Personalized genetic typing guidance body building and weight losing method and equipment application thereof

A technology of alleles and gene chips, which is applied in the field of personalized genotyping to guide fitness and weight loss and its equipment application, and can solve the problems of not comprehensively considering the amount of exercise and diet

Inactive Publication Date: 2016-08-03
SHANGHAI MIJIAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The comprehensive health impact of exercise, diet...

Method used

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  • Personalized genetic typing guidance body building and weight losing method and equipment application thereof
  • Personalized genetic typing guidance body building and weight losing method and equipment application thereof
  • Personalized genetic typing guidance body building and weight losing method and equipment application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] The allele of embodiment 1 SNP and its corresponding phenotype

[0064]The data of the World HapMap Genome Wide Association Study (GWAS, Genome Wide Association Study) project was not complete a few years ago, and it became complete after 2014, allowing trait evaluation. The analysis is by extracting the genomic DNA of individuals in the disease group (thousands of cases) and individuals in the normal group (thousands of cases), using gene chips to analyze the whole genome SNP of each case, and using statistical methods to find out the difference between the two groups. Significantly different SNP sites, so that the etiology of the disease is located on those SNP sites, and the genes of those SNPs may be the "susceptibility gene" sites of the disease. Then select independent samples for verification, preferably tens of thousands of samples. Finally, it is determined that those SNP-related genes are the "susceptibility genes" of the disease. The SNP sites obtained here ...

Embodiment 2

[0081] Embodiment 2 SNP gene chip, preparation method of kit and method of use

[0082] The design principle of the gene chip applied to bodybuilding guidance is that it includes a solid-phase carrier and immobilized on the solid-phase carrier for genes related to obesity susceptibility, individual weight loss potential, diet response and exercise response. Specific oligonucleotide probes for the detection of morphological sites, the single nucleotide polymorphic sites of related genes are:

[0083] SNPs associated with obesity susceptibility risk

[0084] SNPs associated with individual weight loss potential

[0085] Gene SNPs associated with diet response

[0086] Gene SNPs associated with exercise response

[0087] A group of oligonucleotide probes were designed for the single nucleotide polymorphism sites of related genes, and the nucleotide sequences of the oligonucleotide probes are specifically shown in Table 6:

[0088] Table 6 is used for the oligonucleotide probe...

Embodiment 3

[0108] Example 3 Obesity Cause Analysis and Exercise and Diet Guidance of Subject 1

[0109] (1) Extract sample DNA;

[0110] Extraction can be carried out according to conventional methods in the art, and the sample is human saliva. The present invention uses a saliva DNA extraction kit to extract the saliva of a middle-aged fat female;

[0111] (2) Using primers to amplify the DNA sample. Prepare 50u of the following PCR reaction system, and carry out PCR amplification respectively according to the following reaction conditions.

[0112] PCR reaction system

[0113] Components and their concentrations

The amount of each component added

10×PCR Buffer

5μl

MgCl 2

3μl

dNTP mix (10mmol / μl)

1μl

Upstream primer, 10pmol / μl

1μl

Downstream primer, 10pmol / μl

1μl

Taq enzyme (10U / μl)

0.5μl

blood or saliva DNA

1μl

h 2 o

37.5μl

total capacity

50μl

[0114] PCR reac...

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Abstract

The invention relates to data related to influences of different kinds of fat intake on obesity and influences of different types of sports on weight reduction and blood glucose reduction in disclosed human genome single nucleotide polymorphism (SNP) data. According to genetic differences between individuals, a method suitable for determining main reasons of obesity and making personalized diet schemes or giving suggestions about lifestyles is built, and the method is applied to development of wearable mobile devices and application software. The invention further relates to preparation and application of genetic chips related to detection. The personalized weight losing and body building schemes can reasonably, efficiently and selectively use modern sports exercise means and diet regulation according to personal gene characteristics, so that individuals achieve the aims of diet regulation and exercise planning more scientifically and more quickly.

Description

technical field [0001] The present invention relates to a method suitable for a subject's appropriate dietary plan or lifestyle suggestion. The method determines the subject's target by detecting the genotype of SNP sites related to obesity susceptibility, obesity measurement, etc. in the subject and cumulative calculation analysis. Individualized weight loss plan and diet and exercise guidance. Background technique [0002] According to the survey report by McKinsey & Company of the United States, there are 2.1 billion overweight (including obesity) people in the world, accounting for 1 / 3 of the global population. It is said that China has become an important contributor to the "obesity cause". obvious. [0003] Obesity is the root of all evil that corrupts health. According to the World Health Organization (WHO), obesity is already an "epidemic" and is associated with a variety of non-communicable diseases, including type 2 diabetes, cancer and heart disease. Overweight...

Claims

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Application Information

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IPC IPC(8): C12Q1/68G06F19/20
CPCC12Q1/6827C12Q1/6837G16B25/00C12Q2563/107
Inventor 王志勤庄启南
Owner SHANGHAI MIJIAN BIOTECH CO LTD
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