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Irradiation-proof serum separating medium

A serum separation gel and radiation-resistant technology, which is applied in the field of radiation-resistant serum separation gel, can solve the problems of being unable to withstand radiation and cannot meet the requirements of radiation sterilization for medical device enterprises, and achieve simplified production processes, improved product appearance and Thixotropic properties, effects of good physiological inertia

Active Publication Date: 2012-10-31
湖北新德晟材料科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Previously, the domestic serum separation gel (including the products produced by our company) used silicone production technology. This separation gel was not resistant to radiation (Co-60 gamma rays), and could not meet the requirements of radiation sterilization for medical device companies.

Method used

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  • Irradiation-proof serum separating medium
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  • Irradiation-proof serum separating medium

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Add 5.2 g of benzoyl peroxide into a mixed solvent of 100 g of methyl methacrylate and 400 g of n-butyl acrylate, stir well to make it completely dissolve to obtain a mixed solution, 50 g of 2,3-dimethylpentane, 3 -The mixture of 150g of methyl hexane, 200g of methylcyclohexane and 50g of ethyl acetate is used as the reaction solvent, the mixed solution is added dropwise in the reaction solvent, and the temperature of the solvent is controlled at 85-90°C during the dropping process, The dropwise addition time was 1 hour and 12 minutes. After the dropwise addition, keep warm at 95-100°C, continue the reaction for 1 hour, then raise the temperature to 110°C, remove the reaction solvent and low molecules that did not participate in the reaction in vacuo, and obtain a polymer 493.3 g, volatile matter 1.2%, viscosity 73000mPa.s. Stir 100 g of fumed silica (Tokuyama QS-102) and 2 g of hexamethyldisilazane in a planetary mixer at a low speed (15 r / min) for 3 hours, then let it...

Embodiment 2

[0038] Add 6 g of benzoyl peroxide to a mixed solvent of 50 g of methyl methacrylate, 350 g of n-butyl acrylate, and 100 g of ethyl acrylate, and stir fully to make it dissolve to obtain a mixed solution, 300 g of methylcyclohexane, 300 g of n-butyl acrylate, The mixture of heptane 270g, ethyl acetate 30g, and 2-methyl-3-ethylpentane 100g is used as a reaction solvent, and the mixed solution is added dropwise in the reaction solvent, and the temperature of the solvent is controlled at 90- Between 95°C, the dropping time is 1 hour and 05 minutes. After the dropwise addition, keep warm at 100-105°C, continue the reaction for 1 hour, then raise the temperature to 110°C, remove the reaction solvent and low molecular weight that did not participate in the reaction in a vacuum , to obtain polymer 495.6g, 1.5% volatile matter, viscosity 76000mPa.s. Stir 100g of fumed silica (Wacker T40), 1g of hexamethyldisilazane, and 1g of vinyltrimethoxysilane in a planetary mixer at a low speed (...

Embodiment 3

[0044]Add 5.2 g of benzoyl peroxide into a mixed solvent of 150 g of ethyl acrylate and 350 g of n-butyl acrylate and fully stir and dissolve to obtain a mixed solution, 100 g of 2,3-dimethylpentane, 350 g of methylcyclohexane, The mixture of 2-methyl-3-ethylpentane 50g is used as the reaction solvent, and the mixed liquid is added dropwise to the reaction solvent, and the temperature of the solvent is controlled at 90-95°C during the dropping process, and the dropping time is 1 hour and 30 After the dropwise addition, keep warm at 100-105°C, continue the reaction for 1 hour, then increase the temperature to 110°C, remove the reaction solvent and low molecular weight that did not participate in the reaction in vacuo, and obtain 472.1g of polymer, with a volatile content of 1.2% , Viscosity 55000mPa.s. Put 100g of fumed silica (Wacker T40), 0.5g of vinyltriethoxysilane, and 1.5g of γ-methacryloxypropyltrimethoxysilane in a planetary mixer at a low speed (15r / min ) after stirri...

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Abstract

The invention belongs to the technical field of preparation of high polymers and particularly discloses an irradiation-proof serum separating medium and a preparation method thereof. The irradiation-proof serum separating medium is made of the following materials by weight: 100 parts of acrylate, 0.8-2 parts of benzoyl peroxide, 1-4 parts of hydrophilic gas-phase silicon dioxide, 0.02-0.10 part of a silane coupling agent and 60-120 parts of an organic solvent. The irradiation-proof serum separating medium provided by the invention has the advantages that the product performance is stable, favorable physiologic inertia, thixotropy and closure are achieved, the appearance is colorless and transparent, and each physiologic inertia index meets the requirement according to hospital clinical examinations. The irradiation absorbed dose reaches 25 kGy, after irradiation, the irradiation-proof serum separating medium can be stored naturally for one year without obvious change in each product parameter, the performance completely meet customer demands, the product production process is safe and environment-friendly, and the production technology meets the requirement of cleaner production. The successful development of the product fills the gap of irradiation-proof serum separating medium in China.

Description

technical field [0001] The invention relates to the technical field of polymer preparation, in particular to an anti-irradiation serum separating gel. Background technique [0002] Serum separation gel is an important material in the pretreatment of blood tests. Its main function is to completely separate the serum and thrombus in the blood sample and completely accumulate in the center of the test tube to form a barrier to prevent the exchange of components between the two and ensure the accuracy of the test results. accuracy. Especially in the process of storage and transportation of blood samples, it is more necessary to isolate the blood samples. Its working principle is: serum separation gel is a material with good physiological inertia, sealing and thixotropy, and its specific gravity (1.050-1.070g / cm 3 ) between serum (1.032g / cm 3 ) and thrombus (1.090g / cm 3 ), after blood collection, wait for the blood to coagulate, and centrifuge through a centrifuge under certa...

Claims

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Application Information

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IPC IPC(8): C08L33/08C08K9/06C08K3/36C08F220/18C08F220/14G01N1/34
Inventor 王中喜谈怀宗沈典超
Owner 湖北新德晟材料科技有限公司
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