37results about How to "Reduce inflammatory factors" patented technology

The invention relates to bacillus velezensis and an application thereof in prevention and treatment of porcine diarrhea. The invention provides a bacillus velezensis strain LL2018013. The bacillus velezensis is added into a weaned piglet milk replacer, wherein the addition amount is 107 to 109 CFU / L; and the bacillus velezensis is added into a feed for pigs at growth periods, wherein the additionamount is 106 to 108 CFU / g. The bacillus velezensis provided by the invention can improve the diversity of pig intestinal flora, reduces inflammatory factors through regulation of the flora abundance,promotes nutrient digestion and absorption, improves oxidation resistance of a body, improves immunity, increases the resisting capability to viruses, reduces generation of diarrhea, can inhibit common pig intestinal pathogens like escherichia coli K88, salmonella typhimurium and staphylococcus aureus, reduces the rate of diarrhea, improves the daily gain of pigs, can inhibit molds in a feed, improves the metabolic efficiency of the body to lipids, improves digestion and absorption of the pigs to feed nutritional ingredients, and has the trend of reducing chemical residues in excrement at thesame time.

A therapeutic effect of Nurr1 and Foxa2 in inflammatory neurologic disorders by M1-to-M2 polarization of glial cells is provided. Specifically, a method of converting glial cells from an M1 phenotype to an M2 phenotype, wherein Nurr1 and Foxa2 are introduced into the glial cells to be overexpressed in the glial cells and a method of preventing or treating an inflammatory neurologic disorder, which includes glial cells into which Nurr1 and Foxa2 are introduced, or a viral vector loaded with Nurr1 and Foxa2, are provided.

The invention discloses an optical therapy and beauty apparatus which is used for adjusting and filtering light waves emitted from a halogen light source, and specifically relates to an information-content broad-width optical band filter which comprises a heat-removal system, a condensation system and a selective filter system. The heat-removal system is composed of a cooling fan and a heat-removal housing with an inner cavity. The condensation system and the selective filter system are respectively installed in the middle and at the opening of the cavity of the heat-removal housing. The condensation system is composed of a light source and a condensing cup positioned at the front end of the light source. A high temperature resistance lens, a liquid light filter and a selective optical filter are successively arranged at the condensation end of the condensing cup. According to the principle of the invention, heat energy generated by the light source is dissipated through the heat-removal system, and through the liquid light filter and the selective optical filter, a light source with the temperature being about 36 DEG C and optical band respectively being 530nm-1380nm or 580nm-1380nm is obtained.

The invention discloses an application of Elabela polypeptide in preparation of a medicine or functional food for preventing and / or treating diseases related to chronic kidney injury and the medicinethereof. The diseases related to chronic kidney injury comprise (i) chronic renal insufficiency caused by hypertension; or ii) chronic renal insufficiency with hypertension. The Elabela polypeptide isstable in blood pressure reduction, can effectively relieve glomerular pathological injury of SD rats induced by deoxycorticosterone, reduce discharge of urine microalbumin, relieve development of renal fibrosis and reduce expression of inflammatory factors in kidney tissues, and has a remarkable effect on treatment of chronic kidney injury. Meanwhile, the Elabela polypeptide is an endogenous hormone synthesized by a human body and is expressed in kidney tissue, so that the toxic and side effects are smaller than those of the existing medicine for treating chronic kidney injury.

The invention relates to technical field of functional food and medical health care, and discloses application of a broadleaf holly leaf aqueous extract and a drug composition for regulating intestinal microecology. The invention provides application of the broadleaf holly leaf aqueous extract to preparation of a drug for regulating the intestinal microecology, and the drug composition for regulating the intestinal microecology. Through animal experiments, the application of the broadleaf holly leaf aqueous extract to regulating of the intestinal microecology is studied, it is found that by improving diversity of mice intestinal flora, the broadleaf holly leaf aqueous extract effectively regulates intestinal flora disturbance and improves the barrier function of the intestinal tract, lowers expression of inflammatory factors of intestinal tissue, promotes secretion of intestinal mucins, and thus achieves the effects of lowering lipid and losing weight, lowering blood glucose and lowering fat accumulation; and it shows that the broadleaf holly leaf aqueous extract can regulate diseases of obesity, type 2 diabetes, non-alcoholic fatty liver disease and the like caused by intestinal flora disturbance.

