24 results about "Nitrosobenzene" patented technology

The present invention discloses the application of bio-gelatin modified with o-nitroso benzaldehyde group in the preparation of drugs for preventing or treating inflammatory bowel disease; the bio-gelatin modified with o-nitroso benzaldehyde group is prepared by the following method: S1. Add 4-(4-hydroxymethyl-3-nitro-2-methoxyphenoxy) butyric acid into the aqueous gelatin solution, and react the carboxyl group in 4-(4-hydroxymethyl-3-nitro-2-methoxyphenoxy) butyric acid with the amino group in gelatin to obtain bio-gelatin modified with o-nitrobenzyl alcohol group; S2. After irradiating the bio-gelatin modified with o-nitrobenzyl alcohol group with a near-ultraviolet light source, it is converted into bio-gelatin modified with o-nitroso benzaldehyde group. The present invention uses bio-gelatin modified with o-nitroso benzaldehyde group for preventing or treating inflammatory bowel disease, which can form a uniform, dense and stable coating on the intestinal surface and has good preventive and therapeutic effects on inflammatory diseases.

The invention belongs to the field of organic photoelectric materials, and discloses preparation and application of a D-pi-A type molecular motor. A molecule composed of a donor and an acceptor between a C = N double bond and a pi bridge has the following structures I and II: # imgabs 0 #, Ar is two donor groups, namely nitrosobenzene and N-(3, 4, 5-trimethoxyphenyl) ethylenediamine, # imgabs 1 #, imino indole and cyano indanone groups are introduced to one end of the donor, and the structure I and the structure II are shown in the specification. A D-pi-A type molecular motor material mainly based on non-radiative transition is constructed, due to the existence of C = N double bonds, a donor rotates to generate light response under illumination, the molecular motor material enables potential energy under the molecular level to be transferred, and the operation of converting absorbed light energy to near-infrared light has great prospects. Macroscopically speaking, the molecular motor is a molecular-level motor capable of converting optical energy into mechanical energy. Therefore, the introduction of C = N double bonds provides possibility for constructing a D-pi-A type molecular motor material which is mainly based on non-radiative transition. A thought is provided for the design of the molecules.

The application discloses indazole nitrogen oxide and a synthesis method and anticancer activity application thereof, and belongs to the technical field of organic synthesis and drug discovery. N-nitrosoaniline compound 1, diazindione compound 2, a catalyst, an additive and hexafluoroisopropanol are mixed, and the mixture is reacted by temperature rising to obtain indazole nitrogen oxide. The chemical structure of the indazole nitrogen oxide is as follows: researches show that the indazole nitrogen oxide has the activity of inhibiting the proliferation of Hela, A549 and HCT-116 cancer cells, and has potential medicinal value. Meanwhile, the synthesis method provided by the application is completed by one-pot multi-step tandem reaction, and the process is simple and efficient. The synthesis method has the following remarkable characteristics: raw materials are cheap and easy to obtain, the product is valuable, the steps are economical and atomic economy is high.

Provided herein are cationic polymers containing titratable end groups, which polymers are able to bind negatively -charged biological agents (e.g., macromolecules, such as RNA) by electrostatic interactions. The titratable end groups act as proton sponges at mildly acidic pH, allowing endosomal escape of polymers containing the titratable end groups and bound biological agents. Also provided are conjugates between said cationic polymers and polymers containing nitrophenylboronic acid (NPBA) and polyethylene glycol (PEG). Also provided are nanoparticles containing said cationic polymers and said conjugates of cationic polymer and NPBA-PEG. The NPBA-PEG polymers optionally comprise one or more targeting agents, such as antibodies, which are capable of directing the nanoparticles to a cellular target such as a T-cell. Nanoparticles can also comprise, in addition to a biological agent and / or a targeting agent, a therapeutic agent, such as a large-molecule therapeutic.

