37 results about "Hydroxylamine compound" patented technology

The present application relates to a kind of five-ring thiazole indole ketone piperazine amide derivatives and purposes thereof.The derivatives take ethyl cyanoacetate as starting material, generate hydroxylamine compound (A) under the action of sodium nitrite and phosphoric acid;Obtain 2-amino ethyl cyanoacetate (B) by reduction, in turn with acetic anhydride, lawson reagent is reacted, and 5-amino-4-carboxylate thiazole compound (D) is obtained;After bromination by NBS, under the catalysis of phosphorus oxychloride, react with tetrahydropyridine indole ketone, generate 2-bromo-6,7-dihydrothiazolo [5'',4'':4',5'] pyrimido [1',2':1,2] pyrindo [3,4-b] indole-4 (12H) -ketone (F), again under alkaline condition, first with Boc piperazine, then by Boc treatment and obtain compound (H);Finally, react with acyl chloride, and 28 different substitution structures of five-ring thiazole indole ketone piperazine amide compound (I1-I28) are synthesized.The 28 compounds are tested on three kinds of cancer cells, and the results show that: 28 compounds have significant inhibitory activity on Hela cervical cancer cells, HT-29 human colon cancer cells and HGC-27 human gastric cancer cells.

A process for the preparation of a compound of the sterically hindered alkoxyamine class is described, the process comprises the step of alkylating a sterically hindered hydroxylamine compound to a corresponding sterically hindered alkoxyamine by reacting said sterically hindered nitroxyl compound with a compound capable of producing a carbon-central alkyl radical, typically a territorial or secondary alkyl radical, the compounds capable of generating carbon-center alkyl radicals are selected from thermal radical initiators that form radical species in the temperature range of 40 DEG C to 200 DEG C, and from photoinitiators that undergo light excitation when irradiated with UV light or visible light in the range of 180 to 700 nm, in particular UV light in the range of 180 to 380 nm, the compounds capable of generating carbon center alkyl radicals are typically selected from the class of organic peroxides, azo compounds, benzoyl derivatives, benzophenone derivatives, thioxanthone derivatives, benzoin derivatives, benzoyl phosphine oxide derivatives, and the like. The invention relates to a peroxide, for example, selected from the group consisting of diacyl peroxides of formula (A), peracid esters of this formula (A), and oxalic acid peracid esters of formula (D) R-CO-O-O-Z-R (A), r-Z ''-X-CO-CO-O-O-Z''-R (D) wherein each R independently represents a primary or secondary alkyl or cycloalkyl group, preferably comprising from 1 to 15 carbon atoms, and X is oxygen-O-or peroxy-O-O-, Z represents CO or an alkylene group bonded to a quaternary carbon atom, the quaternary carbon atom being an alkylene group of formula (C) R '-C-R' (C), wherein each R'is selected from alkyl groups having 1 to 15 carbon atoms, and Z "represents the alkylene group bonded to a quaternary carbon atom having the formula (C). The described process produces the corresponding O-alkylated derivatives of the sterically hindered hydroxylamines, typically compounds of the class referred to as N-O-alkyl HALS, with very high selectivity and conversion and without the need for the use of catalysts, in particular metal catalysts.

The invention discloses a production method of a hexafluorophosphate product, the hexafluorophosphate product is 2-(inner-5-norbornene-2, 3-dicarboximide)-1, 1, 3, 3-tetramethylurea hexafluorophosphate, the first-step reaction of the invention comprises the following steps: preparing an intermediate from norbornene dianhydride as a raw material and a hydroxylamine compound under the action of organic alkali; in the second-step reaction, the intermediate and TCFH are subjected to a nucleophilic substitution reaction under the action of an alkaline metal catalyst to obtain a crude product, and the crude product is purified to obtain a target product; the synthesis route used in the invention is simple, special high temperature or high pressure is not needed in the reaction process, and the used catalyst is a conventional raw material which is low in price and easy to obtain; according to the method, the purity of the product can be increased to 99.8% or above, the total yield is stabilized to be 85% or above, in addition, the reaction route greatly reduces side reactions, and by-products in the product are few in variety and low in content.

