23 results about "Hydroxylamine compound" patented technology

The present application relates to a kind of five-ring thiazole indole ketone piperazine amide derivatives and purposes thereof.The derivatives take ethyl cyanoacetate as starting material, generate hydroxylamine compound (A) under the action of sodium nitrite and phosphoric acid;Obtain 2-amino ethyl cyanoacetate (B) by reduction, in turn with acetic anhydride, lawson reagent is reacted, and 5-amino-4-carboxylate thiazole compound (D) is obtained;After bromination by NBS, under the catalysis of phosphorus oxychloride, react with tetrahydropyridine indole ketone, generate 2-bromo-6,7-dihydrothiazolo [5'',4'':4',5'] pyrimido [1',2':1,2] pyrindo [3,4-b] indole-4 (12H) -ketone (F), again under alkaline condition, first with Boc piperazine, then by Boc treatment and obtain compound (H);Finally, react with acyl chloride, and 28 different substitution structures of five-ring thiazole indole ketone piperazine amide compound (I1-I28) are synthesized.The 28 compounds are tested on three kinds of cancer cells, and the results show that: 28 compounds have significant inhibitory activity on Hela cervical cancer cells, HT-29 human colon cancer cells and HGC-27 human gastric cancer cells.

A process for the preparation of a compound of the sterically hindered alkoxyamine class is described, the process comprises the step of alkylating a sterically hindered hydroxylamine compound to a corresponding sterically hindered alkoxyamine by reacting said sterically hindered nitroxyl compound with a compound capable of producing a carbon-central alkyl radical, typically a territorial or secondary alkyl radical, the compounds capable of generating carbon-center alkyl radicals are selected from thermal radical initiators that form radical species in the temperature range of 40 DEG C to 200 DEG C, and from photoinitiators that undergo light excitation when irradiated with UV light or visible light in the range of 180 to 700 nm, in particular UV light in the range of 180 to 380 nm, the compounds capable of generating carbon center alkyl radicals are typically selected from the class of organic peroxides, azo compounds, benzoyl derivatives, benzophenone derivatives, thioxanthone derivatives, benzoin derivatives, benzoyl phosphine oxide derivatives, and the like. The invention relates to a peroxide, for example, selected from the group consisting of diacyl peroxides of formula (A), peracid esters of this formula (A), and oxalic acid peracid esters of formula (D) R-CO-O-O-Z-R (A), r-Z ''-X-CO-CO-O-O-Z''-R (D) wherein each R independently represents a primary or secondary alkyl or cycloalkyl group, preferably comprising from 1 to 15 carbon atoms, and X is oxygen-O-or peroxy-O-O-, Z represents CO or an alkylene group bonded to a quaternary carbon atom, the quaternary carbon atom being an alkylene group of formula (C) R '-C-R' (C), wherein each R'is selected from alkyl groups having 1 to 15 carbon atoms, and Z "represents the alkylene group bonded to a quaternary carbon atom having the formula (C). The described process produces the corresponding O-alkylated derivatives of the sterically hindered hydroxylamines, typically compounds of the class referred to as N-O-alkyl HALS, with very high selectivity and conversion and without the need for the use of catalysts, in particular metal catalysts.

The invention discloses a production method of a hexafluorophosphate product, the hexafluorophosphate product is 2-(inner-5-norbornene-2, 3-dicarboximide)-1, 1, 3, 3-tetramethylurea hexafluorophosphate, the first-step reaction of the invention comprises the following steps: preparing an intermediate from norbornene dianhydride as a raw material and a hydroxylamine compound under the action of organic alkali; in the second-step reaction, the intermediate and TCFH are subjected to a nucleophilic substitution reaction under the action of an alkaline metal catalyst to obtain a crude product, and the crude product is purified to obtain a target product; the synthesis route used in the invention is simple, special high temperature or high pressure is not needed in the reaction process, and the used catalyst is a conventional raw material which is low in price and easy to obtain; according to the method, the purity of the product can be increased to 99.8% or above, the total yield is stabilized to be 85% or above, in addition, the reaction route greatly reduces side reactions, and by-products in the product are few in variety and low in content.

