51 results about "Hydroxylamine compound" patented technology

The invention discloses application of a hydroxylamine compound cleaning solution. In particular to application of a hydroxylamine compound cleaning solution in cleaning plasma etched and ashed wafers. The hydroxylamine compound cleaning solution is prepared from the following components in percentage by mass: 1 to 30 percent of a hydroxylamine compound, 1 to 5 percent of a corrosion inhibitor, 0.1 to 5 percent of a chelating agent, 0.01 to 5 percent of a nonionic surfactant and 1 to 50 percent of a water-soluble organic solvent and water. The sum of the mass fractions of the components is 100%. The hydroxylamine compound cleaning fluid is safe and environment-friendly, solves the problem of high cost caused by fixed raw material sources, reduces the cost, and is safe and reliable.

The present application relates to a kind of five-ring thiazole indole ketone piperazine amide derivatives and purposes thereof.The derivatives take ethyl cyanoacetate as starting material, generate hydroxylamine compound (A) under the action of sodium nitrite and phosphoric acid;Obtain 2-amino ethyl cyanoacetate (B) by reduction, in turn with acetic anhydride, lawson reagent is reacted, and 5-amino-4-carboxylate thiazole compound (D) is obtained;After bromination by NBS, under the catalysis of phosphorus oxychloride, react with tetrahydropyridine indole ketone, generate 2-bromo-6,7-dihydrothiazolo [5'',4'':4',5'] pyrimido [1',2':1,2] pyrindo [3,4-b] indole-4 (12H) -ketone (F), again under alkaline condition, first with Boc piperazine, then by Boc treatment and obtain compound (H);Finally, react with acyl chloride, and 28 different substitution structures of five-ring thiazole indole ketone piperazine amide compound (I1-I28) are synthesized.The 28 compounds are tested on three kinds of cancer cells, and the results show that: 28 compounds have significant inhibitory activity on Hela cervical cancer cells, HT-29 human colon cancer cells and HGC-27 human gastric cancer cells.

A process for the preparation of a compound of the sterically hindered alkoxyamine class is described, the process comprises the step of alkylating a sterically hindered hydroxylamine compound to a corresponding sterically hindered alkoxyamine by reacting said sterically hindered nitroxyl compound with a compound capable of producing a carbon-central alkyl radical, typically a territorial or secondary alkyl radical, the compounds capable of generating carbon-center alkyl radicals are selected from thermal radical initiators that form radical species in the temperature range of 40 DEG C to 200 DEG C, and from photoinitiators that undergo light excitation when irradiated with UV light or visible light in the range of 180 to 700 nm, in particular UV light in the range of 180 to 380 nm, the compounds capable of generating carbon center alkyl radicals are typically selected from the class of organic peroxides, azo compounds, benzoyl derivatives, benzophenone derivatives, thioxanthone derivatives, benzoin derivatives, benzoyl phosphine oxide derivatives, and the like. The invention relates to a peroxide, for example, selected from the group consisting of diacyl peroxides of formula (A), peracid esters of this formula (A), and oxalic acid peracid esters of formula (D) R-CO-O-O-Z-R (A), r-Z ''-X-CO-CO-O-O-Z''-R (D) wherein each R independently represents a primary or secondary alkyl or cycloalkyl group, preferably comprising from 1 to 15 carbon atoms, and X is oxygen-O-or peroxy-O-O-, Z represents CO or an alkylene group bonded to a quaternary carbon atom, the quaternary carbon atom being an alkylene group of formula (C) R '-C-R' (C), wherein each R'is selected from alkyl groups having 1 to 15 carbon atoms, and Z "represents the alkylene group bonded to a quaternary carbon atom having the formula (C). The described process produces the corresponding O-alkylated derivatives of the sterically hindered hydroxylamines, typically compounds of the class referred to as N-O-alkyl HALS, with very high selectivity and conversion and without the need for the use of catalysts, in particular metal catalysts.