The invention discloses a method for synthesizing an amide compound by utilizing visible light / benzothiazoline derivative synergistic induction triazine ester, which comprises the following steps: by taking the triazine ester and a nitrobenzene compound as reaction substrates and the benzothiazoline derivative as a light reducing agent, carrying out a reaction on the triazine ester and the nitrobenzene compound in the presence of organic alkali, and carrying out a reaction to obtain the amide compound. Triazine ester and a benzothiazoline derivative form a donor-acceptor compound through intermolecular interaction, a single electron transfer process is triggered through visible light excitation, and then acyl radicals are generated; a nitrobenzene compound can be changed into free radical nitro aromatic hydrocarbon under the reaction system, an acyl free radical addition process is carried out, nitrosobenzene and N-(benzoyloxy)-N-phenylaniline are sequentially changed, and finally the target product amide compound is synthesized. The method has the advantages of being green, safe and easy to operate, the reaction condition is mild and efficient, the reaction time is short, the atom economy is high, the target product yield is high, the substrate applicability is wide, and the wide application prospect is achieved.

The application relates to a preparation method and application of a 2-acyl benzothiazole compound, which comprises the following steps: placing sulfur ylide in a sealed tube, adding a solvent to dissolve, and obtaining a first reaction system; adding nitrosobenzene into the first reaction system, stirring at a certain temperature for a certain time, and obtaining a second reaction system; adding sodium hydrosulfide, dimethyl sulfoxide, a metal salt, potassium persulfate and an alkali into the second reaction system, heating and stirring in the sealed tube to react, and obtaining a third reaction system; and carrying out post-treatment on the third reaction system to obtain the 2-acyl benzothiazole compound.The application has the advantages that the reaction condition is mild, the price of the sodium hydrosulfide sulfur source is low, and the reaction yield is high; the substrate applicability range is wide, various substrate structures can tolerate the reaction condition, and the 2-acyl benzothiazole derivative with diversified structures can be rapidly prepared.

This invention provides a photosensitive diamine monomer, a photosensitive polyimide precursor containing the monomer, a method for preparing thin film materials using the photosensitive polyimide precursor, and the application of this material in patterned hydrophilic surfaces and humidity sensor substrates. The photosensitive diamine monomer has a triphenyldiamine backbone, and its side chain contains o-nitrobenzyl ether photosensitive groups. When polyamic acid or polyimide materials prepared from this diamine monomer are irradiated with ultraviolet light, the o-nitrobenzyl ether groups in the side chain undergo a photolysis reaction to generate o-nitrosobenzaldehyde and release phenolic hydroxyl groups. The phenolic hydroxyl groups are covalently fixed on the polymer backbone, which significantly improves the hydrophilicity of the irradiated area. This material can be used to prepare patterned hydrophilic surfaces and has potential application prospects in fields such as the integrated design of humidity sensor substrates and humidity-sensitive materials.

The invention discloses a preparation method of (3S, 4R)-4-amino tetrahydro-2H-thiapyran-3-ol hydrochloride and a preparation method thereof. According to the invention, tetrahydrothiapyran-4-ketone is used as a reaction starting material; the preparation method comprises the following steps: reacting (S)-3-((2-(trimethylsilyl) ethyoxyl) methoxyl) tetrahydro-4H-thiapyran-4-one with nitrosobenzene to prepare (S)-3-((2-(trimethylsilyl) ethyoxyl) methoxyl) tetrahydro-4H-thiapyran-4-one, removing aniline through catalysis of copper sulfate, protecting a hydroxyl functional group by using 2-(trimethylsilyl) ethoxymethyl chloride, and performing reductive amination reaction with (R)-(+)-tert-butylsulfinamide (compound 5) to obtain relatively stable imine. And carrying out hydrogenation reduction reaction on the imine, and removing tert-butylsulfinyl to obtain the target product. The whole preparation process is carried out at room temperature, the raw materials are easy to obtain, the operation is simple, the yield is relatively high, and a single-target configuration product can be prepared.

The invention relates to a photo-initiated synthetic aminophenol compound method and application, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps: deprotonating a 1-hydroxybenzotriazole compound under an alkaline condition, and carrying out cracking reaction under the excitation of visible light to generate a high-activity biradical intermediate which is unstable and can be rapidly tautomerized into a more stable nitrosobenzene anion intermediate; the intermediate further reacts with cyclohexenone substances to synthesize the aminophenol derivative in one step. The method is simple and efficient, simple and convenient to operate, free of transition metal and additional oxidizing agents, simple and easily available in raw material reagent, high in product yield and capable of realizing large-scale synthesis, and a new method is provided for rapidly synthesizing the aminophenol compound. The synthesized aminophenol compound has good antibacterial activity, and especially has huge potential in the aspect of preventing and treating anthracnose of tea trees.

