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A kind of serum separating gel and preparation method thereof

A serum separation gel and a separation gel technology, which are applied in the field of serum separation gel and its preparation, can solve the problems of difficulty in increasing the specific gravity of products, inaccurate sampling of probes, interference with test results, etc., and achieve mature and perfect production technology and safe production process. The effect of environmental protection and wide product selectivity

Active Publication Date: 2019-05-07
昆泰锐(武汉)生物技术有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent CN1046036C discloses a serum separation gel composed of silicone rubber, macromolecular hydrocarbons, and hydrophobic silica gel. The compatibility between its components is poor, and it is sensitive to relative separation in a short period of time. Poor thixotropy, unable to separate serum and blood cells normally
In some cases, water-insoluble substances can be observed floating in the serum after centrifugation, causing inaccurate sampling of the probe of the automatic analyzer during the test, interfering with the test results, and even causing the analysis instrument to fail to operate
Chinese patent CN1102241C discloses a serum or plasma separation composition, which includes cyclopentadiene oligomer, organic gelling agent and organic gelling agent dispersant, which contains two kinds of polymers, so that the dispersion of molecular weight distribution is not easy to control , to increase the difficulty of controlling the proportion of products
Previously, the domestic serum separation gel (including the products produced by our company) used silicone production technology. This separation gel was not resistant to radiation (Co-60 gamma rays), and could not meet the requirements of radiation sterilization for medical device companies.

Method used

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  • A kind of serum separating gel and preparation method thereof
  • A kind of serum separating gel and preparation method thereof
  • A kind of serum separating gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Prepare serum-separating gels by:

[0031] S1: quaternary ammonium salt ions and halide ions are prepared into an ionic liquid with a density of 1.2g / ml;

[0032] S2: The 5g hydrophilic fumed silica powder (specific surface area 200m 2 / g, the bulk density is 60kg / m 3 ) and 0.02g hexamethyldisilazane were stirred in a planetary mixer for 3 hours (15r / min), then left to stand for 12 hours to obtain a carrier-silane coupling agent blend;

[0033] S3: Stir 100 g of the ionic liquid and the carrier-silane coupling agent blend in a planetary mixer for 4 hours (40 r / min) to fully disperse the carrier in the ionic liquid to obtain the serum separating gel.

[0034] Preferably, in S2, the carrier-silane coupling agent blend is obtained by stirring the carrier and the silane coupling agent in a mixer for 3 hours, and then standing for 12 hours;

[0035] S4: Vacuum (0.1MPa) to remove air bubbles.

[0036] The product testing results are shown in Table 1:

[0037] The charact...

Embodiment 2

[0041] Prepare serum-separating gels by:

[0042] S1: Pyrrole salt ions and tetrafluoroborate ions were prepared into an ionic liquid with a density of 1.15g / ml;

[0043] S2: The 5g hydrophilic fumed silica powder (specific surface area 240m 2 / g, the bulk density is 80kg / m 3 ) and 0.02g hexamethyldisilazane were stirred in a planetary mixer for 3 hours (15r / min), then left to stand for 12 hours to obtain a carrier-silane coupling agent blend;

[0044] S3: Stir 100 g of the ionic liquid and the carrier-silane coupling agent blend in a planetary mixer for 4 hours (40 r / min) to fully disperse the carrier in the ionic liquid to obtain the serum separating gel.

[0045] Preferably, in S2, the carrier-silane coupling agent blend is obtained by stirring the carrier and the silane coupling agent in a mixer for 3 hours, and then standing for 12 hours;

[0046] S4: Vacuum (0.1MPa) to remove air bubbles.

[0047] The product testing results are shown in Table 2:

[0048] The charac...

Embodiment 3

[0052] Prepare serum-separating gels by:

[0053] S1: Preparation of quaternary phosphonium salt ions and halide ions into an ionic liquid with a density of 1.1 g / ml;

[0054] S2: The 6g hydrophilic fumed silica powder (specific surface area 260m 2 / g, the bulk density is 90kg / m 3 ) and 0.05g vinyltrimethoxysilane were stirred in a planetary mixer for 3 hours (15r / min), and then left to stand for 12 hours to obtain a carrier-silane coupling agent blend;

[0055] S3: Stir 100 g of the ionic liquid and the carrier-silane coupling agent blend in a planetary mixer for 4 hours (40 r / min) to fully disperse the carrier in the ionic liquid to obtain the serum separating gel.

[0056] Preferably, in S2, the carrier-silane coupling agent blend is obtained by stirring the carrier and the silane coupling agent in a mixer for 3 hours, and then standing for 12 hours;

[0057] S4: Vacuum (0.1MPa) to remove air bubbles.

[0058] The product testing results are shown in Table 3:

[0059] ...

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Abstract

The invention relates to a preparation method of a serum separation gel. The serum separation gel is prepared from the following raw materials in parts by weight: 100 parts of room temperature ion liquid, 5-10 parts of a carier and 0.02-0.1 part of a silane coupling agent. The invention further relates to the serum separation gel prepared by virtue of the preparation method. The serum separation gel can play a role of the ion liquid, the specific gravity of the separation gel can be adjusted, and the product selectivity is wide; the serum separation gel has the characteristics of being capable of resisting radiation and hydrolysis and good in stability; and the serum separation gel has the features of low toxin, environmental friendless and safety, simultaneously has a natural anti-coagulation effect, is a high-end serum separation gel and has wide market potentials.

Description

technical field [0001] The invention relates to the field of medical materials, more particularly, to a serum separating gel and a preparation method thereof. Background technique [0002] In clinical medical testing, blood samples used for clinical testing items such as biochemical indicators, immunological indicators, coagulation function analysis, and nucleic acid testing are usually separated by serum separation gel. Vacuum blood collection tubes or other non-vacuum collection containers are usually used for blood sample collection, and serum or plasma samples are separated by centrifugation after blood collection. In order to improve the quality of specimens, some compositions that use the difference in specific gravity between blood components to separate serum gradually appear in the market. These compositions are placed at the bottom of the blood collection tube before blood collection, centrifuged after blood collection, and the gradient density principle is used t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D17/02B01D17/038
CPCB01D17/02B01D17/0217
Inventor 谢洪学王美美
Owner 昆泰锐(武汉)生物技术有限责任公司
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