The invention relates to the technical field of far-infrared radiation materials, in particular to a hot-pressing photon polycrystalline semiconductor material and application thereof, and the hot-pressing photon polycrystalline semiconductor material at least comprises the following preparation raw materials in parts by weight: 5-15 parts of zirconium oxide, 2-8 parts of zinc oxide, 9-18 parts ofa rare earth salt compound, 5-16 parts of a silicate compound, 0.3-3 part of a surface treating agent and 60-75 parts of a carrier. The obtained hot-pressing photon polycrystalline semiconductor material can be applied to head-mounted products, and can promote the oxygen carrying capacity of human cells, regulate and dredge channels of water molecules in the human body, spontaneously and self-organize the human body to improve the internal and external permeability and potential difference of cell membranes, activate the cell activity, enhance the energy guarantee of an erythrocyte oxygen metabolism system, stretch blood vessels, and improve the vascular elasticity; therefore, tissue oxygen supplying and oxygen dissolving capacity is improved, inflammatory factors of a human body are reduced, and immunity is improved.

The invention belongs to the fields of cell biology and pharmacology, relates to an application of a natural medicine herba epimedii extract namely Epimedin B, in particular to an application of the Epimedin B to preparation of medicines for treating neuroinflammation. The Epimedin B can reduce the release of inflammatory factors, can reduce damage of dopaminergic neurons, has a certain preventionand protection effect on Parkinson's disease caused by damage of dopaminergic neurons, and can be used for preparing the medicines for preventing and / or treating neuroinflammation and relevant diseases thereof. The application has high clinical application value and high development prospects.

The invention discloses a compound with an indoline skeleton, and a preparation method and medical application of the compound. The compound containing the indoline skeleton provided by the inventioncan interfere with Keap1-Nrf2 interaction activate Nrf2 and a downstream factor, reduce cell inflammatory factors and enhance cell oxidation resistance; and therefore, the compound can reduce inflammatory injuries, has potential anti-inflammatory activity, and can be used for preparing anti-inflammatory drugs for treating inflammatory injuries caused by a plurality of inflammation-related diseases, including myocarditis, chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, intestinal inflammation, rheumatoid arthritis and the like.

The invention belongs to the technical field of cosmetics, and discloses an acne-removing composition as well as a preparation method and application thereof. The acne-removing composition exfoliates cutin and dredges hair follicle sebaceous glands through mild papain, so that the active ingredient quaternary ammonium salt-73 with bacteriostatic and antibacterial effects can play a better role, the palmitoyl tetrapeptide-7 is added to reduce inflammatory factors and eliminate skin inflammations, and then the spiraea ulmus extract is used for balancing an epidermal ecological system, so that the acne-removing composition has a good effect on removing acne. Natural antibacterial protection is formed, sebaceous gland secretion is adjusted, pores are converged, and the skin texture condition is improved; the acne-removing composition has a relatively good inhibition effect on propionibacterium acnes, all the components in the acne-removing composition have a synergistic effect in the aspect of inhibiting the increase of the facial skin grease content, and the acne-removing composition is non-irritant.