The present invention discloses an N-aryl-N-alkyl-O-allylhydroxylamine compound and its synthesis method. The general structural formula is as follows: The synthesis method includes the following steps: Using cheap and easily available aldehydes or ketones as starting materials, reacting with hydroxylamine hydrochloride to form oximes, and then preparing N-alkylhydroxylamines under the action of a supported metal catalyst; N-alkylhydroxylamines react with (R4-substituted) allyl bromide, etc. in the presence of a weak base to prepare N-alkyl-N-allylhydroxylamines; N-alkyl-N-allylhydroxylamines react with aryl alkyne precursors under the action of an initiator fluoride at room temperature to prepare N-aryl-N-alkyl-O-allylhydroxylamine compounds. The method of the present invention can effectively avoid the use of toxic, harmful, and explosive strong oxidants, and at the same time solve the problems of limited raw material sources, high prices, harsh reaction conditions, and low reaction selectivity in the existing synthesis methods.

The present invention addresses the problem of providing a cleaning agent composition for semiconductor devices, which has excellent long-term stability of the ability to remove organic residues and also has excellent corrosion resistance to metal layers. This cleaning agent composition for semiconductor devices contains: one or more hydroxylamine compounds selected from the group consisting of hydroxylamine and hydroxylamine salts; one or more chelating agents selected from the group consisting of carboxylic acid-based chelating agents other than polyaminocarboxylic acids and phosphonic acid-based chelating agents; and a benzotriazole compound.

The invention discloses a production method of a hexafluorophosphate product, the hexafluorophosphate product is 2-(inner-5-norbornene-2, 3-dicarboximide)-1, 1, 3, 3-tetramethylurea hexafluorophosphate, the first-step reaction of the invention comprises the following steps: preparing an intermediate from norbornene dianhydride as a raw material and a hydroxylamine compound under the action of organic alkali; in the second-step reaction, the intermediate and TCFH are subjected to a nucleophilic substitution reaction under the action of an alkaline metal catalyst to obtain a crude product, and the crude product is purified to obtain a target product; the synthesis route used in the invention is simple, special high temperature or high pressure is not needed in the reaction process, and the used catalyst is a conventional raw material which is low in price and easy to obtain; according to the method, the purity of the product can be increased to 99.8% or above, the total yield is stabilized to be 85% or above, in addition, the reaction route greatly reduces side reactions, and by-products in the product are few in variety and low in content.

The present invention discloses a method for preparing a vortioxetine metabolite, comprising the following steps: dissolving compound I (vortioxetine) in an organic solvent, adding a hydroxylamine compound, and reacting at 20-25° C. to obtain compound II. The preparation method has strong operability and reasonable process design, and can realize industrial production. In addition, the reagents used in the synthesis method are simple and easily available, and there are fewer by-products. The prepared vortioxetine metabolite has a purity of over 99%.

The present invention provides an electrochemical pre-activation detection method for identifying isomers of aromatic nitro compounds, belonging to the field of electrochemical detection. Specifically, when performing differential pulse voltammetry (DPV) electrochemical detection on isomers of aromatic nitro compounds, the isomers of aromatic nitro compounds are first electrochemically pre-activated. Electrochemical pre-activation means applying a negative potential first, and the isomers of aromatic nitro compounds are reduced to isomers of aromatic nitroso compounds. The isomers of aromatic nitroso compounds further undergo redox reactions to generate isomers of aromatic hydroxylamine compounds. When using DPV electrochemical detection for redox reactions, the peak positions of the isomers are spaced relatively far apart, thereby achieving effective identification and detection of isomers of aromatic nitro compounds.

The invention discloses a hydroxylamine compound cleaning solution. The hydroxylamine compound cleaning solution is prepared from the following components in percentage by mass: 1 to 30 percent of hydroxylamine compound, 1 to 5 percent of resist, 0.1 to 5 percent of chelating agent, 0.01 to 5 percent of nonionic surfactant, and 1 to 50 percent of water-soluble organic solvent and water, the sum of the mass fractions of the components is 100%. The hydroxylamine compound cleaning fluid has a good cleaning effect, is low in corrosivity, is safe and environment-friendly, and has a good application prospect.

The present application relates to a synthesis method of ortho-aminophenylsulfonylimidate compounds, and belongs to the technical field of organic synthesis. The present application realizes the synthesis of ortho-aminophenylsulfonylimidate by a tandem rearrangement reaction of an aryl hydroxylamine compound and a sulfonylimidyl chloride without pre-functionalization, with the advantages of simplicity, high efficiency and high regioselectivity. The strategy has high universality in substrate range and good functional group compatibility, and has important significance for the further development and application of the strategy in the fields of agricultural chemistry, life science and medicine science.

