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Method for detecting content of trace metal ions in high-purity thiourea through ion chromatography

A technology of ion chromatography and ion content, which is applied in the field of ion chromatography to detect trace metal ion content in high-purity thiourea, can solve the problems of difficult detection and low impurity content, and achieve high accuracy, simple and fast detection method, and excellent test results Accurate and reliable results

Pending Publication Date: 2020-08-14
CHAMBROAD CHEM IND RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This technology can be used easily with small samples like blood or urine without any extra steps needed before testing them accurately. It's very precise but also highly validated due to its ability to measure many different metals simultaneously.

Problems solved by technology

This patented technical problem addressed in this patents relates to producing pure or highly purified thioacene hydride (TSA) without any residual metal contaminants that could affect its quality for use in medicine applications like chemotherapy drugs. Current standards are unable to accurately determine how much TSA has been dissolving during heated storage at room temperature due to lack of an effective method for measuring free acid concentration levels.

Method used

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  • Method for detecting content of trace metal ions in high-purity thiourea through ion chromatography
  • Method for detecting content of trace metal ions in high-purity thiourea through ion chromatography
  • Method for detecting content of trace metal ions in high-purity thiourea through ion chromatography

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] There is a batch of high-purity thiourea solid samples, and the content of five metal ions needs to be detected.

[0031] The ion chromatography conditions used: autosampler, ion chromatography pump, six-way valve, guard column CG12A, size 4*50mm, analytical column CS12A cation exchange column, size 4*250mm, suppressor model is CERS600, size 4mm, Conductivity detector, data processing system, column temperature 30°C, flow rate 1.0mL / min, suppressor current 47mA, sample volume 500μL, analysis time 25min, eluent 16mmol / L methanesulfonic acid aqueous solution.

[0032] Adopt ion chromatograph to detect, external standard method quantitative analysis, concrete steps are as follows:

[0033] (1) Ion chromatography standard curve drawing: Prepare standard solutions of sodium, ammonium, potassium, magnesium, and calcium ions with a concentration of 1000 mg / l; use a pipette to pipette 10.00 mL of each metal ion standard solution into a 100 mL volumetric flask, and set After sh...

Embodiment 2

[0059] To a batch of common thiourea solid samples different from Example 1, its five kinds of metal ion contents are detected:

[0060] The ion chromatography conditions used: autosampler, ion chromatography pump, six-way valve, guard column CG12A, size 4*50mm, analytical column CS12A cation exchange column, size 4*250mm, suppressor model is CERS500, size 4mm, Conductivity detector, data processing system, column temperature 30°C, flow rate 1.0mL / min, suppressor current 47mA, sample volume 500μL, analysis time 25min, eluent 16mmol / L methanesulfonic acid aqueous solution.

[0061] Adopt ion chromatograph to detect, external standard method quantitative analysis, concrete steps are as follows:

[0062] (1) Ion chromatography standard curve drawing: with embodiment 1

[0063] (2) prepare thiourea sample solution

[0064] Accurately weigh 6 parts of 0.80g guanidine hydrochloride sample to the accuracy of 0.0001g, set the volume to a 100mL volumetric flask, and filter with RP ca...

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Abstract

The invention belongs to the technical field of chemical analysis, and particularly relates to a method for detecting the content of trace metal ions in high-purity thiourea through ion chromatography. Sodium, ammonium, potassium, magnesium and calcium cations are detected by adopting an ion chromatography method; a standard working solution is prepared by utilizing five cation standard samples; and according to the response of the metal ions in the cation system, a standard curve is established by using the response peak area of the metal ion standard sample as a vertical coordinate and the ion content as a horizontal coordinate; and the response peak area of the corresponding ions in the sample is substituted into the standard curve to calculate the metal ion content in the sample. The method is simple to operate, rapid in detection, free of complex pretreatment, non-toxic and harmless in detection process, high in accuracy and good in reproducibility.

Description

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Claims

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Application Information

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Owner CHAMBROAD CHEM IND RES INST CO LTD
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