The present invention discloses a method for preparing a vortioxetine metabolite, comprising the following steps: dissolving compound I (vortioxetine) in an organic solvent, adding a hydroxylamine compound, and reacting at 20-25° C. to obtain compound II. The preparation method has strong operability and reasonable process design, and can realize industrial production. In addition, the reagents used in the synthesis method are simple and easily available, and there are fewer by-products. The prepared vortioxetine metabolite has a purity of over 99%.

The present application relates to a synthesis method of ortho-aminophenylsulfonylimidate compounds, and belongs to the technical field of organic synthesis. The present application realizes the synthesis of ortho-aminophenylsulfonylimidate by a tandem rearrangement reaction of an aryl hydroxylamine compound and a sulfonylimidyl chloride without pre-functionalization, with the advantages of simplicity, high efficiency and high regioselectivity. The strategy has high universality in substrate range and good functional group compatibility, and has important significance for the further development and application of the strategy in the fields of agricultural chemistry, life science and medicine science.

The invention provides a preparation method of an environment-friendly antibacterial uranium extraction polyacrylonitrile fiber, and belongs to the technical field of uranium extraction. The preparation method comprises the following steps: preparing quaternized chitosan with the substitution degree of 50-90% from a quaternary ammonium salt cationic etherifying agent and chitosan; enabling the quaternized chitosan to react with the polyacrylonitrile fiber to obtain the quaternized chitosan modified polyacrylonitrile fiber with the grafting rate of 1 to 40 percent; and reacting the quaternized chitosan modified polyacrylonitrile fiber with a hydroxylamine compound to prepare the environment-friendly antibacterial uranium extraction polyacrylonitrile fiber with an amidoximation grafting rate of 10-45%. According to the method, quaternized chitosan is used as an antibacterial agent and amidoxime is used as an adsorbent to be introduced into polyacrylonitrile fibers by adopting a simple, convenient, efficient and low-cost normal-pressure modification method, so that the method has a good antibacterial effect and high uranium adsorption efficiency in a full pH value range, and is environment-friendly.

An electroless ruthenium plating bath contains at least a ruthenium compound, a reducing agent, and a stabilizer. The reducing agent is hydrazines. The stabilizer includes a hydroxylamine compound and an organic compound having a hydroxyl group. The hydroxylamine compound is either or both of hydroxylamine sulfate and hydroxylamine chloride. The organic compound having a hydroxyl group is at least one selected from the group consisting of gluconolactone, sorbitol, mannitol, and citric acid monohydrate.

The present invention relates to an asphalt additive using a hydroxylamine compound or a salt thereof, an asphalt composition comprising the same, and an asphalt mixture comprising the same, the asphalt composition and the asphalt mixture of the present invention, by comprising the asphalt additive of the present invention, not only can surprisingly improve the mixability with aggregates, water resistance, and warm-mixing performance, but also do not have the ammonia odor generated by the existing additives, thus the workability and environmental properties are greatly improved.

The invention discloses a preparation method of a polyfluorinated arylamine compound, and belongs to the technical field of chemical synthesis. The method comprises the following steps: by taking polyfluoroaryl zinc carboxylate as a raw material or a reaction system consisting of polyfluoroaryl carboxylic acid and zinc hydroxide as a raw material, mixing the raw material with an O-benzoyl hydroxylamine compound, and reacting in a solvent at 40-100 DEG C for 8-14 hours under the synergistic effect of a copper-based catalyst and a bipyridine / phenanthroline ligand, the polyfluorinated arylamine compound is efficiently prepared through decarboxylation and C-N coupling reaction. The process does not need strong base and harsh anhydrous and anaerobic conditions, can be compatible with substrates containing various substituent groups such as bromine, phenyl, methoxyl and the like, has the target product yield of 54-82%, has the advantages of wide substrate universality, mild reaction conditions, simplicity and convenience in operation, controllable cost and the like, and provides an efficient and feasible solution for large-scale production in the fields of medicines and materials.

The application provides a deoxidizing agent suitable for medium and high pressure boilers and a preparation method thereof, wherein the deoxidizing agent contains the following raw materials in parts by weight: 20-40 parts of an organic reducing agent, 10-20 parts of an amino heterocyclic compound, 4-8 parts of a hydroxylamine compound, 2-8 parts of a dispersing agent, 3-6 parts of a neutralizing agent, 2-6 parts of modified sodium alginate, 1-3 parts of modified lignin and 20-40 parts of deionized water. The deoxidizing agent is high-temperature resistant, has outstanding dissolved oxygen removal capacity, is suitable for a medium and high pressure boiler water supply system, has a corrosion prevention effect, solves the corrosion problem of boilers, pipelines and heat exchangers, and is environmentally friendly, safe, almost non-toxic and harmless, and has a good market prospect.