The invention provides a large yellow tea polysaccharide with anti-inflammatory activity, a preparation method and application of the large yellow tea polysaccharide and an anti-inflammatory pharmaceutical composition, and belongs to the technical field of application of active substances of large yellow tea. The large yellow tea polysaccharide with the anti-inflammatory activity is novel in structure, has a definite chemical structure, is uniform in composition, has an obvious anti-inflammatory function, can remarkably reduce expression of inflammatory factors in bone marrow-derived macrophages caused by lipopolysaccharide, and has no toxic or side effect on normal macrophages. As the polysaccharide with natural anti-inflammatory activity, the problem that the Huangdan tea lacks an active component with a single composition and a clear structure in the aspect of research and development of new anti-inflammatory drugs is solved, and a reliable material basis is laid for research on the structure-function relationship of the anti-inflammatory action of the Huangdan tea polysaccharide and research and development of the anti-inflammatory drugs.

The invention discloses an application for sulfated mannose glucuronic acid hexasaccharide in prevention and treatment of atherosclerosis. The sulfated mannose glucuronic acid oligosaccharide disclosed by the invention can effectively inhibit inflammatory factors in macrophages related to the atherosclerosis and the absorption effect of the macrophages on oxidized low-density lipoprotein, so a novel means is provided for preventing and treating the atherosclerosis.

The invention discloses an Escherichia coli Nissle 1917 genetically engineered bacterium as well as a preparation method and application thereof. The Escherichia coli Nissle 1917 genetically engineered bacterium with a function of improving sport injury is constructed by inserting a glucagon-like peptide gene sequence secreted by L cells from human intestinal tracts into a nucleophilic chromosome genome of the Escherichia coli Nissle 1917. The engineering probiotics can efficiently express GLP-1 in vitro, the defects that a plasmid overexpression system is unstable, drug resistance is prone to occurring and the like are overcome, meanwhile, the engineering probiotics have good acid resistance, cholate resistance and oxidation resistance, the motor injury of Parkinson mice can be obviously relieved, and neuroinflammation in the brain can be reduced. The Escherichia coli Nissle 1917 genetically engineered bacterium can be used for preparing food or drugs capable of improving sport injury, and has important practical significance and economic value in the aspect of Parkinson's disease treatment.

The invention relates to the field of functional beverages, and discloses a beverage capable of improving intestinal functions and a preparation method of the beverage. The health-care food is prepared from the following raw materials in parts by weight: 150 to 300 parts of ginseng, 150 to 300 parts of fried white hyacinth bean, 150 to 300 parts of poria cocos, 150 to 300 parts of pericarpium citri reticulatae, 150 to 300 parts of honey-fried licorice root, 0 to 1000 parts of polydextrose, 400 to 700 parts of xylooligosaccharide, 0 to 3000 parts of lactobacillus fermentation liquor, 0 to 30 parts of lactobacillus plantarum L-137, 100 to 1000 parts of erythritol, 0 to 0.4 part of stevioside, 0 to 0.2 part of sucralose, 0 to 200 parts of probiotic powder and 0 to 400 parts of resistant starch. According to the functional beverage, the probiotics / prebiotics and the traditional Chinese medicine components are combined and jointly act to synergistically exert the intestinal tract protection function, even if the probiotics / prebiotics cannot smoothly enter the intestinal tract due to different human body constitution reasons, the environment in the intestinal tract can be adjusted through the action of the traditional Chinese medicines, and the effective action of the functional beverage is ensured.

The invention relates to the technical field of new materials, relates to the technical field of polycrystalline semiconductor materials and intelligent wearing, and particularly relates to a preparation method and application of a hot-pressed photonic polycrystalline semiconductor. The preparation method of the hot-pressed photonic polycrystalline semiconductor at least comprises the following steps: (1) mixing a solid inorganic substance and a rare earth salt compound, firing to obtain a fired mixture A, transferring the fired mixture A into a reaction kettle, reacting for a period of time, cooling, and grinding to obtain a powder material B; and (2) heating a carrier, adding a surface treating agent and the powder material B, stirring, feeding into an extruder, and carrying out extrusion granulation and drying to obtain the hot-pressed photonic polycrystalline semiconductor. By reasonably setting the firing temperature, the reaction temperature and the reaction pressure, the hot-pressed photonic polycrystalline semiconductor material prepared by the method in the technical scheme is high in yield and relatively good in mechanical strength, and can be applied to intelligent wearing articles.

