ingredient content, and microbial limits. Products that pass the inspection are labeled, boxed, and stored in warehouses.

[0034] The present invention also provides a compound Jinfeng liniment. Based on the preparation process of the compound Jinfeng liniment as described above, the compound Jinfeng liniment comprises the following components: 15% of goldenrod flower extract, 12% of a mixed extract of chuanxiong rhizome and safflower, 1% of menthol, 0.8% of peppermint oil, 35% of ethanol, 12% of glycerol, 8% of butylene glycol, 2.5% of polysorbate, 0.5% of poloxamer, 0.6% of azone, 0.2% of asiaticoside, 0.3% of allantoin, 0.3% of hydroxypropyl methylcellulose, 0.08% of methylparaben, 0.02% of propylparaben, 0.05% of disodium edetate, and the remainder is purified water; the above percentages are weight percentages, and the total weight percentage of the above components constituting the compound Jinfeng liniment is 100%.

[0035] The present invention uses ultrasound-microwave assisted combined technology in the extraction of medicinal materials, combined with a precisely adapted solvent system, which significantly improves the extraction efficiency of the effective ingredients in medicinal materials such as Golden Phoenix Flower, Chuanxiong, and Carthamus tinctorius, and avoids the degradation of heat-sensitive components; the formula introduces menthol, peppermint oil, azone, and butylene glycol as multi-component transdermal enhancers for synergistic effect, and uses polysorbate and hydroxypropyl methylcellulose as composite solubilizers and sustained-release materials to enhance the drug's transdermal penetration ability, achieve the advantages of rapid onset and long-term drug release, significantly improve the dissolution stability of the preparation, and effectively prevent stratification and precipitation during storage. In addition, by adding asiaticoside in combination with ethanol and 1,3-butylene glycol, skin irritation is significantly reduced, broadening the range of applicable populations; comprehensively improving the effectiveness, safety, and stability of the compound Golden Phoenix liniment, and improving clinical treatment effects.

[0036] It should be noted that, in this document, the terms "comprises," "includes," or any other variations thereof are intended to encompass non-exclusive inclusion, such that a process, apparatus, article, or method comprising a series of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, apparatus, article, or method. In the absence of further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of other identical elements in the process, apparatus, article, or method comprising the element.

[0037] The above description is only a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the present invention description and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A preparation process of compound Jinfeng liniment, characterized in that: include: S1. Accurately weigh the weight of each ingredient in the formula of the compound Jinfeng liniment; wherein the ingredients include goldenrod flower, Chuanxiong rhizome, safflower, menthol, peppermint oil, ethanol, glycerin, butylene glycol, polysorbate, poloxamer, azone, asiaticoside, allantoin, hydroxypropyl methylcellulose, methylparaben, propylparaben, disodium edetate, and purified water; S2. Pre-treating and extracting the medicinal materials of Buttercup Flos, Chuanxiong Rhizome, and Carthamus tinctorius to prepare Buttercup Flos extract, Chuanxiong Rhizome extract, and Carthamus tinctorius extract; S3, menthol, peppermint oil, azone, and butanediol are mixed in a set ratio, and a portion of ethanol preheated to 40° C. is added, and after stirring to dissolve, the polysorbate and poloxamer are added, and stirring is continued until they are completely dissolved to form a uniform solution; S4. Place the mixed extract of Buttercup Flower Extract, Chuanxiong Rhizome, and Carthamus tinctorius in a vacuum emulsifier, add glycerin, and stir at 55° C. to form a uniform colloid; S5. While stirring, slowly add the homogeneous solution from step S3 into the vacuum emulsifying pot, while adding the remaining ethanol dropwise, and continue stirring for 40 minutes; S6. Add pre-dissolved asiaticoside, allantoin, and hydroxypropyl methylcellulose aqueous solution to the vacuum emulsifying pot, stir evenly, then add methylparaben, propylparaben, and disodium edetate aqueous solution, stir evenly, dilute to 1000 g with purified water, and adjust the pH to 5.6±0.1 with 0.05 M phosphoric acid to obtain the compound Jinfeng liniment; S7. Performing three-stage filtration on the compound Jinfeng liniment, and sterilizing and packaging the filtered compound Jinfeng liniment.