A method, reaction system, and product for preparing dihydroxypropyl hydroxylamine are disclosed. The method includes the following steps: S1, dissolving dihydroxypropylamine in a carboxylic acid with or without an organic solvent by stirring; S2, mixing with an aqueous hydrogen peroxide solution, where the hydrogen peroxide and dihydroxypropylamine undergo an oxidation reaction; S3, subjecting the resulting product to vacuum distillation to remove the organic solvent and carboxylic acid, thereby obtaining the dihydroxypropyl hydroxylamine product. The method provided by this invention requires only one reaction step to prepare dihydroxypropyl hydroxylamine, and features high reaction yield, easy product purification, high purity of the obtained dihydroxypropyl hydroxylamine product, and readily available and inexpensive raw materials.

The invention provides a method for converting secondary amine in a desulfurization solution into tertiary amine, and belongs to the technical field of desulfurization solution treatment. According to the method, firstly, an adsorbent is adopted to adsorb aldehydes, so that aldehyde carbonyl carbon atoms are attached to the adsorbent, then a metamorphic MDEA solution containing MMEA and DEA flows through the adsorbent which adsorbs aldehydes, alpha-hydroxylamine compounds are formed, metamorphic products MMEA and DEA are converted in the process, it is guaranteed that the active component MDEA is not changed, and meanwhile new impurities are not introduced into the solution; according to the method, the modified MDEA solution is used as a raw material, alpha-hydroxylamine compounds in the MDEA solution are further treated by adopting strong acid type cation exchange resin, the alpha-hydroxylamine compounds are further converted into tertiary amine which slowly absorbs CO2, and acid is not introduced into the MDEA solution, so that the desulfurization performance of the treated modified MDEA solution is recovered to the level of a fresh MDEA solution.

The application discloses a method for efficiently synthesizing a full-carbon quaternary carbon stereogenic center compound by using nickel-catalyzed asymmetric amination. The method comprises the following steps: under the catalysis of a nickel catalyst, an alpha,alpha-dimethylamide compound is reacted with an O-benzoyl hydroxylamine compound in an organic solvent in the presence of an inorganic base, an additive, a molecular sieve and binaphthyl in a 60 DEG C environment for 24 hours or 36 hours, and then the amination product is separated by thin layer silica gel plate chromatography purification; the method has the advantages of mild reaction condition, cheap and easily obtained catalyst, simple process and convenient operation; the amine group can be directly introduced into the alpha,alpha-dimethylamide substrate, and the amination product containing the full-carbon quaternary carbon stereogenic center can be obtained with high stereoselectivity.

The invention belongs to the field of chemical synthesis, and particularly relates to a hydroxylamine compound containing an aryl allyl structure as well as a synthesis method and application of the hydroxylamine compound. The structure of the hydroxylamine compound is shown as a formula (I), and in the formula (I), R1 is selected from unsubstituted alkyl, cycloalkyl, naphthyl, heteroaryl or substituted or unsubstituted phenyl; r2 is selected from substituted or unsubstituted phenyl; the synthesis method comprises the following steps: by taking nitrone and boric acid as raw materials, efficiently synthesizing through a boron migration reaction under the catalysis of R-1, 1 '-co-2-naphthol. The synthesis method has the characteristics that a metal catalyst is not needed, the operation is simple and convenient, the organic boric acid is easy to obtain and environment-friendly, the reaction condition is mild, the substrate application range is wide, the yield is medium to good and the like, and a new thought is provided for synthesis of the hydroxylamine compound. In-vitro experiments show that the compound has remarkable proliferation inhibition activity on A549, HeLa and MV-411 tumor cells, and has the development potential of antitumor drugs.

