High-yield manna sugar preparation process

Abstract

The invention is a high-yield mannitol preparing method using glucose as raw material, on acidic condition, making the glucose through epimerization reaction to obtain the mixture mannitose-glucose, separate mannitose-glucose by simulated moving bed at 40-85 deg.C, using calcium cation exchange resin as sorbent and water as eluent to continuously obtain glucose-rich component and mannitose-rich component, where the former can repeatedly make epimerization reaction, the latter can generate manitol when added with hydrogen and the mannitol content in the mixed alcohol added with hydrogen is up to above 75%, then crystallizing, centrifuging and drying to obtain the mannitol product, where mannitol productivity is 70% of dry glucose charging capacity.

Description

Technical field: [0001] The invention belongs to the field of preparation of organic compounds. Especially a kind of technology that uses glucose as raw material to prepare mannitol. Background technique: [0002] Mannitol is a commonly used diuretic and dehydrating drug, and it is also one of the widely used pharmaceutical preparations and infusion drugs. It can also be used in the manufacture of sugar-free chewing gum, polyether, explosives, etc. in industry. [0003] The preparation method of industrial mannitol has following several ways: [0004] (1) Kelp extraction method: Dried kelp contains 5-10% mannitol, which can be extracted by physical crystallization after concentration. The quality of mannitol produced by this method is poor, difficult to filter, high heat source, and not suitable for medical use. , and this method consumes a large amount of steam, energy and manpower, and the production cost is high. [0005] (2) Electrolytic reduction method: glucose (or ...

AI Technical Summary

Problems solved by technology

[0004] (1) Kelp extraction method: Dried kelp contains 5-10% mannitol, which can be extracted by physical crystallization after concentration. The quality of mannitol produced by this method is poor, difficult to filter, high heat source, and not suitable for medical use. , and this method consumes a lot of steam, energy and manpower, and the production cost is high

[0005] (2) Electrolytic reduction method: glucose (or invert sugar) can be reduced to a mixture of mannitol and sorbitol under electrolytic conditions, and then extracted by crystallization to obtain mannitol. This method has long reaction time, low efficiency, and high power consumption. Alcohol yield is low (only up to 15%), has long been eliminated

[0010] Some of the various mannitol production methods mentioned above cannot be industrialized at all, such as the method using fructose or mannose as raw materials; Electrolytic reduction method and kelp extraction method; although some are industrially produced and operated, the yield of mannitol is low, such as the yield of sucrose hydrolysis process hydrogenation method is only 19-20%, glucose epimerization and enzyme isomerization The yield of the hydrogenation process is only 35%, and the remaining by-products are low-value and poor-quality sorbitol liquid products, and the economic benefits need to be improved

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