The invention provides a hot-rolled wide and thick plate with good ductility and toughness for low temperature pipelines and a manufacturing method thereof. The steel plate comprises the following components in percentage by weight: 0.035 to 0.060% of C, 0.20 to 0.35% of Si, 1.56 to 1.74% of Mn, 0.01 to 0.04% of Nb, 0.011 to 0.025% of Ti, 0.18 to 0.30% of Cr, 0.06 to 0.15% of Ni, 0.015 to 0.040% of Als, 0 to 0.10% of Cu, 0 to 0.19% of Mo, 0.0020 to 0.0045% of N, not more than 0.009% of P, not more than 0.001% of S, not more than 0.0015% of H, not more than 0.0020% of O, and the balance being iron and inevitable impurities; wherein the total percentage of Mo, Ni, Cu, and Cr is in a range of 0.32 to 0.55%, and the ratio of Ti and N is in a range of 3.42 to 6.10. At the same time, CEIIW is controlled in a range of 0.385 to 0.430%, and CEPcm is controlled in a range of 0.159 to 0.175%. The manufacturing method comprises steps of molten iron pretreatment, converter smelting, external refining, continuous casting, casting blank reheating, rolling, and cooling. The provided wide and thick plate can be used as a raw material to prepare large diameter (not less than 1420 mm) thick wall low temperature steel pipelines, and the ductility and toughness are good.