The application discloses acrylic modified silicone oil and a preparation method thereof, and the method comprises the following steps: subjecting an allyl-containing acrylate to a Michael addition reaction with a secondary amine to obtain an N,N-dialkyl-beta-alanine ester containing an allyl group; subjecting the N,N-dialkyl-beta-alanine ester containing the allyl group to a hydrosilylation reaction with a hydrogen-containing silicone oil in the presence of a platinum gold catalyst to obtain a tertiary amino modified silicone oil; subjecting the tertiary amino modified silicone oil to a reaction with an oxidant to generate an amine oxide modified silicone oil; and subjecting the amine oxide modified silicone oil to heating to undergo Cope elimination, and removing a hydroxylamine compound to obtain the acrylic modified silicone oil. The preparation method of the application effectively solves the problems of crosslinking gelation and wide molecular weight distribution in the direct hydrosilylation method through amine protection and oxidation elimination strategies, and simultaneously avoids the introduction of chloride ions in the acid chloride method and the complex equipment requirement in the ester exchange method.

The invention relates to the technical field of medicine synthesis, in particular to a C3-site oxime ester steroid alkaloid derivative as well as a synthesis method and application thereof. A steroid compound epiandrosterone is used as an initial raw material, a C3-position keto compound is obtained through Wittig alkylenation reaction and oxidation, the C3-position keto compound reacts with hydroxylamine hydrochloride to obtain a hydroxylamine compound, and the hydroxylamine compound reacts with acyl chloride to obtain a series of oxime ester derivatives. The C3-site oxime ester steroid alkaloid derivative provided by the invention has remarkable anti-inflammatory and anti-gastric ulcer activity, and provides a scientific basis for searching novel anti-inflammatory and anti-gastric ulcer lead compounds with high selectivity and safety and developing novel anti-inflammatory and anti-gastric ulcer medicines.

The invention discloses porous spherical vanadium pentoxide as well as a preparation method and application thereof, and belongs to the technical field of batteries. The method comprises the following steps: (1) mixing a vanadium source and a hydroxylamine compound, adding the mixture into deionized water, and stirring to obtain a blue vanadium-containing solution; (2) adjusting the pH value of the vanadium-containing solution to 6.2-8 by using alkali liquor, and reacting at room temperature to obtain a vanadium-based spherical precursor; and (3) drying the vanadium-based spherical precursor, and calcining the dried vanadium-based spherical precursor to obtain porous spherical vanadium pentoxide. The synthesis route is simple and convenient, the energy consumption is low, the consumed time is short, the preparation yield is high, and the prepared spherical vanadium pentoxide has rich pore structures and can be used as an aqueous zinc ion battery positive electrode material and a lithium ion battery positive electrode material, so that the specific capacity and the cycling stability of the battery are improved.

The present invention addresses the problem of providing a cleaning agent composition for semiconductor devices, which has excellent long-term stability of the ability to remove organic residues and also has excellent corrosion resistance to metal layers. This cleaning agent composition for semiconductor devices contains: one or more hydroxylamine compounds selected from the group consisting of hydroxylamine and hydroxylamine salts; one or more chelating agents selected from the group consisting of carboxylic acid-based chelating agents other than polyaminocarboxylic acids and phosphonic acid-based chelating agents; and a benzotriazole compound.

The present invention addresses the problem of providing a cleaning agent composition for semiconductor devices, which has excellent long-term stability of the ability to remove organic residues and also has excellent corrosion resistance to metal layers. This cleaning agent composition for semiconductor devices contains: one or more hydroxylamine compounds selected from the group consisting of hydroxylamine and hydroxylamine salts; one or more chelating agents selected from the group consisting of carboxylic acid-based chelating agents other than polyaminocarboxylic acids and phosphonic acid-based chelating agents; and a benzotriazole compound.

The present invention addresses the problem of providing a cleaning agent composition for semiconductor devices, which has excellent long-term stability of the ability to remove organic residues and also has excellent corrosion resistance to metal layers. This cleaning agent composition for semiconductor devices contains: one or more hydroxylamine compounds selected from the group consisting of hydroxylamine and hydroxylamine salts; one or more chelating agents selected from the group consisting of carboxylic acid-based chelating agents other than polyaminocarboxylic acids and phosphonic acid-based chelating agents; and a benzotriazole compound.