2. The preparation process of the compound Jinfeng liniment according to claim 1, characterized in that: In step S1, the volume fraction of the ethanol is 85%, the butanediol is 1,3-butanediol, the model of the polysorbate is polysorbate 80, and the poloxamer is poloxamer 188.

3. The preparation process of the compound Jinfeng liniment according to claim 1, characterized in that: The step S2 specifically includes: S201, preparing a Buttercup Flower extract: grinding dried Buttercup Flower medicinal materials into a 12-mesh coarse powder, extracting with supercritical CO2 at an extraction pressure of 25 MPa, a temperature of 40° C., a CO2 flow rate of 15 L / h, and an extraction time of 120 minutes to extract volatile oil and flavonoid components; subjecting the residue after extraction to ultrasonic-assisted ethanol extraction, adding 8 times the amount of 65% ethanol, and extracting twice at 55° C. and 400 W ultrasonic conditions for 30 minutes each time, combining the extract and the extract solution, and concentrating under reduced pressure to a relative density of 1.25 to obtain a Buttercup Flower extract; S202. Preparation of a mixed extract of Chuanxiong and Carthamus tinctorius: Grind the Chuanxiong and Carthamus tinctorius medicinal materials into 30-mesh coarse powder, perform ultrasonic-microwave-assisted extraction, add 7 times the amount of 55% ethanol, use ultrasonic power of 350 W, microwave power of 500 W, and extract at 60°C for 30 minutes; combine the extracts, concentrate under reduced pressure to a relative density of 1.25, add 95% ethanol to make the alcohol content reach 70%, let it stand for 72 hours, filter to remove the precipitate, and obtain a mixed extract of Chuanxiong and Carthamus tinctorius.

4. The preparation process of the compound Jinfeng liniment according to claim 1, characterized in that: In step S3, the mixing ratio of menthol, peppermint oil, azone and butanediol is 5:4:3:

40.

5. The preparation process of the compound Jinfeng liniment according to claim 1, characterized in that: In step S7, the three-stage filtration specifically includes: S701, coarse filtration: using a 180-mesh stainless steel mesh to filter the compound Jinfeng liniment liquid obtained in step S6 while hot, with the filtration temperature maintained at 50° C.; S702, fine filtration: filtering the compound Jinfeng liniment liquid after coarse filtration through a 0.3 μm polyethersulfone membrane under reduced pressure; S703, sterilization filtration: the compound Jinfeng liniment liquid after fine filtration is filtered using a 0.22 μm polyvinylidene fluoride membrane under a sterile environment.

6. The preparation process of the compound Jinfeng liniment according to claim 1, characterized in that: In step S7, the sterilization and packaging specifically include: The compound Jinfeng liniment liquid after the three-stage filtration was passed into the sterilization equipment using low-temperature plasma sterilization and sterilized for 18 minutes at a temperature of 35°C, a pressure of 60Pa, and a power of 180W. The liquid was then immediately filled into a sterilized brown high-density polyethylene spray bottle, filled with nitrogen, and sealed.

7. A compound Jinfeng liniment, characterized in that: Based on the preparation process of the compound Jinfeng liniment according to any one of claims 1 to 6, the compound Jinfeng liniment comprises the following components: Buttercup Flower Extract 15% Mixed extract of Chuanxiong and Carthamus tinctorius 12% Menthol 1% Peppermint oil 0.8% Ethanol 35% Glycerin 12% Butanediol 8% Polysorbate 2.5% Poloxamer 0.5% Azone 0.6% Centella asiatica 0.2% Allantoin 0.3% Hydroxypropyl methylcellulose 0.3% Methylparaben 0.08% Propylparaben 0.02% Edetate disodium 0.05% Purified water balance The above percentages are weight percentages, and the total weight percentage of the above components constitutes 100% of the compound Jinfeng liniment.

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