The invention provides a preparation method of an environment-friendly antibacterial uranium extraction polyacrylonitrile fiber, and belongs to the technical field of uranium extraction. The preparation method comprises the following steps: preparing quaternized chitosan with the substitution degree of 50-90% from a quaternary ammonium salt cationic etherifying agent and chitosan; enabling the quaternized chitosan to react with the polyacrylonitrile fiber to obtain the quaternized chitosan modified polyacrylonitrile fiber with the grafting rate of 1 to 40 percent; and reacting the quaternized chitosan modified polyacrylonitrile fiber with a hydroxylamine compound to prepare the environment-friendly antibacterial uranium extraction polyacrylonitrile fiber with an amidoximation grafting rate of 10-45%. According to the method, quaternized chitosan is used as an antibacterial agent and amidoxime is used as an adsorbent to be introduced into polyacrylonitrile fibers by adopting a simple, convenient, efficient and low-cost normal-pressure modification method, so that the method has a good antibacterial effect and high uranium adsorption efficiency in a full pH value range, and is environment-friendly.

An electroless ruthenium plating bath contains at least a ruthenium compound, a reducing agent, and a stabilizer. The reducing agent is hydrazines. The stabilizer includes a hydroxylamine compound and an organic compound having a hydroxyl group. The hydroxylamine compound is either or both of hydroxylamine sulfate and hydroxylamine chloride. The organic compound having a hydroxyl group is at least one selected from the group consisting of gluconolactone, sorbitol, mannitol, and citric acid monohydrate.

The present invention relates to an asphalt additive using a hydroxylamine compound or a salt thereof, an asphalt composition comprising the same, and an asphalt mixture comprising the same, the asphalt composition and the asphalt mixture of the present invention, by comprising the asphalt additive of the present invention, not only can surprisingly improve the mixability with aggregates, water resistance, and warm-mixing performance, but also do not have the ammonia odor generated by the existing additives, thus the workability and environmental properties are greatly improved.

The invention discloses a preparation method of a polyfluorinated arylamine compound, and belongs to the technical field of chemical synthesis. The method comprises the following steps: by taking polyfluoroaryl zinc carboxylate as a raw material or a reaction system consisting of polyfluoroaryl carboxylic acid and zinc hydroxide as a raw material, mixing the raw material with an O-benzoyl hydroxylamine compound, and reacting in a solvent at 40-100 DEG C for 8-14 hours under the synergistic effect of a copper-based catalyst and a bipyridine / phenanthroline ligand, the polyfluorinated arylamine compound is efficiently prepared through decarboxylation and C-N coupling reaction. The process does not need strong base and harsh anhydrous and anaerobic conditions, can be compatible with substrates containing various substituent groups such as bromine, phenyl, methoxyl and the like, has the target product yield of 54-82%, has the advantages of wide substrate universality, mild reaction conditions, simplicity and convenience in operation, controllable cost and the like, and provides an efficient and feasible solution for large-scale production in the fields of medicines and materials.

The application provides a deoxidizing agent suitable for medium and high pressure boilers and a preparation method thereof, wherein the deoxidizing agent contains the following raw materials in parts by weight: 20-40 parts of an organic reducing agent, 10-20 parts of an amino heterocyclic compound, 4-8 parts of a hydroxylamine compound, 2-8 parts of a dispersing agent, 3-6 parts of a neutralizing agent, 2-6 parts of modified sodium alginate, 1-3 parts of modified lignin and 20-40 parts of deionized water. The deoxidizing agent is high-temperature resistant, has outstanding dissolved oxygen removal capacity, is suitable for a medium and high pressure boiler water supply system, has a corrosion prevention effect, solves the corrosion problem of boilers, pipelines and heat exchangers, and is environmentally friendly, safe, almost non-toxic and harmless, and has a good market prospect.