The invention provides a preparation method of an environment-friendly antibacterial uranium extraction polyacrylonitrile fiber, and belongs to the technical field of uranium extraction. The preparation method comprises the following steps: preparing quaternized chitosan with the substitution degree of 50-90% from a quaternary ammonium salt cationic etherifying agent and chitosan; enabling the quaternized chitosan to react with the polyacrylonitrile fiber to obtain the quaternized chitosan modified polyacrylonitrile fiber with the grafting rate of 1 to 40 percent; and reacting the quaternized chitosan modified polyacrylonitrile fiber with a hydroxylamine compound to prepare the environment-friendly antibacterial uranium extraction polyacrylonitrile fiber with an amidoximation grafting rate of 10-45%. According to the method, quaternized chitosan is used as an antibacterial agent and amidoxime is used as an adsorbent to be introduced into polyacrylonitrile fibers by adopting a simple, convenient, efficient and low-cost normal-pressure modification method, so that the method has a good antibacterial effect and high uranium adsorption efficiency in a full pH value range, and is environment-friendly.

An electroless ruthenium plating bath contains at least a ruthenium compound, a reducing agent, and a stabilizer. The reducing agent is hydrazines. The stabilizer includes a hydroxylamine compound and an organic compound having a hydroxyl group. The hydroxylamine compound is either or both of hydroxylamine sulfate and hydroxylamine chloride. The organic compound having a hydroxyl group is at least one selected from the group consisting of gluconolactone, sorbitol, mannitol, and citric acid monohydrate.

The invention discloses a preparation method of a polyfluorinated arylamine compound, and belongs to the technical field of chemical synthesis. The method comprises the following steps: by taking polyfluoroaryl zinc carboxylate as a raw material or a reaction system consisting of polyfluoroaryl carboxylic acid and zinc hydroxide as a raw material, mixing the raw material with an O-benzoyl hydroxylamine compound, and reacting in a solvent at 40-100 DEG C for 8-14 hours under the synergistic effect of a copper-based catalyst and a bipyridine / phenanthroline ligand, the polyfluorinated arylamine compound is efficiently prepared through decarboxylation and C-N coupling reaction. The process does not need strong base and harsh anhydrous and anaerobic conditions, can be compatible with substrates containing various substituent groups such as bromine, phenyl, methoxyl and the like, has the target product yield of 54-82%, has the advantages of wide substrate universality, mild reaction conditions, simplicity and convenience in operation, controllable cost and the like, and provides an efficient and feasible solution for large-scale production in the fields of medicines and materials.

The application provides a deoxidizing agent suitable for medium and high pressure boilers and a preparation method thereof, wherein the deoxidizing agent contains the following raw materials in parts by weight: 20-40 parts of an organic reducing agent, 10-20 parts of an amino heterocyclic compound, 4-8 parts of a hydroxylamine compound, 2-8 parts of a dispersing agent, 3-6 parts of a neutralizing agent, 2-6 parts of modified sodium alginate, 1-3 parts of modified lignin and 20-40 parts of deionized water. The deoxidizing agent is high-temperature resistant, has outstanding dissolved oxygen removal capacity, is suitable for a medium and high pressure boiler water supply system, has a corrosion prevention effect, solves the corrosion problem of boilers, pipelines and heat exchangers, and is environmentally friendly, safe, almost non-toxic and harmless, and has a good market prospect.

