Combined antibiotic medicine for inhibiting beta-lactamase

A lactamase and drug technology, applied in the field of compound preparations and beta-lactamase inhibitors, can solve the problems of decreased efficacy and drug resistance of cefminox

Inactive Publication Date: 2004-09-08
周宇
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  • Abstract
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  • Claims
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Problems solved by technology

[0005] The invention aims at the problem that the curative effect of cefminox is decreased due to the resistant bacteria producing β-lactamase, and provides an antibacterial combination drug for

Method used

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  • Combined antibiotic medicine for inhibiting beta-lactamase

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Embodiment 1

[0041] Embodiment 1: Under aseptic and clean conditions, 10 kilograms of cefminox sodium (calculated by cefminol) and 1 kilogram of potassium clavulanate (calculated by active acid) are mixed, and the powder injection preparation process is operated to prepare this product. Invented 10,000 powder injections.

Embodiment 2

[0042] Embodiment 2: Under aseptic and clean conditions, 10 kilograms of cefminox sodium (calculated by cefminol) and 20 kilograms of clavulanic acid potassium (calculated by active acid) are mixed, and the powder injection preparation process is operated to prepare this product. Invented 10,000 powder injections.

Embodiment 3

[0043] Embodiment 3: under aseptic and clean conditions, 10 kilograms of cefminox sodium (calculated by cefminol) and 2 kilograms of potassium clavulanate (calculated by active acid) are mixed, and are operated by the preparation process of freeze-dried powder injection, Prepare 10000 powder injections of the present invention.

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Abstract

The combined antibiotic medicine for inhibiting beta-lactamase is prepared by combining Cefminox as one kind of the third generation of cephalosporin and beta-lactamase inhibitor in certain weight ratio. The Cefminox is in the form of its alkali metal salt or its free acid plus co-solvent; and the beta-lactamase inhibitor is Sulbactam, Clavulanic acid, tazobactam or their derivative, such as Sulperazon, tazobactam sodium, potassium Clavulanate, etc. The beta-lactamase inhibitor and Cefminox of the present invention have obvious synergistic antibiotic effect and this makes it possible to solve the increasing resistance of pathogenetic bacteria to Cefminox clinically.

Description

technical field [0001] The invention relates to an antibiotic compound drug for inhibiting β-lactamase produced by bacteria, specifically a compound preparation composed of a β-lactamase inhibitor and third-generation cephalosporin antibiotic-cefminox. Background technique [0002] Cephalosporin antibiotics have been widely used clinically, and have achieved therapeutic effects that are difficult to achieve with traditional antibiotics. However, due to the long-term and extensive clinical use of antibiotics, and even the abuse of antibiotics, bacteria have become increasingly resistant to antibiotics. For example, penicillin in β-lactams was particularly effective when used 200,000 units each time in clinical practice in the 1950s, but now it is difficult to achieve results when 800,000 units are used each time. Cephalosporins, which belong to the same β-lactam class, also have obvious bacterial resistance. Cefminox (Cefminox) is the third-generation cep...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/546A61P31/04
Inventor 周宇
Owner 周宇
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