The present application provides a visible light responsive thienyl azobenzene compound, which belongs to the technical field of azo compounds. 3-aminothiophene-2-carboxylic acid methyl ester and nitrosobenzene are added to glacial acetic acid as raw materials, and the reaction is stirred at a temperature of 40-60°C until the nitrosobenzene reaction is complete. Deionized water is added to the reaction system, extracted, the organic phases are combined, the organic phases are washed, dried, and separated by column chromatography to obtain the finished product visible light responsive thienyl azobenzene compound. The above-mentioned compound is based on readily available raw materials and has mild reaction conditions. By adjusting the types of substituents on the benzene ring of the thienyl azobenzene molecule, not only the yield of bidirectional visible light isomerization can be improved, but also the yield of the product can be significantly improved. Z The half-life of the isomers is achieved at the monthly level of half-life.

This invention discloses a targeted nanodelivery system, its preparation method, and its applications. The targeted nanodelivery system is a pH / ROS-responsive sustained-release system loaded with chlorophyll copper / doxorubicin / NO donors. Specifically, it includes: a carrier material: a polythioacetal formed by the dimethylchlorosilane-catalyzed dehydration condensation of 4-formylphenylboronic acid and 3,6-dioxa-1,8-octanedithiol; a system modification component: DSPE-PEG-methyl; and active ingredients: doxorubicin as a chemotherapeutic drug, sodium chlorophyll copper as a photosensitizer / adjuvant therapy component, and N,N′-disec-butyl-N,N′-dinitroso-1,4-phenylenediamine as a NO donor. This nanodelivery system based on a dual-response mechanism provides a new and effective strategy for the precise and synergistic treatment of gliomas and has the potential for further clinical translation.

The present invention relates to the technical field of printing inks, and in particular to an antibacterial LED-UV curing rotary red ink. The antibacterial LED-UV curing rotary red ink is composed of the following raw materials in percentage by weight: 20-25% of an organic monomer, 8-10% of a photoinitiator, 0.3-0.8% of tris(N-nitroso-N-phenylhydroxylamine)aluminum salt, 1-2% of polyethylene wax, 5-8% of a functional additive, 1.5-2.5% of a dispersant, 12-15% of a red pigment, 0.6-1.2% of a drying agent, and the balance being a binder. The binder is formed by compounding vinyl ester resin and lauryl acrylate in a mass ratio of 1:0.8-1.0. The rotary red ink provided by the present invention has not only excellent antibacterial properties but also excellent wear resistance, effectively ensuring its quality and grade while also extending its service life to a certain extent.

The invention discloses a polyphosphomolybdate heterogeneous catalyst for preparing nitrosobenzene through aniline oxidation under the condition of a room temperature darkroom. The molecular formula of the catalyst is as follows: [Co (H2O) 6] 2 [(Mo2O4) 16Co36 (H2O) 42 (HPO4) 36 (PO4) 12]. The preparation method comprises the following steps: mixing CoCl2. 6H2O, Na2MoO4. 2H2O, L-tryptophan and phosphoric acid, adding water, stirring for 1.5 hours, adjusting the pH value to 2.65 by using a NaOH solution, reacting for 4 days at the temperature of 160 DEG C, and cooling to room temperature to obtain the polyphosphomolybdate catalyst. When the catalyst is used as a polyphosphomolybdate heterogeneous catalyst for preparing nitrosobenzene through aniline oxidation under the condition of a room-temperature darkroom, the catalyst shows excellent aniline conversion rate and high nitrosobenzene selectivity. Meanwhile, the catalyst has good stability and can be repeatedly used, so that the whole oxidation process can be efficiently and stably carried out under mild conditions.