A method, reaction system, and product for preparing dihydroxypropyl hydroxylamine are disclosed. The method includes the following steps: S1, dissolving dihydroxypropylamine in a carboxylic acid with or without an organic solvent by stirring; S2, mixing with an aqueous hydrogen peroxide solution, where the hydrogen peroxide and dihydroxypropylamine undergo an oxidation reaction; S3, subjecting the resulting product to vacuum distillation to remove the organic solvent and carboxylic acid, thereby obtaining the dihydroxypropyl hydroxylamine product. The method provided by this invention requires only one reaction step to prepare dihydroxypropyl hydroxylamine, and features high reaction yield, easy product purification, high purity of the obtained dihydroxypropyl hydroxylamine product, and readily available and inexpensive raw materials.

The invention provides a method for converting secondary amine in a desulfurization solution into tertiary amine, and belongs to the technical field of desulfurization solution treatment. According to the method, firstly, an adsorbent is adopted to adsorb aldehydes, so that aldehyde carbonyl carbon atoms are attached to the adsorbent, then a metamorphic MDEA solution containing MMEA and DEA flows through the adsorbent which adsorbs aldehydes, alpha-hydroxylamine compounds are formed, metamorphic products MMEA and DEA are converted in the process, it is guaranteed that the active component MDEA is not changed, and meanwhile new impurities are not introduced into the solution; according to the method, the modified MDEA solution is used as a raw material, alpha-hydroxylamine compounds in the MDEA solution are further treated by adopting strong acid type cation exchange resin, the alpha-hydroxylamine compounds are further converted into tertiary amine which slowly absorbs CO2, and acid is not introduced into the MDEA solution, so that the desulfurization performance of the treated modified MDEA solution is recovered to the level of a fresh MDEA solution.

The invention belongs to the field of chemical synthesis, and particularly relates to a hydroxylamine compound containing an aryl allyl structure as well as a synthesis method and application of the hydroxylamine compound. The structure of the hydroxylamine compound is shown as a formula (I), and in the formula (I), R1 is selected from unsubstituted alkyl, cycloalkyl, naphthyl, heteroaryl or substituted or unsubstituted phenyl; r2 is selected from substituted or unsubstituted phenyl; the synthesis method comprises the following steps: by taking nitrone and boric acid as raw materials, efficiently synthesizing through a boron migration reaction under the catalysis of R-1, 1 '-co-2-naphthol. The synthesis method has the characteristics that a metal catalyst is not needed, the operation is simple and convenient, the organic boric acid is easy to obtain and environment-friendly, the reaction condition is mild, the substrate application range is wide, the yield is medium to good and the like, and a new thought is provided for synthesis of the hydroxylamine compound. In-vitro experiments show that the compound has remarkable proliferation inhibition activity on A549, HeLa and MV-411 tumor cells, and has the development potential of antitumor drugs.

The invention relates to the technical field of medicine synthesis, in particular to a C3-site oxime ester steroid alkaloid derivative as well as a synthesis method and application thereof. A steroid compound epiandrosterone is used as an initial raw material, a C3-position keto compound is obtained through Wittig alkylenation reaction and oxidation, the C3-position keto compound reacts with hydroxylamine hydrochloride to obtain a hydroxylamine compound, and the hydroxylamine compound reacts with acyl chloride to obtain a series of oxime ester derivatives. The C3-site oxime ester steroid alkaloid derivative provided by the invention has remarkable anti-inflammatory and anti-gastric ulcer activity, and provides a scientific basis for searching novel anti-inflammatory and anti-gastric ulcer lead compounds with high selectivity and safety and developing novel anti-inflammatory and anti-gastric ulcer medicines.

The purpose of the present invention is to provide an electroless ruthenium plating bath in which hydrazine is used as a reducing agent, said electroless ruthenium plating bath being capable of improving bath stability, having excellent ruthenium deposition properties, and being capable of suppressing shrinkage of a coating film during annealing treatment. The electroless ruthenium plating bath at least contains a ruthenium compound, a reducing agent and a stabilizing agent, the reducing agent is hydrazine, the stabilizing agent is composed of a hydroxylamine compound and an organic compound with hydroxyl, and the hydroxylamine compound is at least one of hydroxylamine sulfate and hydroxylamine chloride; the organic compound having a hydroxyl group is at least one selected from the group consisting of gluconolactone, sorbitol, mannitol, and citric acid monohydrate.