The invention discloses oligomerization nucleic acid inhibiting an MYD88 gene. The oligomerization nucleic acid is double-strand RNA (ribonucleic acid), a basic group of the oligomerization nucleic acid comprises an antisense strand and a positive-sense strand, the antisense strand comprises SEQ. ID NO.12 components, more than 70% of the components are homologous, the positive-sense strand comprises oligomerization nucleic acid reversely and complementarily paired with the antisense strand, more than 50% of sequences are homologous, and the positive-sense strand and the antisense strand can form a double-strand structure after annealing. The invention further discloses DNA (deoxyribonucleic acid) containing the oligomerization nucleic acid, a carrier, a composition and an application of the oligomerization nucleic acid. The oligomerization nucleic acid has a remarkable inhibiting function for an MYD88, can achieve an inflammation inhibition function in an animal experiment, remarkably reduces various inflammatory factors and is a quite promising inflammation therapy medicine.

The invention discloses a method for skin acne removing and repairing. According to the method for skin acne removing and repairing, components comprise, by weight: a nano silver acne removing essence, nano silver acne removing gel, nano silver acne removing essence cream, and a nano silver acne removing night mask. According to the method for skin acne removing and repairing, by adding nano silver, bacterial replication is effectively inhibited, a bacterial cell membrane is destroyed, or sulfydryl of beta protein in a bacterial body is strongly attracted and combined quickly, the original biological activity of enzymes is reduced, at the same time, the lasting antibacterial effect is played by slowly releasing silver ions, wherein silver particles can emit negative ions with the high concentration, the skin can be relieved, the blood circulation is accelerated to improve the metabolism speed, then through the addition of hibiscus taiwanensis can help injured tissue repair quickly, andthe anti-inflammatory, antibacterial effect is achieved. For skin ulcer, wound healing, scald and wound surfaces, repair and healing can be promoted, scars are reduced, skin tissue activation is promoted, skin regeneration is rebuilt, and the damaged skin is effectively smoothed.

The invention discloses oligomerization nucleic acid inhibiting an MYD88 gene. The oligomerization nucleic acid is double-strand RNA (ribonucleic acid), a basic group of the oligomerization nucleic acid comprises an antisense strand and a positive-sense strand, the antisense strand comprises SEQ. ID NO.12 components, more than 70% of the components are homologous, the positive-sense strand comprises oligomerization nucleic acid reversely and complementarily paired with the antisense strand, more than 50% of sequences are homologous, and the positive-sense strand and the antisense strand can form a double-strand structure after annealing. The invention further discloses DNA (deoxyribonucleic acid) containing the oligomerization nucleic acid, a carrier, a composition and an application of the oligomerization nucleic acid. The oligomerization nucleic acid has a remarkable inhibiting function for an MYD88, can achieve an inflammation inhibition function in an animal experiment, remarkably reduces various inflammatory factors and is a quite promising inflammation therapy medicine.

The invention provides an escherichia coli Nissel 1917 genetically engineered bacterium with a hypoglycemic effect, and a preparation method and application of the escherichia coli Nissel 1917 genetically engineered bacterium. According to the invention, a glucagon-like peptide gene sequence from a human body is inserted into a genome of Escherichia coli Nissle 1917 to construct an Escherichia coli Nissle 1917 genetically engineered bacterium with a hypoglycemic function. The engineering probiotics can efficiently express GLP-1 in vitro; the defects that a plasmid overexpression system is unstable, drug resistance is prone to occurring and the like are overcome; meanwhile, the engineering probiotics have good acid resistance, cholate resistance and oxidation resistance; pancreatitis can be obviously reduced; and blood sugar and sugar resistance can be improved. The Escherichia coli Nissle 1917 genetically engineered bacterium disclosed by the invention can be used for preparing food or medicines with a hypoglycemic function, and has important practical significance and economic value in the aspect of human body type 2 diabetes.

