12 results about "Nitrosobenzene" patented technology

The application discloses indazole nitrogen oxide and a synthesis method and anticancer activity application thereof, and belongs to the technical field of organic synthesis and drug discovery. N-nitrosoaniline compound 1, diazindione compound 2, a catalyst, an additive and hexafluoroisopropanol are mixed, and the mixture is reacted by temperature rising to obtain indazole nitrogen oxide. The chemical structure of the indazole nitrogen oxide is as follows: researches show that the indazole nitrogen oxide has the activity of inhibiting the proliferation of Hela, A549 and HCT-116 cancer cells, and has potential medicinal value. Meanwhile, the synthesis method provided by the application is completed by one-pot multi-step tandem reaction, and the process is simple and efficient. The synthesis method has the following remarkable characteristics: raw materials are cheap and easy to obtain, the product is valuable, the steps are economical and atomic economy is high.

The application relates to a preparation method and application of a 2-acyl benzothiazole compound, which comprises the following steps: placing sulfur ylide in a sealed tube, adding a solvent to dissolve, and obtaining a first reaction system; adding nitrosobenzene into the first reaction system, stirring at a certain temperature for a certain time, and obtaining a second reaction system; adding sodium hydrosulfide, dimethyl sulfoxide, a metal salt, potassium persulfate and an alkali into the second reaction system, heating and stirring in the sealed tube to react, and obtaining a third reaction system; and carrying out post-treatment on the third reaction system to obtain the 2-acyl benzothiazole compound.The application has the advantages that the reaction condition is mild, the price of the sodium hydrosulfide sulfur source is low, and the reaction yield is high; the substrate applicability range is wide, various substrate structures can tolerate the reaction condition, and the 2-acyl benzothiazole derivative with diversified structures can be rapidly prepared.

This invention provides a photosensitive diamine monomer, a photosensitive polyimide precursor containing the monomer, a method for preparing thin film materials using the photosensitive polyimide precursor, and the application of this material in patterned hydrophilic surfaces and humidity sensor substrates. The photosensitive diamine monomer has a triphenyldiamine backbone, and its side chain contains o-nitrobenzyl ether photosensitive groups. When polyamic acid or polyimide materials prepared from this diamine monomer are irradiated with ultraviolet light, the o-nitrobenzyl ether groups in the side chain undergo a photolysis reaction to generate o-nitrosobenzaldehyde and release phenolic hydroxyl groups. The phenolic hydroxyl groups are covalently fixed on the polymer backbone, which significantly improves the hydrophilicity of the irradiated area. This material can be used to prepare patterned hydrophilic surfaces and has potential application prospects in fields such as the integrated design of humidity sensor substrates and humidity-sensitive materials.

The invention relates to a photo-initiated synthetic aminophenol compound method and application, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps: deprotonating a 1-hydroxybenzotriazole compound under an alkaline condition, and carrying out cracking reaction under the excitation of visible light to generate a high-activity biradical intermediate which is unstable and can be rapidly tautomerized into a more stable nitrosobenzene anion intermediate; the intermediate further reacts with cyclohexenone substances to synthesize the aminophenol derivative in one step. The method is simple and efficient, simple and convenient to operate, free of transition metal and additional oxidizing agents, simple and easily available in raw material reagent, high in product yield and capable of realizing large-scale synthesis, and a new method is provided for rapidly synthesizing the aminophenol compound. The synthesized aminophenol compound has good antibacterial activity, and especially has huge potential in the aspect of preventing and treating anthracnose of tea trees.

This invention discloses a targeted nanodelivery system, its preparation method, and its applications. The targeted nanodelivery system is a pH / ROS-responsive sustained-release system loaded with chlorophyll copper / doxorubicin / NO donors. Specifically, it includes: a carrier material: a polythioacetal formed by the dimethylchlorosilane-catalyzed dehydration condensation of 4-formylphenylboronic acid and 3,6-dioxa-1,8-octanedithiol; a system modification component: DSPE-PEG-methyl; and active ingredients: doxorubicin as a chemotherapeutic drug, sodium chlorophyll copper as a photosensitizer / adjuvant therapy component, and N,N′-disec-butyl-N,N′-dinitroso-1,4-phenylenediamine as a NO donor. This nanodelivery system based on a dual-response mechanism provides a new and effective strategy for the precise and synergistic treatment of gliomas and has the potential for further clinical translation.