A method, reaction system, and product for preparing dihydroxypropyl hydroxylamine are disclosed. The method includes the following steps: S1, dissolving dihydroxypropylamine in a carboxylic acid with or without an organic solvent by stirring; S2, mixing with an aqueous hydrogen peroxide solution, where the hydrogen peroxide and dihydroxypropylamine undergo an oxidation reaction; S3, subjecting the resulting product to vacuum distillation to remove the organic solvent and carboxylic acid, thereby obtaining the dihydroxypropyl hydroxylamine product. The method provided by this invention requires only one reaction step to prepare dihydroxypropyl hydroxylamine, and features high reaction yield, easy product purification, high purity of the obtained dihydroxypropyl hydroxylamine product, and readily available and inexpensive raw materials.

The invention provides a method for converting secondary amine in a desulfurization solution into tertiary amine, and belongs to the technical field of desulfurization solution treatment. According to the method, firstly, an adsorbent is adopted to adsorb aldehydes, so that aldehyde carbonyl carbon atoms are attached to the adsorbent, then a metamorphic MDEA solution containing MMEA and DEA flows through the adsorbent which adsorbs aldehydes, alpha-hydroxylamine compounds are formed, metamorphic products MMEA and DEA are converted in the process, it is guaranteed that the active component MDEA is not changed, and meanwhile new impurities are not introduced into the solution; according to the method, the modified MDEA solution is used as a raw material, alpha-hydroxylamine compounds in the MDEA solution are further treated by adopting strong acid type cation exchange resin, the alpha-hydroxylamine compounds are further converted into tertiary amine which slowly absorbs CO2, and acid is not introduced into the MDEA solution, so that the desulfurization performance of the treated modified MDEA solution is recovered to the level of a fresh MDEA solution.

The application discloses a method for efficiently synthesizing a full-carbon quaternary carbon stereogenic center compound by using nickel-catalyzed asymmetric amination. The method comprises the following steps: under the catalysis of a nickel catalyst, an alpha,alpha-dimethylamide compound is reacted with an O-benzoyl hydroxylamine compound in an organic solvent in the presence of an inorganic base, an additive, a molecular sieve and binaphthyl in a 60 DEG C environment for 24 hours or 36 hours, and then the amination product is separated by thin layer silica gel plate chromatography purification; the method has the advantages of mild reaction condition, cheap and easily obtained catalyst, simple process and convenient operation; the amine group can be directly introduced into the alpha,alpha-dimethylamide substrate, and the amination product containing the full-carbon quaternary carbon stereogenic center can be obtained with high stereoselectivity.

The invention belongs to the field of chemical synthesis, particularly relates to an N, N-disubstituted hydroxylamine compound and a synthesis method and application thereof, and provides an efficient method for reducing 1, 3-dipolar nitrone into the N, N-disubstituted hydroxylamine compound, on the basis of nitrone synthesis, nitrone is reduced by taking trichlorosilane as a reducing agent, and the N, N-disubstituted hydroxylamine compound is obtained. The hydroxylamine compound is suitable for a plurality of different substituted benzene rings or heterocyclic compounds. The synthesis method has the characteristics of high efficiency, greenness, mild conditions, wide substrate application range and the like, and provides a new thought for synthesis of the hydroxylamine compound.

The invention discloses a water-based drilling fluid inhibitor, a water-based drilling fluid and application of the water-based drilling fluid, and belongs to the technical field of drilling fluids. The water-based drilling fluid inhibitor is prepared by the following steps: reacting 4, 4 '-diaminodiphenyl ether with epichlorohydrin to generate a substitution product, reacting the substitution product with 10-aminodecanoic acid to generate a hydroxylamine compound, and finally reacting the hydroxylamine compound with N, N-bis (3-aminopropyl) dodecylamine. The water-based drilling fluid comprises the following components in parts by weight: 100 parts of deionized water, 2-4 parts of an inhibitor, 5-10 parts of bentonite, 1-3 parts of a blocking agent, 2-8 parts of a lubricant, 1-4 parts of a filtrate reducer, 10-40 parts of barite powder and 0.5-1 part of sodium hydroxide. The water-based drilling fluid prepared by the invention can be used for inhibiting hydration expansion of shale, and has good lubricating property.