The invention discloses a composition capable of intelligently regulating skin oil-water balance. The composition comprises capryloyl glycine, fragrant citrus extract, pseudoalteromonas fermentation product extract, Laminaria saccharina extract, zinc gluconate, dipotassium glycyrrhizinate and auxiliary components. The composition has the advantages that skin oil-water secretion balance care is performed through multiple approaches by compounding the components, and the skin can fast adapt to different environment conditions and keep a good oil-water balance healthy state.

The invention belongs to the technical field of biological medicines, and particularly relates to a composition for daily prevention and treatment of microthrombus and application. The composition is prepared from the following substances in parts by weight: earthworm protein, nattokinase and corn stigma in a weight ratio of (3-1): (3-1): (3-1). According to the invention, earthworm protein and nattokinase are utilized to directly dissolve fibrin in microthrombus or indirectly activate other plasmin so as to play a role in prevention and treatment; corn stigma is used for improving the antioxidant capacity of the body, reducing inflammatory factors and enhancing the antithrombotic effect of earthworm protein and nattokinase, and can remarkably dissolve microthrombus, improve old thrombus, reduce blood viscosity and improve the blood microenvironment.

The invention discloses a saxifraga stolonifera extract with anti-inflammatory activity as well as a preparation method and application thereof, the preparation method comprises the following steps: S1, extracting fresh saxifraga stolonifera and hay saxifraga stolonifera by adopting different extraction methods to obtain an extract; S2, comparing the content differences of total flavonoids and total phenolic acids in the fresh saxifraga stolonifera extract and the dry saxifraga stolonifera extract obtained by adopting different extraction methods; S3, performing qualitative analysis on active ingredients in the fresh saxifraga stolonifera extract and the hay saxifraga stolonifera extract; and S4, establishing an inflammation model, and respectively adding the fresh saxifraga stolonifera extract and the hay saxifraga stolonifera extract which interact with each other to verify the effects of the fresh saxifraga stolonifera extract and the hay saxifraga stolonifera extract. The method solves the technical problem that the use of fresh grass and hay of saxifraga stolonifera is limited in the prior art.

The invention relates to a diet intervention product and application of whole grain and compositions thereof for controlling body weight regain. The diet intervention product is prepared from the composition A and the composition B or a combination of the composition A and the composition B. The composition A is prepared from whole grain food. The composition B is prepared from bitter gourd powder, soluble dietary fibers and other prebiotics components. By means of the diet intervention product and the application of the whole grain and the compositions thereof for controlling body weight regain, the weight losing method is further improved, people are guided to achieve nutrition weight losing through diet intervention, and the diet intervention product and the application of the whole grain and the compositions thereof are especially oriented to body weight control over body weight regain after weight losing.

The invention discloses an artesunate succinylated derivative and a preparation method thereof. The artesunate succinylated derivative is dihydroartemisinin-1, 2-alpha-succinic acid-ethylene glycol-succinic acid diester, and the artesunate succinylated derivative has stronger pharmacological activity and safety than artesunate, and can be used for preparing medicines for preventing and treating sepsis and pancreatitis.

The invention provides application of a compound of a structure shown in a formula 1 as shown in the description in production of a medicine for treating pharyngitis. According to application of the compound of the structure shown in the formula 1 as shown in the description in production of the medicine for treating pharyngitis, studies show that the compound has significant improving effects onpharyngitis, especially acute pharyngitis.

A therapeutic effect of Nurr1 and Foxa2 in inflammatory neurologic disorders by M1-to-M2 polarization of glial cells is provided. Specifically, a method of converting glial cells from an M1 phenotype to an M2 phenotype, wherein Nurr1 and Foxa2 are introduced into the glial cells to be overexpressed in the glial cells and a method of preventing or treating an inflammatory neurologic disorder, which includes glial cells into which Nurr1 and Foxa2 are introduced, or a viral vector loaded with Nurr1 and Foxa2, are provided.