The invention relates to a tricyclic thiazolo [5, 4-d] pyrimidone amine derivative and application thereof.The preparation method comprises the steps that ethyl cyanoacetate serves as a raw material, a hydroxylamine compound (A) is generated under the action of sodium nitrite and phosphoric acid, 2-amino ethyl cyanoacetate (B) is obtained through reduction, the 2-amino ethyl cyanoacetate (B) is subjected to a reaction with acetic anhydride and Lawson to obtain a 5-amino-4-formate thiazole compound (D), and the 5-amino-4-formate thiazole compound (D) is subjected to a reaction with acetic anhydride and Lawson to obtain the tricyclic thiazolo [5, 4-d] pyrimidone amine derivative. The preparation method comprises the following steps: under the action of phosphorus oxychloride, obtaining a 2-bromo-pyrroline [1, 2-a] thiazolo [5, 4-d] pyrimidinone compound (F), a 2-bromine-7, 8-dihydro-5H-pyridine [1, 2-a] thiazolo [5, 4-d] pyrimidine-10 (6H) ketone derivative (G) and a 2-bromine-6, 7, 8, 9-tetrahydrothiazolo [5 ', 4': 4, 5] pyrimidino [1, 2-a] azepine-11 (5H)-ketone (H); 36 different substituted tricyclic thiazolopyrimidinone amine compounds F1-F12, G1-G12 and H1-H12 are obtained under the action of alkali, and the inhibitory activity of the 36 compounds on cancer cells is investigated.

The purpose of the present invention is to provide an electroless ruthenium plating bath in which hydrazine is used as a reducing agent, said electroless ruthenium plating bath being capable of improving bath stability, having excellent ruthenium deposition properties, and being capable of suppressing shrinkage of a coating film during annealing treatment. The electroless ruthenium plating bath at least contains a ruthenium compound, a reducing agent and a stabilizing agent, the reducing agent is hydrazine, the stabilizing agent is composed of a hydroxylamine compound and an organic compound with hydroxyl, and the hydroxylamine compound is at least one of hydroxylamine sulfate and hydroxylamine chloride; the organic compound having a hydroxyl group is at least one selected from the group consisting of gluconolactone, sorbitol, mannitol, and citric acid monohydrate.

The present invention addresses the problem of providing a cleaning agent composition for semiconductor devices, which has excellent long-term stability of the ability to remove organic residues and also has excellent corrosion resistance to metal layers. This cleaning agent composition for semiconductor devices contains: one or more hydroxylamine compounds selected from the group consisting of hydroxylamine and hydroxylamine salts; one or more chelating agents selected from the group consisting of carboxylic acid-based chelating agents other than polyaminocarboxylic acids and phosphonic acid-based chelating agents; and a benzotriazole compound.

The invention provides a light-promoted non-activated secondary amine nitrogen atom deletion method which specifically comprises the following steps: adding secondary amine, a hydroxylamine compound, alkali and a solvent into a solvent, and carrying out a nitrogen atom removal reaction under light promotion to generate a compound which does not contain nitrogen atoms compared with a reactant; the reactant is secondary amine; the light-promoted nitrogen atom deletion reaction of the non-activated secondary amine is realized for the first time, so that the secondary amine is converted into the corresponding denitrified alkane, the application range of a substrate is wide, a metal catalyst does not need to be introduced, the compatibility of functional groups and the inclusiveness of reaction conditions are strong, the method is suitable for various secondary amines, and a brand new method is provided for construction of C-C bonds. The method can be stably amplified to a gram-level scale, and has good amplification potential and industrial application prospects.

This application relates to the field of polypropylene masterbatch processing technology, and more specifically, to a medical-grade polypropylene masterbatch resistant to gamma-ray radiation color change and its preparation method. It is prepared from the following raw materials in parts by weight: 40-80 parts polypropylene carrier resin, 5-10 parts radiation-resistant composite stabilizer, 3-5 parts dispersant, 1-2 parts processing aid, and 0-5 parts pigment. The radiation-resistant composite stabilizer is composed of a non-phenolic antioxidant, an N-alkoxy hindered amine light stabilizer, and a crystallization regulator. The non-phenolic antioxidant is a benzofuranone compound and / or a hydroxylamine compound. The crystallization regulator is at least one of a sorbitol nucleating agent, liquid paraffin, and low molecular weight polyolefin wax. This formulation can improve the color stability and mechanical property retention of medical polypropylene products, prevent embrittlement during storage, and meet the stringent requirements of medical devices for high transparency, high toughness, and long-term storage stability.

