Montmorillonite suspension for treating acute diarrhea, and preparation method thereof

A technology of acute diarrhea and montmorillonite, applied in the field of pharmaceutical preparations, can solve the problems of unsuitable temperature control, reduction of montmorillonite particle size, poor curative effect, etc., and achieve the effect of qualified sedimentation volume ratio and easy redispersion
CN109718201AActive Publication Date: 2019-05-07昆明正祺医药科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
昆明正祺医药科技有限公司
Publication Date
2019-05-07

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Abstract

The invention belongs to the technical field of medicinal preparations, and especially relates to a montmorillonite suspension for treating acute diarrhea, and a preparation method thereof. Sodium carboxymethyl cellulose contains sodium cations, which can switch with some calcium cations in montmorillonite, so that partial CMC-Na can enter the interlayer or surface of the montmorillonite; when theconcentration of the CMC-Na and the exchangeable calcium cations on the surface of the montmorillonite can reach a balance state, deflocculation effects can be achieved, so that the settlement volumeratio of the formed montmorillonite suspension can be qualified and stabilized, and easy re-dispersion can be realized; and two bacteriostatic agents which are methyl hydroxybenzoate and propyl hydroxybenzoate can have antibacterial activity when pH is 4-8, can give protons with the increasing of the pH, so that anions of phenol groups can be formed, and bacteriostatic effects can decrease with the increasing of the pH. The composition formula of the montmorillonite suspension is in a balanced deflocculation state, so that the montmorillonite suspension with stable settlement volume ratio reliable in dispersing and qualified in bacteriostatic effect can be obtained.
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Description

technical field

[0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a montmorillonite suspension for treating acute diarrhea and a preparation method thereof. Background technique

[0002] Montmorillonite is a dioctahedral layered structure composed of silicon-oxygen tetrahedrons and aluminum-oxygen octahedrons, with a general structural formula of (K, Na, Ca, Mg) y (Al, Mg) 2 (Si,Al) 4 o 10 (OH) 2 xH2O, where (K, Na, Ca, Mg) y For interlayer exchangeable cations, (Al, Mg) 2 is the cation in the octahedron, (Si, Al) 4 It is a cation in the tetrahedron. The random substitution of A1 and Mg for Si and Al in the structure causes an imbalance of charge, making it have the characteristics of charging and ion exchange. It is called "the king of mycotoxin adsorption". The mechanism is to rely on its uniform distribution to cover the digestive tract mucosa, which can combine with mucus glycoproteins, increase mucus volume, impr...

Claims

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