The invention provides a light-promoted non-activated secondary amine nitrogen atom deletion method which specifically comprises the following steps: adding secondary amine, a hydroxylamine compound, alkali and a solvent into a solvent, and carrying out a nitrogen atom removal reaction under light promotion to generate a compound which does not contain nitrogen atoms compared with a reactant; the reactant is secondary amine; the light-promoted nitrogen atom deletion reaction of the non-activated secondary amine is realized for the first time, so that the secondary amine is converted into the corresponding denitrified alkane, the application range of a substrate is wide, a metal catalyst does not need to be introduced, the compatibility of functional groups and the inclusiveness of reaction conditions are strong, the method is suitable for various secondary amines, and a brand new method is provided for construction of C-C bonds. The method can be stably amplified to a gram-level scale, and has good amplification potential and industrial application prospects.

This application relates to the field of polypropylene masterbatch processing technology, and more specifically, to a medical-grade polypropylene masterbatch resistant to gamma-ray radiation color change and its preparation method. It is prepared from the following raw materials in parts by weight: 40-80 parts polypropylene carrier resin, 5-10 parts radiation-resistant composite stabilizer, 3-5 parts dispersant, 1-2 parts processing aid, and 0-5 parts pigment. The radiation-resistant composite stabilizer is composed of a non-phenolic antioxidant, an N-alkoxy hindered amine light stabilizer, and a crystallization regulator. The non-phenolic antioxidant is a benzofuranone compound and / or a hydroxylamine compound. The crystallization regulator is at least one of a sorbitol nucleating agent, liquid paraffin, and low molecular weight polyolefin wax. This formulation can improve the color stability and mechanical property retention of medical polypropylene products, prevent embrittlement during storage, and meet the stringent requirements of medical devices for high transparency, high toughness, and long-term storage stability.

The application discloses a method for adjusting the valence state of vanadium ions in a solution, which comprises the following steps: (1) adding a hydroxylamine compound into a vanadium-containing solution and reacting; (2) adding an acid into the solution obtained in the step (1) and reacting to obtain a tetravalent vanadium ion solution. The method of the application uses a hydroxylamine compound as an adjusting agent, adjusts the pH value of the solution by adding an acid, and unifies the solution containing vanadium ions with any valence state into a tetravalent vanadium solution. The method can be applied to a solution containing vanadium ions with any valence state, especially a vanadium-containing solution with unknown valence state composition or a solution possibly containing vanadium ions with different valence states. The method does not need to detect and quantitatively analyze the valence state and valence state composition of vanadium ions in the solution in advance, and unifies the vanadium ions with any valence state in the solution into tetravalent vanadium ions. The existing form of vanadium ions in the final solution is only tetravalent.

The invention provides a phosphate-amidoxime synergistic functional cellulose adsorbent as well as a preparation method and application thereof, and belongs to the field of sewage treatment and environmental protection. The preparation method comprises the following steps: firstly, enabling a nitrile compound to react with cellulose, and introducing cyano into the cellulose; then hydroxylamine compounds and alkali react with cyanoethyl cellulose to obtain amidoxime group modified cellulose, and finally phosphorylation reaction is performed to obtain the phosphate group-amidoxime group synergistic functional cellulose. The amidoxime group and the phosphate group are introduced into the cellulose through the three-step reaction, the reaction condition is mild, the process is controllable, the operation is simple, and large-scale production is easy to realize. The phosphate group-amidoxime group synergistic functional cellulose is prepared by the method provided by the invention, and amidoxime group and phosphate group in the prepared cellulose adsorbent are coordinated synergistically, so that the coordination capability of the adsorbent and uranium ions is greatly improved.