The invention belongs to the field of chemical synthesis, and particularly relates to a hydroxylamine compound containing an aryl allyl structure as well as a synthesis method and application of the hydroxylamine compound. The structure of the hydroxylamine compound is shown as a formula (I), and in the formula (I), R1 is selected from unsubstituted alkyl, cycloalkyl, naphthyl, heteroaryl or substituted or unsubstituted phenyl; r2 is selected from substituted or unsubstituted phenyl; the synthesis method comprises the following steps: by taking nitrone and boric acid as raw materials, efficiently synthesizing through a boron migration reaction under the catalysis of R-1, 1 '-co-2-naphthol. The synthesis method has the characteristics that a metal catalyst is not needed, the operation is simple and convenient, the organic boric acid is easy to obtain and environment-friendly, the reaction condition is mild, the substrate application range is wide, the yield is medium to good and the like, and a new thought is provided for synthesis of the hydroxylamine compound. In-vitro experiments show that the compound has remarkable proliferation inhibition activity on A549, HeLa and MV-411 tumor cells, and has the development potential of antitumor drugs.

The application discloses acrylic modified silicone oil and a preparation method thereof, and the method comprises the following steps: subjecting an allyl-containing acrylate to a Michael addition reaction with a secondary amine to obtain an N,N-dialkyl-beta-alanine ester containing an allyl group; subjecting the N,N-dialkyl-beta-alanine ester containing the allyl group to a hydrosilylation reaction with a hydrogen-containing silicone oil in the presence of a platinum gold catalyst to obtain a tertiary amino modified silicone oil; subjecting the tertiary amino modified silicone oil to a reaction with an oxidant to generate an amine oxide modified silicone oil; and subjecting the amine oxide modified silicone oil to heating to undergo Cope elimination, and removing a hydroxylamine compound to obtain the acrylic modified silicone oil. The preparation method of the application effectively solves the problems of crosslinking gelation and wide molecular weight distribution in the direct hydrosilylation method through amine protection and oxidation elimination strategies, and simultaneously avoids the introduction of chloride ions in the acid chloride method and the complex equipment requirement in the ester exchange method.

The invention provides a preparation method of olpinapone, which comprises the following steps: 1, dissolving a compound SM1 and a hydroxylamine compound in a solvent, heating, and carrying out addition reaction to obtain M1; 2, dissolving M1 and a compound SM2 in a solvent, heating, carrying out a cyclization reaction to generate a dihydrodioxazole intermediate, adding alkali into a reaction system, carrying out an oxidation reaction to generate a 1, 2, 4-oxadiazole intermediate, when R is equal to H, pulping and purifying to obtain M2-1, and carrying out a nitration reaction to obtain a compound M2; 3, dissolving the M2 in a reaction solvent, adding aluminum trichloride, adding pyridine, heating, and carrying out a demethylation reaction to obtain M3; and step 4, adding the M3 into a reaction solvent, adding an oxidizing agent and acid anhydride, carrying out oxidation reaction, after the reaction is finished, evaporating to remove the solvent, adding residues into a benign solvent 1, heating, stirring and dissolving, dropwise adding an anti-solvent 2, and recrystallizing to obtain the oxicapone. The preparation method provided by the invention has the advantages of short reaction steps, reduced cost, mild reaction conditions and highest product purity.

The invention relates to the technical field of medicine synthesis, in particular to a C3-site oxime ester steroid alkaloid derivative as well as a synthesis method and application thereof. A steroid compound epiandrosterone is used as an initial raw material, a C3-position keto compound is obtained through Wittig alkylenation reaction and oxidation, the C3-position keto compound reacts with hydroxylamine hydrochloride to obtain a hydroxylamine compound, and the hydroxylamine compound reacts with acyl chloride to obtain a series of oxime ester derivatives. The C3-site oxime ester steroid alkaloid derivative provided by the invention has remarkable anti-inflammatory and anti-gastric ulcer activity, and provides a scientific basis for searching novel anti-inflammatory and anti-gastric ulcer lead compounds with high selectivity and safety and developing novel anti-inflammatory and anti-gastric ulcer medicines.