The invention discloses a polyphosphomolybdate heterogeneous catalyst for preparing nitrosobenzene through aniline oxidation under the condition of a room temperature darkroom. The molecular formula of the catalyst is as follows: [Co (H2O) 6] 2 [(Mo2O4) 16Co36 (H2O) 42 (HPO4) 36 (PO4) 12]. The preparation method comprises the following steps: mixing CoCl2. 6H2O, Na2MoO4. 2H2O, L-tryptophan and phosphoric acid, adding water, stirring for 1.5 hours, adjusting the pH value to 2.65 by using a NaOH solution, reacting for 4 days at the temperature of 160 DEG C, and cooling to room temperature to obtain the polyphosphomolybdate catalyst. When the catalyst is used as a polyphosphomolybdate heterogeneous catalyst for preparing nitrosobenzene through aniline oxidation under the condition of a room-temperature darkroom, the catalyst shows excellent aniline conversion rate and high nitrosobenzene selectivity. Meanwhile, the catalyst has good stability and can be repeatedly used, so that the whole oxidation process can be efficiently and stably carried out under mild conditions.

This aqueous treatment agent is used for producing a coating film of a rubber-reinforcing member having the coating film, and contains dinitrosobenzene, a chlorinated polyolefin, and an isocyanate compound. The rubber reinforcing member according to the present invention comprises a reinforcing base material and a coating film provided so as to cover at least a part of the surface of the reinforcing base material, wherein the coating film contains dinitrosobenzene, chlorinated polyolefin, and an isocyanate compound.

The invention discloses photo-writable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of intelligent materials. The preparation method specifically comprises the following steps: (1) synthesizing 1-bromo-2-nitrosobenzene; (2) synthesis of (E)-1-(2-bromophenyl)-2-(2, 6-dimethoxyphenyl) diazene; (3) synthesizing o-azobenzeneboronic acid; and (4) preparing the hydrogel. The invention develops the photo-writable hydrogel and the intelligent rewritable display system which integrate remote control, quick response and fluorescent display functions, so that transient photo-writing / self-erasing / photo-rewriting of any information can be realized, residual / accumulation of chemical ink is avoided, and the rewritable performance and response sensitivity of the photo-writable hydrogel and the intelligent rewritable display system are improved.

This invention relates to a photo-initiated method for synthesizing asymmetric azo aromatic compounds and its applications, belonging to the field of organic synthesis technology. A 1-hydroxybenzotriazole compound is deprotonated under alkaline conditions and then undergoes a cleavage reaction under visible light excitation to generate a highly reactive diradical intermediate. This intermediate is unstable and rapidly tautomerizes to a more stable nitrosophenyl anion intermediate. Under aprotic polar solvent conditions, this highly reactive intermediate is proton-quenched to obtain a highly reactive nitrosobenzene intermediate, which subsequently polymerizes with aniline compounds to generate asymmetric azo aromatic compounds. The raw materials are readily available, the synthetic route is short, the process is simple, and the products are easily separated and purified, making it suitable for large-scale synthesis. This provides a new route for the rapid preparation of asymmetric azo aromatic compounds. The synthesized asymmetric azo aromatic compounds exhibit good antibacterial activity and have significant application potential in the control of anthracnose in tea trees.

The invention relates to the field of chemical preparation, and discloses a method for preparing paranitroaniline and paranitroaniline, which comprises the following steps: in a mixed solvent of a polar solvent and a non-polar solvent, urea and nitrobenzene react in the presence of an alkali catalyst to obtain paranitroaniline and paranitroaniline.

The invention relates to a photosensitive tissue sealant and a preparation method thereof. A network of the photosensitive tissue sealant is formed by interweaving CSLA, CSNB and a bridging agent polyethylene glycol derivative; under the irradiation of ultraviolet light, disulfide bonds on CSLA molecules are reversibly broken and reconstructed, so that the gel is endowed with strong adhesive capacity and toughness; under the irradiation of ultraviolet light, an o-nitrobenzene group on the CSNB molecule is converted into o-nitrosobenzaldehyde, the o-nitrosobenzaldehyde reacts with amino to form a C = N bond, and an S-N bond and a C-N bond are formed between the CSLA molecule and the CSNB molecule; the above reactions are the key to realize high adhesion and high crosslinking density of the photosensitive tissue sealing glue. The invention also relates to application of the photosensitive tissue sealing glue in preparation of biological glue, experiments prove that the photosensitive tissue sealing glue has good biocompatibility, short gel forming time, tissue adhesion strength of 86.5 kPa and bursting pressure of 667 mmHg, animal experiments prove that the photosensitive tissue sealing glue has excellent tissue sealing and hemostasis effects in large and small body bleeding scenes, and the photosensitive tissue sealing glue has good application prospects. The method is suitable for high-pressure bleeding on complex sites and has wide application prospects.