12results about How to "Improve purpose" patented technology

The present invention relates to LSD1 inhibitors for use in the treatment of NF1-mutant tumors, i.e. Tumors having one or more mutations or genetic alterations that affect the NF1 gene. The invention also provides a method of treating an NF1-mutant tumor in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an LSD1 inhibitor.

The invention discloses a diselenide-bond-containing poly-beta amino ester carrier for mRNA delivery and a preparation method and application thereof, and the preparation method of the diselenide-bond-containing poly-beta amino ester carrier comprises the following steps: taking a synthesized diselene-1, 6-hexanediol diacrylate monomer (DSEDA) and hydrophobic amine as raw materials to react to obtain a product as a polymer intermediate; the raw material of the hydrophobic amine is one of C8, C12 and C16; the # imgabs0 # hydrophilic amine raw material is one of 2A1, 2A4 and 2A5; a diselenide bond is introduced into a main chain of the structure of the synthesized linear cationic polymer product, tertiary amine N capable of being protonated into cations exists in the main chain structure, and the tertiary amine N can be effectively combined with nucleic acid with negative charges through electrostatic interaction, so that the nucleic acid loading rate is increased; according to the invention, hydrophobic alkane chains with proper number and length are provided, a hydrophobic cavity can be formed when the nanoparticles are formed, the stability of the nanoparticles is improved, and the nanoparticles have good application in delivery of mRNA (messenger Ribonucleic Acid) molecules.

The invention provides a path planning method based on an improved ant colony algorithm. The method is mainly used for optimizing and improving the efficiency and accuracy of the ant colony algorithm in path planning. A traditional ant colony algorithm has the problems of low convergence speed, easy falling into local optimum and the like. In order to solve the problems, the invention provides a series of improvement measures. First, the present invention initializes pheromone concentrations using non-uniform initialization. Secondly, an enhanced direction guiding mechanism is used, and the convergence speed of the algorithm is increased; in addition, the distance between the to-be-selected node and the target point is added into the heuristic function, so that the purposiveness and efficiency of path searching are improved. Finally, according to the invention, a strategy of combining a plurality of transfer strategies is adopted for transfer, and finally, an optimal path with a shorter distance and a relatively smooth path can be obtained more quickly.

The invention provides a three-dimensional ventilation digital twinning system, which comprises a ventilation information investigation module, a three-dimensional visual modeling module, a ventilation system analysis module and a ventilation system optimization module, and is characterized in that the ventilation information investigation module collects underground ventilation system engineering, production operation, ventilation structures and ventilation equipment materials, combines mining area ventilation lines, and optimizes the ventilation system engineering, the production operation, the ventilation structures and the ventilation equipment materials; temperature, humidity, air volume and wind direction information parameter detection is carried out on main nodes of an underground ventilation system; the three-dimensional visual modeling module is used for establishing a three-dimensional visual model of the whole mine ventilation system according to 1: 1 in combination with ventilation information basic data and related materials; the ventilation system analysis module diagnoses and analyzes air volume distribution, air speed standard reaching, ventilation resistance distribution and a diesel oil equipment tail gas diffusion path in a multi-dimensional mode based on a ventilation numerical value analysis model; the change condition of the mine ventilation system can be scientifically and reasonably predicted, and the mine ventilation cost and working conditions can be quantitatively analyzed.

The invention relates to the technical field of power system fault diagnosis, and discloses a voltage transformer secondary circuit fault positioning method and system, and the method comprises the steps: applying a low voltage to a voltage transformer secondary circuit, monitoring the current of the circuit, and judging the state of the voltage transformer secondary circuit according to the current of the circuit; when the fault is judged to exist, carrying out segmentation processing on the to-be-checked secondary circuit of the voltage transformer; and repeatedly applying low voltage and monitoring current, and positioning a fault point through a segmented searching method. Through the accurate detection method, the fault of the secondary circuit of the voltage transformer can be effectively identified, misdiagnosis and missed diagnosis are reduced, the fault processing time is shortened, the power failure time is shortened, and the reliability of a power system is improved. And by detecting and positioning the fault in time, equipment damage in a larger range caused by fault expansion can be avoided, so that the cost of maintaining and replacing the equipment is reduced.

This invention belongs to the field of functional substance research, specifically relating to the use of casein hydrolyzed peptide compositions in improving aging, and more specifically to their use in the preparation of products for improving aging. The casein hydrolyzed peptide compositions are obtained by enzymatically hydrolyzing casein solution using serine protease and flavor protease. Furthermore, in the casein hydrolyzed peptide compositions, the relative strength of total functional peptides is above 25%, the relative strength of casein phosphopeptides is above 9%, and the relative strength of functional peptides other than casein phosphopeptides is above 11%. This casein hydrolyzed peptide composition can effectively alleviate oxidative stress caused by aging, inhibit chronic low-grade inflammation, reduce aging-related damage to vital organs such as the liver and brain, improve the body's immune function, and improve the external phenotype of aging, thereby comprehensively exerting an anti-aging effect.