The invention discloses porous spherical vanadium pentoxide as well as a preparation method and application thereof, and belongs to the technical field of batteries. The method comprises the following steps: (1) mixing a vanadium source and a hydroxylamine compound, adding the mixture into deionized water, and stirring to obtain a blue vanadium-containing solution; (2) adjusting the pH value of the vanadium-containing solution to 6.2-8 by using alkali liquor, and reacting at room temperature to obtain a vanadium-based spherical precursor; and (3) drying the vanadium-based spherical precursor, and calcining the dried vanadium-based spherical precursor to obtain porous spherical vanadium pentoxide. The synthesis route is simple and convenient, the energy consumption is low, the consumed time is short, the preparation yield is high, and the prepared spherical vanadium pentoxide has rich pore structures and can be used as an aqueous zinc ion battery positive electrode material and a lithium ion battery positive electrode material, so that the specific capacity and the cycling stability of the battery are improved.

The present invention addresses the problem of providing a cleaning agent composition for semiconductor devices, which has excellent long-term stability of the ability to remove organic residues and also has excellent corrosion resistance to metal layers. This cleaning agent composition for semiconductor devices contains: one or more hydroxylamine compounds selected from the group consisting of hydroxylamine and hydroxylamine salts; one or more chelating agents selected from the group consisting of carboxylic acid-based chelating agents other than polyaminocarboxylic acids and phosphonic acid-based chelating agents; and a benzotriazole compound.

The present invention addresses the problem of providing a cleaning agent composition for semiconductor devices, which has excellent long-term stability of the ability to remove organic residues and also has excellent corrosion resistance to metal layers. This cleaning agent composition for semiconductor devices contains: one or more hydroxylamine compounds selected from the group consisting of hydroxylamine and hydroxylamine salts; one or more chelating agents selected from the group consisting of carboxylic acid-based chelating agents other than polyaminocarboxylic acids and phosphonic acid-based chelating agents; and a benzotriazole compound.

The present invention addresses the problem of providing a cleaning agent composition for semiconductor devices, which has excellent long-term stability of the ability to remove organic residues and also has excellent corrosion resistance to metal layers. This cleaning agent composition for semiconductor devices contains: one or more hydroxylamine compounds selected from the group consisting of hydroxylamine and hydroxylamine salts; one or more chelating agents selected from the group consisting of carboxylic acid-based chelating agents other than polyaminocarboxylic acids and phosphonic acid-based chelating agents; and a benzotriazole compound.

The invention relates to a tricyclic thiazolo [5, 4-d] pyrimidone amine derivative and application thereof.The preparation method comprises the steps that ethyl cyanoacetate serves as a raw material, a hydroxylamine compound (A) is generated under the action of sodium nitrite and phosphoric acid, 2-amino ethyl cyanoacetate (B) is obtained through reduction, the 2-amino ethyl cyanoacetate (B) is subjected to a reaction with acetic anhydride and Lawson to obtain a 5-amino-4-formate thiazole compound (D), and the 5-amino-4-formate thiazole compound (D) is subjected to a reaction with acetic anhydride and Lawson to obtain the tricyclic thiazolo [5, 4-d] pyrimidone amine derivative. The preparation method comprises the following steps: under the action of phosphorus oxychloride, obtaining a 2-bromo-pyrroline [1, 2-a] thiazolo [5, 4-d] pyrimidinone compound (F), a 2-bromine-7, 8-dihydro-5H-pyridine [1, 2-a] thiazolo [5, 4-d] pyrimidine-10 (6H) ketone derivative (G) and a 2-bromine-6, 7, 8, 9-tetrahydrothiazolo [5 ', 4': 4, 5] pyrimidino [1, 2-a] azepine-11 (5H)-ketone (H); 36 different substituted tricyclic thiazolopyrimidinone amine compounds F1-F12, G1-G12 and H1-H12 are obtained under the action of alkali, and the inhibitory activity of the 36 compounds on cancer cells is investigated.

The purpose of the present invention is to provide an electroless ruthenium plating bath in which hydrazine is used as a reducing agent, said electroless ruthenium plating bath being capable of improving bath stability, having excellent ruthenium deposition properties, and being capable of suppressing shrinkage of a coating film during annealing treatment. The electroless ruthenium plating bath at least contains a ruthenium compound, a reducing agent and a stabilizing agent, the reducing agent is hydrazine, the stabilizing agent is composed of a hydroxylamine compound and an organic compound with hydroxyl, and the hydroxylamine compound is at least one of hydroxylamine sulfate and hydroxylamine chloride; the organic compound having a hydroxyl group is at least one selected from the group consisting of gluconolactone, sorbitol, mannitol, and citric acid monohydrate.