The application discloses a method for preparing dihydroxypropyl hydroxylamine, which comprises the following steps: S1, mixing a hydrogen peroxide solution and an anhydride to obtain an oxidizing solution; S2, mixing dihydroxypropyl amine with a solvent, and adding the oxidizing solution in S1 to perform an oxidation reaction; and S3, contacting the obtained oxidation product with an extraction solvent to perform solvent extraction, obtaining an extraction liquid which is the anhydride and the organic solvent, and obtaining a raffinate which is the hydrophilic solvent and the dihydroxypropyl hydroxylamine, wherein the raffinate is subjected to vacuum distillation to remove the hydrophilic solvent, and then dihydroxypropyl hydroxylamine product is obtained. The method uses the anhydride and the hydrogen peroxide as oxidants, and uses dihydroxypropyl amine as raw material, and only one step is needed to prepare the dihydroxypropyl hydroxylamine compound, the raw material is cheap and easy to obtain, the reaction yield is high, the product is easy to purify, and the dihydroxypropyl hydroxylamine product obtained is high in purity.

The present invention addresses the problem of providing a cleaning agent composition for semiconductor devices, which has excellent long-term stability of the ability to remove organic residues and also has excellent corrosion resistance to metal layers. This cleaning agent composition for semiconductor devices contains: one or more hydroxylamine compounds selected from the group consisting of hydroxylamine and hydroxylamine salts; one or more chelating agents selected from the group consisting of carboxylic acid-based chelating agents other than polyaminocarboxylic acids and phosphonic acid-based chelating agents; and a benzotriazole compound.

The application discloses a method for adjusting the valence state of vanadium ions in a solution, which comprises the following steps: (1) adding a hydroxylamine compound into a vanadium-containing solution and reacting; (2) adding an acid into the solution obtained in the step (1) and reacting to obtain a tetravalent vanadium ion solution. The method of the application uses a hydroxylamine compound as an adjusting agent, adjusts the pH value of the solution by adding an acid, and unifies the solution containing vanadium ions with any valence state into a tetravalent vanadium solution. The method can be applied to a solution containing vanadium ions with any valence state, especially a vanadium-containing solution with unknown valence state composition or a solution possibly containing vanadium ions with different valence states. The method does not need to detect and quantitatively analyze the valence state and valence state composition of vanadium ions in the solution in advance, and unifies the vanadium ions with any valence state in the solution into tetravalent vanadium ions. The existing form of vanadium ions in the final solution is only tetravalent.

The invention discloses an alpha-tertiary primary amine direct deamination and halogenation method, a halogenated compound and application, and belongs to the technical field of organic synthesis.The alpha-tertiary primary amine direct deamination and halogenation method comprises the steps that alpha-tertiary primary amine, alkali, a halogenation reagent, a hydroxylamine compound and a solvent are mixed and heated for a deamination and functionalization reaction, and a halogenated compound is obtained; a halogenated compound containing a C (sp3)-X bond is generated, and X is chlorine, bromine or iodine. The method has the advantages of being wide in substrate range, mild in condition, simple and convenient to operate, easy to amplify and the like, can be widely applied to later-stage structure modification of drug molecules, and provides a novel efficient synthesis path for development of halogen-containing drug candidate compounds.

The invention provides a phosphate-amidoxime synergistic functional cellulose adsorbent as well as a preparation method and application thereof, and belongs to the field of sewage treatment and environmental protection. The preparation method comprises the following steps: firstly, enabling a nitrile compound to react with cellulose, and introducing cyano into the cellulose; then hydroxylamine compounds and alkali react with cyanoethyl cellulose to obtain amidoxime group modified cellulose, and finally phosphorylation reaction is performed to obtain the phosphate group-amidoxime group synergistic functional cellulose. The amidoxime group and the phosphate group are introduced into the cellulose through the three-step reaction, the reaction condition is mild, the process is controllable, the operation is simple, and large-scale production is easy to realize. The phosphate group-amidoxime group synergistic functional cellulose is prepared by the method provided by the invention, and amidoxime group and phosphate group in the prepared cellulose adsorbent are coordinated synergistically, so that the coordination capability of the adsorbent and uranium ions is greatly improved.