The present invention discloses an inquiry method and device for intelligently achieving spot bond transactions, and relates to the field of artificial intelligence technology. The method includes: obtaining the spot bond trading tasks configured for the institution, and the configured risk verification rules; based on the spot bond trading tasks, automatically talking with potential transaction objects; obtaining the corpus content during the conversation with the potential transaction object, and when determining that the other party has a clear transaction intention, confirming the transaction elements during the conversation based on the corpus content; calling the risk verification module to perform risk verification on the transaction elements, and when the risk verification passes, collecting the complete transaction elements of the transaction and generating formatted transaction details of the intended transaction; sending the formal transaction to the foreign exchange trading center platform through the quotation sending module. The present invention improves the purposefulness of automatic conversation, helps to promote the intended transaction in the inter-bank spot bond market, and greatly reduces the manual workload while controlling transaction risks.

The invention discloses an atmospheric environment intelligent monitoring system, and relates to the technical field of atmospheric monitoring, and the system comprises the following modules: a data collection module which sets a monitoring period, and obtains the hydrogen sulfide concentration in a monitoring range of a monitoring station by taking the monitoring period as a time interval; a monitoring range of a monitoring station is divided into a plurality of monitoring areas including an industrial area, a sewage area and a landfill area, and an industrial coefficient, a sewage coefficient and a landfill coefficient are obtained by combining the specific hydrogen sulfide concentration condition of each area and the hydrogen sulfide concentration condition in the whole monitoring range; therefore, the pollution source with serious hydrogen sulfide pollution can be subjected to key monitoring and rectification warning subsequently according to the industrial coefficient, the sewage coefficient and the landfill coefficient, the purposiveness and practicability of atmospheric monitoring can be improved, and the linkage of targeted intelligent management of the monitoring result and the pollution source can be improved.

The invention belongs to the technical field of electrical element wiring identification, and particularly relates to an electrical element wiring diagram identification system utilizing an image segmentation technology, which comprises the following steps of: extracting an original image quality indication and an image quality indication after electrical element segmentation by virtue of a historical identification record of an electrical element wiring diagram; therefore, the sensitive image quality indications of the electrical elements are analyzed and identified according to the fluctuation of the image quality indications, the image processing purpose can be effectively improved, the segmentation efficiency is improved to the maximum extent, and meanwhile, the segmentation duration is predicted by utilizing the electrical elements in the current electrical element wiring diagram, so that the segmentation accuracy is improved. And determining an initial segmentation sequence of the electrical elements according to a prediction result, and performing system resource detection in real time in operation according to the initial segmentation sequence, thereby dynamically adjusting the initial segmentation sequence. According to the method, self-adaptive adjustment based on the limited condition of the system resources can be realized, so that the electrical element segmentation is more in line with the actual condition of the system resources.

This invention relates to the field of permanent magnet motor design and optimization technology, specifically a high-efficiency integrated permanent magnet rotor magnetic circuit optimization design system, comprising: a configuration module, a topology generation module, an analytical calculation module, an index evaluation module, a parameter analysis module, and a scheme output module. The system generates multiple candidate magnetic circuit schemes based on initial parameters and performs rapid magnetic field analysis and comprehensive performance scoring using the equivalent magnetic circuit method. The parameter analysis module performs parameter perturbation analysis on the preferred schemes, accurately identifying the key design variables that have the most significant impact on performance; the scheme output module then iteratively optimizes these sensitive variables as the main optimization objects. This technical solution transforms traditional high-dimensional global optimization into low-dimensional directional search targeting key variables, reducing computational complexity and optimization time, effectively improving the efficiency and accuracy of permanent magnet motor rotor magnetic circuit design, and ultimately outputting optimal configuration parameters and a complete magnetic circuit design model.

This invention proposes a method for constructing and applying a structured ontology oriented towards intelligence search needs, comprising the following steps: constructing structured intelligence terms; constructing a structured intelligence ontology using these terms; and applying the constructed structured intelligence ontology. This invention can aggregate data from multiple sources to quickly mine terms and ontology data suitable for intelligence search needs; based on the constructed terms and ontology data, it can effectively enhance the purposefulness and comprehensiveness of current intelligence search and analysis, and significantly improve the efficiency of user intelligence search and analysis.

The utility model relates to the technical field of intelligence toys, and discloses an infant intelligence development toy based on a horse mark, which comprises a storage box, a plurality of first horse mark plates and a plurality of second horse mark plates, the lower end faces of the multiple first horse printing plates are fixedly connected with first limiting clamping plates correspondingly, and the multiple first limiting clamping plates are arranged in the corresponding first limiting clamping grooves in a clamped mode correspondingly. According to the utility model, through the arrangement of the two different patterns and the splicing and assembling structure, a better intellectual development effect on children can be achieved, and better development and guidance are achieved, so that the children can achieve better entertainment and cognitive learning effects when using the toy; and meanwhile, better protectiveness can be achieved through the arranged structure capable of stably placing the horse printing plate, the problem that the horse printing plate is damaged due to collision in the transferring process is solved, and better protectiveness is achieved.