The present invention relates to a kind of 4-hydroxy-5-phenylaminoimidazole compound and its preparation method and application, comprising the following steps: dissolving sulfur ylide and nitrosobenzene in a solvent and stirring the reaction; adding amidine hydrochloride and alkali, continuing the stirring reaction; suction filtration, washing the filter cake, and obtaining the target compound after drying. The beneficial effects of the present invention are: without any heavy / precious metal catalyst, the reaction conditions are mild, the steps are simple, the time is short, the reaction yield is high, and the separation yield of most products is more than 80%; the substrate applicability range is wide, and a variety of substrate structures can tolerate the reaction conditions, which is conducive to large-scale production; a method for preparing α-carbonyl amide compounds using 4-hydroxy-5-phenylaminoimidazole compounds is proposed, and the reaction can be completed without a catalyst.

This aqueous treatment agent is used for producing a coating film of a rubber-reinforcing member having the coating film, and contains dinitrosobenzene, a chlorinated polyolefin, and an isocyanate compound. The rubber reinforcing member according to the present invention comprises a reinforcing base material and a coating film provided so as to cover at least a part of the surface of the reinforcing base material, wherein the coating film contains dinitrosobenzene, chlorinated polyolefin, and an isocyanate compound.

The present invention provides a method for preparing p-phenylenediamine from nitrobenzene, comprising the following steps: S1) contacting nitrobenzene and urea with an MgO-based solid base catalyst and conducting a first reaction to obtain a mixture of p-nitroaniline and p-nitrosoaniline; S2) contacting the p-nitroaniline and p-nitrosoaniline mixture obtained in step S1) with an N-doped, C-supported, non-precious metal Ni-based bimetallic single-atom catalyst and conducting a second reaction under an H2 atmosphere to obtain p-phenylenediamine. The method for preparing p-phenylenediamine from nitrobenzene and urea provided herein has the advantages of low catalyst and raw material costs, good catalyst activity and reusability, high conversion rate and product selectivity, and a clean reaction process.

The invention discloses photo-writable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of intelligent materials. The preparation method specifically comprises the following steps: (1) synthesizing 1-bromo-2-nitrosobenzene; (2) synthesis of (E)-1-(2-bromophenyl)-2-(2, 6-dimethoxyphenyl) diazene; (3) synthesizing o-azobenzeneboronic acid; and (4) preparing the hydrogel. The invention develops the photo-writable hydrogel and the intelligent rewritable display system which integrate remote control, quick response and fluorescent display functions, so that transient photo-writing / self-erasing / photo-rewriting of any information can be realized, residual / accumulation of chemical ink is avoided, and the rewritable performance and response sensitivity of the photo-writable hydrogel and the intelligent rewritable display system are improved.

This invention relates to a photo-initiated method for synthesizing asymmetric azo aromatic compounds and its applications, belonging to the field of organic synthesis technology. A 1-hydroxybenzotriazole compound is deprotonated under alkaline conditions and then undergoes a cleavage reaction under visible light excitation to generate a highly reactive diradical intermediate. This intermediate is unstable and rapidly tautomerizes to a more stable nitrosophenyl anion intermediate. Under aprotic polar solvent conditions, this highly reactive intermediate is proton-quenched to obtain a highly reactive nitrosobenzene intermediate, which subsequently polymerizes with aniline compounds to generate asymmetric azo aromatic compounds. The raw materials are readily available, the synthetic route is short, the process is simple, and the products are easily separated and purified, making it suitable for large-scale synthesis. This provides a new route for the rapid preparation of asymmetric azo aromatic compounds. The synthesized asymmetric azo aromatic compounds exhibit good antibacterial activity and have significant application potential in the control of anthracnose in tea trees.

The present invention discloses a method for synthesizing aminated polyethylene. Under the action of cheap metal salts, suitable temperature and light energy are provided, and nitrosobenzene compounds are used to post-functionalize the carbon-hydrogen bonds of polyethylene compounds, thereby achieving catalytic amination functionalization conversion to obtain aminated polyethylene. The present invention directly utilizes commercial polyethylene compounds or waste polyethylene plastics to functionalize carbon-hydrogen bonds. It has the advantages of simple reaction, simple operation, short reaction time, mild reaction conditions, high reaction efficiency, easy separation and purification of products, and good substrate universality. It avoids the use of large amounts of precious metals and heavy metal salts, is very attractive in industrial production, and has great application potential in the fields of polymer modification, new material synthesis, and waste plastic recycling. At the same time, the aminated polyethylene obtained by the present invention has good adhesion strength, and its adhesion performance is 5 to 10 times that of ordinary polyethylene materials, making it suitable for the development of new plastic adhesives.