The invention provides a healthy meal composition as well as a processing method and application thereof. The composition comprises 80-90 parts of protein, 60-75 parts of lipid and 180-190 parts of carbohydrate; the mass ratio of saturated fatty acid to polyunsaturated fatty acid to monounsaturated fatty acid in the lipids is 1: (0.95-1.05): (1.95-2.05). A healthy meal is a whole meal, meets the psychological needs of people for normal eating, improves psychological safety and behavioral compliance, combines a scientific diet mode with Chinese resident diet and cooking habits, can effectively reduce the body weight, reduces the proportion of fat in the body and visceral fat, and muscle mass reduction is not caused while the weight is reduced; inflammatory factors of the body can be reduced, and the chronic aseptic inflammation state of the body caused by obesity is corrected; the intestinal flora is regulated. The composition is suitable for people with obesity, central obesity, hypertriglyceridemia, constipation and chronic inflammation states, including teenagers, middle-aged people and old people. The preparation form of the healthy meal is flexible, and the healthy meal is suitable for large-scale popularization and application.

The invention discloses the application of sulfated mannoglucuronic acid hexasaccharide in preventing and treating atherosclerosis. The invention discloses that sulfated mannoglucuronide oligosaccharides can effectively inhibit the inflammatory factors in macrophages related to atherosclerosis and the absorption effect of macrophages on oxidized low-density lipoprotein, thereby contributing to the development of atherosclerosis The prevention and treatment of sclerosis provide new means.

The invention discloses a novel application of a quadruple viable bacterium composition, and belongs to the technical field of biological medicines. In order to obtain a medicine or health-care food with a prevention or treatment effect on anaphylactic reaction, the invention provides a novel application of a quadruple viable bacterium composition, and the quadruple viable bacterium composition comprises bifidobacterium, lactobacillus, coccus and bacillus. Experiments prove that the quadruple viable bacterium composition disclosed by the invention can be used for effectively relieving allergic symptoms and changing a flora structure, has good prevention and treatment effects on allergic reactions, and can be used for preparing the medicine or health-care food or food for preventing or treating the allergic reactions.

The invention discloses mouthwash for preventing and treating gingivitis. The mouthwash is prepared from the following raw materials in percentage by mass of 2 to 5 percent of enzymolysis bee pollen, 2 to 5 percent of glycerol, 0.5 to 1 percent of vitamin C, 0.3 to 0.5 percent of hydrolyzed fish skin collagen, 0.5 to 1 percent of menthol, 1.5 to 2.5 percent of a surfactant, 0.1 to 0.5 percent of sodium carboxymethyl cellulose, 0.01 to 0.1 percent of a preservative, 0 to 1 percent of a sweetening agent and the balance of water. The invention also discloses a preparation method of the mouthwash for preventing and treating gingivitis. The mouthwash provided by the invention has good prevention and treatment effects on gingivitis, the components are safe and harmless, the processing method is simple, and the use frequency is low.

The invention discloses an immunologic tolerance dendritic cell, a preparation method thereof and a special culture medium. The culture medium is formed by the way that mesenchyma stem cells are added into a dendritic cell culture medium. The preparation method comprises: the precursors and the inducible factors of dendritic cells are added into the culture medium. The co-culture proportion of the mesenchyma stem cells to the dendritic cells is (1-2) to (1-10), preferably 1 to 1; the precursors of the dendritic cells are CD34<+> cells; and the inducible factors comprise GM-CSF, TNF- alpha, IL-4 and LPS. The invention provides the application of the immunologic tolerance dendritic cell during preparing immunologic tolerance medicine for organisms. The immunologic tolerance dendritic cell can lowly express co-stimulatory molecule, reduce inflammatory factors, increase the secretion of suppressor cytokines, have vasculogenesis activity, and inhibit the multiplication of variant T cells. The invention has the advantages of simple operation, convenience and practicality, and establishes a stable culture technical system for selective activation dendritic cells.