The invention relates to the technical field of preparation of amidoxime chelate resin, in particular to a method for preparing amidoxime chelate resin based on ternary polymerization and the amidoxime chelate resin. The method comprises the following steps: mixing a cross-linking agent, a functional monomer and a polar monomer containing a nitrile group to obtain a mixed raw material; carrying out suspension polymerization reaction on the mixed raw material by using a composite pore-foaming agent and an initiator to obtain a precursor; mixing an ethanol solvent, a sodium ethoxide catalyst and a bidentate bridging agent to obtain a bridging system; carrying out bridging reaction on the precursor by using a bridging system to obtain a bridging densification intermediate; and in an alkaline environment, carrying out amidoximation reaction on a hydroxylamine compound and the bridging densification intermediate to obtain the amidoxime chelate resin. According to the method, the amidoxime chelate resin has the dual advantages of high mass transfer efficiency and long cycle life through the collaborative design of pore structure pre-construction, mechanical strength reinforcement and uniform loading of functional groups.

This invention discloses a method for preparing hydroxylamine compounds by reducing nitroketone compounds without a metal catalyst. This method uses benzylsilane as a hydrogen source and toluene as a solvent, requiring no additional metal catalyst. The reduction product is obtained by stirring the reaction at 70–80°C under inert gas protection and a closed system. This invention employs a metal catalyst-free system for the reduction of nitroketone compounds, offering advantages such as low cost, mild reaction conditions, and high selectivity. It avoids the use of special equipment such as hydrogen and autoclaves, as well as excessive sodium borohydride reducing agents.

The application provides an On-DNA-gamma-hydroxylamine compound and a preparation method thereof, and belongs to the field of gene coding compound library construction. The On-DNA-gamma-hydroxylamine compound is a compound shown in formula I. The method for synthesizing the On-DNA-gamma-hydroxylamine compound has small DNA damage, good universality, simple operation and mild conditions. The On-DNA-gamma-hydroxylamine compound has high yield, and the DNA integrity in the product is good. The application enriches the chemical reaction type for synthesizing the coding compound library on DNA, establishes a method for constructing a gene coding compound library with a new gamma-hydroxylamine skeleton, and has a very good application prospect in lead drug development.

The application discloses vanadyl sulfate and a preparation method thereof. The preparation method comprises the following steps: adding a hydroxylamine compound into a vanadium-containing solution to react; adding acid into the obtained solution to react, so as to obtain a tetravalent vanadium ion solution; adding an alkali solution into the tetravalent vanadium ion solution to react, filtering, and obtaining a precipitate; dissolving the precipitate by using sulfuric acid to obtain a solution; evaporating and crystallizing the solution to obtain vanadyl sulfate. The method of the application uses a hydroxylamine compound as an adjusting agent, adjusts the pH value by adding acid, and adjusts the vanadium ions in the solution into tetravalent vanadium ions, which is suitable for a solution containing vanadium ions with any valence, especially a vanadium-containing solution with unknown valence composition of vanadium ions or a solution possibly containing vanadium ions with different valences, and the valence and valence composition of vanadium ions in the solution do not need to be detected and quantitatively analyzed in advance. The method of precipitating by adding alkali and then dissolving can effectively separate impurities. The method of segmental evaporation and crystallization can obtain flaky vanadyl sulfate crystals.

The present application mainly relates to the efficient synthesis of a kind of tri-substituted hydroxylamine compound by transition metal Pd catalytic C-O bond coupling.The present application realizes the one-pot reaction of tertiary chloroalkane or secondary chloroalkane and O-acyl hydroxylamine compound under the action of catalyst, ligand and base in argon atmosphere, realizes C-O bond coupling in the case of keeping the fragile N-O bond unbroken, and obtains a kind of big steric hindrance N,N,O-trialkyl substituted hydroxylamine derivative with high chemical selectivity.The present application has the characteristics of excellent chemical selectivity to construct C-O bond, simple experimental operation, wide source of raw materials, high yield, wide substrate application range and excellent functional group tolerance, and the synthesized product is suitable for being contained in drug small molecule screening library for the discovery of lead drug.