The invention discloses a persimmon leaf polyphenol with whitening and sunscreen activity and its preparation method and application. Persimmon leaf residue powder; (2) Add 3 times the weight of distilled water to the persimmon leaf residue powder, adjust the pH to 5.5, add protease, mix thoroughly, place in a constant temperature water bath at 60°C for 1 hour, add an organic extractant and let it stand 8h, sonicate for 20min, and centrifuge at 3000r/min to obtain a supernatant, repeat twice, combine the supernatant, recover the organic extractant under reduced pressure, and obtain a concentrated solution; (3) extract the concentrated solution with an organic extractant, The mixed extract was left to stand for 10 hours, and after the layers were separated, the organic extract layer was discarded, concentrated under reduced pressure, and vacuum freeze-dried to obtain persimmon leaf polyphenols. The invention can scavenge free radicals, has anti-oxidation effect, can well absorb ultraviolet rays, and inhibits the formation of melanin, so as to achieve the effect of whitening and sun protection.