The invention provides a preparation method of an oxime ester compound, and belongs to the technical field of photoresist. The preparation method of the oxime ester compound comprises the following steps: carrying out Friedel-Crafts reaction on a compound shown in a formula I and a compound shown in a formula II to obtain a compound shown in a formula III; performing oximation reaction on the compound in the formula III to obtain a compound in a formula IV; performing esterification reaction on the compound in formula IV to obtain a compound in formula V; therefore, 2-[(E)-acetoxyl nitrogen subunit]-1-[4-(phenyl sulfenyl) phenyl] octyl-1-ketone is prepared through the reaction of diphenyl sulfide and n-caprylic acid, the reaction of 1-[4-(phenyl sulfenyl) phenyl]-1-octanone and sodium nitrite or alkyl nitrite, and the reaction of (2E)-2-(isonitroso)-1-[4-(phenyl sulfenyl) phenyl] octane-1-ketone and an acetylation reagent. The production cost for preparing the oxime ester compound is reduced, and the yield and the purity of the oxime ester compound are improved.

The invention relates to the field of chemical preparation, and discloses a method for preparing paranitroaniline and paranitroaniline, which comprises the following steps: in a mixed solvent of a polar solvent and a non-polar solvent, urea and nitrobenzene react in the presence of an alkali catalyst to obtain paranitroaniline and paranitroaniline.

The invention relates to the technical field of adhesives, in particular to a high-reactivity adhesive for a heat-vulcanized rubber surface at a low temperature and a preparation method of the adhesive. The adhesive is prepared from the following raw materials in percentage by mass: 1-15% of a film-forming agent, 5-20% of a rubber base material, 3-15% of a modified latent curing agent, 5-15% of phenolic resin and the balance of a solvent. According to the invention, p-aminobenzene sulfonyl guanidine is preferably selected to modify p-dinitrosobenzene, active nitrogen atoms of p-dinitrosobenzene are captured at a depolymerization temperature of p-dinitrosobenzene, and existence of a polymerization state is avoided, so that the curing and bonding functions can be fully exerted under a low-temperature reaction condition, and low-temperature limit vulcanization is realized. Meanwhile, the thermosetting phenolic resin with high free phenol content is used in a matched manner, so that an interface penetration type cross-linking reaction is realized, the bonding strength of the adhesive is improved, and the bonding stability of a low-temperature reaction part in the center of a shock insulation support product is ensured.

The invention relates to a photosensitive tissue sealant and a preparation method thereof. A network of the photosensitive tissue sealant is formed by interweaving CSLA, CSNB and a bridging agent polyethylene glycol derivative; under the irradiation of ultraviolet light, disulfide bonds on CSLA molecules are reversibly broken and reconstructed, so that the gel is endowed with strong adhesive capacity and toughness; under the irradiation of ultraviolet light, an o-nitrobenzene group on the CSNB molecule is converted into o-nitrosobenzaldehyde, the o-nitrosobenzaldehyde reacts with amino to form a C = N bond, and an S-N bond and a C-N bond are formed between the CSLA molecule and the CSNB molecule; the above reactions are the key to realize high adhesion and high crosslinking density of the photosensitive tissue sealing glue. The invention also relates to application of the photosensitive tissue sealing glue in preparation of biological glue, experiments prove that the photosensitive tissue sealing glue has good biocompatibility, short gel forming time, tissue adhesion strength of 86.5 kPa and bursting pressure of 667 mmHg, animal experiments prove that the photosensitive tissue sealing glue has excellent tissue sealing and hemostasis effects in large and small body bleeding scenes, and the photosensitive tissue sealing glue has good application prospects. The method is suitable for high-pressure bleeding on complex sites and has wide application prospects.