7 results about "Cyanoacetamide" patented technology

The invention relates to the technical field of organic synthesis, in particular to a preparation method of 1, 1-cyclohexyl diacetic acid. The preparation method comprises the following steps: taking cyclohexanone and ethyl cyanoacetate as raw materials to react and dehydrate to prepare a product 1, then reacting cyanoacetamide, sodium methoxide and the product 1 at low temperature to obtain a product 2, and then hydrolyzing the product 2 under the catalysis of a magnetic solid double-acid catalyst to obtain the 1, 1-cyclohexyl diacetic acid. The used magnetic solid double-acid catalyst is prepared by loading a metal active layer and a sulfonic acid group on a magnetic mesoporous silicon dioxide carrier step by step, and has Lewis acid and Bronsted acid sites, and the catalyst is separated by an external magnetic field after the reaction. The method is short in reaction time and high in catalytic efficiency, the catalyst can be recycled, the separation problem of traditional homogeneous acid catalysis is avoided, and the method has the advantages of being mild in reaction condition, high in yield, environmentally friendly and the like and is suitable for industrial production of 1, 1-cyclohexyl diacetic acid.

The application discloses a catalyst for preparing malononitrile, a preparation method of the catalyst and a method for preparing malononitrile by using the catalyst. The catalyst is a solid catalyst, which is an acidic catalyst loaded with rare earth metal oxide. The method for preparing malononitrile is that cyanoacetic acid or cyanoacetate or cyanoacetamide and an ammonia source are subjected to ammoniation dehydration reaction in a continuous reactor to prepare malononitrile according to a certain molar ratio. Then, vacuum distillation (20 torr-25 torr) is carried out, and a fraction collected at 110 DEG C-120 DEG C is malononitrile product. The ammonia source can be ammonia gas, ammonia water, ammonium carbonate or urea. The method for preparing malononitrile can reduce production cost, improve production safety, reduce the discharge amount of three wastes in the preparation of malononitrile by using an existing process, and improve product quality, and is a sustainable and green synthesis route.

A method of decreasing aldehyde content in a polyoxymethylene (POM) polymer, increasing Oxidative Induction Time (OIT) and / or increasing thermal stability comprises contacting the POM polymer with an aldehyde scavenger selected from: (i) a compound XX which includes at least three moieties of formula (AA) wherein each moiety (AA) includes an amine moiety (—NH2) bonded ortho or meta to the amide moiety (—CONH), each R1 independently represents a substituent and m is an integer from 0 to 4; and the three moieties (AA) are bonded, via their respective amide nitrogen atoms, to respective carbon atoms of a Main Fragment, wherein the Main Fragment includes carbon and hydrogen atoms only and is saturated; and (ii) a cyanoacetamide.

The application belongs to the technical field of medicine synthesis, and particularly relates to a gemigim intermediate compound and a preparation method thereof. The gemigim new intermediate compound is obtained by reacting alpha-cyanoacetamide, triethyl orthoacetate and triethyl orthoformate as starting materials. The new intermediate is cyclized to obtain a gemigim key intermediate compound 3-cyano-4-methoxy-2(1H)-pyridinone. The new intermediate synthesis method provided by the application is simple, triethyl orthoformate is used as a 'one-carbon unit' donor, the reagent only produces ethanol in the cyclization process, the use of DMF-DMA can be effectively avoided, and then the generation of dimethylamine gas or its acetate salt is avoided, so that the reaction operation is safer and more environmentally friendly.

The invention relates to the technical field of chemical analysis, and particularly discloses a method for detecting cyanoacetamide related substances. SHIMADZU SH-624 (0.53 mm * 30m * 3.0 [mu] m) is adopted as a detection chromatographic column, 38-42 DEG C is set and maintained for 4-6 min, then the temperature is raised to 235-245 DEG C at the rate of 9-11 DEG C / min and maintained for 8-12 min, the temperature of a sample inlet is 245-255 DEG C, the temperature of a detector is 295-305 DEG C, and the split ratio is 3: 1-15: 1, so that simultaneous quantitative detection of various impurities in cyanoacetamide is realized, and the detection accuracy is high. The method is more beneficial to truly reflecting the quality of the cyanoacetamide, is beneficial to monitoring a cyanoacetamide synthesis process, and has a relatively high practical value.

The application discloses a purification method of C5-C7 components in bio-naphtha, and particularly relates to the technical field of bio-naphtha purification, and comprises the following steps: mixing bio-naphtha with a specific impurity removal reaction liquid, standing, centrifuging, suction filtering to remove water, inorganic salt and acidic gas, and obtaining impurity-removed naphtha; then mixing the impurity-removed naphtha with a target extraction liquid for extraction, distilling to recover the solvent, and rectifying and separating to obtain high-purity C5-C7 components. The impurity removal reaction liquid is prepared from 2-cyanoacetamide and 3-aminopropyl triethoxysilane under the catalysis of anhydrous zinc chloride, and the target extraction liquid is prepared from alpha-angelica lactone and 1-phenylethylamine under the action of triethylamine. The method is simple in operation, mild in conditions, and can efficiently remove impurities, the purity of C5-C7 components is up to 99.8%, the extraction yield is up to 95%, the recovery rate of n-pentane is high, the problems of poor purification effect and high energy consumption in the prior art are solved, the method is suitable for industrial production, and the utilization value of bio-naphtha is improved.

The application provides a synthesis method of resmetirom. Compound 1 is used as a starting material, is reacted with hydrazine hydrate to obtain compound 2, is chlorinated to obtain 3,6-dichloro-4-isopropyl pyridazine compound 3, is hydrolyzed to obtain compound 4, is condensed with compound 5 to obtain a key compound 6 of resmetirom, is subjected to nitrosation, is condensed with a cyanoacetamide compound 7 to obtain an intermediate compound 8, and is subjected to ring closure to obtain the target product resmetirom 9. The method has mild reaction conditions and high conversion rate. The route not only greatly shortens the synthesis route, greatly improves the route efficiency, reduces the process cost, but also reduces the nitrosamine risk, is beneficial to improving the purity of the final product, and is suitable for scale-up production.