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Optical method and device for modulation of biochemical processes in adipose tissue

A fat tissue, biochemical technology, applied in medical science, surgery, etc.

Inactive Publication Date: 2009-10-14
NOMIR MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the problem with these probes is that they generate too much heat at the distal end of the probe, which can easily exceed the temperature needed to melt fat tissue

Method used

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  • Optical method and device for modulation of biochemical processes in adipose tissue
  • Optical method and device for modulation of biochemical processes in adipose tissue
  • Optical method and device for modulation of biochemical processes in adipose tissue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0183] LDOAM Treatment Parameters for In Vitro Adipocyte Assays

[0184] The following parameters indicate that the method according to the invention is applied to human adipocytes under the threshold of thermal injury. Cultured human adipocytes were obtained from Zen-Bio (North Carolina) and used for in vitro experiments. Adipocyte precursor cells (preadipoblasts) were isolated from subcutaneous adipose tissue from elective surgery in healthy non-diabetic donors between 18 and 60 years of age. The preadipoblasts were isolated by centrifugation following collagenase treatment and then cultured as vegetative precursor cells. These cells are then differentiated into adipocytes by media supplemented with adipogenesis and adipogenesis hormones. The process of differentiation of preadipoblasts into adipocytes is disclosed in US 6,153,432.

[0185] Glycerin determination

[0186] Selected methods to measure glycerol released into the medium are used to assess lipolytic activ...

Embodiment I

[0195] Radiation dose value of 870nm wavelength in vitro

[0196] A single wavelength of NIMEL at about 870 nm indicates inhibition of lipolysis in vitro over the following radiation dose ranges.

[0197] Table I

[0198] NIMEL lost

output energy

(W)

870NM

Beam spot 6CM diameter

Treatment time

(SEC)

total energy

(joule)

Energy Density

(J / CM 2 )

Power density (irradiation

degrees) (W / CM 2 )

board 5

0.5W

28.26CM 2

15min

900sec

450J

15.3J / CM 2

0.017W / CM 2

[0199]

[0200]

[0201]

[0202] A single wavelength at 870nm demonstrated increased lipolysis in vitro over the following radiation dose ranges.

[0203] Table I-A

[0204] NIMEL lost

Output energy (W)

870NM

Beam spot 6CM

diameter

...

Embodiment II

[0209] Radiation dose value of 930nm wavelength in vitro

[0210] A single wavelength at 930nm demonstrated increased parenchymal lipolysis in vitro over the following radiation dose ranges.

[0211] Table II

[0212] NIMEL lost

Output energy (W)

930NM

Beam spot 6CM

diameter

Treatment time

(SEC)

total energy

(joule)

Energy Density

(J / CM 2 )

power density

(radioactivity)

(W / CM 2 )

board 6

0.5W

28.26CM 2

15min

900sec

450J

15.3J / CM 2

0.017W / CM 2

[0213]

[0214]

[0215]

[0216] A single wavelength at 930nm demonstrated increased parenchymal lipolysis in vitro over the following radiation dose ranges.

[0217] Table II-A

[0218] NIMEL lost

output energy

(W)

930NM

Beam spot 6CM

diam...

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PUM

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Abstract

Optical methods and devices are provided for the reduction of the lipid content of adipocytes without significant heat or intolerable adverse effect on the cells and their surrounding tissues. The optical method and device can be used to irradiate adipose tissue through the skin with non-thermal and non-destructive effects by application of near infrared (NIR) irradiation at selected wave bands in selected ranges to affect modulation of innate enzymatic processes involved in lipolysis, lipogenesis, leptin secretion, adiponectin secretion, and / or glucose absorption.

Description

[0001] Cross References to Related Applications [0002] This patent application claims priority to U.S. Provisional Application No. 60 / 761,717, filed January 24, 2006, and U.S. Provisional Application No. 60 / 781,260, filed March 9, 2006, both U.S. Provisional Applications The entire content of the Provisional Patent Application is hereby expressly incorporated by reference. technical field [0003] The present invention relates to optical methods and devices for generating infrared light radiation in selected wavelength bands through a large area of ​​skin to regulate lipolysis and lipogenesis energy metabolism of adipocytes in the subcutaneous tissue. The methods and devices of the present disclosure can be used to alter triglyceride levels in adipocytes during exercise or in combination with pharmacological approaches (alone). Background technique [0004] Obesity is a multi-etiological disorder that develops in humans (thought to have genetic, environmental and behavior...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/20
Inventor E·博姆斯泰因
Owner NOMIR MEDICAL TECH
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